教育背景

2015.9-2020.7          中国科学院动物研究所      博士

2012.9-2015.7          中国科学院动物研究所      硕士

2008.9-2012.7          山西大学                  学士

工作经历

2023.7-至  今          中国科学院动物研究所      副研究员

2020.7-2023.6          中国科学院动物研究所      博士后

主要从事生态衰老和衰老可塑研究。衰老是动物不可避免的生活史过程，然而衰老速率却是响应环境高度可塑的。飞蝗具有种群密度依赖的表型可塑性，群居型和散居型飞蝗拥有差异巨大的寿命和衰老速率。利用飞蝗特有的衰老可塑性特征，解析衰老进程响应环境改变的分子机制，以及衰老调控对于动物的生态适应意义。

第十七届北京青年优秀科技论文

2019年博士研究生国家奖学金

中国科学院动物研究所自主部署项目：利用单细胞转录组解析飞蝗飞行肌衰老可塑的细胞异质性。项目编号：2023IOZ0308。起止时间：2024.01-2026.12。

国家自然科学基金青年项目：飞蝗群居和散居型衰老特征差异及分子机制。项目编号：32100388。起止时间：2022.01-2024.12。

中国博士后基金第70批面上资助：飞蝗衰老可塑性的组蛋白调控机制。项目编号：2021M703204，起止时间：2022.01-2023.12。

1. Guo Siyuan^#, Hou Li^#, Dong Liushu, Nie Xin, Kang Le* and Wang Xianhui*. PLIN2-induced ectopic lipid accumulation promotes muscle aging in gregarious locusts. Nature Ecology & Evolution (2023). (Cover Story) 10.1038/s41559-023-02059-z
2. Hou Li^#, Guo Siyuan^#, Ding Ding, Du Baozhen and Wang Xianhui*. Neuroendocrinal and molecular basis of flight performance in locusts. Cellular and Molecular Life Sciences (2022). 10.1007/s00018-022-04344-9
3. Guo Siyuan^#, Yang Pengcheng^#, Liang Bo, Zhou Feng, Hou Li, Kang Le* and Wang Xianhui*. Aging features of the migratory locust at physiological and transcriptional levels. BMC Genomics (2021). 10.1186/s12864-021-07585-3
4. Guo Siyuan, Wang Xianhui and Kang Le*. Special significance of non-Drosophila insects in aging. Frontiers in Cell and Developmental Biology (2020). 10.3389/fcell.2020.576571
5. Guo Siyuan^#, Jiang Feng^#, Yang Pengcheng, Liu Qing, Wang Xianhui* and Kang Le*. Characteristics and expression patterns of histone-modifying enzyme systems in the migratory locust. Insect Biochemistry and Molecular Biology (2016). 10.1016/j.ibmb.2016.06.010
6. Hou Li, Guo Siyuan, Wang Yuanyuan, Shaoye Liu and Wang Xianhui*. Neuropeptide ACP is required for fat body lipid metabolism homeostasis in locusts. Insect Science (2024) 10.1111/1744-7917.13321
7. Hou Li, Guo Siyuan, Wang Yuanyuan, Nie Xin, Ding Ding, Li Beibei, Kang Le* and Wang Xianhui*. Neuropeptide ACP facilitates lipid oxidation and utilization during long-term flight in locusts. eLife (2021). 10.7554/eLife.65279
8. Zhu Dan^#, Ge Jin^#, Guo Siyuan, Hou Li, Shi Rangjun, Zhou Xian, Nie Xin and Wang Xianhui*. Independent variations in genome-wide expression, alternative splicing, and DNA methylation in brain tissues among castes of the buff-tailed bumblebee, Bombus terrestris. Journal of Genetics and Genomics (2021). 10.1016/j.jgg.2021.04.008
9. Chen Dafeng^#, Hou Li^#, Wei jianing, Guo Siyuan, Cui Weichan, Yang Pengcheng, Kang Le* and Wang Xianhui*. Aggregation pheromone 4-vinylanisole promotes the synchrony of sexual maturation in female locusts. eLife (2022). 10.7554/eLife.74581
10. Ding Ding, Zhang Jie, Du Baozhen, Wang Xuanzhao, Hou Li, Guo Siyuan, Chen Bing* and Kang Le*. Non-canonical function of an Hif-1α splice variant contributes to the sustained flight of locusts. eLife (2022). 10.7554/eLife.74554
11. Chen Bing*, Jiang Chunyan, Guo Siyuan, Guo Kun and Hao Shuguang. Phenological asynchrony is associated with diapause program and heat shock protein expression in three grasshopper species in the inner Mongolian steppe. Frontiers in Ecology and Evolution (2021). 10.3389/fevo.2021.743872