李鑫，中国科学院动物研究所、北京干细胞与再生医学研究院双聘研究员，博士生导师，2022年入选国家海外优秀青年学者计划。2015年毕业于东北农业大学八年制“国家理科基地班”（中国科学院动物所联合培养）获得发育生物学博士学位。随后于加州大学圣地亚哥分校以及麻省理工学院著名癌症生物学家Robert Weinberg 实验室进行博士后研究工作。2021年12月全职加入中国科学院动物研究所。主要从事人工智能生物学、干细胞与发育、衰老以及癌症转移等方向研究和转化应用。以第一作者（含共同第一）或通讯作者身份在Cell，Science，Cell Research,Nature Cell Biology，Cell Stem Cell等著名刊物发表多篇重要论文。代表性工作包括建立首例大鼠单倍体及大小鼠跨物种异源二倍体胚胎干细胞并对干细胞多形性维持及基因调控的进化差异等重要科学问题进行了研究 (Cell stem cell 2014,Cell 2016);揭示了哺乳动物获得性代谢异常性状可以通过tsRNA为载体的跨代遗传机制以及表观遗传与脂代谢调控衰老机制(Science 2016， Nature cell biology 2018，STTT 2022) ，该工作同时入选2016年度中国科学十大进展；构建了世界首个跨物种生命基础大模型（Cell Research 2024封面）、基于迁移学习的基因调控网络生成模型、以及基于图深度学习的数字细胞转录基础模型（National Science Review 2025）；建立了来自13个物种、超1亿单细胞转录组的多物种、高标准AI训练数据和数据库Sccompass（http://www.bdbe.cn/kun）（Advanced Science，2025）；通过建立可靠的人源休眠乳腺癌细胞模型，阐明了肺部炎症微环境通过调控EMT状态而激活休眠肿瘤细胞的分子机制（PNAS，2025）。目前担任东北农业大学博士生导师、中国老年学和老年医学学会抗衰老分会委员、中国遗传学会衰老遗传学分会委员。

研究组将聚焦干细胞如何协调其细胞内表观遗传修饰、细胞极性、细胞粘附和细胞骨架等动态变化来响应来自不同组织微环境的各种复杂信号从而参与调控正常组织发育、组织稳态平衡，损伤修复以及癌症产生与转移等过程。我们将广泛应用各种细胞、分子和发育生物学技术来阐明组织发育以及组织稳态下干细胞的精细动态变化并为我们进一步了解并干预组织衰老，损伤修复和癌症产生及转移建立基础。

1. 基于生物大数据的和人工智能的算法揭示细胞内部基因表达调控的机制和规律推断细胞命运的变化，为解析发育机制，器官稳态维持、疾病早期诊断、治疗和干预提供预测模型。
2. 基于人类干细胞和多种模式动物解析组织再生、衰老和疾病过程中组织微环境参与调控干细胞行为及其命运决定的机制。

1. Zhang J^#*, Zhang J^#, Han L^#, Wu S, Li J, Eaton EN, Yuan B, Reinhardt F, Li H, Strasser PC, Das S, Liu Donaher J, Khalil MI, Jiang H, Deuschel A, Lin D, Sebastiany C, Maranga M, Shubitidze S, Liu X, Lambert AW, Zhang Y, Liu Y, Sui L, Elmiligy S, Pozza U, Gunsay R, Mishra R, Velarde J, Iyer S, Henry WS, Weiskopf K, Feng G, Oni TE, Watnick RS, Li X^* and Weinberg RA^* , Inflammation awakens dormant cancer cells by modulating the epithelial-mesenchymal phenotypic state. Proc Natl Acad Sci U S A, 2025（共同通讯）.

2. Wu W^#, Liu W^#, Liu Z^* and Li X^*, Construction of a Genetic Prognostic Model in the Glioblastoma Tumor Microenvironment. Genes (Basel), 2025（最后通讯）.

3.  Wang P^#, Liu W^#, Wang J^#, Liu Y^#, Li P^#, Xu P, Cui W, Zhang R, Long Q, Hu Z, Fang C, Dong J, Zhang C, Chen Y, Wang C, Liu G, Xie H, Zhang Y, Xiao M, Chen S, Jiang H, Consortium XC, Chen Y, Yang G, Zhang S, Meng Z^*, Wang X^*, Feng G^*, Li X^* and Zhou Y^*, scCompass: An Integrated Multi-Species scRNA-seq Database for AI-Ready. Adv Sci (Weinh), 2025（共同通讯）.

4.  Li P^#, Ying S^#, Zou Y^#, Wang X, Zhang R, Huang C, Dai M, Xu K, Feng G, Li X, Jiang H, Li Z, Zhang Y^*, Li W^* and Zhou Q^*, NSun2-Mediated tsRNAs Alleviate Liver Fibrosis via FAK Dephosphorylation. Cell Prolif, 2025（共同作者）.

5. Fang C^#, Cui W^#, Hu Z^#, Liu W, Chen S, Chang S, Long Q, Li C, Liu Y, Jiang H, Wang P, Pan J, Hu G, Liu G, Meng Z^*, Zhou Y^*, Chen L^*, Feng G^* and Li X^*, Cell-GraphCompass: Modeling Single Cells with Graph Structure Foundation Model. National Science Review, 2025（最后通讯）.

6. Yang X^#, Liu G^#, Feng G^#, Bu D^#, Wang P^#, Jiang J^#, Chen S^#, Yang Q^#, Miao H, Zhang Y, Man Z, Liang Z, Wang Z, Li Y, Li Z, Liu Y, Tian Y, Liu W, Li C, Li A, Dong J, Hu Z, Fang C, Cui L, Deng Z, Jiang H, Cui W, Zhang J, Yang Z, Li H, He X, Zhong L, Zhou J, Wang Z, Long Q, Xu P, Consortium XC, Wang H, Meng Z, Wang X, Wang Y, Wang Y, Zhang S, Guo J, Zhao Y^*, Zhou Y^*, Li F^*, Liu J^*, Chen Y^*, Yang G^* and Li X^*, GeneCompass: deciphering universal gene regulatory mechanisms with a knowledge-informed cross-species foundation model. Cell Res, 2024（最后通讯）.

-首个跨物种知识嵌入的单细胞基础模型

-被Cell Research杂志（Vol 34, Issue 12）选为当期封面故事

7. Hao M^#, Wei L, Yang F, Yao J^*, Theodoris CV^*, Wang B^*, Li X^*, Yang G^* and Zhang X^*, Current opinions on large cellular models. Quantitative Biology, 2024（共同通讯）.

8. Fang C^#, Wang Y^#, Song Y, Long Q, Lu W, Chen L, Feng G, Zhou Y^* and Li X^*, How do large language models understand genes and cells. ACM Transactions on Intelligent Systems and Technology, 2024（最后通讯）.

9. 李鑫^# and 于汉超^*, 人工智能驱动的生命科学研究新范式. 中国科学院院刊, 2024（第一作者）.

10. 江海平^#, 高纯纯, 刘文豪, 杨运桂 and 李鑫^*, 数据驱动的生命科学研究进展. 中国科学院院刊, 2024（最后通讯）.

11. Zhang Y^#*, Donaher JL, Das S, Li X, Reinhardt F, Krall JA, Lambert AW, Thiru P, Keys HR, Khan M, Hofree M, Wilson MM, Yedier-Bayram O, Lack NA, Onder TT, Bagci-Onder T, Tyler M, Tirosh I, Regev A, Lees JA and Weinberg RA^*, Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis. Nat Cell Biol, 2022（共同作者）.

12. Li X^#, Wang J^#, Wang L^#, Gao Y^#, Feng G, Li G, Zou J, Yu M, Li YF, Liu C, Yuan XW, Zhao L, Ouyang H, Zhu JK^*, Li W^*, Zhou Q^* and Zhang K^*, Lipid metabolism dysfunction induced by age-dependent DNA methylation accelerates aging. Signal Transduct Target Ther, 2022（第一作者）.

13. Zhang Y^#, Zhang X^#, Shi J^#, Tuorto F^#, Li X^#, Liu Y, Liebers R, Zhang L, Qu Y, Qian J, Pahima M, Liu Y, Yan M, Cao Z, Lei X, Cao Y, Peng H, Liu S, Wang Y, Zheng H, Woolsey R, Quilici D, Zhai Q, Li L, Zhou T, Yan W, Lyko F, Zhang Y^*, Zhou Q^*, Duan E^* and Chen Q^*, Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs. Nat Cell Biol, 2018（共同一作）.

14.  Xia H^#, Li X^#, Gao W^#, Fu X^#, Fang RH, Zhang L^* and Zhang K^*, Tissue repair and regeneration with endogenous stem cells. Nature Reviews Materials, 2018（共同一作）.

15. Wang J^#, Li X^#, Wang L^#, Li J^#, Zhao Y, Bou G, Li Y, Jiao G, Shen X, Wei R, Liu S, Xie B, Lei L, Li W, Zhou Q^* and Liu Z^*, A novel long intergenic noncoding RNA indispensable for the cleavage of mouse two-cell embryos. EMBO Rep, 2016（共同一作）.

16. Li X^#, Cui XL^#, Wang JQ^#, Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Liu ZH, Wang XJ, Li W^* and Zhou Q^*, Generation and Application of Mouse-Rat Allodiploid Embryonic Stem Cells. Cell, 2016（第一作者）.

17. Chen Q^#, Yan M^#, Cao Z^#, Li X^#, Zhang Y^#, Shi J^#, Feng GH, Peng H, Zhang X, Zhang Y, Qian J, Duan E^*, Zhai Q^* and Zhou Q^*, Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder. Science, 2016（共同一作）.

-两院院士评选2016年度中国生命科学十大进展

18. Wang J^#, Li X^#, Zhao Y, Li J, Zhou Q^* and Liu Z^*, Generation of cell-type-specific gene mutations by expressing the sgRNA of the CRISPR system from the RNA polymerase II promoters. Protein & cell, 2015（共同一作）.

19. Shi J^#, Chen Q^#, Li X^#, Zheng X^#, Zhang Y, Qiao J, Tang F, Tao Y^*, Zhou Q^* and Duan E^*, Dynamic transcriptional symmetry-breaking in pre-implantation mammalian embryo development revealed by single-cell RNA-seq. Development, 2015（共同一作）.

20. Li X^#, Wang JQ^#, Wang LY^#, Wan HF, Li YF, Li TD, Wang YK, Shuai L, Mao YH, Cui XL, Wang L, Liu ZH, Li W and Zhou Q^*, Co-participation of paternal and maternal genomes before the blastocyst stage is not required for full-term development of mouse embryos. J Mol Cell Biol, 2015（第一作者）.

21. Li X^#, Xia B-l, Li W and Zhou Q^*, Assessing reprogramming by chimera formation and tetraploid complementation. Nuclear Reprogramming: Methods and Protocols, 2014（第一作者）.

22. Li W^#, Li X^#, Li T^#, Jiang MG^#, Wan H, Luo GZ, Feng C, Cui X, Teng F, Yuan Y, Zhou Q, Gu Q, Shuai L, Sha J, Xiao Y, Wang L, Liu Z, Wang XJ, Zhao XY and Zhou Q^*, Genetic modification and screening in rat using haploid embryonic stem cells. Cell Stem Cell, 2014（共同一作）.