| 论文题目： | Population genomics reveals low genetic diversity and adaptation to hypoxia in snub-nosed monkeys |
| 论文题目英文： | |
| 作者： | 周旭明①*，#Xue-Hong Meng①，刘志瑾①，#常江①，王博石①，#Ming-Zhou Li①，#Pablo Orozco-terWengel，#Shi-Lin Tian，#Chang-Long Wen，王子明，#Paul A Garber，#潘慧娟，#Xin-Ping Ye，#向左甫，#Michael W. Bruford，#Scott V. Edwards，#Yin-Chuan Cao，#Shuan-Cang Yu，#Lian-Ju Gao，#Zhi-Sheng Cao，刘广建，任宝平，史芳磊，#Zalan Peterfi，#黎大勇，#李保国，#Zhi Jiang，#李俊生，#Vadim N. Gladyshev，#李瑞强*，李明* |
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| 年： | 2016 |
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| 期： | DOI: 10.1093/molbev/msw150 |
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| 联系作者： | 周旭明，#李瑞强，李明 |
| 发表期刊： | Molecular Biology and Evolution |
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| 论文连接 | http://mbe.oxfordjournals.org/content/early/2016/07/17/molbev.msw150.abstract |
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| 摘要: | Snub-nosed monkeys (genus Rhinopithecus) are a group of endangered colobines endemic to South Asia. Here, we re-sequenced the whole genomes of 38 snub-nosed monkeys representing four species within this genus. By conducting population genomic analyses, we observed an similar load of deleterious variation in snub-nosed monkeys living in both smaller and larger populations and found that genomic diversity was lower than that reported in other primates. Reconstruction of Rhinopithecusevolutionary history suggested that episodes of climatic variation over the past 2 million years, associated with glacial advances and retreats and population isolation, have shaped snub-nosed monkey demography and evolution. We further identified several hypoxia-related genes under selection in R. bieti (black snub-nosed monkey), a species that exploits habitats higher than any other nonhuman primate. These results provide the first detailed and comprehensive genomic insights into genetic diversity, demography, genetic burden and adaptation in this radiation of endangered primates. |
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