论文
论文题目: Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor
论文题目英文:
作者: Liu, Zunpeng; Li, Wei; Geng, Lingling; Sun, Liang; Wang, Qiaoran; Yu, Yang; Yan, Pengze; Liang, Chuqian; Ren, Jie; Song, Moshi; Zhao, Qian; Lei, Jinghui; Cai, Yusheng; Li, Jiaming; Yan, Kaowen; Wu, Zeming; Chu, Qun; Li, Jingyi; Wang, Si; Li, Chunyi; Han, Jing-Dong J.; Hernandez-Benitez, Reyna; Shyh-Chang, Ng; Belmonte, Juan Carlos Izpisua; Zhang, Weiqi; Qu, Jing; Liu, Guang-Hui
论文出处:
年: 2022
卷: 8
期: 1
页:
联系作者: 刘光慧
发表期刊: Cell Discovery
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论文连接 https://www.nature.com/articles/s41421-021-00361-3
影响因子: 38.101
摘要: Regenerative capacity declines throughout evolution and with age. In this study, we asked whether metabolic programs underlying regenerative capability might be conserved across species, and if so, whether such metabolic drivers might be harnessed to promote tissue repair. To this end, we conducted metabolomic analyses in two vertebrate organ regeneration models: the axolotl limb blastema and antler stem cells. To further reveal why young individuals have higher regenerative capacity than the elderly, we also constructed metabolic profiles for primate juvenile and aged tissues, as well as young and aged human stem cells. In joint analyses, we uncovered that active pyrimidine metabolism and fatty acid metabolism correlated with higher regenerative capacity. Furthermore, we identified a set of regeneration-related metabolite effectors conserved across species. One such metabolite is uridine, a pyrimidine nucleoside, which can rejuvenate aged human stem cells and promote regeneration of various tissues in vivo. These observations will open new avenues for metabolic intervention in tissue repair and regeneration.
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