论文
论文题目: DEAD-box helicases modulate dicing body formation in Arabidopsis
论文题目英文:
作者: Li,Qi;Liu,Ningkun;Liu,Qing;Zheng,Xingguo;Lu,Lu;Gao,Wenrui;Liu,Yang;Liu,Yan;Zhang,Shicheng;Wang,Qian;Pan,Jing;Chen,Chen;Mi,Yingjie;Yang,Meiling;Cheng,Xiaofei;Ren,Guodong;Yuan,Yao-Wu;Zhang,Xiaoming
论文出处:
年: 2021
卷: 7
期: 18
页:
联系作者: 张晓明
发表期刊: Science Advances
ISSN:
第一作者所在部门:
收录类别:
论文连接 http://advances-sciencemag-org-s.webvpn.ioz.ac.cn/content/7/18/eabc6266
影响因子: 14.972
摘要: Eukaryotic cells contain numerous membraneless organelles that are made from liquid droplets of proteins and nucleic acids and that provide spatiotemporal control of various cellular processes. However, the molecular mechanisms underlying the formation and rapid stress-induced alterations of these organelles are relatively uncharacterized. Here, we investigated the roles of DEAD-box helicases in the formation and alteration of membraneless nuclear dicing bodies (D-bodies) in Arabidopsis thaliana. We uncovered that RNA helicase 6 (RH6), RH8, and RH12 are previously unidentified D-body components. These helicases interact with and promote the phase separation of SERRATE, a key component of D-bodies, and drive the formation of D-bodies through liquid-liquid phase separations (LLPSs). The accumulation of these helicases in the nuclei decreases upon Turnip mosaic virus infections, which couples with the decrease of D-bodies. Our results thus reveal the key roles of RH6, RH8, and RH12 in modulating D-body formation via LLPSs.
英文摘要:
外单位作者单位: