邵璇，男，博士，副研究员，硕士生导师；中国科学院动物研究所生殖病理学研究组成员。主持国家自然科学基金面上项目和青年科学基金项目，作为主要骨干参与国家重点研发计划项目和国家自然科学基金重大项目和重点项目等。2006年毕业于河北大学；2014年于中国科学院动物研究所获得理学博士学位，师从王雁玲研究员；2021年晋升为副研究员。

主要从事妊娠适应性调节和滋养层细胞代谢相关研究，以此为切入点研究胎盘内分泌功能和代谢机能的调节机制和子痫前期等妊娠疾病的胎盘源性机制。具体的研究内容包括：胎盘营养传输功能单元的构建及其调控机制；子痫前期、胎儿生长受限等重要妊娠疾病的病因学。在Natl Sci Rev, PNAS, J Pineal Res, J Biomed Sci, Genomics Proteomics Bioinformatics, Cell Chem Biol, Hypertension等杂志上发表论文26篇；获得国家发明专利1项和国际PCT专利1项；目前担任北京市自然科学基金项目评审专家，Adv Sci, Commun Biol, Sci Rep, Reprod Biol Endocrinol, Front Cell Dev Biol, Front Endocrinol, Biol Reprod, Placenta, BMC Pregnancy Childbirth等杂志的审稿人。在读硕士研究生1名。

• 国家重点研发计划（2022YFA1103601）：母胎界面免疫耐受形成的时空图谱解析（2022.12-2027.11），研究骨干，223万元
• 国家自然科学基金重大项目（82192872）：灵长类胚外组织发育与反复妊娠失败（2022.01-2026.12），研究骨干，150万元
• 国家自然科学基金面上项目（32171115）：糖代谢调节胎盘滋养层细胞合体化的机制研究（2022.01-2025.12），主持，58万元
• 国家自然科学基金青年科学基金项目（31800986）：胎盘滋养层细胞通过合体化增强巨胞饮能力以应对不良营养微环境的机制（2019.01-2021.12），主持，25万元
• 国家重点研发计划（2018YFC1004100）：胎盘形成的分子机制（2018.12-2021.12），研究骨干，108万元
• 国家自然科学基金重点项目（81730040）：妊娠过程中类固醇激素合成和代谢紊乱导致子痫前期发生发展的机制（2018.01-2021.12），参加人，294万元

1. Jia W^#, Ma L^#, Yu X^#, Wang F, Yang Q, Wang X, Fan M, Gu Y, Meng R, Wang J, Li YX, Li R*, Shao X*, Wang YL*. Human CD56⁺CD39⁺ dNK cells support fetal survival through controlling trophoblastic cell fate: immune mechanisms of recurrent early pregnancy loss. Natl Sci Rev. 2024 Apr 11;11(6):nwae142.
2. Fan M^#, Wu H^#, Sferruzzi-Perri AN*, Wang YL*, Shao X*. Endocytosis at the Maternal-Fetal Interface: Balancing Nutrient Transport and Pathogen Defense. Front Immunol. 2024 Jun 18:15:1415794.
3. Shao X^#, Yang Y^#, Liu Y^#, Wang Y^#, Zhao Y, Yu X, Liu J, Li YX, Wang YL*. Orchestrated feedback regulation between melatonin and sex hormones involving GPER1-PKA-CREB signaling in the placenta. J Pineal Res. 2023 :e12913.
4. Shao X^#, Yu W^#, Yang Y^#, Wang F, Yu X, Wu H, Ma Y, Cao B*, Wang YL*. The mystery of the life tree: the placenta. Biol Reprod. 2022;107(1):301-316.
5. Chen J^#, Du L^#, Wang F^#, Shao X^#, Wang X, Yu W, Bi S, Chen D, Pan X, Zeng S, Huang L, Liang Y, Li Y, Chen R, Xue F, Li X, Wang S, Zhuang M, Liu M, Lin L, Yan H, He F, Yu L, Jiang Q, Xiong Z, Zhang L, Cao B*, Wang YL*, Chen D*. Cellular and molecular atlas of the placenta from a COVID-19 pregnant woman infected at mid-gestation highlights the defective impacts on fetal health. Cell Prolif. 2022;55(4):e13204.
6. Yu X^#, Wu Hong^#, Yang Y, Wang F, Wang YL*, Shao X*. Placental development and Pregnancy-Associated Diseases. Maternal-Fetal Medicine. 2022;4(1):36-51.
7. Li G^#, Wang Y^#, Cao G^#, Ma Y, Li YX, Zhao Y*, Shao X*, Wang YL*. Hypoxic stress disrupts HGF/Met signaling in human trophoblasts: implications for the pathogenesis of preeclampsia. J Biomed Sci. 2022;29(1):8.
8. Shao X^#, Cao G^#, Chen D^#, Liu J, Yu B, Liu M, Li YX, Cao B*, Sadovsky Y*, Wang YL*. Placental trophoblast syncytialization potentiates macropinocytosis via mTOR signaling to adapt to reduced amino acid supply. Proc Natl Acad Sci U S A. 2021;118(3):e2017092118.
9. Liu J^#, Shao X^#, Qin W^#, Yanling Zhang^#, Dang F, Yang Q, Yu X, Li YX, Chen X, Wang C*, Wang YL*. Quantitative chemoproteomics reveals O-GlcNAcylation of Cystathionine γ-lyase (CSE) represses trophoblast syncytialization. Cell Chem Biol. 2021;S2451-9456(21)00050-7. (Cover story)
10. Wang F^#, Jia W^#, Fan M^#, Shao X^#. Li Z, Liu Y, Ma Y, Shao X, Li YX, Li R*, Tu Q*, Wang YL*. Single-cell immune landscape of human recurrent miscarriage. Genomics Proteomics Bioinformatics. 2021;19:S1672-0229(21)00003-6. (Editorial highlight)
11. Bian X, Liu J, Yang Q, Liu Y, Jia W, Zhang X, Li YX, Shao X*, Wang YL*. miR-210 regulates placental adaptation to maternal hypoxic stress during pregnancy. Biol Reprod. 2021;104(2):418-429.
12. Ma Y^#, Yang Q^#, Fan M^#, Zhang L, Gu Y, Jia W, Li Z, Wang F, Li YX, Wang J, Li R*, Shao X*, Wang YL*. Placental endovascular extravillous trophoblasts (enEVTs) educate maternal T-cell differentiation along the maternal-placental circulation. Cell Prolif. 2020;53(5):e12802.
13. Li Z^#, Bian X^#, Ma Y, Yang Q, Jia W, Liu J, Wang F, Liu M, Li YX, Shao X*, Wang YL*. Uterine Scarring Leads to Adverse Pregnant Consequences by Impairing the Endometrium Response to Steroids. Endocrinology, 2020;161(11):bqaa174.
14. Shao X^#, Wang Y^#, Liu Y^#, Guo X, Li D, Huo R, Jia W, Cao G, Li YX, Liu M, Sha J, Zhao Y, Wang YL*. Association of imbalanced sex hormone production with excessive procoagulation factor SerpinF2 in preeclampsia. J Hypertens. 2019;37(1):197-205.
15. Shao X, Tan C, Chen D, Wang YL*. Placental defects are involved in most gene mutations that cause embryonic and fetal death. Biol Reprod. 2018;99(3):476-478.
16. Shao X^#, Liu Y^#, Liu M, Wang Y, Yan L, Wang H, Ma L, Li YX, Zhao Y*, Wang YL*. Testosterone Represses Estrogen Signaling by Upregulating miR-22: A Mechanism for Imbalanced Steroid Hormone Production in Preeclampsia. Hypertension. 2017;69(4):721-730. (Editorial highlight)
17. Luo R^#, Shao X^#, Xu P, Liu Y, Wang Y, Zhao Y, Liu M, Ji L, Li YX, Chang C, Qiao J, Peng C*, Wang YL*. MicroRNA-210 contributes to preeclampsia by down-regulating KCMF1. Hypertension, 2014;64:839-847.