2025年3月31日 星期一
姓  名: 刘佩佩
学  科: 再生医学
电话/传真:  / 
电子邮件: liupeipei@ioz.ac.cn
通讯地址: 北京市朝阳区北辰西路1号院5号 中国科学院动物研究所
中国科学院动物研究所干细胞与生殖生物学国家重点实验室 100101
更多信息: 干细胞与神经发育疾病研究组     

简历介绍:

教育经历:

(1) 2015-09 至 2018-07,中国科学院动物研究所,发育生物学,博士

(2) 2011-09 至 2014-07,厦门大学,细胞生物学,硕士

(3) 2007-09 至 2011-07,山东师范大学,生物科学,学士

科研与学术工作经历:

(1) 2018-07 至 2024-12,中国科学院动物研究所,干细胞与生殖生物学国家重点实验室,助理研究员

(2) 2025-01 至 今,中国科学院动物研究所,干细胞与生殖生物学国家重点实验室,副研究员

研究领域:

以小鼠、人多能干细胞及病人来源的组织或细胞为模型,从事神经发育、神经疾病机制与药物靶点探索的研究,发现新型的相关疾病分子靶标及干预治疗策略

承担科研项目情况:

  • 国家自然科学青年基金项目(31900690),主持,2020-2022
  • 国家重点研发计划项目(2021YFA1101400),科研骨干,2021-2025
  • 中国科学院青促会,主持,2023- 2027

代表论著:

(#共同第一作者)

  1. Liu, P.P.,# Han, X#., Li, X.#, Dai, S.K., Xu, Y.J., Jiao, L.F., Du, H.Z., Zhao, L.H., Li, R.F., Teng, Z.Q., et al. (2025). An EED/PRC2-H19 Loop Regulates Cerebellar Development. Adv Sci (Weinh) 12, e2403591.
  2. Liu, P.P.#, Lu, S.P.#, Li, X.#, Tang, G.B., Liu, X., Dai, S.K., Jiao, L.F., Lin, X.W., Li, X.G., Hu, B., et al. (2023). Abnormal chromatin remodeling caused by ARID1A deletion leads to malformation of the dentate gyrus. Cell Death Differ 30, 2187-2199. 10.1038/s41418-023-01199-w.
  3. Liu, P.P.#, Dai, S.K.#, Mi, T.W.#, Tang, G.B., Wang, Z., Wang, H., Du, H.Z., Tang, Y., Teng, Z.Q., and Liu, C.M. (2022). Acetate supplementation restores cognitive deficits caused by ARID1A haploinsufficiency in excitatory neurons. EMBO Mol Med 14, e15795. 10.15252/emmm.202215795.
  4. Liu, X., Dai, S.K., Liu, P.P., and Liu, C.M. (2021). Arid1a regulates neural stem/progenitor cell proliferation and differentiation during cortical development. Cell Prolif 54, e13124. 10.1111/cpr.13124.
  5. Dai SK, Liu PP, Du HZ, Liu X, Xu YJ, Liu C, Wang YY, Teng ZQ*, Liu CM*. Histone crotonylation regulates neural stem cell fate decisions by activating bivalent promoters. EMBO Reports 2021, 22 (10): e52023.
  6. Liu PP#, Xu YJ#, Dai SK, Du HZ, Wang YY, Li XG, Teng ZQ, Liu CM#. Polycomb Protein EED Regulates Neuronal Differentiation through Targeting SOX11 in Hippocampal Dentate Gyrus. Stem Cell Reports. 2019 Jul 9;13(1):115-131. doi: 10.1016/j.stemcr.2019.05.010.
  7. Liu C, Dai SK, Sun Z, Wang Z, Liu PP, Du HZ, Yu S*, Liu CM*, Teng ZQ*. GA-binding protein GABPβ1 is required for the proliferation of neural stem/progenitor cells. Stem Cell Res. 2019 Jul 15;39:101501. doi: 10.1016/j.scr.2019.101501.
  8. Xu YJ#, Liu PP#, Ng SC, Teng ZQ, Liu CM*. Regulatory Networks between Polycomb Complexes and Non-coding RNAs in Central Nervous System. J Mol Cell Biol. 2019 Jul 10. pii: mjz058. doi: 10.1093/jmcb/mjz058.)
  9. Duan RS, Liu PP, Xi F, Wang WH, Tang GB, Wang RY*, Saijilafu*, Liu CM*. Wnt3 and Gata4 regulate axon regeneration in adult mouse DRG neurons. Biochem Biophys Res Commun. 2018 May 5;499(2):246-252
  10. Duan RS, Tang GB, Du HZ, Hu YW, Liu PP, Xu YJ, Zeng YQ, Zhang SF, Wang RY, Teng ZQ, Liu CM*. Polycomb protein family member CBX7 regulates intrinsic axon growth and regeneration. Cell Death Differ. 2018 Sep;25(9):1598-1611.
  11. Liu PP#, Xu YJ#, Teng ZQ, Liu CM*. Polycomb Repressive Complex 2: Emerging Roles in the Central Nervous System. Neuroscientist. 2018 Jun;24(3):208-220.
  12. Liu PP, Tang GB, Xu YJ, Zeng YQ, Zhang SF, Du HZ, Teng ZQ*, Liu CM*. MiR-203 Interplays with Polycomb Repressive Complexes to Regulate the Proliferation of Neural Stem/Progenitor Cells. Stem Cell Reports. 2017 Jul 11;9(1):190-202.
  13. Tang GB#, Zeng YQ#, Liu PP#, Mi TW, Zhang SF, Dai SK, Tang QY, Yang L, Xu YJ, Yan HL, Du HZ, Teng ZQ*, Zhou FQ*, Liu CM*. The Histone H3K27 Demethylase UTX Regulates Synaptic Plasticity and Cognitive Behaviors in Mice. Front Mol Neurosci. 2017 Aug 24;10:267. 
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