李鑫，博士，研究员，中国科学院动物研究所干细胞与生殖生物学国家重点实验室研究组组长。2015年毕业于东北农业大学八年制“国家理科基地班”（中科院动物所联合培养）获得发育生物学博士学位。2016-2021年先后于加州大学圣地亚哥分校以及麻省理工学院著名癌症生物学家Robert Weinberg 实验室进行博士后研究工作。2021年12月加入中国科学院动物研究所干细胞与生殖生物学国家重点实验室。从事研究主要在干细胞与发育，表观遗传与衰老以及肿瘤干细胞与癌症转移等领域。以第一作者(含共同)身份在Cell，Science，Nature Cell Biology，Cell Stem Cell等著名刊物发表多篇重要论文。研究成果包括: 建立大鼠单倍体胚胎干细胞并证明其同时具有干细胞多能性及配子功能特性（Cell stem cell 2014）; 首例跨物种杂合异源二倍体胚胎干细胞并证实具有稳定基因组和干细胞的多能性并以此为模型对干细胞多形性维持,X染色体失活以及基因调控的进化差异等重要科学问题进行了阐述(Cell 2016); 揭示了小鼠父本获得性代谢异常性状可以通过tsRNA为载体的跨代遗传机制(Science 2016， Nature cell biology 2018) 等。

　　研究组将聚焦干细胞如何协调其细胞内表观遗传修饰、细胞极性、细胞粘附和细胞骨架等动态变化来响应来自不同组织微环境的各种复杂信号从而参与调控正常组织发育、组织稳态平衡，损伤修复以及癌症产生与转移等过程。我们将广泛应用各种细胞、分子和发育生物学技术来阐明组织发育以及组织稳态下干细胞的精细动态变化并为我们进一步了解并干预组织衰老，损伤修复和癌症产生及转移建立基础。

1. Guihai Feng, Xin Qin, Jiahao Zhang, Wuliang Huang, et al., Xin Li*. CellPolaris: Decoding Cell Fate through Generalization Transfer Learning of Gene Regulatory Networks. bioRxiv (2023).
2. Xiaodong Yang, Guole Liu, Guihai Feng, Dechao Bu, Pengfei Wang, Jie Jiang, et al., Xin Li*. GeneCompass: Deciphering Universal Gene Regulatory Mechanisms with Knowledge-Informed Cross-Species Foundation Model. bioRxiv (2023).
3. Yun Zhang, Joana Liu Donaher, Sunny Das, Xin Li, et al., Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis. Nat Cell Biol (2022).
4. Li X, Wang J, Wang L, Gao Y, Feng G, Li G, Zou J, Yu M, Li YF, Liu C, Yuan XW, Zhao L, Ouyang H, Zhu JK, Li W, Zhou Q, Zhang K. Lipid metabolism dysfunction induced by age-dependent DNA methylation accelerates aging. Signal Transduct Target Ther (2022).
5. Xia HM*, Li Xin*, Gao WW*, Fu X, Ronnie H. Fang, Zhang LF, Zhang Kang. Tissue repair and regeneration with endogenous stem cells. Nat Rev Mater (2018). 
6. Zhang Y*, Zhang X*, Shi J*, Tuorto F*, Li Xin*, Liu Y, Liebers R, Zhang L, Qu Y, Qian J, Pahima M, Liu Y, Yan M, Cao Z, Lei X, Cao Y, Peng H, Liu S, Wang Y, Zheng H, Woolsey R, Quilici D, Zhai Q, Li L, Zhou T, Yan W, Lyko F, Zhang Y, Zhou Q, Duan E, Chen Q. Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs. Nature Cell Biology (2018).
7. Li Xin*, Cui XL*, Wang JQ*, Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Liu ZH, Wang XJ, Li W*, Zhou Q*. Generation and application of mouse-rat allodiploid embryonic stem cells. Cell (2016).
8. Wang JQ*, Li Xin*, Wang L*, Li J, Zhao Y, Bou G, Li Y, Jiao G, Shen X, Wei R, Liu S, Xie B, Lei L, Li W, Zhou Q, Liu Z. A novel long intergenic noncoding RNA indispensable for the cleavage of mouse two-cell embryos. EMBO Rep (2016).
9. Chen Q*, Yan M*, Cao Z*, Li Xin*, Zhang Y*, Shi J*, Feng GH, Peng H, Zhang X, Zhang Y, Qian J, Duan E#, Zhai Q, Zhou Q. Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder. Science (2016).
10. Li Xin*, Wang J.*, Wang L.*, Wan H., Li Y., Li TD., Wang Y., Shuai L., Mao Y., Cui X., Wang L., Liu Z., Zhou Q. Co-participation of paternal and maternal genomes before blastocyst stage is not required for full-term development of mouse embryos. Journal of Molecular Cell Biology (2015). 
11. Wang J*, Li Xin*, Zhao Y., Li J., Zhou Q., and Liu Z. (2015). Generation of cell-type-specific gene mutations by expressing the sgRNA of the CRISPR system from the RNA polymerase II promoters. Protein & cell (2015).
12. Shi J.*, Chen Q.*, Li Xin*, Zheng X.*, Zhang Y.*, Qiao J., Tang F., Tao Y., Zhou Q., and Duan E. Dynamic transcriptional symmetry-breaking in pre-implantation mammalian embryo development revealed by single-cell RNA-seq. Development (2015).
13. Li Wei*, Li Xin*, Li TD*, Jiang MG*, Wan H, Luo GZ, Feng C, Cui X, Teng F, Yuan Y, Zhou Q, Gu Q, Shuai L, Sha J, Xiao Y, Wang L, Liu Z, Wang XJ, Zhao XY, Zhou Q. Genetic modification and screening in rat using haploid embryonic stem cells. Cell Stem Cell (2014).
14. Li Xin*, Xia BL*, Li W, Zhou Q. Assessing reprogramming by chimera formation and Tetraploid complementation. Methods Mol Biol (2014).