姓  名: 王 明
学  科: 表观遗传调控机制与编辑技术/植物保护学
电话/传真: +86-10-64807230 / 
电子邮件: wangming@ioz.ac.cn
通讯地址: 北京市朝阳区北辰西路1号院5号
中国科学院动物研究所农业虫害鼠害综合治理研究国家重点实验室 D513 100101
更多信息: 表观遗传工程研究组     

简历介绍:

王明,研究员,博士生导师,中国科学院动物研究所表观遗传工程研究组组长。 2010年于中国农业大学生物学院获得学士学位,2015年于美国加州大学河滨分校获得博士学位,2015-2023年分别在美国加州大学河滨分校和加州大学洛杉矶分校进行博士后研究。2023年6月起加入中国科学院动物研究所,担任表观遗传工程研究组组长,主要从事植物、昆虫、病原三者互作过程中的表观遗传信号的传递与调控机制的研究,以及表观基因组编辑工具的开发。代表性研究成果包括首次揭示了小RNA跨界调控植物与病菌互作,并开发了多个表观基因组编辑工具调控植物基因表达。以第一或通讯作者(含共同)身份在ScienceNature Plants (x2) ,Nature Communications (x3) ,Trends in MicrobiologyCurrent Opinion in Plant Biology(x2)等杂志发表,总引用超过3700次,并取得2项美国专利。

研究领域:

媒介昆虫传播的植物病毒病害对我国农业生产构成了严重威胁,然而,目前对于植物的防御机制、昆虫的传播途径及病毒的致病机理的认识仍相对有限。本研究组专注于探索表观遗传信号在植物、昆虫和病原间的传递与调控机制,结合表观遗传学、基因组学、分子生物学和合成生物学等方法,挖掘植物抗病基因并解析分子机理。同时,研究组也致力于开发和优化表观基因组编辑工具,将其用于调控植物抗病基因的表达,创制农作物抗病种质。

1.表观遗传信号调控植物、昆虫与病原互作

通过高通量测序技术,解析植物的转录组、翻译组、和表观基因组等在植物与病虫害互作前后所发生的变化,挖掘植物潜在的抗病基因,并使用分子生物学与遗传学等方法进行验证。

2.开发表观基因组编辑工具调控基因表达

以CRISPR/dCas和Zinc finger等系统为基因靶标系统结合不同的表观遗传相关蛋白,开发高效且精准的表观基因组编辑工具,通过改造目标位点的表观遗传修饰,调控基因表达。并将该工具运用于植物抗病基因的调控,创制抗病种质。

社会任职:

获奖及荣誉:

承担科研项目情况:

代表论著:

(* 共同第一作者,#通讯作者):

  1. Yuejing Cheng*, Yu Zhou*, Ming Wang#. Targeted gene regulation through epigenome editing in plants. Current Opinion in Plant Biology, 80:102552 (2024)
  2. Ming Wang*, Zhenhui Zhong*, Javier Gallego-Bartolomé, Zheng Li, Suhua Feng, Hsuan Yu Kuo, Ryan L Kan, Hoiyan Lam, John Curtis Richey, Linli Tang, Jessica Zhou, Mukun Liu, Yasaman Jami-Alahmadi, James Wohlschlegel, Steven E Jacobsen, A gene silencing screen uncovers diverse tools for targeted gene repression in Arabidopsis. Nature Plants 1-13 (2023)
  3. Ming Wang*, Zhenhui Zhong*, Javier Gallego-Bartolome, Suhua Feng, Yuan-Hsin Shih, Mukun Liu, Jessica Zhou, John Curtis Richey, Charmaine Ng, Yasaman Jami-Alahmadi, James Wohlschlegel, Keqiang Wu, Steven E Jacobsen. Arabidopsis TRB proteins function in H3K4me3 demethylation by recruiting JMJ14. Nature Communications 14, 1736 (2023)
  4. Arne Weiberg*, Ming Wang*, Feng-Mao Lin, Hongwei Zhao, Zhihong Zhang, Isgouhi Kaloshian, Hsien-Da Huang, Hailing Jin, Fungal small RNAs suppress plant immunity by hijacking host RNA interference pathways. Science 342, 118–123 (2013)
  5. Ming Wang, Arne Weiberg, Feng-Mao Lin, Bart P. H. J. Thomma, Hsien-Da Huang, Hailing Jin. Bidirectional cross-kingdom RNAi and fungal uptake of external RNAs confer plant protection. Nature Plants 2, 16151 (2016)
  6. Zheng Li*, Ming Wang*, Zhenhui Zhong*, Javier Gallego-Bartolomé, Suhua Feng, Yasaman Jami-Alahmadi, Xinyi Wang, James Wohlschlegel, Sylvain Bischof, Jeffrey A. Long, Steven E. Jacobsen. The MOM1 complex recruits the RdDM machinery via MORC6 to establish de novo DNA methylation. Nature Communications 14, 4135 (2023)
  7. Zhenhui Zhong*, Yafei Wang*, Ming Wang*, Fan Yang, Quentin Angelo Thomas, Yan Xue, Yaxin Zhang, Wanlu Liu, Yasaman Jami-Alahmadi, Linhao Xu, Suhua Feng, Sebastian Marquardt, James A Wohlschlegel, Israel Ausin, Steven E Jacobsen. Histone chaperone ASF1 mediates H3. 3-H4 deposition in Arabidopsis. Nature Communications 13, 6970 (2022)
  8. Ming Wang, Hailing Jin. Spray-Induced Gene Silencing: a Powerful Innovative Strategy for Crop Protection. Trends in microbiology 25: 4-6 (2017)
  9. Ming Wang*, Arne Weiberg*, Exequiel Dellota Jr, Daniel Yamane, Hailing Jin. Botrytis small RNA Bc-siR37 suppresses plant defense genes by cross-kingdom RNAi. RNA Biology, 14:421-428 (2017)
  10. Ming Wang, Nicholas Thomas and Hailing Jin. Cross-kingdom RNA trafficking and environmental RNAi for powerful innovative pre- and post-harvest plant protection. Current Opinion in Plant Biology, 38:133-141 (2017)
  11. Ming Wang*, Arne Weiberg*, Hailing Jin. Pathogen small RNAs: a new class of effectors for pathogen attacks. Molecular plant pathology 16.3 219-223 (2015)
  12. Gardiner, Jason*, Basudev Ghoshal*, Ming Wang*, and Steven E. Jacobsen. CRISPR-CAS mediated transcriptional control and epi-mutagenesis. Plant Physiology (2022)
  13. Cai, Qiang, Lulu Qiao, Ming Wang, Baoye He, Feng-Mao Lin, Jared Palmquist, Sienna-Da Huang, and Hailing Jin. Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes. Science 360 1126-1129 (2018)
  14. Wang, Shuya, Ming Wang, Lucia Ichino, Brandon A. Boone, Zhenhui Zhong, Ranjith K. Papareddy, Evan K. Lin, Jaewon Yun, Suhua Feng, and Steven E. Jacobsen. MBD2 couples DNA methylation to transposable element silencing during male gametogenesis. Nature Plants 1-12 (2024)
  15. Zhenhui Zhong, Yan Xue, C Jake Harris, Ming Wang, Zheng Li, Yunqing Ke, Mukun Liu, Jessica Zhou, Yasaman Jami-Alahmadi, Suhua Feng, James A Wohlschlegel, Steven E Jacobsen. MORC proteins regulate transcription factor binding by mediating chromatin compaction in active chromatin regions. Genome Biology 24, no. 1 96 (2023)
  16. Liu, Wanlu, Javier Gallego-Bartolomé, Yuxing Zhou, Zhenhui Zhong, Ming Wang, Somsakul Pop Wongpalee, Jason Gardiner, Suhua Feng, Peggy Hsuanyu Kuo, and Steven E. Jacobsen. Ectopic targeting of CG DNA methylation in Arabidopsis with the bacterial SssI methyltransferase. Nature communications 12, no. 1 1-14 (2021)
  17. Xue, Yan, Zhenhui Zhong, C. Jake Harris, Javier Gallego-Bartolomé, Ming Wang, Colette Picard, Xueshi Cao et al. Arabidopsis MORC proteins function in the efficient establishment of RNA directed DNA methylation. Nature communications 12, no. 1 1-13 (2021)
  18. Weiberg, Arne, Ming Wang, Marschal Bellinger, and Hailing Jin. Small RNAs: A New Paradigm in Plant-Microbe Interactions. Annual Review of Phytopathology 52, no. 1 (2014)
  19. Feng, Suhua, Zhenhui Zhong, Ming Wang, and Steven E. Jacobsen. Efficient and accurate determination of genome-wide DNA methylation patterns in Arabidopsis thaliana with enzymatic methyl sequencing. Epigenetics & chromatin 13, no. 1 1-17 (2020)
  20. Dong, Oliver X., Louis-Valentin Meteignier, Melodie B. Plourde, Bulbul Md Ahmed, Ming Wang, Cassandra Jensen, Hainling Jin, Peter Moffett, Xin Li, and Hugo Germain. Arabidopsis TAF15b localizes to RNA processing bodies and contributes to snc1-mediated autoimmunity. Molecular Plant-Microbe Interactions 29.4 247-257 (2016)
  21. Hamby, Rachael, Ming Wang, Lulu Qiao, and Hailing Jin. Synthesizing Fluorescently Labeled dsRNAs and sRNAs to Visualize Fungal RNA Uptake. RNA Tagging, pp. 215-225. Humana, New York, NY, (2020)

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