王红梅，博士，研究员，博士生导师；中国科学院动物研究所干细胞与生殖生物学国家重点实验室主任，北京干细胞与再生医学研究院副院长。国家杰出青年基金获得者，万人计划领军人才，国家百千万人才工程 “有突出贡献中青年专家”，国家自然科学基金重大项目负责人，国家重点研发计划“基于干细胞的生育力维持与重建”项目负责人。

1995年于北京师范大学生物系获得学士学位，2002年于中国科学院动物研究所获得理学博士学位，2003-2005年在加拿大渥太华健康研究所从事博士后研究。王红梅课题组研究方向包括：（1）哺乳动物早期胚胎和胎盘发育；（2）干细胞与生育力的维持和重建。曾获谈家桢生命科学创新奖，全国妇幼健康科学技术奖一等奖及中国科学院优秀导师奖、“朱李月华优秀教师奖”、“领雁银奖、振翅奖”等。培养的研究生获得中华人民共和国教育部硕士/博士研究生国家奖学金；中国科学院院长特别奖；中国科学院大学三好学生、优秀毕业生等荣誉称号。目前担任Cell Proliferation、Cell Reports Medicine、Biology of Reproduction、Reproduction、Fundamental Research、生物医学转化、动物学杂志期刊副主编或编委，在Science、Nature、Cell、Nature Genetics、Nature Nanotechnology等期刊发表论文80余篇，相关工作被Science亮点评价、在Nature网页头条报道、登上Cell期刊封面。受邀在Gordon、Keystone等国际学术会议做报告。

主要学习经历：

• 1999.09～2002.06 中国科学院动物研究所生理学博士
• 1995.09～1998.07 北京师范大学生物系细胞生物学硕士
• 1991.09～1995.07 北京师范大学生物系生物学学士

主要工作经历：

• 2021.12～ 北京干细胞与再生医学研究院 副院长
• 2017.05～ 干细胞与生殖生物学国家重点实验室主任
• 2013.01～2017.05 干细胞与生殖生物学国家重点实验室副主任
• 2013.01～2020.09 干细胞与生殖生物学国家重点实验室党总支书记
• 2006.09～ 干细胞与生殖生物学国家重点实验室研究员、博士生导师、生殖生理学研究组组长
• 2003.12～2005.12 加拿大渥太华健康研究所(OHRI)博士后
• 2003.01～2006.09 计划生育生殖生物学国家重点实验室 副研究员
• 2002.01～2002.12 计划生育生殖生物学国家重点实验室 助理研究员
• 1998.07～2002.01 中国科学院动物研究所计划生育生殖生物学国家重点实验室 研究实习员

　　本组致力于女性生殖与疾病的研究。主要研究方向为早期胚胎发育、胎盘发育与生理和病理的妊娠结局、干细胞与女性生育力的维持和重建。

　　早期胚胎发育与成功妊娠密切相关，团队多年来致力于哺乳动物胚胎体外培养体系的优化，结合仿生材料、动态培养体系、实时监测系统等条件的搭建和完善，目前可将小鼠囊胚体外长时程培养至受精后8.5天（Embryonic day 8.5）阶段，人类囊胚体外长时程培养至E14，非人灵长类囊胚体外培养至E20阶段。其中“利用食蟹猴胚胎体外长时程培养体系研究灵长类动物早期原肠运动特征的研究”于2019年发表于science杂志。

　　胎盘绒毛滋养层细胞的合体化及对子宫内膜的适当侵润是成功妊娠的关键，其异常将导致自然流产、葡萄胎、先兆子痫和胎儿宫内生长受限（Intrauterine growth restriction，IUGR）等病理事件。生殖生理组通过利用人胎盘绒毛滋养层细胞侵润/转移和合体化、胚胎-子宫内膜共培养、小鼠胎盘特异敲低或敲除等模型结合蛋白质组学和单核苷酸基因多态性等方法研究胎盘早期发育和滋养层细胞分化的分子机制及相关疾病的发病机理。

　　原始卵泡库从根本上决定了雌性生育力，原始卵泡激活和卵泡发生控制着生殖和生理周期。卵泡发育异常在临床上可引发卵巢早衰（POF）和多囊卵巢综合症（PCOS）等多种生殖疾病，严重威胁女性生育力。生殖生理组首先应用化疗药物制造小鼠卵巢功能不全模型（POI），随后进行干细胞注射治疗小鼠POI，验证干细胞治疗的安全性和有效性，通过转录组学，代谢组学等研究卵泡发育和生育力维持的的分子机制，并将这种疗法运用于临床前研究。

• 2023年入选“中国生命科学十大进展”。
• 2023年谈家桢生命科学创新奖。
• 2023年获中国细胞生物学学会干细胞生物学分会，干细胞研究创新科学家奖。
• 2023年第五届妇幼健康科学技术奖自然科学奖一等奖：（2023-Z-F-7-01）早期胚胎发育与不良妊娠结局；
• 2023年中国实验动物学会科学技术奖一等奖：（20201004-1-P1403）利用ENU诱变方法大规模创制小型猪突变模型；
• 2017年全国妇幼健康科学技术奖二等奖：（自然科学奖，2017-B-F-04-03）微小RNA对卵泡生长发育的调控及其在卵巢早衰中的作用研究；
• 2017年全国妇幼健康科学技术奖二等奖：（自然科学奖，2017-B-D-01-02）母胎免疫耐受与排斥（流产）转换的分子机理；
• 2011年国家人口和计划生育委员会优秀科技成果奖一等奖（2011-01-D01）胚胎植入的分子基础与相关疾病；
• 2008年教育部高等学校科学研究优秀成果奖（科学技术）二等奖（自然科学类）蝙蝠的行为、进化及其与病毒相互关系的研究；
• 2021年中国科学院大学教学科研工作“领雁银奖、振翅奖”；
• 2020年“中国科学院朱李月华优秀教师奖”；
• 2020年度中国科学院优秀导师奖；

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