周旭明，博士，研究员，博士生导师。2014年博士毕业于中国科学院动物研究所，2014年至2018年在哈佛大学医学院从事博士后研究，2018年9月至今任中国科学院动物研究所研究员，动物功能进化与适应研究组组长。兼任中国科学院神农架生物多样性国家野外科学观测研究站副站长、中国科学院动物所动物生态与保护生物学院重点实验室副主任，中国科学技术大学兼职博士生导师。

获国家及中国科学院人才计划择优支持、北京市自然基金杰出青年基金获得者。现聘为中国科学院动物研究所学术委员会委员、中国生态学会动物生态专业委员会秘书长、中国动物学会兽类分会理事、进化理论委员会委员、中国生物物理学会衰老生物学分会理事、中国遗传学会衰老遗传分会委员等。受邀担任《Molecular Biology and Evolution》、《Zoological Research》、《Genes》、《Frontiers in Bioinformatics》、《BMC genomics》、《生物学杂志》、《兽类学报》和《动物学杂志》等期刊编委、《Science》、《Science Advances》、《Nature Communications》、《PNAS》、《National Science Review》等期刊审稿人。曾获中国生态学学会优秀科技工作者、湖南省自然科学奖、中国科学院优秀博士学位论文等奖项和荣誉称号。

主要研究方向涵盖动物寿命调控机制、动物生态与进化、以及野生动物疫病防控等领域。代表性成果包括：率先完成我国旗舰濒危物种金丝猴、白鱀豚和江豚的基因组研究与遗传负荷评估，创新性提出并发展了适用于跨物种比较的遗传负荷指标（LDcor）；开发了哺乳动物系统学的新型分子标记，厘清了猛真有蹄类（Fereuungulata）的分类地位，构建了哺乳动物目和科级别进化的新框架模型——Long-tran-KPg模型；通过群体社会结构与寿命模式的比较分析，揭示了群居物种从短寿向长寿转变的普遍规律，并发现与寿命相关的基因多受到强化选择影响，但选择压力在不同器官中表现出显著差异；提出了一个寿命进化假说，强调动物的长寿特性可能无直接自然选择压力作用；首次发展“疫源动物生物学”理论，系统性评估哺乳动物对代表性冠状病毒的易感性，发现PDZK1等基因在跨物种传播中具有关键调控作用等。

中国生态学学会优秀科技工作者、湖南省自然科学奖等

国家自然科学基金指南引导类原创探索项目、面上等项目、北京市自然科学基金杰出青年项目、科技部基础资源调查专项以及国家重点研发计划等。

独立及末位通讯作者论文：

1. Dai Y, Pan R, Pan Q, Wu X, Cai Z, Fu Y, Shi C, Sheng Y, Li J, Lin Z, Liu G, Zhu P, Li M, Li G*, Zhou X*. Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates. Sci Adv. 2024; 10(51):eadq0702.
2. Hu C, Liu G, Zhang Z, Pan Q, Zhang X, Liu W, Li Z, Li M, Zhu P, Ji T, Garber PA, Zhou X*. Genetic linkage disequilibrium of deleterious mutations in threatened mammals. EMBO Rep. 2024; 25(12):5620-5634.
3. Liu G^#, Pan Q^#, Zhu P^#, Guo X, Zhang Z, Li Z, Zhang Y, Zhang X, Wang J, Liu W, Hu C, Yu Y, Wang X, Chen W, Li M, Yu W, Liu X, Seim I, Fan G, Zhou X*. Comparative Genomics Provides Insights into Adaptive Evolution and Demographics of Bats. Mol Biol Evol. 2024; 41(12):msae208.
4. Du J^#, Liu W^#, Li M^#, Li Z, Li X, Dai Y, Liu G, Wang X, Zhu P, Gladyshev VN, Zhou X*. Comparative time-series multi-omics analyses suggest H1. 2 involvement in anoxic adaptation and cancer resistance. PLoS Biol. 2024;22(8):e3002778.
5. Liu G, Pan Q, Dai Y, Wang X, Li M, Zhu P, Zhou X*. Phylogenomics of Afrotherian mammals and improved resolution of extant Paenungulata. Mol Phylogenet Evol. 2024;195:108047.
6. Liu G, Pan Q, Du J, Zhu P, Liu W, Li Z, Wang L, Hu C, Dai Y, Zhang X, Zhang Z, Yu Y, Li M, Wang P, Wang X, Li M, Zhou X*. Improved mammalian family phylogeny using gap-rare multiple sequence alignment: A timetree of extant placentals and marsupials. Zool Res. 2023;44(6):1064-1079.
7. Zhu P^#, Liu W^#, Zhang X, Li M, Liu G, Yu Y, Li Z, Li X, Du J, Wang X, Grueter CC, Li M*, Zhou X*. Correlated evolution of social organization and lifespan in mammals. Nat Commun. 2023;14(1):372.
8. Li M^#, Du J^#, Liu W, Li Z, Lv F, Hu C, Dai Y, Zhang X, Zhang Z, Liu G, Pan Q, Yu Y, Wang X, Zhu P, Tan X, Garber PA, Zhou X*. Comparative susceptibility of SARS-CoV-2, SARS-CoV, and MERS-CoV across mammals. ISME J. 2023; 23:1-12.
9. Liu W^#, Zhu P^#, Li M, Li Z, Yu Yang, Liu G, Du J, Wang X, Yang J, Tian R, Seim I, Kaya A, Li M, Li M, Gladyshev NV, Zhou X*. Large-scale across species transcriptomic analysis identifies genetic selection signatures associated with longevity in mammals. EMBO J. 2023; e112740.
10. Li X^#, Wang P^#, Pan Q, Liu G, Liu W, Omotoso O, Du J, Li Z, Yu Y, Huang Y, Zhu P, Li M, Zhou X*. Chromosome-level Asian elephant genome assembly and comparative genomics of long-lived mammals reveal the common substitutions for cancer resistance. Aging Cell. 2023; e13917.
11. Omotoso O, Gladyshev V, Zhou X*. Lifespan Extension in Long-lived Vertebrates Rooted in Ecological Adaptation. Front Cell Dev Biol. 2021;9:704966.
12. Zhu P, Garber P, Wang L, Li M, Belov K, Gillespie T, Zhou X*. Comprehensive Knowledge of Reservoir Hosts is Key to Mitigating Future Pandemics. Innovation. 2020;1(3):100065.

第一作者论文：

1. Zhou X, Dou Q, Fan G, Zhang Q, Sanderford M, Kaya A, Johnson J, Karlsson E, Tian X, Mikhalchenko A, Kumar S, Seluanov A, Zhang Z, Gorbunova V, Liu X, Gladyshev V*. Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity. Cell Rep. 2020; 32:107949.
2. Zhou X*. Thoughts on Convergence Science of high-risk animals responsible for zoonotic epidemics. Scichina. 2020; doi: 10.1360/TB-2020-0372.
3. Zhou X^#, Guang X^#, Sun D^#, Xu S^#, Li M, Seim I, Jie W, Yang L, Zhu Q, Xu J, Gao Q, Kaya A, Dou Q, Chen B, Ren W, Li S, Zhou K, Gladyshev VN, Nielsen R*, Fang X*, Yang G*. Population genomics of finless porpoises reveal an incipient cetacean species adapted to freshwater. Nat Commun. 2018;9(1):1276.
4. Zhou X^#, Sun D^#, Guang X^#, Ma S, Fang X, Mariotti M, Nielsen R, Gladyshev VN*, Yang G*. Molecular Footprints of Aquatic Adaptation Including Bone Mass Changes in Cetaceans. Genome Biol Evol. 2018;10(3):967-975.
5. Zhou X^#*, Meng X^#, Liu Z^#, Chang J^#, Wang B^#, Li M^#, Wengel PO, Tian S, Wen C, Wang Z, Garber PA, Pan H, Ye X, Xiang Z, Bruford MW, Edwards SV, Cao Y, Yu S, Gao L, Cao Z, Liu G, Ren B, Shi F, Peterfi Z, Li D, Li B, Jiang Z, Li J, Gladyshev VN, Li R*, Li M*. Population Genomics Reveals Low Genetic Diversity and Adaptation to Hypoxia in Snub-Nosed Monkeys. Mol Biol Evol. 2016;33(10):2670-81.

13. Zhou X, Seim I, Gladyshev VN*. Convergent evolution of marine mammals is associated with distinct substitutions in common genes. Sci Rep. 2015;5:16550.
14. Zhou X, Sun F, Xu S, Yang G*, Li M*. The position of tree shrews in the mammalian tree: Comparing multi-gene analyses with phylogenomic results leaves monophyly of Euarchonta doubtful. Integr Zool. 2015;10(2):186-98.
15.  Zhou X^#, Wang B^#, Pan Q^#, Zhang J, Kumar S, Sun X, Liu Z, Pan H, Lin Y, Liu G, Zhan W, Li M, Ren B, Ma X, Ruan H, Cheng C, Wang D, Shi F, Hui Y, Tao Y, Zhang C, Zhu P, Xiang Z, Jiang W, Chang J, Wang H, Cao Z, Jiang Z, Li B, Yang G, Roos C, Garber PA, Bruford MW, Li R*, Li M*. Whole-genome sequencing of the snub-nosed monkey provides insights into folivory and evolutionary history. Nat Genet. 2014;46(12):1303-10.
16.  Zhou X^#, Sun F^#, Xu S^#, Fan G, Zhu K, Liu X, Chen Y, Shi C, Yang Y, Huang Z, Chen J, Hou H, Guo X, Chen W, Chen Y, Wang X, Lv T, Yang D, Zhou J, Huang B, Wang Z, Zhao W, Tian R, Xiong Z, Xu J, Liang X, Chen B, Liu W, Wang J, Pan S, Fang X, Li M, Wei F, Xu X, Zhou K, Wang J*, Yang G*. Baiji genomes reveal low genetic variability and new insights into secondary aquatic adaptations. Nat Commun. 2013;4:2708.
17.  Zhou X, Xu S, Xu J, Chen B, Zhou K, Yang G*. Phylogenomic analysis resolves the interordinal relationships and rapid diversification of the laurasiatherian mammals. Syst Biol. 2012;61(1):150-64.
18.  Zhou X, Xu S, Yang Y, Zhou K, Yang G*. Phylogenomic analyses and improved resolution of Cetartiodactyla. Mol Phylogenet Evol. 2011;61(2):255-64.
19.  Zhou X, Xu S, Zhang P, Yang G*. Developing a series of conservative anchor markers and their application to phylogenomics of Laurasiatherian mammals. Mol Ecol Resour. 2011;11(1):134-40.

　　自强不息，追求卓越