论文
论文题目: Decoding the Temporal and Regional Specification of Microglia in the Developing Human Brain
论文题目英文:
作者: Li, Yanxin; Li, Zhongqiu; Yang, Min; Wang, Feiyang; Zhang, Yuehong; Li, Rong; Li, Qian; Gong, Yunxia; Wang, Binhong; Fan, Baoguang; Wang, Chunyue; Chen, Lei; Li, Hong; Ong, Jennie; Teng, Zhaoqian; Jin, Lei; Wang, Yan-Ling; Du, Peng; Jiao, Jianwei
论文出处:
年: 2022
卷: 29
期: 4
页: 620-
联系作者: 焦建伟
发表期刊: Cell Stem Cell
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论文连接 https://doi.org/10.1016/j.stem.2022.02.004
影响因子: 25.269
摘要: Region-related heterogeneity and state transitions of microglia are important for brain development and neurological pathogenesis. However, regional specialization and state transition in microglia during early human CNS development remain unclear. Here, we profile single-cell transcriptomes of microglia from distinct regions of the developing human brain, and combined with experimental verification, we define and characterize early microglial fate determinations related to regional specification and state transition. We identified several subclasses of neuronal gene-enriched microglia with regional specification that dynamically and transiently appeared as early brain regions formed. In contrast, immune-related microglia were regionally specialized at later stages of CNS development. Surprisingly, we discovered that region-specialized immune-related microglia exit from a relative resting state and transition into distinct active states. In addition, we experimentally verified the microglial state transition. Finally, we showed that the state transition is conserved but that there are molecular differences in developing microglia in humans and mice.
英文摘要:
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