论文
论文题目: Epigenetic Inheritance of Acquired Traits Through Sperm RNAs and Sperm RNA Modifications
论文题目英文:
作者: #陈琦*,#闫威*,段恩奎*
论文出处:
年: 2016
卷:
期: DOI: 10.1038/nrg.2016.106
页:
联系作者: #陈琦,#闫威,段恩奎
发表期刊: Nat Rev Genet
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论文连接 http://www.nature.com/nrg/journal/vaop/ncurrent/full/nrg.2016.106.html
影响因子:
摘要: Once deemed heretical, emerging evidence now supports the notion that the inheritance of acquired characteristics can occur through ancestral exposures or experiences and that certain paternally acquired traits can be 'memorized' in the sperm as epigenetic information. The search for epigenetic factors in mammalian sperm that transmit acquired phenotypes has recently focused on RNAs and, more recently, RNA modifications. Here, we review insights that have been gained from studying sperm RNAs and RNA modifications, and their roles in influencing offspring phenotypes. We discuss the possible mechanisms by which sperm become acquisitive following environmental–somatic–germline interactions, and how they transmit paternally acquired phenotypes by shaping early embryonic development.
英文摘要:
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