(#第一作者,*通讯作者):
- Zhao Y, Cao J, Xu H, Cao W, Cheng C, Tan S, Zhao T*. Optimizing in vitro T cell differentiation by using induced pluripotent stem cells with GFP-RUNX1 and mCherry-TCF7 labelling. Cell Proliferation, 2024, e13661. DOI: 10.1111/cpr.13661
- Zhu W#, Li M#, Zou J#, Zhang D, Fang M, Sun Y, Li C, Tang M, Wang Y, Zhou Q, Zhao T*, Li W*, Hu Z*, Hu B*. Induction of local immunosuppression in allogeneic cell transplantation by cell-type-specific expression of PD-L1 and CTLA4Ig. Stem Cell Reports, 2023,18(12):2344-2355. DOI: 10.1016/j.stemcr.2023.10.016
- Ren J#, Song M#, Zhang W#, Cai JP, Cao F, Cao Z, Chan P, Chen C, Chen G, Chen HZ, Chen J, Chen XC, Ci W, Ding BS, Ding Q, Gao F, Gao S, Han JJ, He QY, Huang K, Ju Z, Kong QP, Li J, Li J, Li J, Li X, Liu B, Liu F, Liu JP, Liu L, Liu Q, Liu Q, Liu X, Liu Y, Luo X, Ma S, Ma X, Mao Z, Nie J, Peng Y, Qu J, Ren R, Song W, Songyang Z, Sun L, Sun YE, Sun Y, Tian M, Tian XL, Tian Y, Wang J, Wang S, Wang S, Wang W, Wang X, Wang X, Wang YJ, Wang Y, Wong CCL, Xiang AP, Xiao Y, Xiao ZX, Xie Z, Xiong W, Xu D, Yang Z, Ye J, Yu W, Yue R, Zhang C, Zhang H, Zhang L, Zhang X, Zhang Y, Zhang YW, Zhang Z, Zhao T, Zhao Y, Zhou Z, Zhu D, Zou W, Pei G, Liu GH*. The Aging Biomarker Consortium represents a new era for aging research in China. Nat Med, 2023,29(9):2162-2165. DOI: 10.1038/s41591-023-02444-y
- Han M#, Hu L#, Wu D#, Zhang Y, Li P, Zhao X, Zeng Y, Ren G, Hou Z, Pang Y, Zhao T, Zhong C*. IL-21R-STAT3 signalling initiates a differentiation program in uterine tissue-resident NK cells to support pregnancy. Nature Communications, 2023 4;14(1):7109. DOI: 10.1038/s41467-023-42990-0
- Xu H#, Tan S, Zhao Y, Zhang L, Cao W, Li X, Tian J, Wang X, Li X, Wang F, Cao J*, Zhao T*. Lin-PU.1dimGATA-1-defines haematopoietic stem cells with long-term multilineage reconstitution activity. Cell Proliferation, 2023, e13490. DOI: 10.1111/cpr.13490
- Cao W#, Cao J#, Li X, Xu H, Tian J, Li X, Wang F, Zhao T*. A novel inducible haematopoietic cell-depleting mouse model for chimeric complementation of blood cells. Cell Proliferation, 2023,56(5): e13472. DOI: 10.1111/cpr.13472
- Cao J#, Li M#, Liu K, Shi X, Sui N, Yao Y, Wang X, Li S, Tian Y, Tan S, Zhao Q, Wang L, Chai X, Zhang L, Liu C, Li X. Chang Z, Li D, Zhao T*. Oxidative phosphorylation safeguards pluripotency via UDP-N-acetylglucosamine. Protein Cell, 2023,14(5): 376-381.DOI: 10.1093/procel/pwac009
- Liu K#, Li X#, Li Z#, Cao J, Li X, Xu Y, Liu L, Zhao T*. Evaluating mitophagy in embryonic stem cells by using fluorescence-based imaging. Frontiers In Cell and Developmental Biology,2022,10:910464. DOI: 10.3389/fcell.2022.910464
- Zhao Q#, Liu K#, Zhang L#, Li Z, Wang L, Cao J, Xu Y, Zheng A, Chen Q, Zhao T*. BNIP3-dependent mitophagy safeguards ESC genomic integrity via preventing oxidative stress-induced DNA damage and protecting homologous recombination. Cell Death and Disease,2022,13(11):976. DOI: 10.1038/s41419-022-05413-4
- Liu K#, Zhao Q#, Sun H#, Liu L, Wang C, Li Z, Xu Y, Wang L, Zhang L, Zhang H, Chen Q, Zhao T*. BNIP3(BCL2 interacting protein 3) regulates pluripotency by modulating mitochondrial homeostasis via mitophagy. Cell Death and Disease,2022, 13(4):334. DOI: 10.1038/s41419-022-04795-9
- Wen D#, Ding LS#, Zhang Y, Li X, Zhang X, Yuan F, Zhao T, Zheng A*. Suppression of flavivirus transmission from animal hosts to mosquitoes with a mosquito-delivered vaccine. Nature Communications, 2022,13(1):7780. DOI: 10.1038/s41467-022-35407-x
- Wang C#, Liu K#, Cao J#, Wang L, Zhao Q, Li Z, Zhang H, Chen Q, Zhao T*. PINK1-mediated mitophagy maintains pluripotency through optineurin. Cell Proliferation, 2021,54(5): e13034. DOI: 10.1111/cpr.13034
- Jin L#, Cao L#, Zhu Y#, Cao J#, Li X, Zhou J, Liu B, Zhao T*. Enhance anti-lung tumor efficacy of chimeric antigen receptor-T cells by ectopic expression of C–C motif chemokine receptor 6. Science Bulletin, 2021,66(8):803-812. DOI: 10.1016/j.scib.2020.12.027
- Zhou J#, Jin L, Wang F, Zhang Y, Liu B, Zhao T*. Chimeric antigen receptor T (CAR-T) cells expanded with IL-7/IL-15 mediate superior antitumor effects. Protein Cell, 2019, 10(10): 764-769. DOI: 10.1007/s13238-019-0643-y
- Gu H#, Shi X#, Liu C#, Wang C#, Sui N, Zhao Y, Gong J, Wang F, Zhang H, Li W*, Zhao T*. USP8 maintains embryonic stem cell stemness via deubiquitination of EPG5. Nature Communications, 2019, 10(1): 1465. DOI: 10.1038/s41467-019-09430-4
- Gong J#, Gu H#, Zhao L#, Wang L, Liu P, Wang F, Xu H, Zhao T*. Phosphorylation of ULK1 by AMPK is essential for mouse embryonic stem cell self-renewal and pluripotency. Cell Death and Disease, 2018, 9(2): 38. DOI: 10.1038/s41419-017-0054-z
- Liu P#, Liu K#, Gu H, Wang W, Gong J, Zhu Y, Zhao Q, Cao J, Han C, Gao F, Chen Q, Li W, Jiao J, Hu B, Zhou Q, Zhao T*. High autophagic flux guards ESC identity through coordinating autophagy machinery gene program by FOXO1. Cell Death and Differentiation, 2017, 24(10): 1672-1680. DOI: 10.1038/cdd.2017.90
- Sun H#, Cao J#, Zhao L#, Zhu S, Chen S, Li Y, Zhao B, Zhao T*. PIM2 regulates stemness through phosphorylation of 4E-BP1. Science Bulletin, 2017, 62(10): 679-685. (Cover story) DOI: 10.1016/j.scib.2017.04.018
- Liu K#, Zhao Q#, Liu P#, Cao J, Gong J, Wang C, Wang W, Li X, Sun H, Zhang C, Li Y, Jiang M, Zhu S, Sun Q, Jiao J, Hu B, Zhao X, Li W, Chen Q, Zhou Q*, Zhao T*. ATG3-dependent autophagy mediates mitochondrial homeostasis in pluripotency acquirement and maintenance. Autophagy, 2016, 12(11): 2000-2008. DOI: 10.1080/15548627.2016.1212786
- Zhu S, Cao J, Sun H, Liu K, Li Y, Zhao T*. p18 inhibits reprogramming through inactivation of Cdk4/6. Scientific Reports, 2016, 6: 31085. DOI: 10.1038/srep31085
- Zhang C, Cao J, Li X, Xu H, Wang W, Wang L, Zhao X, Li W, Jiao J, Hu B, Zhou Q*, Zhao T*. Treatment of multiple sclerosis by transplantation of neural stem cells derived from induced pluripotent stem cells. Science China Life Sciences, 2016, 59(9): 950-957. DOI: 10.1007/s11427-016-0114-9
- Zhao T#, Zhang Z#, Westenskow P#, Todorova D, Hu Z, Lin T, Rong Z, Kim J, He J, Wang M, Clegg D, Yang Y, Zhang K, Friedlander M, Xu Y*. Humanized mice reveal differential immunogenicity of cells derived from autologous induced pluripotent stem cells. Cell Stem Cell, 2015, 17(3): 353-359. DOI: 10.1016/j.stem.2015.07.021
- Wang L#, Cao J#, Wang Y#, Lan T#, Liu L, Wang W, Jin N, Gong J, Zhang C, Teng F, Yan G, Li C, Li J, Wan H, Hu B, Li W, Zhao X, Qi Z*, Zhao T*, Zhou Q*. Immunogenicity and functional evaluation of iPSC-derived organs for transplantation. Cell Discovery, 2015, 1: 15015. DOI: 10.1038/celldisc.2015.15
- Zhao T, Zhang Z, Rong Z, Xu Y*. Immunogenicity of induced pluripotent stem cells. Nature, 2011, 474(7350): 212-216. DOI: 10.1038/nature10135
Highlighted by Nature (Nature 474:165); Nature Medicine (Nature Medicine 17: 670)
Recommended by Faculty of 1000 (F1000.com/11136956)
Reported by Nature, Science, New York Time, New Scientist, ScienceDaily, UK Guardian, USA today et al.
- Hou Q#, Zhao T#, Zhang H, Lu H, Zhang Q, Sun L, Fan Z*. Granzyme H induces apoptosis of target tumor cells characterized by DNA fragmentation and Bid-dependent mitochondrial damage. Molecular Immunology, 2008, 45(4): 1044-1055. DOI:10.1016/j.molimm.2007.07.032
- Zhao T#, Zhang H#, Guo Y, Fan Z*. Granzyme K directly processes bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death. Journal of Biological Chemistry, 2007, 282(16): 12104-12111. DOI:10.1074/jbc.M611006200
- Zhao T#, Zhang H, Guo Y, Zhang Q, Hua G, Lu H, Hou Q, Liu H, Fan Z*. Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells. Cell Death and Differentiation, 2007, 14(3):489-499. DOI: 10.1038/sj.cdd.4402040
综述论文:
- Ludwig TE#*, Andrews PW#, Barbaric I, Benvenisty N, Bhattacharyya A, Crook JM, Daheron LM, Draper JS, Healy LE, Huch M, Inamdar MS, Jensen KB, Kurtz A, Lancaster MA, Liberali P, Lutolf MP, Mummery CL, Pera MF, Sato Y, Shimasaki N, Smith AG, Song J, Spits C, Stacey G, Wells CA, Zhao T, Mosher JT. ISSCR standards for the use of human stem cells in basic research. Stem Cell Reports, 2023,18(9):1744-1752. DOI: 10.1016/j.stemcr.2023.08.003
- Aging Biomarker Consortium; Bao H#, Cao J#, Chen M#, Chen M#, Chen W#, Chen X#, Chen Y#, Chen Y#, Chen Y#, Chen Z#, Chhetri JK#, Ding Y#, Feng J#, Guo J#, Guo M#, He C#, Jia Y#, Jiang H#, Jing Y#, Li D#, Li J#, Li J#, Liang Q#, Liang R#, Liu F#, Liu X#, Liu Z#, Luo OJ#, Lv J#, Ma J#, Mao K#, Nie J#, Qiao X#, Sun X#, Tang X#, Wang J#, Wang Q#, Wang S#, Wang X#, Wang Y#, Wang Y#, Wu R#, Xia K#, Xiao FH#, Xu L#, Xu Y#, Yan H#, Yang L#, Yang R#, Yang Y#, Ying Y#, Zhang L#, Zhang W#, Zhang W#, Zhang X#, Zhang Z#, Zhou M#, Zhou R#, Zhu Q#, Zhu Z#, Cao F*, Cao Z*, Chan P*, Chen C*, Chen G*, Chen HZ*, Chen J*, Ci W*, Ding BS*, Ding Q*, Gao F*, Han JJ*, Huang K*, Ju Z*, Kong QP*, Li J*, Li J*, Li X*, Liu B*, Liu F*, Liu L*, Liu Q*, Liu Q*, Liu X*, Liu Y*, Luo X*, Ma S*, Ma X*, Mao Z*, Nie J*, Peng Y*, Qu J*, Ren J*, Ren R*, Song M*, Song YZ*, Sun YE*, Sun Y*, Tian M*, Wang S*, Wang S*, Wang X*, Wang X*, Wang YJ*, Wang Y*, Wong CCL*, Xiang AP*, Xiao Y*, Xie Z*, Xu D*, Ye J*, Yue R*, Zhang C, Zhang H, Zhang L, Zhang W, Zhang Y, Zhang YW, Zhang Z*, Zhao T*, Zhao Y*, Zhu D*, Zou W*, Pei G*, Liu GH*. Biomarkers of aging. Sci China Life Sci, 2023,66(5):893-1066. DOI: 10.1007/s11427-023-2305-0
- Cao J#, Hao J#, Wang L#, Tan Y, Tian Y, Li S, Ma A, Fu B, Dai J, Zhai P, Xiang P, Zhang Y, Cheng T*, Peng Y*, Zhou Q*, Zhao T* Developing standards to support the clinical translation of stem cells. Stem Cells Translational Medicine, 2021,10: S85-S95. DOI:10.1002/sct3.13035
- Cao J, Stacey G, Chang N, Zhao T*. Developing standards to support cell technology applications, Cell Proliferation, 2022,55(4): e13210. DOI:10.1111/cpr.13210
- Liu K#, Cao J#, Shi X#, Wang L, Zhao T*. Cellular metabolism and homeostasis in pluripotency regulation. Protein Cell, 2020,11(9): 630-640. DOI:10.1007/s13238-020-00755-1
- Wang L#, Ye X#, Zhao T*. The physiological roles of autophagy in the mammalian life cycle. Biological Reviews, 2019, 94(2): 503-516. DOI: 10.1111/brv.12464
- Liu K, Wang L, Zhao T*. Autophagy in Normal Stem Cells and Specialized Cells. Adv Exp Med Biol,2019.1206:489-508. DOI: 10.1007/978-981-15-0602-4
- Cao J, Zhao T*. Single-cell sequencing delivers hematopoietic stem cell specification. Science Bulletin, 2016, 61(18): 1419-1421. DOI: 10.1007/s11434-016-1163-2
- Liu K#, Song Y#, Yu H#, Zhao T*. Understanding the roadmaps to induced pluripotency. Cell Death Disease, 2014, 5: e1232. DOI: 10.1038/cddis.2014.205
- Cao J#, Li X#, Lu X, Zhang C, Yu H, Zhao T*. Cells derived from iPSC can be immunogenic–Yes or No? Protein Cell, 2014, 5(1): 1-3. DOI:10.1007/s13238-013-0003-2
- Lu X, Zhao T*. Clinical therapy using iPSCs: hopes and challenges. Genomics Proteomics Bioinformatics, 2013, 11(5): 294-298. DOI: 10.1016/j.gpb.2013.09.002
- Zhao T, Xu Y*. p53 and stem cells: new developments and new concerns. Trends in Cell Biology, 2010, 20(3): 170-175. DOI: 10.1016/j.tcb.2009.12.004
标准论文:
- Niu S#, Xia C#, Huang D#, Wang L#, Hu H, Yu S, Wu N, Dong Z, Zhou J, Wu J, Yu J, Zhang Y, Wang C, Fu B, Cao J, Liang L, Xu L, Chen L, Zhou Q, Ma A*, Zhao T*, Hao J*, Wang J*. Requirements for human natural killer cells. Cell Prolif, 2024, 57(5): e13588. DOI: 10.1111/cpr.13588. Epub 2023 Dec 20
- Wang YK#, Yu J#, Zhang TT#, Ma AJ, Hao J, Chen YJ, Liu CM, Liu Y, Wang CL, Zhai PJ, Xiang AP, Li TQ, Tang TS, Chen H, Bao XJ, Wang YL, He WY, Fan J, Teng ZQ, Wang L, Zhou JX, Fu BQ, Fu YV, Feng L, Cao JN, Liang LM, Wang L, Zhou Q, Zhang Y*, Hu BY*, Zhao TB*. Human neural stem cells. Cell Prolif, 2024, 57(4): e13564. DOI: 10.1111/cpr.13564
- Peng Y#*, Ma A#, Xiao Z#, Hao J#, Feng R, Wang C, Hu B, Zhai P, Li K, Wang L, Cao J, Xiang P, Zhang Y, Wei J, Wang X, Fu B, Chen Q, Wei Q, Gao H, Lv J, Liu X, Ma Y, Cheng T, Huang X, Su Y, Zhang H, Zhou Q*, Zhao T*. Technical specifications for ethics review of human stem cell research. Cell Prolif, 2024,57(3): e13556. DOI: 10.1111/cpr.13556
- Wang L#, Liu S#, Li K#, Ma A#, Hu C#, Wang C, Cao N, Zhao Y, Fu R, Jia W, Xiang P, Liu H, Qi Z, Zhu N, Liang L, Wang L, Cao J, Zhai P, Zhou J, Wei J, Na T, Wu J, He Z, Zhou G, Yu W, Wu J, Zeng W, Zhang Y, Zhu L, Fu B, Zhang J, Yang S, Dai C, Cui H, Jing J, Yan H, He X, Lu Y, Tong C, Zhao T*, Hao J*, Liu X*, Jin Y*, Wang Y*. General requirements for the production of extracellular vesicles derived from human stem cells. Cell Prolif, 2024, 57(3): e13554. DOI: 10.1111/cpr.13554
- Wang YK, Feng L, Ma AJ, Hao J, Zhang Y, Chen YJ, Chen ZG, Yu JY, Liu Y, Liu CM, Zhang Y, Wang CL, Teng ZQ, Zhou JX, Li TQ, Wang L, Fu BQ, Fu YV, Zhu LJ, Liang LM, Cao JN, Wang L, Zhou Q, Xiang AP*, Hu BY*, Zhao TB*. Human midbrain dopaminergic progenitors. Cell Prolif, 2024, 57(4): e13563. DOI: 10.1111/cpr.13563
- Lin H#, Wang Y#, Cheng C#, Qian Y#, Hao J, Zhang Z, Sheng W, Song L, Deng CX, Zhao B, Cao J, Wang L, Wang L, Liang L, Chen WK, Yu C, Sun Z, Yang Y, Wang C, Zhang Y, Li Q, Li K, Ma A*, Zhao T*, Chen YG*, Hua G*. Standard: Human intestinal cancer organoids. Cell Regen, 2023, 12(1):24. DOI: 10.1186/s13619-023-00167-6
- Wang Y#, Lin H#, Zhao L#, Hong F#, Hao J, Zhang Z, Sheng W, Song L, Deng C, Zhao B, Cao J, Wang L, Wang L, Liang L, Chen W, Yu C, Sun Z, Yang Y, Wang C, Zhang Y, Li Q, Li K, Ma A*, Zhao T*, Hua G*, Chen Y*. Standard: Human intestinal organoids. Cell regeneration,2023,12(1):23. DOI:10.1186/s13619-023-00168-5
- Zhang Y#, Wei J#, Cao J#, Zhang K#, Peng Y, Deng H, Kang J, Pan G, Zhang Y, Fu B, Hu S, Na J, Liu Y, Wang L, Liang L, Zhu H, Zhang Y, Jin Z, Hao J*, Ma A*, Zhao T*, Yu J*. Requirements for human-induced pluripotent stem cells. Cell Proliferation, 2022,55(4): e13182. DOI:10.1111/cpr.13182
- Wang L#, Cao J#, Peng Y#, Fu B, Jin Z, Hu Y, Wu W, Xiang P, Hu S, Yu J, Zhang Y, Wei J, Zhang Y, Li Q, Zhou J, Zhai P, Zhu H, Liang L, Ma A, Glyn Stacey*, Zhao T*, Hao J*.Human retinal pigment epithelial cells. Cell Proliferation, 2022, 55(4): e13153. DOI:10.1111/cpr.13153
- Yu M#, Lei W#, Cao J#, Wang L#, Ma A, Zhao Z, Yang H, Shen Z, Lan F, Cao F. Liang P, Pei X, Xiang P, Yu J, Zhang Y, Zhang Y, Li Q, Zhou J, Wei J, Peng Y, Zhu H, Liang L, Cao N, Fu B*, Hao J*, Zhao T*, Hu S*. Requirements for Human Cardiomyocytes. Cell Proliferation, 2022,55(4): e13150. DOI:10.1111/cpr.13150
- Peng Z#, Wu J#, Hu S#, Ma A#, Wang L, Cao N, Zhang Y, Li Q, Yu J, Meng S, Na T, Shi X, Li M, Liu H, Qian L, Tian E, Lin F, Cao J, Peng Y, Zhu H, Liang L, Hao J*, Zhao T*, Cheng X*, Pan G*. Requirments for Primary Human Hepatocyte. Cell Proliferation, 2022,55(4): e13147. DOI:10.1111/cpr.13147
- Chen X#, Huang J#, Wu J#, Hao J#, Fu B, Wang Y, Zhou B, Tao N, Wei J, Zhang Y, Li Q, Hu S, Zhou J, Yu J, Wu Z, Zhu H, Cao J, Wang L, Peng Y, Liang L, Ma A*, Zhang Y*, Zhao T*, Xiang P*. Human mesenchymal stem cells. Cell Proliferation, 2022,55: e13141. DOI:10.1111/cpr.13141
- Nan X#, Zhang BW#, Hao J#, Wen Y#, Fu B, Qu M, Zhang Y, Wang H, Fang F, Wei J, Li Q, Hu S, Yu J, Gao Y, Liu Q, Cao J, Wang L, Peng Y, Zhu H, Liang L, Ma A*, Zhou J*, Zhao T*, Pei X*. Requirements for human haematopoietic stem/progenitor cells. Cell Proliferation, 2022,55(4): e13152. DOI:10.1111/cpr.13152
- Hao J#, Ma A#, Wang L#, Cao J#, Chen S, Wang L, Fu B, Zhou J, Pei X, Zhang Y, Xiang P, Hu S, Li Q, Zhang Y, Xia Y, Zhu H, Stacey G, Zhou Q*, Zhao T*. General requirements for stem cells. Cell Proliferation, 2020, 53(12): e12926. DOI:10.1111/cpr.12926
- Hao J#, Cao J#, Wang L#, Ma A#, Chen S, Ding J, Wang L, Fu B, Zhang Y, Pei X, Xiang P, Li Q, Zhang Y, Zhou J, Hu S, Yu J, Wei J, Zhu H, Stacey G, Zhao T*, Zhou Q*. Requirements for human embryonic stem cells. Cell Proliferation, 2020,53(12): e12925. DOI:10.1111/cpr.12925
国际标准:
1. Tongbiao Zhao*,Qi Zhou*. ISO 24603:2022 Biotechnology — Biobanking — Requirements for human and mouse pluripotent stem cells. www.iso.org/standard/79046.html
2. Yong Zhang*, Tongbiao Zhao*. ISO 8472-1:2024 Biotechnology — Data interoperability for stem cell data — Part 1: Framework. www.iso.org/standard/83185.html
3. Tongbiao Zhao*,Qi Zhou*. ISO 18162:2024 Biotechnology — Biobanking — Requirements for human neural stem cells derived from pluripotent stem cells. www.iso.org/standard/85207.html
4. ISSCR Standard Steering Committee*. Standards for Human Stem Cell Use in Research. ISSCR, www.isscr.org/basic-research-standards
专利:
赵同标; 靳利远; 朱颖婕; 曹磊; 曹佳妮; 李晓燕。修饰的免疫细胞及其应用。ZL202010062327.7(中国发明专利);2022-567698 (日本发明专利)。
赵同标;曹卫云;曹佳妮;李晓燕;李兴;徐昊宇。HSV1-tk_GCV诱导型血液系统缺陷小鼠模型的制备方法及应用。ZL202110753676.8(中国发明专利)。