张晓明，男，博士，二级研究员，博士生导师；中国科学院动物研究所 “表观遗传与抗病毒免疫研究组”组长。中国科学院特聘研究骨干，中国科学院大学岗位教师。国家高层次人才项目（青年）、国家自然科学基金委“优秀青年项目”与“杰出青年项目”项目获得者，中国科学院引才计划评估优秀获得者、科技部重点研发计划专项首席科学家。中国昆虫学会理事、媒介昆虫与病原互作专委会副主任，中国植物病理学会病毒专业委员会、中国昆虫学会昆虫比较免疫与互作专业委员会委员。

2001年在南开大学获得学士学位。2007年于北京大学获得博士学位。

2008-2014年在加州大学河滨分校进行博士后研究。

聚焦RNA在机体抗性免疫反应中的作用，解析动植物内非编码RNA的调控机理和免疫功能，揭示蛋白编码RNA的发生机制和抗性功能，并尝试进行RNA农药等RNA相关产品的开发与应用。相关研究在 Cell Host & Microbe、Science Advances，Nature Communications 和 The Plant Cell 等期刊发表。

以解析动植物对病原和虫媒的抗性机制为目的，本研究组的研究重点为：1）非编码RNA在机体抗性反应过程中功能；2）细胞器互作对机体抗性反应的意义。

1. Huang, J., Du, J., Liu, Y., Lu, L., Xu, Y., Shi, J., Liu, Q., Li, Q., Liu, Y., Chen, Y., Du, M., Zhao, Y., Huo, L., Wang, W., Ding, C., Wei, L., Wu, J., Yuan, Y.-W., Chen, J., Li, R., Cui, F.* and Zhang, X*. (2025). RH3 enhances antiviral defense by facilitating small RNA loading into Argonaute 2 at endoplasmic reticulum–chloroplast membrane contact sites. Nature communications 16, 1953.
2. Zhao, W., Li, Q., Sun, M., Luo, L., Zhang, X.,* and Cui, F*. (2025). Small interfering RNAs generated from the terminal panhandle structure of negative-strand RNA virus promote viral infection. PLoS Pathogens 21, e1012789.
3. Song, S., Wang, Q., Huo, L., Xie, L., Chen, J., Cui, H., Dai, Z., Kang, J., Li, Y., Guo, W., Chen, J., Kang, L.* and Zhang, X*. (2024). The phytoplasma (Candidatus Phytoplasma arecae) is the crucial pathogen to cause areca palm yellow leaf disease. Science bulletin.
4. Huang, J., Zhao, Y., Liu, S., Chen, Y., Du, M., Wang, Q., Zhang, J., Yang, X., Chen, J* and Zhang, X*. (2024). RH20, a phase-separated RNA helicase protein, facilitates plant resistance to viruses. Plant science 347, 112176.
5. Li, Q#., Liu, Y#., and Zhang, X*. (2024). Biomolecular condensates in plant RNA silencing: insights into formation, function, and stress responses. The Plant cell, 36(2), 227–245.
6. Wu, J#., Zhang, Y#., Li, F#., Zhang, X#., Ye, J., Wei, T., Li, Z., Tao, X., Cui, F., Wang, X., Zhang, L., Yan, F., Li, S., Liu, Y., Li, D., Zhou, X* and Li, Y*. (2024). Plant virology in the 21st century in China: Recent advances and future directions. Journal of integrative plant biology, 66(3), 579–622.
7. Zhou, W., Huang, J., Yang, X*., and Zhang, X*. (2024). Detection of dsRNA with Fluorescence In Situ Hybridization (FISH). Methods Mol Biol 2771, 35-38.
8. Chen, X., Li, W.W., Gao, J., Wu, Z., Du, J., Zhang, X., and Zhu, Y.X. *. (2024). Arabidopsis PDLP7 modulated plasmodesmata function is related to BG10-dependent glucosidase activity required for callose degradation. Science bulletin.
9. Lu, T., Ji, Y., Chang, M., Zhang, X., Wang, Y., and Zou, Z. (2024). The accumulation of modular serine protease mediated by a novel circRNA sponging miRNA increases Aedes aegypti immunity to fungus. BMC Biology 22, 7.
10. Chen, J#., Liu, Y#., Liu, M#., Guo, W#., Wang, Y#., He, Q#., Chen, W., Liao, Y., Zhang, W., Gao, Y., Dong, K., Ren, R., Yang, T., Zhang, L., Qi, M., Li, Z., Zhao, M., Wang, H., Wang, J., Qiao, Z., Li, H., Jiang, Y., Liu, G., Song, X., Deng, Y., Li, H., Yan, F., Dong, Y., Li, Q., Li, T., Yang, W., Cui, J., Wang, H., Zhou, Y., Zhang, X., Jia, G., Lu, P., Zhi, H., Tang, S* and Diao, X*. (2023). Pangenome analysis reveals genomic variations associated with domestication traits in broomcorn millet. Nature Genetics 55, 2243-2254.
11. Huang, J#., Zhou, W#., Zhang, X* and Li, Y*. (2023). Roles of long non-coding RNAs in plant immunity. PLoS pathogens, 19(5), e1011340.
12. Du, J., Liu, Y., Lu, L., Shi, J., Xu, L., Li, Q., Cheng, X., Chen, J* and Zhang, X*. (2022). Accumulation of DNA damage alters microRNA gene transcription in Arabidopsis thaliana. BMC plant biology, 22(1), 576.
13. Liu, Y#., Rao, J#., Mi, Y#., Chen, L., Feng, L., Li, Q., Geng, J., Yang, X., Zhan, X., Ren, L., Chen, J* and Zhang, X*. (2022). SARS-CoV-2 RNAs are processed into 22-nt vsRNAs in Vero cells. Frontiers in immunology, 13, 1008084.
14. Liu, N#., Xu, Y#., Li, Q., Cao, Y., Yang, D., Liu, S., Wang, X., Mi, Y., Liu, Y., Ding, C., Liu, Y., Li, Y., Yuan, Y. W., Gao, G., Chen, J*., Qian, W* and Zhang, X*. (2022). A lncRNA fine-tunes salicylic acid biosynthesis to balance plant immunity and growth. Cell host & microbe, 30(8), 1124–1138.e8.
15. Cheng, Y., Lu, T., Guo, J., Lin, Z., Jin, Q., Zhang, X* & Zou, Z*. (2022). Helicoverpa armigera miR-2055 regulates lipid metabolism via fatty acid synthase expression. Open biology, 12(3), 210307.
16. Li, Q#., Liu, N#., Liu, Q#., Zheng, X., Lu, L., Gao, W., Liu, Y., Liu, Y., Zhang, S., Wang, Q., Pan, J., Chen, C., Mi, Y., Yang, M., Cheng, X., Ren, G., Yuan, Y. W and Zhang, X*. (2021). DEAD-box helicases modulate dicing body formation in Arabidopsis. Science advances, 7(18), eabc6266.
17. Gao, W#., Liu, Y#., Huang, J#., Chen, Y., Chen, C., Lu, L., Zhao, H., Men, S* and Zhang, X*. (2021). MES7 Modulates Seed Germination via Regulating Salicylic Acid Content in Arabidopsis. Plants, 10(5), 903.
18. Liu, Q., Liu, Y., Li, Q., Qian, W and Zhang, X*. (2021). Determining the Phase Separation Characteristics of Plant Proteins. Current protocols, 1(9), e237.
19. Liu, Y#., Gao, W#., Wu, S#., Lu, L., Chen, Y., Guo, J., Men, S and Zhang, X*. (2020). AtXRN4 Affects the Turnover of Chosen miRNA*s in Arabidopsis. Plants, 9(3), 362.
20. Zhang, B., Zhao, L., Ning, J., Wickham, J. D., Tian, H., Zhang, X., Yang, M., Wang, X and Sun, J. (2020). miR-31-5p regulates cold acclimation of the wood-boring beetle Monochamus alternatus via ascaroside signaling. BMC biology, 18(1), 184.
21. RNA沉默转基因技术在植物抗病虫害研究中的作用 杨美玲; 李琦; 陈佳琦; 张晓明《植物保护》 2020，46(4)：1-6
22. Yang, M#., Xu, Z#., Zhao, W#., Liu, Q., Li, Q., Lu, L., Liu, R*., Zhang, X* and Cui, F*. (2018). Rice stripe virus-derived siRNAs play different regulatory roles in rice and in the insect vector Laodelphax striatellus. BMC plant biology, 18(1), 219. 
23. Zhao, W#., Xu, Z#., Zhang, X., Yang, M., Kang, L*., Liu, R* and Cui, F*. (2018). Genomic variations in the 3'-termini of Rice stripe virus in the rotation between vector insect and host plant. The New phytologist, 219(3), 1085–1096.
24. Huang, J#., Yang, M#., Lu, L* and Zhang, X*. (2016). Diverse Functions of Small RNAs in Different Plant-Pathogen Communications. Frontiers in microbiology, 7, 1552.
25. Huang, J., Yang, M and Zhang, X*. (2016). The function of small RNAs in plant biotic stress response. Journal of integrative plant biology. 58(4):312-27 14.
26. Zhang, X., Niu, D., Carbonell, A., Wang, A., Lee, A., Tun, V., Wang, Z., Carrington, J. C., Chang, C. E and Jin, H*. (2014). ARGONAUTE PIWI domain and microRNA duplex structure regulate small RNA sorting in Arabidopsis. Nature communications, 5, 5468.
27. Zhang, X., Lii, Y., Wu, Z., Polishko, A., Zhang, H., Chinnusamy, V., Lonardi, S., Zhu, J. K*., Liu, R* and Jin, H*. (2013). Mechanisms of small RNA generation from cis-NATs in response to environmental and developmental cues. Molecular plant, 6(3), 704–715.
28. Zhang, X#., Xia, J#., Lii, Y. E., Barrera-Figueroa, B. E., Zhou, X., Gao, S., Lu, L., Niu, D., Chen, Z., Leung, C., Wong, T., Zhang, H., Guo, J., Li, Y., Liu, R., Liang, W., Zhu, J. K., Zhang, W* and Jin, H*. (2012). Genome-wide analysis of plant nat-siRNAs reveals insights into their distribution, biogenesis and function. Genome biology, 13(3), R20.
29. Zhang, X#., Zhao, H#., Gao, S., Wang, W. C., Katiyar-Agarwal, S., Huang, H. D., Raikhel, N and Jin, H*. (2011). Arabidopsis Argonaute 2 regulates innate immunity via miRNA393(∗)-mediated silencing of a Golgi-localized SNARE gene, MEMB12. Molecular cell, 42(3), 356–366.
30. Zhang, W*., Gao, S., Zhou, X., Chellappan, P., Chen, Z., Zhou, X., Zhang, X., Fromuth, N., Coutino, G., Coffey, M and Jin, H*. (2011). Bacteria-responsive microRNAs regulate plant innate immunity by modulating plant hormone networks. Plant molecular biology, 75(1-2), 93–105. 3
31. Zhang, W*#., Gao, S#., Zhou, X., Xia, J., Chellappan, P., Zhou, X., Zhang, X and Jin, H*. (2010). Multiple distinct small RNAs originate from the same microRNA precursors. Genome biology, 11(8), R81.
32. Chellappan, P., Xia, J., Zhou, X., Gao, S., Zhang, X., Coutino, G., Vazquez, F., Zhang, W* and Jin, H*. (2010). siRNAs from miRNA sites mediate DNA methylation of target genes. Nucleic acids research, 38(20), 6883–6894.
33. Zhou, P., Ren, B., Zhang, X., Wang, Y., Wei, C. H and Li, Y*. (2010). Stable expression of rice dwarf virus Pns10 suppresses the post-transcriptional gene silencing in transgenic Nicotiana benthamiana plants. Acta virologica, 54(2), 99–104.
34. Padmanabhan, C#., Zhang, X# and Jin, H*. (2009). Host small RNAs are big contributors to plant innate immunity. Current opinion in plant biology, 12(4), 465–472.
35. Tsuchisaka, A., Yu, G., Jin, H., Alonso, J. M., Ecker, J. R., Zhang, X., Gao, S and Theologis, A*. (2009). A combinatorial interplay among the 1-aminocyclopropane-1-carboxylate isoforms regulates ethylene biosynthesis in Arabidopsis thaliana. Genetics, 183(3), 979–1003.
36. Zhang, X., Du, P., Lu, L., Xiao, Q., Wang, W., Cao, X., Ren, B., Wei, C and Li, Y*. (2008). Contrasting effects of HC-Pro and 2b viral suppressors from Sugarcane mosaic virus and Tomato aspermy cucumovirus on the accumulation of siRNAs. Virology, 374(2), 351–360.  
37. Cao, X., Zhou, P., Zhang, X., Zhu, S., Zhong, X., Xiao, Q., Ding, B and Li, Y*. (2005). Identification of an RNA silencing suppressor from a plant double-stranded RNA virus. Journal of virology, 79(20), 13018–13027.

本实验室专注于非编码RNA调控和细胞器互作在表观遗传和机体抗性反应过程中功能等前沿领域的研究，欢迎有科研激情并勇于挑战自我的同学们加入。背景专业需要但不限于分子生物学、细胞生物学、表观遗传学、植物学、微生物学等。

科研队伍

张晓明   研究员，研究组组长

李  琦   副研究员

黄  娟   助理研究员

陈佳琦   科研助理

刘  青   博士后

刘  洋   博士后

宋双伟   博士后

王  乾   博士研究生

周文玲   博士研究生

刘莎莎   博士研究生

霍梁霄   博士研究生

朱孟杰   博士研究生

王炳婷   博士研究生

刘思佳  博士研究生

柴春莲   硕士研究生

赵一鸣   硕士研究生

谢立强   硕士研究生

李  玥   硕士研究生

蔡志豪   硕士研究生

郭宇挺   硕士研究生

杨佳佳   硕士研究生