论文
论文题目: The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution
论文题目英文:
作者: 王桂珍①,程昕①,周博,#温浙盛,#黄云超,#Hao-Bin Chen,#Gao-Feng Li,#Zhi-Liang Huang,#Yong-Chun Zhou,#Lin Feng,魏明明,曲丽威,#Yi Cao,周光飚*
论文出处:
年: 2015
卷: 4
期:
页: Article No. e09419
联系作者: 周光飚
发表期刊: eLife
ISSN:
第一作者所在部门:
收录类别:
论文连接 http://elifesciences.org/content/early/2015/11/13/eLife.09419#api_box
影响因子:
摘要: More than 90% of lung cancers are caused by cigarette smoke and air pollution, with polycyclic aromatic hydrocarbons (PAHs) as key carcinogens. In Xuanwei City of Yunnan Province the lung cancer incidence is among the highest in China attributed to smoky coal combustion-generated PAH pollution. Here we screened for abnormal inflammatory factors in non-small cell lung cancers (NSCLCs) from Xuanwei and control regions (CR) where smoky coal was not used, and found that a chemokine CXCL13 was overexpressed in 63/70 (90%) of Xuanwei NSCLCs and 44/71 (62%) of smoker and 27/60 (45%) of non-smoker CR patients. CXCL13 overexpression was associated with the region Xuanwei and cigarette smoke. The key carcinogen bezo(a)pyrene (BaP) induced CXCL13 production in lung epithelial cells and in mice prior to development of detectable lung cancer. Deficiency in cxcl13 or its receptor, cxcr5, abrogated BaP-induced lung cancer in mice, demonstrating CXCL13's critical role in PAH-induced lung carcinogenesis. - See more at: http://elifesciences.org/content/early/2015/11/13/eLife.09419#api_box
英文摘要:
外单位作者单位: