姓  名: 赵同标
学  科: 再生医学
电话/传真: +86-10-64805262 / 
电子邮件: tbzhao@ioz.ac.cn or tongbiaozhao@gmail.com
通讯地址: 北京市朝阳区北辰西路1号院5号
中国科学院动物研究所干细胞与生殖生物学国家重点实验室 100101
更多信息: 干细胞与免疫学研究组     

简历介绍:

赵同标,博士,中国科学院动物研究所研究员,博士生导师,干细胞与免疫学研究组组长;兼任北京干细胞与再生医学研究院副院长,中国科学院大学岗位教授;国家海外高层次引进人才,科技部科技创新领军人才,国家重点研发计划项目首席科学家。2000年毕业于曲阜师范大学,获学士学位,2004年毕业于中国科学院西北高原生物研究所,获博士学位;2004年至2006年在中国科学院生物物理研究所做博士后,2006年获该所副研究员任职资格;2006年至2007年在威斯康星血液研究所从事免疫学研究;2007年至2010年在加州大学圣地亚哥分校做从事干细胞研究,2010年任该校Assistant Specialist III;2012年加入动物研究所,组建干细胞与免疫学实验室。承担国家重点研发计划、中国科学院战略先导专项、国家自然科学基金重点等项目。

主要从事干细胞免疫和干细胞转化研究。发现了小鼠和人iPSC的免疫原性(Nature, 2011; Cell Stem Cell, 2015; Cell Discovery, 2015);提出了氧化磷酸化和高自噬流作为干细胞基本特征维持多能性新观点(Protein & Cell, 2022; Nat. Commun., 2019; Cell Death Differ.;Autophagy, 2016);研制了全球首个干细胞国际标准(ISO 24603:2022)、干细胞数据国际标准(ISO 8472-1:2024)、神经干细胞国际标准(ISO 18162:2024),首个人源干细胞国家标准(GB-T 42466-2023)及《干细胞通用要求》等30余项团体标准。

研究领域:

研究组围绕干细胞基础与临床转化研究中的瓶颈问题,重点聚焦于以下研究方向:(1)天然免疫耐受机制及其在干细胞移植中的应用;(2)多能干细胞的代谢调控及其衍生功能细胞在肿瘤免疫治疗中的应用;(3)干细胞标准研究。

社会任职:

现任中国细胞生物学会标准工作委员主任委员、中国细胞生物学会理事、中国动物学会理事、干细胞生物学分会委员、CNAS专门委员会生物样本库专业委员会委员、中国遗传学会类器官分会委员;国际标准化组织/生物技术委员会/类器官工作委员会(ISO/TC276/AHG1)主任委员、ISO/TC276/WG2、WG4、SC1委员、国际干细胞学会(ISSCR)标准指导委员会委员、“一带一路”区域标准化委员会副主席委员。国际期刊《Animal Models and Experimental Medicine》、《Frontiers in Cell and Developmental Biology》副主编,《Cell Proliferation》、《发育医学电子杂志》等期刊编委。

获奖及荣誉:

承担科研项目情况:

代表论著:

#第一作者,*通讯作者):

  1. Zhao Y, Cao J, Xu H, Cao W, Cheng C, Tan S, Zhao T*. Optimizing in vitro T cell differentiation by using induced pluripotent stem cells with GFP-RUNX1 and mCherry-TCF7 labelling. Cell Proliferation, 2024, e13661. DOI: 10.1111/cpr.13661
  2. Zhu W#, Li M#, Zou J#, Zhang D, Fang M, Sun Y, Li C, Tang M, Wang Y, Zhou Q, Zhao T*, Li W*, Hu Z*, Hu B*. Induction of local immunosuppression in allogeneic cell transplantation by cell-type-specific expression of PD-L1 and CTLA4Ig. Stem Cell Reports, 2023,18(12):2344-2355. DOI: 10.1016/j.stemcr.2023.10.016
  3. Ren J#, Song M#, Zhang W#, Cai JP, Cao F, Cao Z, Chan P, Chen C, Chen G, Chen HZ, Chen J, Chen XC, Ci W, Ding BS, Ding Q, Gao F, Gao S, Han JJ, He QY, Huang K, Ju Z, Kong QP, Li J, Li J, Li J, Li X, Liu B, Liu F, Liu JP, Liu L, Liu Q, Liu Q, Liu X, Liu Y, Luo X, Ma S, Ma X, Mao Z, Nie J, Peng Y, Qu J, Ren R, Song W, Songyang Z, Sun L, Sun YE, Sun Y, Tian M, Tian XL, Tian Y, Wang J, Wang S, Wang S, Wang W, Wang X, Wang X, Wang YJ, Wang Y, Wong CCL, Xiang AP, Xiao Y, Xiao ZX, Xie Z, Xiong W, Xu D, Yang Z, Ye J, Yu W, Yue R, Zhang C, Zhang H, Zhang L, Zhang X, Zhang Y, Zhang YW, Zhang Z, Zhao T, Zhao Y, Zhou Z, Zhu D, Zou W, Pei G, Liu GH*. The Aging Biomarker Consortium represents a new era for aging research in China. Nat Med, 2023,29(9):2162-2165. DOI: 10.1038/s41591-023-02444-y
  4. Han M#, Hu L#, Wu D#, Zhang Y, Li P, Zhao X, Zeng Y, Ren G, Hou Z, Pang Y, Zhao T, Zhong C*. IL-21R-STAT3 signalling initiates a differentiation program in uterine tissue-resident NK cells to support pregnancy. Nature Communications, 2023 4;14(1):7109. DOI: 10.1038/s41467-023-42990-0
  5. Xu H#, Tan S, Zhao Y, Zhang L, Cao W, Li X, Tian J, Wang X, Li X, Wang F, Cao J*, Zhao T*. Lin-PU.1dimGATA-1-defines haematopoietic stem cells with long-term multilineage reconstitution activity. Cell Proliferation, 2023, e13490. DOI: 10.1111/cpr.13490
  6. Cao W#, Cao J#, Li X, Xu H, Tian J, Li X, Wang F, Zhao T*. A novel inducible haematopoietic cell-depleting mouse model for chimeric complementation of blood cells. Cell Proliferation, 2023,56(5): e13472. DOI: 10.1111/cpr.13472
  7. Cao J#, Li M#, Liu K, Shi X, Sui N, Yao Y, Wang X, Li S, Tian Y, Tan S, Zhao Q, Wang L, Chai X, Zhang L, Liu C, Li X. Chang Z, Li D, Zhao T*. Oxidative phosphorylation safeguards pluripotency via UDP-N-acetylglucosamine. Protein Cell, 2023,14(5): 376-381.DOI: 10.1093/procel/pwac009
  8. Liu K#, Li X#, Li Z#, Cao J, Li X, Xu Y, Liu L, Zhao T*. Evaluating mitophagy in embryonic stem cells by using fluorescence-based imaging. Frontiers In Cell and Developmental Biology,2022,10:910464. DOI: 10.3389/fcell.2022.910464
  9. Zhao Q#, Liu K#, Zhang L#, Li Z, Wang L, Cao J, Xu Y, Zheng A, Chen Q, Zhao T*. BNIP3-dependent mitophagy safeguards ESC genomic integrity via preventing oxidative stress-induced DNA damage and protecting homologous recombination. Cell Death and Disease,2022,13(11):976. DOI: 10.1038/s41419-022-05413-4
  10. Liu K#, Zhao Q#, Sun H#, Liu L, Wang C, Li Z, Xu Y, Wang L, Zhang L, Zhang H, Chen Q, Zhao T*. BNIP3(BCL2 interacting protein 3) regulates pluripotency by modulating mitochondrial homeostasis via mitophagy. Cell Death and Disease,2022, 13(4):334. DOI: 10.1038/s41419-022-04795-9
  11. Wen D#, Ding LS#, Zhang Y, Li X, Zhang X, Yuan F, Zhao T, Zheng A*. Suppression of flavivirus transmission from animal hosts to mosquitoes with a mosquito-delivered vaccine. Nature Communications, 2022,13(1):7780. DOI: 10.1038/s41467-022-35407-x
  12. Wang C#, Liu K#, Cao J#, Wang L, Zhao Q, Li Z, Zhang H, Chen Q, Zhao T*. PINK1-mediated mitophagy maintains pluripotency through optineurin. Cell Proliferation, 2021,54(5): e13034. DOI: 10.1111/cpr.13034 
  13. Jin L#, Cao L#, Zhu Y#, Cao J#, Li X, Zhou J, Liu B, Zhao T*. Enhance anti-lung tumor efficacy of chimeric antigen receptor-T cells by ectopic expression of C–C motif chemokine receptor 6. Science Bulletin, 2021,66(8):803-812. DOI: 10.1016/j.scib.2020.12.027
  14. Zhou J#, Jin L, Wang F, Zhang Y, Liu B, Zhao T*. Chimeric antigen receptor T (CAR-T) cells expanded with IL-7/IL-15 mediate superior antitumor effects. Protein Cell, 2019, 10(10): 764-769. DOI: 10.1007/s13238-019-0643-y
  15. Gu H#, Shi X#, Liu C#, Wang C#, Sui N, Zhao Y, Gong J, Wang F, Zhang H, Li W*, Zhao T*. USP8 maintains embryonic stem cell stemness via deubiquitination of EPG5. Nature Communications, 2019, 10(1): 1465. DOI: 10.1038/s41467-019-09430-4
  16. Gong J#, Gu H#, Zhao L#, Wang L, Liu P, Wang F, Xu H, Zhao T*. Phosphorylation of ULK1 by AMPK is essential for mouse embryonic stem cell self-renewal and pluripotency. Cell Death and Disease, 2018, 9(2): 38. DOI: 10.1038/s41419-017-0054-z
  17. Liu P#, Liu K#, Gu H, Wang W, Gong J, Zhu Y, Zhao Q, Cao J, Han C, Gao F, Chen Q, Li W, Jiao J, Hu B, Zhou Q, Zhao T*. High autophagic flux guards ESC identity through coordinating autophagy machinery gene program by FOXO1. Cell Death and Differentiation, 2017, 24(10): 1672-1680. DOI: 10.1038/cdd.2017.90
  18. Sun H#, Cao J#, Zhao L#, Zhu S, Chen S, Li Y, Zhao B, Zhao T*. PIM2 regulates stemness through phosphorylation of 4E-BP1. Science Bulletin, 2017, 62(10): 679-685. (Cover story) DOI: 10.1016/j.scib.2017.04.018
  19. Liu K#, Zhao Q#, Liu P#, Cao J, Gong J, Wang C, Wang W, Li X, Sun H, Zhang C, Li Y, Jiang M, Zhu S, Sun Q, Jiao J, Hu B, Zhao X, Li W, Chen Q, Zhou Q*, Zhao T*. ATG3-dependent autophagy mediates mitochondrial homeostasis in pluripotency acquirement and maintenance. Autophagy, 2016, 12(11): 2000-2008. DOI: 10.1080/15548627.2016.1212786
  20. Zhu S, Cao J, Sun H, Liu K, Li Y, Zhao T*. p18 inhibits reprogramming through inactivation of Cdk4/6. Scientific Reports, 2016, 6: 31085. DOI: 10.1038/srep31085
  21. Zhang C, Cao J, Li X, Xu H, Wang W, Wang L, Zhao X, Li W, Jiao J, Hu B, Zhou Q*, Zhao T*. Treatment of multiple sclerosis by transplantation of neural stem cells derived from induced pluripotent stem cells. Science China Life Sciences, 2016, 59(9): 950-957. DOI: 10.1007/s11427-016-0114-9
  22. Zhao T#, Zhang Z#, Westenskow P#, Todorova D, Hu Z, Lin T, Rong Z, Kim J, He J, Wang M, Clegg D, Yang Y, Zhang K, Friedlander M, Xu Y*. Humanized mice reveal differential immunogenicity of cells derived from autologous induced pluripotent stem cells. Cell Stem Cell, 2015, 17(3): 353-359. DOI: 10.1016/j.stem.2015.07.021
  23. Wang L#, Cao J#, Wang Y#, Lan T#, Liu L, Wang W, Jin N, Gong J, Zhang C, Teng F, Yan G, Li C, Li J, Wan H, Hu B, Li W, Zhao X, Qi Z*, Zhao T*, Zhou Q*. Immunogenicity and functional evaluation of iPSC-derived organs for transplantation. Cell Discovery, 2015, 1: 15015. DOI: 10.1038/celldisc.2015.15
  24. Zhao T, Zhang Z, Rong Z, Xu Y*. Immunogenicity of induced pluripotent stem cells. Nature, 2011, 474(7350): 212-216. DOI: 10.1038/nature10135

Highlighted by Nature (Nature 474:165); Nature Medicine (Nature Medicine 17: 670)

Recommended by Faculty of 1000 (F1000.com/11136956)

Reported by Nature, Science, New York Time, New Scientist, ScienceDaily, UK Guardian, USA today et al.

  1. Hou Q#, Zhao T#, Zhang H, Lu H, Zhang Q, Sun L, Fan Z*. Granzyme H induces apoptosis of target tumor cells characterized by DNA fragmentation and Bid-dependent mitochondrial damage. Molecular Immunology, 2008, 45(4): 1044-1055. DOI:10.1016/j.molimm.2007.07.032
  2. Zhao T#, Zhang H#, Guo Y, Fan Z*. Granzyme K directly processes bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death. Journal of Biological Chemistry, 2007, 282(16): 12104-12111. DOI:10.1074/jbc.M611006200
  3. Zhao T#, Zhang H, Guo Y, Zhang Q, Hua G, Lu H, Hou Q, Liu H, Fan Z*. Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells. Cell Death and Differentiation, 2007, 14(3):489-499. DOI: 10.1038/sj.cdd.4402040

综述论文:

  1. Ludwig TE#*, Andrews PW#, Barbaric I, Benvenisty N, Bhattacharyya A, Crook JM, Daheron LM, Draper JS, Healy LE, Huch M, Inamdar MS, Jensen KB, Kurtz A, Lancaster MA, Liberali P, Lutolf MP, Mummery CL, Pera MF, Sato Y, Shimasaki N, Smith AG, Song J, Spits C, Stacey G, Wells CA, Zhao T, Mosher JT. ISSCR standards for the use of human stem cells in basic research. Stem Cell Reports, 2023,18(9):1744-1752. DOI: 10.1016/j.stemcr.2023.08.003
  2. Aging Biomarker Consortium; Bao H#, Cao J#, Chen M#, Chen M#, Chen W#, Chen X#, Chen Y#, Chen Y#, Chen Y#, Chen Z#, Chhetri JK#, Ding Y#, Feng J#, Guo J#, Guo M#, He C#, Jia Y#, Jiang H#, Jing Y#, Li D#, Li J#, Li J#, Liang Q#, Liang R#, Liu F#, Liu X#, Liu Z#, Luo OJ#, Lv J#, Ma J#, Mao K#, Nie J#, Qiao X#, Sun X#, Tang X#, Wang J#, Wang Q#, Wang S#, Wang X#, Wang Y#, Wang Y#, Wu R#, Xia K#, Xiao FH#, Xu L#, Xu Y#, Yan H#, Yang L#, Yang R#, Yang Y#, Ying Y#, Zhang L#, Zhang W#, Zhang W#, Zhang X#, Zhang Z#, Zhou M#, Zhou R#, Zhu Q#, Zhu Z#, Cao F*, Cao Z*, Chan P*, Chen C*, Chen G*, Chen HZ*, Chen J*, Ci W*, Ding BS*, Ding Q*, Gao F*, Han JJ*, Huang K*, Ju Z*, Kong QP*, Li J*, Li J*, Li X*, Liu B*, Liu F*, Liu L*, Liu Q*, Liu Q*, Liu X*, Liu Y*, Luo X*, Ma S*, Ma X*, Mao Z*, Nie J*, Peng Y*, Qu J*, Ren J*, Ren R*, Song M*, Song YZ*, Sun YE*, Sun Y*, Tian M*, Wang S*, Wang S*, Wang X*, Wang X*, Wang YJ*, Wang Y*, Wong CCL*, Xiang AP*, Xiao Y*, Xie Z*, Xu D*, Ye J*, Yue R*, Zhang C, Zhang H, Zhang L, Zhang W, Zhang Y, Zhang YW, Zhang Z*, Zhao T*, Zhao Y*, Zhu D*, Zou W*, Pei G*, Liu GH*. Biomarkers of aging. Sci China Life Sci, 2023,66(5):893-1066. DOI: 10.1007/s11427-023-2305-0
  3. Cao J#, Hao J#, Wang L#, Tan Y, Tian Y, Li S, Ma A, Fu B, Dai J, Zhai P, Xiang P, Zhang Y, Cheng T*, Peng Y*, Zhou Q*, Zhao T* Developing standards to support the clinical translation of stem cells. Stem Cells Translational Medicine, 2021,10: S85-S95. DOI:10.1002/sct3.13035
  4. Cao J, Stacey G, Chang N, Zhao T*. Developing standards to support cell technology applications, Cell Proliferation, 2022,55(4): e13210. DOI:10.1111/cpr.13210
  5. Liu K#, Cao J#, Shi X#, Wang L, Zhao T*. Cellular metabolism and homeostasis in pluripotency regulation. Protein Cell, 2020,11(9): 630-640. DOI:10.1007/s13238-020-00755-1
  6. Wang L#, Ye X#, Zhao T*. The physiological roles of autophagy in the mammalian life cycle. Biological Reviews, 2019, 94(2): 503-516. DOI: 10.1111/brv.12464
  7. Liu K, Wang L, Zhao T*. Autophagy in Normal Stem Cells and Specialized Cells. Adv Exp Med Biol,2019.1206:489-508. DOI: 10.1007/978-981-15-0602-4
  8. Cao J, Zhao T*. Single-cell sequencing delivers hematopoietic stem cell specification. Science Bulletin, 2016, 61(18): 1419-1421. DOI: 10.1007/s11434-016-1163-2
  9. Liu K#, Song Y#, Yu H#, Zhao T*. Understanding the roadmaps to induced pluripotency. Cell Death Disease, 2014, 5: e1232. DOI: 10.1038/cddis.2014.205
  10. Cao J#, Li X#, Lu X, Zhang C, Yu H, Zhao T*. Cells derived from iPSC can be immunogenic–Yes or No? Protein Cell, 2014, 5(1): 1-3. DOI:10.1007/s13238-013-0003-2
  11. Lu X, Zhao T*. Clinical therapy using iPSCs: hopes and challenges. Genomics Proteomics Bioinformatics, 2013, 11(5): 294-298. DOI: 10.1016/j.gpb.2013.09.002
  12. Zhao T, Xu Y*. p53 and stem cells: new developments and new concerns. Trends in Cell Biology, 2010, 20(3): 170-175. DOI: 10.1016/j.tcb.2009.12.004

标准论文:

  1. Niu S#, Xia C#, Huang D#, Wang L#, Hu H, Yu S, Wu N, Dong Z, Zhou J, Wu J, Yu J, Zhang Y, Wang C, Fu B, Cao J, Liang L, Xu L, Chen L, Zhou Q, Ma A*, Zhao T*, Hao J*, Wang J*. Requirements for human natural killer cells. Cell Prolif, 2024, 57(5): e13588. DOI: 10.1111/cpr.13588. Epub 2023 Dec 20
  2. Wang YK#, Yu J#, Zhang TT#, Ma AJ, Hao J, Chen YJ, Liu CM, Liu Y, Wang CL, Zhai PJ, Xiang AP, Li TQ, Tang TS, Chen H, Bao XJ, Wang YL, He WY, Fan J, Teng ZQ, Wang L, Zhou JX, Fu BQ, Fu YV, Feng L, Cao JN, Liang LM, Wang L, Zhou Q, Zhang Y*, Hu BY*, Zhao TB*. Human neural stem cells. Cell Prolif, 2024, 57(4): e13564. DOI: 10.1111/cpr.13564
  3. Peng Y#*, Ma A#, Xiao Z#, Hao J#, Feng R, Wang C, Hu B, Zhai P, Li K, Wang L, Cao J, Xiang P, Zhang Y, Wei J, Wang X, Fu B, Chen Q, Wei Q, Gao H, Lv J, Liu X, Ma Y, Cheng T, Huang X, Su Y, Zhang H, Zhou Q*, Zhao T*. Technical specifications for ethics review of human stem cell research. Cell Prolif, 2024,57(3): e13556. DOI:  10.1111/cpr.13556
  4. Wang L#, Liu S#, Li K#, Ma A#, Hu C#, Wang C, Cao N, Zhao Y, Fu R, Jia W, Xiang P, Liu H, Qi Z, Zhu N, Liang L, Wang L, Cao J, Zhai P, Zhou J, Wei J, Na T, Wu J, He Z, Zhou G, Yu W, Wu J, Zeng W, Zhang Y, Zhu L, Fu B, Zhang J, Yang S, Dai C, Cui H, Jing J, Yan H, He X, Lu Y, Tong C, Zhao T*, Hao J*, Liu X*, Jin Y*, Wang Y*. General requirements for the production of extracellular vesicles derived from human stem cells. Cell Prolif, 2024, 57(3): e13554. DOI: 10.1111/cpr.13554
  5. Wang YK, Feng L, Ma AJ, Hao J, Zhang Y, Chen YJ, Chen ZG, Yu JY, Liu Y, Liu CM, Zhang Y, Wang CL, Teng ZQ, Zhou JX, Li TQ, Wang L, Fu BQ, Fu YV, Zhu LJ, Liang LM, Cao JN, Wang L, Zhou Q, Xiang AP*, Hu BY*, Zhao TB*. Human midbrain dopaminergic progenitors. Cell Prolif, 2024, 57(4): e13563. DOI: 10.1111/cpr.13563
  6. Lin H#, Wang Y#, Cheng C#, Qian Y#, Hao J, Zhang Z, Sheng W, Song L, Deng CX, Zhao B, Cao J, Wang L, Wang L, Liang L, Chen WK, Yu C, Sun Z, Yang Y, Wang C, Zhang Y, Li Q, Li K, Ma A*, Zhao T*, Chen YG*, Hua G*. Standard: Human intestinal cancer organoids. Cell Regen, 2023, 12(1):24. DOI: 10.1186/s13619-023-00167-6
  7. Wang Y#, Lin H#, Zhao L#, Hong F#, Hao J, Zhang Z, Sheng W, Song L, Deng C, Zhao B, Cao J, Wang L, Wang L, Liang L, Chen W, Yu C, Sun Z, Yang Y, Wang C, Zhang Y, Li Q, Li K, Ma A*, Zhao T*, Hua G*, Chen Y*. Standard: Human intestinal organoids. Cell regeneration,2023,12(1):23. DOI:10.1186/s13619-023-00168-5
  8. Zhang Y#, Wei J#, Cao J#, Zhang K#, Peng Y, Deng H, Kang J, Pan G, Zhang Y, Fu B, Hu S, Na J, Liu Y, Wang L, Liang L, Zhu H, Zhang Y, Jin Z, Hao J*, Ma A*, Zhao T*, Yu J*. Requirements for human-induced pluripotent stem cells. Cell Proliferation, 2022,55(4): e13182. DOI:10.1111/cpr.13182
  9. Wang L#, Cao J#, Peng Y#, Fu B, Jin Z, Hu Y, Wu W, Xiang P, Hu S, Yu J, Zhang Y, Wei J, Zhang Y, Li Q, Zhou J, Zhai P, Zhu H, Liang L, Ma A, Glyn Stacey*, Zhao T*, Hao J*.Human retinal pigment epithelial cells. Cell Proliferation, 2022, 55(4): e13153. DOI:10.1111/cpr.13153
  10. Yu M#, Lei W#, Cao J#, Wang L#, Ma A, Zhao Z, Yang H, Shen Z, Lan F, Cao F. Liang P, Pei X, Xiang P, Yu J, Zhang Y, Zhang Y, Li Q, Zhou J, Wei J, Peng Y, Zhu H, Liang L, Cao N, Fu B*, Hao J*, Zhao T*, Hu S*. Requirements for Human Cardiomyocytes. Cell Proliferation, 2022,55(4): e13150. DOI:10.1111/cpr.13150
  11. Peng Z#, Wu J#, Hu S#, Ma A#, Wang L, Cao N, Zhang Y, Li Q, Yu J, Meng S, Na T, Shi X, Li M, Liu H, Qian L, Tian E, Lin F, Cao J, Peng Y, Zhu H, Liang L, Hao J*, Zhao T*, Cheng X*, Pan G*. Requirments for Primary Human Hepatocyte. Cell Proliferation, 2022,55(4): e13147. DOI:10.1111/cpr.13147
  12. Chen X#, Huang J#, Wu J#, Hao J#, Fu B, Wang Y, Zhou B, Tao N, Wei J, Zhang Y, Li Q, Hu S, Zhou J, Yu J, Wu Z, Zhu H, Cao J, Wang L, Peng Y, Liang L, Ma A*, Zhang Y*, Zhao T*, Xiang P*. Human mesenchymal stem cells. Cell Proliferation, 2022,55: e13141. DOI:10.1111/cpr.13141
  13. Nan X#, Zhang BW#, Hao J#, Wen Y#, Fu B, Qu M, Zhang Y, Wang H, Fang F, Wei J, Li Q, Hu S, Yu J, Gao Y, Liu Q, Cao J, Wang L, Peng Y, Zhu H, Liang L, Ma A*, Zhou J*, Zhao T*, Pei X*. Requirements for human haematopoietic stem/progenitor cells. Cell Proliferation, 2022,55(4): e13152. DOI:10.1111/cpr.13152
  14. Hao J#, Ma A#, Wang L#, Cao J#, Chen S, Wang L, Fu B, Zhou J, Pei X, Zhang Y, Xiang P, Hu S, Li Q, Zhang Y, Xia Y, Zhu H, Stacey G, Zhou Q*, Zhao T*. General requirements for stem cells. Cell Proliferation, 2020, 53(12): e12926. DOI:10.1111/cpr.12926
  15. Hao J#, Cao J#, Wang L#, Ma A#, Chen S, Ding J, Wang L, Fu B, Zhang Y, Pei X, Xiang P, Li Q, Zhang Y, Zhou J, Hu S, Yu J, Wei J, Zhu H, Stacey G, Zhao T*, Zhou Q*. Requirements for human embryonic stem cells. Cell Proliferation, 2020,53(12): e12925. DOI:10.1111/cpr.12925

国际标准:

1. Tongbiao Zhao*,Qi Zhou*. ISO 24603:2022 Biotechnology — Biobanking — Requirements for human and mouse pluripotent stem cells. www.iso.org/standard/79046.html

2. Yong Zhang*, Tongbiao Zhao*. ISO 8472-1:2024 Biotechnology — Data interoperability for stem cell data — Part 1: Framework. www.iso.org/standard/83185.html

3. Tongbiao Zhao*,Qi Zhou*. ISO 18162:2024 Biotechnology — Biobanking — Requirements for human neural stem cells derived from pluripotent stem cells. www.iso.org/standard/85207.html

4. ISSCR Standard Steering Committee*. Standards for Human Stem Cell Use in Research. ISSCR, www.isscr.org/basic-research-standards

专利:

赵同标; 靳利远; 朱颖婕; 曹磊; 曹佳妮; 李晓燕。修饰的免疫细胞及其应用。ZL202010062327.7(中国发明专利);2022-567698 (日本发明专利)。

赵同标;曹卫云;曹佳妮;李晓燕;李兴;徐昊宇。HSV1-tk_GCV诱导型血液系统缺陷小鼠模型的制备方法及应用。ZL202110753676.8(中国发明专利)。


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