张晓明，男，博士，研究员，博士生导师；中国科学院动物研究所表观与抗性研究组组长。国家高层次人才项目（青年）、国家自然科学基金委“优秀青年基金”、“杰出青年基金”项目、中国科学院引才计划评估优秀获得者。

2001年在南开大学获得学士学位。2007年于北京大学获得博士学位。2008-2014年在加州大学河滨分校进行博士后研究。

聚焦非编码RNA在机体抗性反应中的作用以及细胞器互作对机体抗性反应的意义，从分子生物学、细胞生物学和组学水平上深入解析病原、宿主和虫媒的相互作用：解析机体病毒互作过程中，蛋白质相变介导的与RNA沉默相关的无膜细胞器的发生动态平衡机制，以及这些无膜细胞器对RNA沉默抗性机制发生和病毒增殖的关键调控功能；阐释lncRNA在在作物抗病虫中的作物-病毒互作中的调控功能和作用机制以及非编码RNA在植物抗病虫中的调控网络；阐明哺乳动物免疫过程中非编码RNA的抗性功能和作用机制。相关研究结果在Cell Host & Microbe，Molecular Cell、Science Advances、和The Plant Cell等期刊发表。

　　以解析动植物对病原和虫媒的抗性机制为目的，本研究组的研究重点为：1）非编码RNA在机体抗性反应过程中功能；2）细胞器互作对机体抗性反应的意义。

1. Li Q^#, Liu Y^#, Zhang X*. Biomolecular condensates in plant RNA silencing: insights into formation, function, and stress responses. Plant Cell. 2023; Online ahead of print.
2. Huang J^#, Zhou W^#, Zhang X*, Li Y*. A lncRNA fine-tunes salicylic acid biosynthesis to balance plant immunity and growth. PLoS Pathogens. 2023; e1011340.
3. Liu N^#, Xu Y^#, Li Q, Cao Y, Yang D, Liu S, Wang X, Mi Y, Liu Y, Ding C, Liu Y, Li Y, Yuan YW, Gao G, Chen J*, Qian W*, Zhang X*. A lncRNA fine-tunes salicylic acid biosynthesis to balance plant immunity and growth. Cell Host & Microbe. 2022;30(8):1124-38 e8.
4. Liu Y^#, Rao J^#, Mi Y^#, Chen L, Feng L, Li Q, Geng J, Yang X, Zhan X, Ren L*, Chen J*, Zhang X*. SARS-CoV-2 RNAs are processed into 22-nt vsRNAs in Vero cells. Front Immunol. 2022;13:1008084.
5. Du J, Liu Y, Lu L, Shi J, Xu L, Li Q, Cheng X, Chen J*, Zhang X*. Accumulation of DNA damage alters microRNA gene transcription in Arabidopsis thaliana. BMC Plant Biol. 2022;22(1):576.
6. Cheng Y, Lu T, Guo J, Lin Z, Jin Q, Zhang X*, Zou Z*. Helicoverpa armigera miR-2055 regulates lipid metabolism via fatty acid synthase expression. Open Biol. 2022;12(3):210307.
7. Liu Q^#, Liu Y^#, Li Q^#, Qian W, Zhang X*. Determining the phase separation characteristics of plant proteins. Curr Protoc. 2021;1(9):e237.
8. Li Q^#, Liu N^#, Liu Q^#, Zheng X, Lu L, Gao W, Liu Y, Liu Y, Zhang S, Wang Q, Pan J, Chen C, Mi Y, Yang M, Cheng X, Ren G, Yuan YW, Zhang X*. DEAD-box helicases modulate dicing body formation in Arabidopsis. Science Advances. 2021;7(18).
9. Gao W^#, Liu Y^#, Huang J^#, Chen Y, Chen C, Lu L, Zhao H, Men S*, Zhang X*. MES7 modulates seed germination via regulating salicylic acid content in Arabidopsis. Plants (Basel). 2021;10(5).
10. Zhang B^#, Zhao L^#, Ning J, Wickham JD, Tian H, Zhang X, Yang M, Wang X, Sun J*. miR-31-5p regulates cold acclimation of the wood-boring beetle Monochamus alternatus via ascaroside signaling. BMC Biol. 2020;18(1):184.
11. Liu Y^#, Gao W^#, Wu S^#, Lu L, Chen Y, Guo J, Men S, Zhang X*. AtXRN4 affects the turnover of chosen miRNA*s in Arabidopsis. Plants (Basel). 2020;9(3).
12. 杨美玲, 李琦, 陈佳琦, 张晓明*. RNA 沉默转基因技术在植物抗病虫害研究中的作用. 植物保护, 46 (4), 1-6.
13. Zhao W^#, Xu Z^#, Zhang X, Yang M, Kang L*, Liu R*, Cui F*. Genomic variations in the 3'-termini of Rice stripe virus in the rotation between vector insect and host plant. New Phytol. 2018;219(3):1085-96.
14. Yang M^#, Xu Z^#, Zhao W^#, Liu Q, Li Q, Lu L, Liu R*, Zhang X*, Cui F*. Rice stripe virus-derived siRNAs play different regulatory roles in rice and in the insect vector Laodelphax striatellus. BMC Plant Biol. 2018;18(1):219.
15. Huang J^#, Yang M^#, Zhang X*. The function of small RNAs in plant biotic stress response. J Integr Plant Biol. 2016;58(4):312-27.
16. Huang J^#, Yang M^#, Lu L*, Zhang X*. Diverse functions of small RNAs in different plant-pathogen communications. Front Microbiol. 2016;7:1552.
17. Zhang X, Niu D, Carbonell A, Wang A, Lee A, Tun V, Wang Z, Carrington JC, Chang CE, Jin H*. ARGONAUTE PIWI domain and microRNA duplex structure regulate small RNA sorting in Arabidopsis. Nat Commun. 2014;5:5468.
18. Zhang X, Lii Y, Wu Z, Polishko A, Zhang H, Chinnusamy V, Lonardi S, Zhu JK*, Liu R*, Jin H*. Mechanisms of small RNA generation from cis-NATs in response to environmental and developmental cues. Mol Plant. 2013;6(3):704-15.
19. Zhang X^#, Xia J^#, Lii YE, Barrera-Figueroa BE, Zhou X, Gao S, Lu L, Niu D, Chen Z, Leung C, Wong T, Zhang H, Guo J, Li Y, Liu R, Liang W, Zhu JK, Zhang W*, Jin H*. Genome-wide analysis of plant nat-siRNAs reveals insights into their distribution, biogenesis and function. Genome Biol. 2012;13(3):R20.
20. Zhang X^#, Zhao H^#, Gao S, Wang WC, Katiyar-Agarwal S, Huang HD, Raikhel N, Jin H*. Arabidopsis Argonaute 2 regulates innate immunity via miRNA393(*)-mediated silencing of a Golgi-localized SNARE gene, MEMB12. Mol Cell. 2011;42(3):356-66.
21. Zhang W*, Gao S, Zhou X, Chellappan P, Chen Z, Zhou X, Zhang X, Fromuth N, Coutino G, Coffey M, Jin H*. Bacteria-responsive microRNAs regulate plant innate immunity by modulating plant hormone networks. Plant Mol Biol. 2011;75(1-2):93-105.
22. Zhang W^#, Gao S^#, Zhou X, Xia J, Chellappan P, Zhou X, Zhang X, Jin H*. Multiple distinct small RNAs originate from the same microRNA precursors. Genome Biol. 2010;11(8):R81.
23. Chellappan P, Xia J, Zhou X, Gao S, Zhang X, Coutino G, Vazquez F, Zhang W*, Jin H*. siRNAs from miRNA sites mediate DNA methylation of target genes. Nucleic Acids Res. 2010;38(20):6883-94.
24. Zhou P, Ren B, Zhang X, Wang Y, Wei CH, Li Y*. Stable expression of rice dwarf virus Pns10 suppresses the post-transcriptional gene silencing in transgenic Nicotiana benthamiana plants. Acta Virol. 2010;54(2):99-104.
25. Tsuchisaka A^#, Yu G^#, Jin H, Alonso JM, Ecker JR, Zhang X, Gao S, Theologis A*. A combinatorial interplay among the 1-aminocyclopropane-1-carboxylate isoforms regulates ethylene biosynthesis in Arabidopsis thaliana. Genetics. 2009;183(3):979-1003.
26. Padmanabhan C^#, Zhang X^#, Jin H*. Host small RNAs are big contributors to plant innate immunity. Curr Opin Plant Biol. 2009;12(4):465-72.
27. Zhang X, Du P, Lu L, Xiao Q, Wang W, Cao X, Ren B, Wei C, Li Y*. Contrasting effects of HC-Pro and 2b viral suppressors from Sugarcane mosaic virus and Tomato aspermy cucumovirus on the accumulation of siRNAs. Virology. 2008;374(2):351-60.
28. Cao X, Zhou P, Zhang X, Zhu S, Zhong X, Xiao Q, Ding B, Li Y*. Identification of an RNA silencing suppressor from a plant double-stranded RNA virus. J Virol. 2005;79(20):13018-27

　　本实验室专注于非编码RNA调控和细胞器互作在表观遗传和机体抗性反应过程中功能等前沿领域的研究，欢迎有科研激情并勇于挑战自我的同学们加入。背景专业需要但不限于分子生物学、细胞生物学、表观遗传学、植物学、微生物学等。