论文
论文题目: The roles of ERAS during cell lineage specification of mouse early embryonic development
论文题目英文:
作者: 赵振奥①,余洋①,马怀孝①,王晓晓,卢绪坤,Yan-Hua Zhai,张小欣,王海滨,李磊*
论文出处:
年: 2015
卷: 5
期: 8
页: Article No. 150092
联系作者: 李磊
发表期刊: Open Biology
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论文连接 http://rsob.royalsocietypublishing.org/content/5/8/150092
影响因子:
摘要: Eras encodes a Ras-like GTPase protein that was originally identified as an embryonic stem cell-specific Ras. ERAS has been known to be required for the growth of embryonic stem cells and stimulates somatic cell reprogramming, suggesting its roles on mouse early embryonic development. We now report a dynamic expression pattern of Eras during mouse peri-implantation development: its expression increases at the blastocyst stage, and specifically decreases in E7.5 mesoderm. In accordance with its expression pattern, the increased expression of Eras promotes cell proliferation through controlling AKT activation and the commitment from ground to primed state through ERK activation in mouse embryonic stem cells; and the reduced expression of Eras facilitates primitive streak and mesoderm formation through AKT inhibition during gastrulation. The expression of Eras is finely regulated to match its roles in mouse early embryonic development during which Eras expression is negatively regulated by the β-catenin pathway. Thus, beyond its well-known role on cell proliferation, ERAS may also play important roles in cell lineage specification during mouse early embryonic development.
英文摘要:
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