论文
论文题目: Telomere- and telomerase-interacting protein that unfolds telomere G-quadruplex and promotes telomere extension in mammalian cells
论文题目英文:
作者: 汪峰①,汤明亮①,#Zhi-xiong Zeng, 吴壬乙, #Yong Xue, 郝玉华,#Dai-Wen Pang,#赵勇①,谭铮*
论文出处:
年: 2012
卷: 109
期: 50
页: 20413-20418
联系作者: 谭铮
发表期刊: PNAS
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第一作者所在部门:
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论文连接 http://www.pnas.org/content/early/2012/11/21/1200232109.abstract
影响因子: 9.681
摘要:
Telomere extension by telomerase is essential for chromosome stability and cell vitality. Here, we report the identification of a splice variant of mammalian heterogeneous nuclear ribonucleoprotein A2 (hnRNP A2), hnRNP A2*, which binds telomeric DNA and telomerase in vitro. hnRNP A2* colocalizes with telomerase in Cajal bodies and at telomeres. In vitro assays show that hnRNP A2* actively unfolds telomeric G-quadruplex DNA, exposes 5 nt of the 3' telomere tail and substantially enhances the catalytic activity and processivity of telomerase. The expression level of hnRNP A2* in tissues positively correlates with telomerase activity, and overexpression of hnRNP A2* leads to telomere elongation in vivo. Thus, hnRNP A2* plays a positive role in unfolding telomere G-quadruplexes and in enhancing telomere extension by telomerase. 
 
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