王明，研究员，博士生导师，中国科学院动物研究所表观遗传工程研究组组长。 2010年于中国农业大学生物学院获得学士学位，2015年于美国加州大学河滨分校获得博士学位，2015-2023年分别在美国加州大学河滨分校和加州大学洛杉矶分校进行博士后研究。2023年6月起加入中国科学院动物研究所，担任表观遗传工程研究组组长，主要从事植物、昆虫、病原三者互作过程中的表观遗传信号的传递与调控机制的研究，以及表观基因组编辑工具的开发。代表性研究成果包括首次揭示了小RNA跨界调控植物与病菌互作，并开发了多个表观基因组编辑工具调控植物基因表达。以第一或通讯作者（含共同）身份在Science， Nature Plants (3篇) ，Nature Communications (3篇) ，Trends in Microbiology，Current Opinion in Plant Biology（2篇）等杂志发表，总引用超过4300次，并取得2项美国专利。主持国家自然科学基金面上项目和动物所自主部署建制化攻关项目，并参与农业生物育种重大项目等，为Nature Plants, New Phytologist等杂志担任审稿人。

媒介昆虫传播的植物病毒病害对我国农业生产构成了严重威胁，然而，目前对于植物的防御机制、昆虫的传播途径及病毒的致病机理的认识仍相对有限。本研究组专注于探索表观遗传信号在植物、昆虫和病原间的传递与调控机制，结合表观遗传学、基因组学、分子生物学和合成生物学等方法，挖掘植物抗病基因并解析分子机理。同时，研究组也致力于开发和优化表观基因组编辑工具，将其用于调控植物抗病基因的表达，创制农作物抗病种质。

1. 表观遗传信号调控植物、昆虫与病原互作

通过高通量测序技术，解析植物的转录组、翻译组、和表观组等在植物与病虫害互作前后所发生的变化，挖掘植物潜在的抗病基因，并使用分子生物学与遗传学等方法进行验证。

2. 开发表观基因组编辑工具调控基因表达

以CRISPR/dCas和Zinc finger等系统为基因靶标系统结合不同的表观遗传相关蛋白，开发高效且精准的表观基因组编辑工具，通过改造目标位点的表观遗传修饰，调控基因表达。并将该工具运用于植物抗病基因的调控，创制抗病种质。

（* 共同第一作者，#通讯作者）：

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8. Li Z*, Wang M*, Zhong Z*, Gallego-Bartolomé J, Feng S, Jami-Alahmadi Y, Wang X, Wohlschlegel J, Bischof S, Long JA, Jacobsen SE. The MOM1 complex recruits the RdDM machinery via MORC6 to establish de novo DNA methylation. Nature Communications. 2023 Jul 12;14(1):4135.
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11. Wang M, Thomas N, Jin H. Cross-kingdom RNA trafficking and environmental RNAi for powerful innovative pre-and post-harvest plant protection. Current opinion in plant biology. 2017 Aug 1;38:133-41.
12. Wang M*, Weiberg A*, DellotaE, Yamane D, Jin H. Botrytis small RNA Bc-siR37 suppresses plant defense genes by cross-kingdom RNAi. RNA biology. 2017 Apr 3;14(4):421-8.
13. Wang M*, Weiberg A*, Jin H. Pathogen small RNAs: a new class of effectors for pathogen attacks. Molecular Plant Pathology. 2015 Mar 12;16(3):219.
14. Gardiner J*, Ghoshal B*, Wang M*, Jacobsen SE. CRISPR–Cas-mediated transcriptional control and epi-mutagenesis. Plant physiology. 2022 Apr 1;188(4):1811-24.
15. Cai Q, Qiao L, Wang M, He B, Lin FM, Palmquist J, Huang SD, Jin H. Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes. Science. 2018 Jun 8;360(6393):1126-9.
16. Wang S, Wang M, Ichino L, Boone BA, Zhong Z, Papareddy RK, Lin EK, Yun J, Feng S, Jacobsen SE. MBD2 couples DNA methylation to transposable element silencing during male gametogenesis. Nature Plants. 2024 Jan;10(1):13-24.
17. Zhong Z, Xue Y, Harris CJ, Wang M, Li Z, Ke Y, Liu M, Zhou J, Jami-Alahmadi Y, Feng S, Wohlschlegel JA. MORC proteins regulate transcription factor binding by mediating chromatin compaction in active chromatin regions. Genome Biology. 2023 Apr 26;24(1):96.
18. Liu W, Gallego-Bartolomé J, Zhou Y, Zhong Z, Wang M, Wongpalee SP, Gardiner J, Feng S, Kuo PH, Jacobsen SE. Ectopic targeting of CG DNA methylation in Arabidopsis with the bacterial SssI methyltransferase. Nature communications. 2021 May 25;12(1):3130.
19. Xue Y, Zhong Z, Harris CJ, Gallego-Bartolomé J, Wang M, Picard C, Cao X, Hua S, Kwok I, Feng S, Jami-Alahmadi Y. Arabidopsis MORC proteins function in the efficient establishment of RNA directed DNA methylation. Nature communications. 2021 Jul 13;12(1):4292.
20. Weiberg A, Wang M, Bellinger M, Jin H. Small RNAs: a new paradigm in plant-microbe interactions. Annual Review of Phytopathology. 2014 Aug 4;52(1):495-516.
21. Feng S, Zhong Z, Wang M, Jacobsen SE. Efficient and accurate determination of genome-wide DNA methylation patterns in Arabidopsis thaliana with enzymatic methyl sequencing. Epigenetics & chromatin. 2020 Dec;13:1-7.
22. Dong OX, Meteignier LV, Plourde MB, Ahmed B, Wang M, Jensen C, Jin H, Moffett P, Li X, Germain H. Arabidopsis TAF15b localizes to RNA processing bodies and contributes to snc1-mediated autoimmunity. Molecular Plant-Microbe Interactions. 2016 Apr 6;29(4):247-57.
23. Hamby R, Wang M, Qiao L, Jin H. Synthesizing fluorescently labeled dsRNAs and sRNAs to visualize fungal RNA uptake. RNA Tagging: Methods and Protocols. 2020:215-25.