论文
论文题目: Hepatokine pregnancy zone protein governs the diet-induced thermogenesis through activating brown adipose tissue
论文题目英文:
作者: Lin,Jun;Jiang,Xiaoxiao;Dong,Meng;Liu,Xiaomeng;Shen,Qiwei;Huang,Yuanyuan;Zhang,Hanlin;Ye,Rongcai;Zhou,Huiqiao;Yan,Chunlong;Yuan,Shouli;Wu,Xiangnan;Chen,Li;Wang,Yanfang;He,Min;Tao,Yi;Zhang,Zhaoyun;Jin,Wanzhu
论文出处:
年: 2021
卷: 8
期: 21
页:
联系作者: 金万洙
发表期刊: Advanced Science
ISSN:
第一作者所在部门:
收录类别:
论文连接 http://onlinelibrary-wiley-com-s.webvpn.ioz.ac.cn/doi/10.1002/advs.202101991
影响因子: 17.521
摘要: Intermittent fasting (IF), as a dietary intervention for weight loss, takes effects primarily through increasing energy expenditure. However, whether inter-organ systems play a key role in IF remains unclear. Here, a novel hepatokine, pregnancy zone protein (PZP) is identified, which has significant induction during the refeeding stage of IF. Further, loss of function studies and protein therapeutic experiment in mice revealed that PZP promotes diet-induced thermogenesis through activating brown adipose tissue (BAT). Mechanistically, circulating PZP can bind to cell surface glucose-regulated protein of 78 kDa (GRP78) to promote uncoupling protein 1 (UCP1) expression via a p38 MAPK-ATF2 signaling pathway in BAT. These studies illuminate a systemic regulation in which the IF promotes BAT thermogenesis through the endocrinal system and provide a novel potential target for treating obesity and related disorders.
英文摘要:
外单位作者单位: