论文
论文题目: Syndecan-4 Negatively Regulates Antiviral Signalling by Mediating RIG-I Deubiquitination via CYLD
论文题目英文:
作者: 林蔚①,张菁①,林海燕①,李泽兴①,孙晓枫,辛帝,杨萌,孙立伟,李林,王红梅,陈大华*,孙钦秒*
论文出处:
年: 2016
卷: 7
期:
页: Article No. 11848
联系作者: 陈大华,孙钦秒
发表期刊: Nature Communications
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论文连接 http://www.nature.com/ncomms/2016/160609/ncomms11848/full/ncomms11848.html
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摘要: Retinoic acid-inducible gene I (RIG-I) plays important roles in pathogen recognition and antiviral signalling transduction. Here we show that syndecan-4 (SDC4) is a RIG-I-interacting partner identified in a yeast two-hybrid screen. We find that SDC4 negatively regulates the RIG-I-mediated antiviral signalling in a feedback-loop control manner. The genetic evidence obtained by using knockout mice further emphasizes this biological role of SDC4 in antiviral signalling. Mechanistically, we show that SDC4 interacts with both RIG-I and deubiquitinase CYLD via its carboxyl-terminal intracellular region. SDC4 likely promotes redistribution of RIG-I and CYLD in a perinuclear pattern post viral infection, and thus enhances the RIG-I–CYLD interaction and potentiates the K63-linked deubiquitination of RIG-I. Collectively, our findings uncover a mechanism by which SDC4 antagonizes the activation of RIG-I in a CYLD-mediated deubiquitination-dependent process, thereby balancing antiviral signalling to avoid deleterious effects on host cells.
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