| 论文题目： |
Convergent evolution-guided design of antimicrobial peptides derived from influenza A virus hemagglutinin |
| 论文题目英文： |
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| 作者： |
朱顺义*，#Andr e Aumelas，高斌 |
| 论文出处： |
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| 年： |
2011 |
| 卷： |
54 |
| 期： |
4 |
| 页： |
1091-1095 |
| 联系作者： |
朱顺义 |
| 发表期刊： |
Journal of Medicinal Chemistry |
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| 第一作者所在部门： |
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| 收录类别： |
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| 论文连接 |
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| 影响因子： |
5.207 |
| 摘要: |
Antimicrobial activity and solution structures of four 13-amino acid peptides derived from the fusion domain of viral hemagglutinin proteins are presented. The results show that carboxyl-terminal amidation is a key factor to switch a viral fusion domain-derived sequence into an antimicrobial peptide. Optimization of amphiphilic balance on the amidated analogue largely improves efficacy and enlarges antimicrobial spectra of these peptides. Our work indicates that viral fusion domains have potential to be engineered into potent antimicrobial peptides.
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| 英文摘要： |
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| 外单位作者单位： |
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