| 论文题目： | De novo generation of macrophage from placenta-derived hemogenic endothelium |
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| 作者： | Liang,Guixian;Zhou,Chunyu;Jiang,Xiangxiang;Zhang,Yifan;Huang,Baofeng;Gao,Suwei;Kang,Zhixin;Ma,Dongyuan;Wang,Fengchao;Gottgens,Berthold;Wang,Hongmei;Han,Jing-Dong J.;Liu,Feng |
| 论文出处： | |
| 年： | 2021 |
| 卷： | 56 |
| 期： | 14 |
| 页： | 2121–2133 |
| 联系作者： | 刘峰 |
| 发表期刊： | Developmental Cell |
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| 论文连接 | https://doi.org/10.1016/j.devcel.2021.06.005 |
| 影响因子： | 13.417 |
| 摘要: | Macrophages play pivotal roles in immunity, hematopoiesis, and tissue homeostasis. In mammals, macrophages have been shown to originate from yolk-sac-derived erythro-myeloid progenitors and aorta-gonad-mesonephros (AGM)-derived hematopoietic stem cells. However, whether macrophages can arise from other embryonic sites remains unclear. Here, using single-cell RNA sequencing, we profile the transcriptional landscape of mouse fetal placental hematopoiesis. We uncover and experimentally validate that a CD44(+) subpopulation of placental endothelial cells (ECs) exhibits hemogenic potential. Importantly, lineage tracing using the newly generated Hoxa13 reporter line shows that Hoxa13-labeled ECs can produce placental macrophages, named Hofbauer cell (HBC)-like cells. Furthermore, we identify two subtypes of HBC-like cells, and cell-cell interaction analysis identifies their potential roles in angiogenesis and antigen presentation, separately. Our study provides a comprehensive understanding of placental hematopoiesis and highlights the placenta as a source of macrophages, which has important implications for both basic and translational research. |
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