| 论文题目： | CRL4 Complex Regulates Mammalian Oocyte Survival and Reprogramming by Activation of TET Proteins |
| 论文题目英文： | |
| 作者： | #Chao Yu， #Yin-Li Zhang， #Wei-Wei Pan， #Xiao-Meng Li， 2王忠伟， 2葛照嘉， #Jian-Jie Zhou， #Yong Cang， #佟超， 2孙青原*， #范衡宇* |
| 论文出处： | |
| 年： | 2013 |
| 卷： | 342 |
| 期： | 6165 |
| 页： | 1518-1521 |
| 联系作者： | 孙青原, #范衡宇 |
| 发表期刊： | SCIENCE |
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| 论文连接 | http://www.sciencemag.org/content/342/6165/1518.abstract?sid=59c63f3d-b2ae-4825-bbff-3bc3a8b1b5af |
| 影响因子： | |
| 摘要: | The duration of a woman’s reproductive period is determined by the size and persistence of a dormant oocyte pool. Specific oocyte genes are essential for follicle maintenance and female fertility. The mechanisms that regulate the expression of these genes are poorly understood. We found that a cullin-ring finger ligase-4 (CRL4) complex was crucial in this process. Oocyte-specific deletion of the CRL4 linker protein DDB1 or its substrate adaptor VPRBP (also known as DCAF1) caused rapid oocyte loss, premature ovarian insufficiency, and silencing of fertility maintaining genes. CRL4VPRBP activates the TET methylcytosine dioxygenases, which are involved in female germ cell development and zygote genome reprogramming. Hence, CRL4VPRBP ubiquitin ligase is a guardian of female reproductive life in germ cells and a maternal reprogramming factor after fertilization. |
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