张云峰，博士，中国科学院动物研究所, 研究员，博士生导师；动物行为与神经编码研究组组长。

2006年获山东师范大学学士学位，2011年获中国科学院动物研究所博士学位（硕博连读）。2011-2016任温州医科大学助理研究员。2016-2022在美国宾夕法尼亚大学进行博士后研究并担任Research Associate。2022年9月入选中国科学院相关人才计划、担任农业虫害鼠害综合治理研究国家重点实验室研究组组长(独立PI)。北京朝阳区“凤凰计划”高层次人才。

主要从事动物行为生理和神经编码机制的研究。人类大脑计划 (Human Brain Project, HBP)-中国实验室核心骨干成员 (2013-2016；中国唯一参与此项目的实验室)。美国化学感官协会会员，美国化学感官协会Polak青年科学家奖获得者。Physiology & Behavior杂志特邀编委，Animal Research and One Health (AROH)杂志和Sensory Neuroscience杂志首届青年编委，中国动物学会理事，中国动物学会动物行为学分会委员兼副秘书长。主持国家重点研发计划课题、国家自然科学青年和面上基金等项目，发表论文30余篇，主要研究成果发表于Nature Neuroscience, Nature Communications, Journal of Neuroscience, Molecular Psychiatry, iScience, Neurosciecne, Neuroscience Letters, Journal of Insect Physiology, Journal of Experimental Biology等刊物。

大脑的终极功能体现在行为输出。自然状态下，动物处于极其复杂、动态变化的环境之中，大脑如何感知和编码外界信息并指导动物做出适宜的行为，对生存和繁衍至关重要。实验模式鼠生存环境简单单一，而野生鼠生存环境复杂多变。迫于生存和繁衍的需求，鼠类会根据外界信息的变化实时调整其行为（如觅食、社交、防御以及交配等），阐明这些行为产生和适应背后的生理和神经调控机制，包括大脑如何编码外界信息以及神经环路结构和功能的可塑性，有利于探索和开发行为调控的新策略，对于更好的实现鼠害预警、防控和综合治理具有重要意义。

研究组以实验模式鼠和野生鼠（如小家鼠、褐家鼠、黄雄鼠、长爪沙鼠和布氏田鼠等）为研究对象，综合借助在体和体外电生理记录、光遗传学、化学遗传学、病毒介导的神经环路示踪以及行为学分析等技术手段，在体外和在体水平，分别从分子、细胞、环路和行为生理等不同层面和角度，解析行为精准调控的生理和神经机制。主要研究方向（包括但不限于）：（1）嗅觉系统调控摄食行为的分子和神经编码机制；（2）嗅觉系统调控社交行为的分子和神经编码机制；（3）嗅觉系统介导情绪相关行为的分子和神经编码机制；（4）在有潜在风险或利弊冲突状态下，不同行为之间“博弈”的神经生理机制。最终目标：通过综合比较研究，揭示实验模式鼠和野生鼠在这些方面的差异及其神经基础，解析鼠类行为调控在种群发生和危害中的作用机制，为鼠害精准防控和治理以及人类相关疾病治疗提供新思路、新途径和新方法。

1. 鼠害安全、精准防控基础研究及新技术开发，国家重点研发计划课题，主持，2024.11-2027.11。

2. 基于小鼠过度理毛模型探讨强迫症样行为的神经环路机制，国家自然科学基金面上基金， 主持，2024.1-2027.12。

3. 基于全细胞膜片嵌技术探讨Otx1癫痫中的生理作用机制，国家自然科学基金青年基金，主持，2014.1-2016.12。

（#共同第一作者，*通讯作者）

1. Guanqing Li, Chanyi Lu, Miaomiao Yin, Peng Wang, Pengbo Zhang, Jialiang Wu, Wenqiang Wang, Ding Wang, Mengyue Wang, Jiahan Liu, Xinghan Lin, Jian-Xu Zhang, Zhenshan Wang*, Yiqun Yu*, Yun-Feng Zhang*. Neural substrates for regulating self-grooming behavior in rodents. Journal of Zhejiang University-SCIENCE B. 2024, 1-16.
2. Wenqiang Wang, Haiping Wang, Jian Yang, Mengyue Wang, Pengbo Zhang, Zheng Zhu, Liya Wei, Yanbiao Zhong, Yun-Feng Zhang*. A Short Glance at the Role of Olfactory Tubercle in Odour Processing. Flavour and Fragrance Journal. 2024, 1-9.
3. Kun Yang, Yuto Hasegawa, Janardhan P. Bhattarai, Jun Hua, Milan Dower, Semra Etyemez, Neal Prasad, Lauren Duvall, Adrian Paez, Amy Smith, Yingqi Wang, Yun-Feng Zhang, Yun-Feng Zhang, Andrew P. Lane, Koko Ishizuka, Vidyulata Kamath, Minghong Ma, Atsushi Kamiya*, Akira Sawa*. Inflammation-related pathology in the olfactory epithelium: its impact on the olfactory system in psychotic disorders. Molecular Psychiatry. 2024, https://doi.org/10.1038/s41380-024-02425-8.
4. Ming-Yu Zhang, Rui-Dong Cao, Yi Chen, Jian-Cang Ma, Cheng-Min Shi, Yun-Feng Zhang, Jian-Xu Zhang*, Yao-Hua Zhang*. Genomic and phenotypic adaptations of Rattus tanezumi to cold limit its further northward expansion and range overlap with R. norvegicus. Molecular Biology and Evolution. 2024, Jun 1;41(6).
5. Yun-Feng Zhang*, Jialiang Wu, Yingqi Wang, Natalie L. Johnson, Janardhan P. Bhattarai, Guanqing Li, Wenqiang Wang, Camilo Guevara, Hannah Shoenhard, Marc V. Fuccillo, Daniel W. Wesson, Minghong Ma*. Ventral striatal islands of Calleja neurons bidirectionally mediate depression-like behaviors in mice. Nature Communications. 2023, 14:6887. https://doi.org/10.1038/s41467-023-42662-z.
6. Yun-Feng Zhang*, Emma Janke, Janardhan P. Bhattarai, Daniel W. Wesson, Minghong Ma*. Self-grooming promotes social interaction in mice via chemosensory communication. iScience. 2022, doi: https://doi.org/10.1016/j.isci.2022.104284.
7. Yun-Feng Zhang, Luigim Vargas Cifuentes, Janardhan P. Bhattarai, Julia Mohrhardt1, David Fleck, Emma Janke1, Suna L. Cranfill, Andrew H. Moberly, Yiqun Yu, Benjamin R. Arenkiel, Wenqin Luo, Johannes Stegmaier, Daniel W. Wesson*, Marc Spehr*, Marc V. Fuccillo*, Minghong Ma*. The Islands of Calleja, a Ventral Striatal Circuit for Grooming Control. Nature Neuroscience. 2021, 24:1699-1710.
8. Kate A. White^#, Yun-Feng Zhang^#, Zhijian Zhang^#, Janardhan P. Bhattarai, Andrew H. Moberly, Estelle E. in 't Zandt, José I. Pena-Bravo, Huijie Mi, Xianglian Jia, Marc V. Fuccillo, Fuqiang Xu, Minghong Ma and Daniel W. Wesson*. Glutamatergic Neurons in the Piriform Cortex Influence the Activity of D1-and D2-Type Receptor-Expressing Olfactory Tubercle Neurons. Journal of Neuroscience. 2019, 39:9546-9559.
9. Chanyi Lu, Qi-Qin Li, Yao-Yao Li, Hua-Zhen Lin, Jia Qu, Yun Wang* and Yun-Feng Zhang*. Light deprivation produces distinct morphological orchestrations on RGCs and cortical cells in a depressive-like YFP-H mouse model. Neuroscience Letters, 2017, 659:60-68.
10. Haiyan Jiang, Mengjuan Wu, Yimei Liu, Liping Song, Shifeng Li, Xianwei Wang, Yun-Feng Zhang, Junxu Fang, Shengzhou Wu*. Serine racemase deficiency attenuates choroidal neovascularization and reduces nitric oxide and VEGF levels by retinal pigment epithelial cells. Journal of Neurochemistry, 2017, 143(3):375-388.
11. Yun-Feng Zhang*，Qi-Qin Li, Jia Qu, Cui-Min Sun and Yun Wang*. Alterations of motor cortical microcircuit in a depressive-like mouse model produced by light deprivation. Neuroscience, 2017, 341: 79-94.
12. Chanyi Lu, Yun Wang, Yun-Feng Zhang*. Light deprivation produces a sexual dimorphic effect on neural excitability and depression-like behavior in mice. Neuroscience Letters. 2016, 633:69-76.
13. Yun-Feng Zhang，Li-Xiong Liu, Hua-Teng Cao, Li Ou, Jia Qu, Yun Wang* & Jie-Guang Chen*. Otx1 promotes basal dendritic growth and regulates intrinsic electrophysiological and synaptic properties of layer V pyramidal neurons in mouse motor cortex. Neuroscience, 2015, 285:139-54.
14. Yun-Feng Zhang, Ling-Qiao Huang, Feng Ge, Chen-Zhu Wang*. Tarsal taste neurons of Helicoverpa assulta (Guenée) respond to sugars and amino acids, suggesting a role in feeding and oviposition. Journal of Insect Physiology. 2011, 57: 1332-1340.
15. Yun-Feng Zhang, van Loon JJA, Chen-Zhu Wang*. Tarsal taste neuron activity and proboscis extension reflex in response to sugars and amino acids in Helicoverpa armigera (Hübner). The Journal of Experimental Biology. 2010, 213: 2889-2895.

本实验室的愿景和使命：培养有温度、有情怀、有思想、有责任、有担当的优秀青年科研工作者！热烈欢迎对光遗传学、化学遗传学、电生理记录、行为学以及分子生物学感兴趣的同学报考。热忱期待与年轻的你们一起揭开动物行为精准调控的“神秘面纱”！

2024年招生视频：https://mp.weixin.qq.com/s/43GgRBfP3PYe5X3X-3DUXg