论文题目: | Hedgehog Signaling: From Basic Biology to Cancer Therapy |
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作者: | 吴付佳,张玉,孙博,#Andrew P. McMahon,王宇* |
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年: | 2017 |
卷: | 24 |
期: | 3 |
页: | 252-280 |
联系作者: | 王宇 |
发表期刊: | Cell Chemical Biology |
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论文连接 | http://www.sciencedirect.com/science/article/pii/S2451945617300582 |
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摘要: | The Hedgehog (HH) signaling pathway was discovered originally as a key pathway in embryonic patterning and development. Since its discovery, it has become increasingly clear that the HH pathway also plays important roles in a multitude of cancers. Therefore, HH signaling has emerged as a therapeutic target of interest for cancer therapy. In this review, we provide a brief overview of HH signaling and the key molecular players involved and offer an up-to-date summary of our current knowledge of endogenous and exogenous small molecules that modulate HH signaling. We discuss experiences and lessons learned from the decades-long efforts toward the development of cancer therapies targeting the HH pathway. Challenges to develop next-generation cancer therapies are highlighted.
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