论文
论文题目: PPM1A Regulates Antiviral Signaling by Antagonizing TBK1-Mediated STING Phosphorylation and Aggregation
论文题目英文:
作者: 李泽兴,Ge Liu,孙立伟,#Yan Teng,#Xue-Jiang Guo,#Jian-Hang Jia,#Jia-Hao Sha,#Xiao Yang,陈大华,孙钦秒*
论文出处:
年: 2015
卷: 11
期: 3
页: e1004783
联系作者: 孙钦秒
发表期刊: PLoS Pathog
ISSN:
第一作者所在部门:
收录类别:
论文连接 http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1004783
影响因子:
摘要: Stimulator of interferon genes (STING, also known as MITA and ERIS) is critical in protecting the host against DNA pathogen invasion. However, the molecular mechanism underlying the regulation of STING remains unclear. Here, we show that PPM1A negatively regulates antiviral signaling by targeting STING in its phosphatase activity-dependent manner, and in a line with this, PPM1A catalytically dephosphorylates STING and TBK1 in vitro. Importantly, we provide evidence that whereas TBK1 promotes STING aggregation in a phosphorylation-dependent manner, PPM1A antagonizes STING aggregation by dephosphorylating both STING and TBK1, emphasizing that phosphorylation is crucial for the efficient activation of STING. Our findings demonstrate a novel regulatory circuit in which STING and TBK1 reciprocally regulate each other to enable efficient antiviral signaling activation, and PPM1A dephosphorylates STING and TBK1, thereby balancing this antiviral signal transduction.
英文摘要:
外单位作者单位: