论文
论文题目: Whole-Genome Sequencing of Native Sheep Provides Insights into Rapid Adaptations to Extreme Environments
论文题目英文:
作者: 杨继①,#Wen-Rong Li①,吕锋骅①,#San-Gang He①,#Shi-Lin Tian①,彭威风,#Ya-Wei Sun,赵永欣,#Xiao-Long Tu,张敏,谢兴龙,#Yu-Tao Wang,#Jin-Quan Li,#Yong-Gang Liu,#Zhi-Qiang Shen,#Feng Wang,#Guang-Jian Liu,#Hong-Feng Lu,#Juha Kantanen,#Jian-Lin Han,李孟华*,#刘明军*
论文出处:
年: 2016
卷:
期: DOI: 10.1093/molbev/msw129
页:
联系作者: 李孟华,#刘明军
发表期刊: Molecular Biology and Evolution
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论文连接 http://mbe.oxfordjournals.org/content/early/2016/07/07/molbev.msw129.abstract
影响因子:
摘要: Global climate change has a significant effect on extreme environments and a profound influence on species survival. However, little is known of the genome-wide pattern of livestock adaptations to extreme environments over a short time frame following domestication. Sheep (Ovis aries) have become well adapted to a diverse range of agroecological zones, including certain extreme environments (e.g., plateaus and deserts), during their post-domestication (approximately 8–9 kya) migration and differentiation. Here, we generated whole-genome sequences from 77 native sheep, with an average effective sequencing depth of ~5× for 75 samples and ~42× for two samples. Comparative genomic analyses among sheep in contrasting environments, i.e., plateau (> 4,000 m above sea level) versus lowland (< 100 m), high-altitude region (> 1,500 m) versus low-altitude region (< 1,300 m), desert (< 10 mm average annual precipitation) versus highly humid region (> 600 mm), and arid zone (< 400 mm) versus humid zone (> 400 mm), detected a novel set of candidate genes as well as pathways and GO categories that are putatively associated with hypoxia responses at high altitudes and water reabsorption in arid environments. Additionally, candidate genes and GO terms functionally related to energy metabolism and body size variations were identified. This study offers novel insights into rapid genomic adaptations to extreme environments in sheep and other animals, and provides a valuable resource for future research on livestock breeding in response to climate change.
英文摘要:
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