论文
论文题目: Windpipe Controls Drosophila Intestinal Homeostasis by Regulating JAK/STAT Pathway via Promoting Receptor Endocytosis and Lysosomal Degradation
论文题目英文:
作者: 任文燕①,张岩①,#Min Li,武龙飞,汪国轮,#Gyeong-Hun Baeg,#尤佳,李周华*,林鑫华*
论文出处:
年: 2015
卷: 11
期: 4
页: e1005180-e1005180
联系作者: 李周华*,林鑫华*
发表期刊: PLoS Genetics
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论文连接 http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005180
影响因子:
摘要: The adult intestinal homeostasis is tightly controlled by proper proliferation and differentiation of intestinal stem cells. The JAK/STAT (Janus Kinase/Signal Transducer and Activator of Transcription) signaling pathway is essential for the regulation of adult stem cell activities and maintenance of intestinal homeostasis. Currently, it remains largely unknown how JAK/STAT signaling activities are regulated in these processes. Here we have identified windpipe (wdp) as a novel component of the JAK/STAT pathway. We demonstrate that Wdp is positively regulated by JAK/STAT signaling in Drosophila adult intestines. Loss of wdp activity results in the disruption of midgut homeostasis under normal and regenerative conditions. Conversely, ectopic expression of Wdp inhibits JAK/STAT signaling activity. Importantly, we show that Wdp interacts with the receptor Domeless (Dome), and promotes its internalization for subsequent lysosomal degradation. Together, these data led us to propose that Wdp acts as a novel negative feedback regulator of the JAK/STAT pathway in regulating intestinal homeostasis.
英文摘要:
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