群聚信息素是蝗灾暴发的核心驱动因素。继发现4VA为飞蝗群聚信息素（Nature，2020）后，动物所康乐院士团队于2025年再次取得突破性进展：完整解析4VA 的生物合成途径，开发出特异性小分子抑制剂可有效阻断4VA合成，实现了蝗虫聚集行为的精准调控。Nature发表专文评述，成果入选 2025 年度“中国生命科学十大进展”，其科学价值与应用潜力获得多位权威专家的高度认可，被认为“将成为化学生态学教科书级范例”。另外，4VA 信号转导的解析，重塑了领域对昆虫嗅觉信号处理机制的认识；发现蝗虫群、散居型转变的表观遗传机制，为蝗灾防控提供了关键靶点。

研究团队：康乐院士团队

相关科研成果（发表论文、专利、标准等）：

1. Guo, X.J. , Gao, L. , Li, S.W.  , Gao, J., Wang, Y.Y., Lv, J., Wei, J.Y., Yang, J., Ke, H., Ding, Q., Yang, J., Guo, F.S., Zhang, H.W., Lei, X.G. and Kang, L. (2025). Decoding 4-vinylanisole biosynthesis and pivotal enzymes in locusts. Nature, 644: 420-429.
2. Liu, Q., Jiang, F., Li, R., Liu, S.L., Fang, W.J., Li, X., Hu, T., Feng, L.Y., Zhang, J., Liu, Z.K., He, J., Guo, W., Wang, X.H., Sun, Z.Y., Li, J.J., Gao, Y.N., Yi, J.C., Li, Q.Y., Wang, X.X., Wei, L.Y., Kang, L. (2025). Chromatin dynamics of a large-sized genome provides insights into polyphenism and X0 dosage compensation of locusts. Nature Genetics, 57: 2264-2275.
3. Li, X., Jiang, F., Liu, Q., Zhang, Z.Z., Fang, W.J., Wang, Y.T., Liu, H.R., and Kang, L. (2025). GAF-dependent chromatin plasticity determines promoter usage to mediate locust gregarious behavior. The EMBO Journal, 44 (10): 2928-2948. 
4. Yu, Q.Q, Yang, J. , Yu, J., Lei, H., Kang, L. and Guo, X.J. (2025). Locusts employ neuronal sensory prioritization to reconcile two conflicting olfactory signals while aggregating. PNAS, 122: e 2501490122.
5. Yang J., He H., Dong S.J., Lv J., Cheng LL., Yu Q.Q., Kang L. and Guo X.J. (2025). Locusts adopt IP3 as a second messenger for olfactory signal transduction. Science Advances, 11(37): e2375-2548.