李伟，研究员，博士生导师，器官再生与智造重点实验室（中国科学院）主任。2006年获武汉大学理学学士学位，2012年获中国科学院大学理学博士学位，2013年加入中国科学院动物研究所工作。作为通讯/共同通讯作者在Cell、Science、Nature等期刊发表论文60余篇，获授权发明专利20余项；研究成果多次入选“中国科学十大进展”和“中国生命科学十大进展”；基于工作进展转化的多个基因与细胞治疗药物进入临床试验阶段。获得国家杰出青年科学基金、优秀青年科学基金、日本实验动物学会“国际奖”、中国科学院“青年科学家奖”、中国科学院杰出科技成就奖（突出贡献者）、中国科学院朱李月华优秀教师奖等资助和奖励。

结合基因工程、细胞工程和合成生物学等手段发展哺乳动物工程生物学这一新的使能平台，探索哺乳动物器官再生修复的机理与路径，开发重大疾病的生物治疗新方法。

　　主持国家重点研发计划项目、中国科学院稳定支持基础研究领域青年团队计划项目等。

(^#：第一作者；*：通讯作者)

1. Chen Y^#, Luo S^#, Hu Y^#, Mao B^#, Wang X^#, Lu Z^#, Shan Q, Zhang J, Wang S, Feng G, Wang C, Liang C, Tang N, Niu R, Wang J, Han J, Yang N, Wang H, Zhou Q*, Li W*. All-RNA-mediated targeted gene integration in mammalian cells with rationally engineered R2 retrotransposons. Cell 2024 Aug 22;187(17):4674-4689.e18. doi: 10.1016/j.cell.2024.06.020. Epub 2024 Jul 8.
2. Cui T^#, Cai B^#, Tian Y, Liu X, Liang C, Gao Q, Li B, Ding Y, Li R, Zhou Q, Li W*, Teng F*. Therapeutic In Vivo Gene Editing Achieved by a Hypercompact CRISPR-Cas12f1 System Delivered with All-in-One Adeno-Associated Virus. Advanced Science (Weinh) 2024 May;11(19):e2308095. doi: 10.1002/advs.202308095. Epub 2024 Feb 26. (Cover story)
3. Wang C^#, Fang S^#, Chen Y^#, Tang N, Jiao G, Hu Y, Li J, Shan Q, Wang X, Feng G, Zhou Q*, Li W*. High-efficiency targeted transgene integration via primed micro-homologues. Cell Discovery 2023 Jul 4;9(1):69. doi: 10.1038/s41421-023-00552-0.
4. Wang LB^#, Li ZK^#, Wang LY^#, Xu K^#, Ji TT^#, Mao YH, Ma SN, Liu T, Tu CF, Zhao Q, Fan XN, Liu C, Wang LY, Shu YJ, Yang N, Zhou Q*, Li W*. A sustainable mouse karyotype created by programmed chromosome fusion. Science 2022 Aug 26;377(6609):967-975. doi: 10.1126/science.abm1964. Epub 2022 Aug 25.
5. Chen Y^#, Hu Y^#, Wang X^#, Luo S, Yang N, Chen Y, Li Z, Zhou Q*, Li W*. Synergistic engineering of CRISPR-Cas nucleases enables robust mammalian genome editing. Innovation (Camb). 2022 May 26;3(4):100264. doi: 10.1016/j.xinn.2022.100264.
6. He ZQ^#, Li YH^#, Feng GH^#, Yuan XW^#, Lu ZB^#, Dai M, Hu YP, Zhang Y, Zhou Q*, Li W*. Pharmacological Perturbation of Mechanical Contractility Enables Robust Transdifferentiation of Human Fibroblasts into Neurons. Advanced Science (Weinh). 2022 May;9(13):e2104682. doi: 10.1002/advs.202104682.
7. Hu Y^#, Chen Y^#, Xu J^#, Wang X, Luo S, Mao B, Zhou Q*, Li W*. Metagenomic discovery of novel CRISPR-Cas13 systems. Cell Discovery 2022 Oct 11;8(1):107. doi: 10.1038/s41421-022-00464-5.
8. Guo L, Sun X, Wang X, Liang C, Jiang H, Gao Q, Dai M, Qu B, Fang S, Mao Y, Chen Y, Feng G, Gu Q, Wang RR*, Zhou Q*, Li W*. SARS-CoV-2 detection with CRISPR diagnostics. Cell Discovery 2020 May 19;6:34. doi: 10.1038/s41421-020-0174-y.
9. Wang LY^#, Li ZK^#, Wang LB^#, Liu C^#, Sun XH^#, Feng GH^#, Wang JQ, Li YF, Qiao LY, Nie H, Jiang LY, Sun H, Xie YL, Ma SN, Wan HF, Lu FL*, Li W*, Zhou Q*. Overcoming Intrinsic H3K27me3 Imprinting Barriers Improves Post-implantation Development after Somatic Cell Nuclear Transfer. Cell Stem Cell 2020 Aug 6;27(2):315-325.e5. doi: 10.1016/j.stem.2020.05.014.
10. Qu B^#, Wu S^#, Jiao G^#, Zou X^#, Li Z^#, Guo L^#, Sun X, Huang C, Sun Z, Zhang Y, Li H, Zhou Q, Sui R*, Li W*. Treating Bietti crystalline dystrophy in a high-fat diet-exacerbated murine model using gene therapy. Gene Therapy 2020 Aug; 27(7-8):370-382.doi: 10.1038/s41434-020-0159-3.
11. Mao J^#, Xu K^#, Han J^#, Feng G, Zhang Y*, Li W*. Rapid construction of a whole-genome mutant library by combining haploid stem cells and inducible self-inactivating PiggyBac transposon. Protein & Cell 2020 Jun;11(6):452-457. doi: 10.1007/s13238-020-00702-0.
12. Teng F^#, Guo L^#, Cui T, Wang XG, Xu K, Gao Q, Zhou Q*, Li W*. CDetection: CRISPR-Cas12b-based DNA detection with sub-attomolar sensitivity and single-base specificity. Genome Biology 2019b Jul 1;20(1):132. doi: 10.1186/s13059-019-1742-z.
13. Teng F^#, Li J^#, Cui T^#, Xu K, Guo L, Gao Q, Feng G, Chen C, Han D, Zhou Q*, Li W*. Enhanced mammalian genome editing by new Cas12a orthologs with optimized crRNA scaffolds. Genome Biology 2019a Feb 5;20(1):15. doi: 10.1186/s13059-019-1620-8.
14. Li Y^#, Wang L^#, Zhang L^#, He Z^#, Feng G, Sun H, Wang J, Li Z, Liu C, Han J, Mao J, Li P, Yuan X, Jiang L, Zhang Y*, Zhou Q*, Li W*. Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I. Journal Of Cell Biology 2019 May 6;218(5):1553-1563. doi: 10.1083/jcb.201808088.
15. Wang J^#, Wang L^#, Feng G^#, Wang Y^#, Li Y, Li X, Liu C, Jiao G, Huang C, Shi J, Zhou T, Chen Q, Liu Z, Li W*, Zhou Q*. Asymmetric expression of LincGET biases cell fate in two-cell mouse embryos. Cell 2018 Dec 13;175(7):1887-1901.e18. doi: 10.1016/j.cell.2018.11.039.
16. Teng F^#, Cui T^#, Feng G, Guo L, Xu K, Gao Q, Li T, Li J, Zhou Q, Li W*. Repurposing CRISPR-Cas12b for mammalian genome engineering. Cell Discovery 2018 Nov 27;4:63. doi: 10.1038/s41421-018-0069-3.
17. Zhang W^#, Wan H^#, Feng G^#, Qu J^#, Wang J, Jing Y, Ren R, Liu Z, Zhang L, Chen Z, Wang S, Zhao Y, Wang Z, Yuan Y, Zhou Q, Li W*, Liu G*, Hu B*. SIRT6 deficiency results in developmental retardation in cynomolgus monkeys. Nature 2018 Aug;560(7720):661-665. doi: 10.1038/s41586-018-0437-z.
18. Li ZK^#, Wang LY^#, Wang LB^#, Feng GH^#, Yuan XW^#, Liu C, Xu K, Li YH, Wan HF, Zhang Y, Li YF, Li X, Li W*, Zhou Q*, Hu BY*. Generation of bimaternal and bipaternal mice from hypomethylated haploid escs with imprinting region deletions. Cell Stem Cell 2018 Nov 1;23(5):665-676.e4. doi: 10.1016/j.stem.2018.09.004.
19. Xu K^#, Yang Y^#, Feng GH^#, Sun BF^#, Chen JQ^#, Li YF, Chen YS, Zhang XX, Wang CX, Jiang LY, Liu C, Zhang ZY, Wang XJ, Zhou Q*, Yang YG*, Li W*. Mettl3-mediated m⁶A regulates spermatogonial differentiation and meiosis initiation. Cell Research 2017 Sep;27(9):1100-1114. doi: 10.1038/cr.2017.100. (Cover story)
20. Li X^#, Cui XL^#, Wang JQ^#, Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Liu ZH, Wang XJ, Li W*, Zhou Q*. Generation and application of mouse-rat allodiploid embryonic stem cells. Cell 2016 Jan 14;164(1-2):279-292. doi: 10.1016/j.cell.2015.11.035.
21. Wan HF^#, Feng CJ^#, Teng F^#, Yang SH^#, Hu BY, Niu YY, Xiang P, Fang WZ, Ji WZ, Li W*, Zhao XY*, Zhou Q*. One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system. Cell Research 2015 Feb;25(2):258-261. doi: 10.1038/cr.2014.158.
22. Li W^#, Li X^#, Li TD^#, Jiang MG^#, Wan HF, Luo GZ, Feng CJ, Cui XL, Teng F, Yuan Y, Zhou Q, Gu Q, Shuai L, Sha JH, Xiao YM, Wang L, Liu ZH, Wang XJ, Zhao XY, Zhou Q*. Genetic modification and screening in rat using haploid embryonic stem cells. Cell Stem Cell 2014 Mar 6;14(3):404-414. doi: 10.1016/j.stem.2013.11.016.
23. Li W^#, Teng F^#, Li T, Zhou Q*. Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems. Nature Biotechnology 2013 Aug;31(8):684-686. doi: 10.1038/nbt.2652.
24. Li W^#, Shuai L^#, Wan H^#, Dong M^#, Wang M, Sang L, Feng C, Luo GZ, Li T, Li X, Wang L, Zheng QY, Sheng C, Wu HJ, Liu Z, Liu L, Wang L, Wang XJ, Zhao XY*, Zhou Q*. Androgenetic haploid embryonic stem cells produce live transgenic mice. Nature 2012 Oct 18;490(7420):407-411. doi: 10.1038/nature11435.
25. Zhao XY^#, Li W^#, Lv Z^#, Liu L, Tong M, Hai T, Hao J, Guo CL, Ma QW, Wang L, Zeng F*, Zhou Q*. iPS cells produce viable mice through tetraploid complementation. Nature 2009 Sep 3;461(7260):86-90. doi: 10.1038/nature08267.

　　独立之精神，自由之思想。