王雁玲，女，博士，研究员，博士生导师；中国科学院动物研究所生殖病理学研究组组长。1993年毕业于中国科学技术大学；1998年于中国科学院动物研究所获得生理学博士学位，师从庄临之研究员；2004年晋升为研究员。主持“国家杰出青年科学基金”项目、国家重点研发计划项目、国家自然科学基金重大项目、重点项目等。

主要从事胎盘发育机制及生殖相关疾病机理研究。在胎盘营养传输和代谢模式及其决定细胞命运的机制、子宫螺旋动脉改建的调节机理、母胎界面免疫适应性的细胞和分子调控等方面取得系列成果，解析了母胎界面多细胞互作紊乱参与子痫前期、复发性流产、胎儿发育迟缓等疾病发生发展的机理。在Cell Stem Cell, Natl Sci Rev, PNAS等期刊发表学术论文百余篇；曾获“国家科技进步奖”二等奖、全国妇幼健康科学技术奖二等奖、“华夏医学科技奖”、“中国科学院朱李月华优秀教师奖”等荣誉。在读研究生12名，其中博士生10名，硕士生2名。

• 国家自然科学基金创新研究群体项目（82421003）:胚胎发育和生殖健康（2025.01-2029.12），研究骨干，160/1000万元
• 国家重点研发计划（2022YFC2702400）：胎盘发育和功能的调节机制（2022.12-2025.11），项目负责人，340/1000万元
• 国家重点研发计划（2021YFC2700303）: 谱系发育异常与胚胎停育及早期流产（2021.12-2024.11），研究骨干，300万元
• 国家重点研发计划（2018YFC1004100）：胎盘形成的分子机制（2018.12-2021.12），项目负责人，254/2733万元
• 国家自然科学基金重点项目（81730040）：妊娠过程中类固醇激素合成和代谢紊乱导致子痫前期发生发展的机制（2018.01-2022.12），项目主持人，294万元
• 国家自然科学基金重大项目（81490740）：母胎互作调控紊乱致复发流产和子痫前期等妊娠疾病的分子机制（2015.01-2019.12），项目主持人，200/1800万元
• 国家杰出青年基金（81025004）：胎盘发育与子痫前期发病机制（2011.01-2014.12），200万元

1. Yu X^#, Wu H^#, Su J^#, Liu X, Liang K, Li Q, Yu R, Shao X, Wang H*, Wang YL*, Shyh-Chang N*. Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells. Cell Stem Cell. 2024 Sep 5;31(9):1280-1297.e7.
2. Jia W^#, Ma L^#, Yu X^#, Wang F, Yang Q, Wang X, Fan M, Gu Y, Meng R, Wang J, Li YX, Li R*, Shao X*, Wang YL*. Human CD56+CD39+ dNK cells support fetal survival through controlling trophoblastic cell fate: immune mechanisms of recurrent early pregnancy loss. Natl Sci Rev. 2024 Apr 11;11(6):nwae142.
3. Zheng W^#, Zhang Y^#, Xu P, Wang Z, Shao X, Chen C, Cai H, Wang Y, Sun MA, Deng W, Liu F, Lu J, Zhang X, Chen D, Mysorekar IU, Wang H, Wang YL*, Hu X*, Cao B*. TFEB safeguards trophoblast syncytialization in humans and mice. Proc Natl Acad Sci U S A. 2024 Jul 9;121(28):e2404062121.
4. Ma Y^#, Yu X^#, Ye S^#, Li W, Yang Q, Li YX, Wang Y*, Wang YL*. Immune-regulatory properties of endovascular extravillous trophoblast cells in human placenta. Placenta. 2024 Jan;145:107-116.
5. Li Y, Li Z, Wang C, Yang M, He Z, Wang F, Zhang Y, Li R, Gong Y, Wang B, Fan B, Wang C, Chen L, Li H, Shi P, Wang N, Wei Z, Wang YL, Jin L, Du P, Dong J, Jiao J. Spatiotemporal transcriptome atlas reveals the regional specification of the developing human brain. Cell. 2023 Dec;186(26):5892-5909.e22.
6. Shao X^#, Yang Y^#, Liu Y^#, Wang Y^#, Zhao Y, Yu X, Liu J, Li YX, Wang YL*. Orchestrated feedback regulation between melatonin and sex hormones involving GPER1-PKA-CREB signaling in the placenta. J Pineal Res. 2023:e12913.
7. Shao X^#, Yu W^#, Yang Y^#, Wang F, Yu X, Wu H, Ma Y, Cao B*, Wang YL*. The mystery of the life tree: the placenta. Biol Reprod. 2022; 25;107(1):301-316.
8. Li Y^#, Li Z^#, Yang M^#, Wang F^#, Zhang Y^#, Li R^#, Li Q, Gong Y, Wang B, Fan B, Wang C, Chen L, Li H, Ong J, Teng Z, Jin L*, Wang YL*, Du P*, Jiao J*. Decoding the temporal and regional specification of microglia in the developing human brain. Cell Stem Cell. 2022;29(4):620-634.e6.
9. Chen J^#, Du L^#, Wang F^#, Shao X^#, Wang X, Yu W, Bi S, Chen D, Pan X, Zeng S, Huang L, Liang Y, Li Y, Chen R, Xue F, Li X, Wang S, Zhuang M, Liu M, Lin L, Yan H, He F, Yu L, Jiang Q, Xiong Z, Zhang L, Cao B*, Wang YL*, Chen D*. Cellular and molecular atlas of the placenta from a COVID-19 pregnant woman infected at mid-gestation highlights the defective impacts on fetal health. Cell Prolif. 2022;55(4):e13204.
10. Li G^#, Wang Y^#, Cao G^#, Ma Y, Li YX, Zhao Y*, Shao X*, Wang YL*. Hypoxic stress disrupts HGF/Met signaling in human trophoblasts: implications for the pathogenesis of preeclampsia. J Biomed Sci. 2022;29(1):8.
11. Ma Y^#, Yu X^#, Zhang L^#, Liu J, Shao X, Li YX, Wang YL*. Uterine decidual niche modulates the progressive dedifferentiation of spiral artery vascular smooth muscle cells during human pregnancy. Biol Reprod. 2021 Mar 11;104(3):624-637.(Editorial Choice; Faculty Opinions)
12. Shao X^#, Cao G^#, Chen D^#, Liu J, Yu B, Liu M, Li YX, Cao B*, Sadovsky Y*, Wang YL*. Placental trophoblast syncytialization potentiates macropinocytosis via mTOR signaling to adapt to reduced amino acid supply. Proc Natl Acad Sci U S A. 2021;118(3):e2017092118.
13. Wang F^#, Jia W^#, Fan M^#, Shao X^#, Li Z, Liu Y, Ma Y, Li YX, Li R*, Tu Q*, Wang YL*. Single-cell immune landscape of human recurrent miscarriage. Genomics Proteomics Bioinformatics. 2021;S1672-0229(21)00003-6. (Editorial Highlight)
14. Liu J^#, Shao X^#, Qin W^#, Yanling Zhang^#, Dang F, Yang Q, Yu X, Li YX, Chen X, Wang C*, Wang YL*. Quantitative chemoproteomics reveals O-GlcNAcylation of Cystathionine γ-lyase (CSE) represses trophoblast syncytialization. Cell Chem Biol. 2021;S2451-9456(21)00050-7. (Cover story)
15. Ma Y^#, Yang Q^#, Fan M^#, Zhang L, Gu Y, Jia W, Li Z, Wang F, Li YX, Wang J, Li R*, Shao X*, Wang YL*. Placental endovascular extravillous trophoblasts (enEVTs) educate maternal T-cell differentiation along the maternal-placental circulation. Cell Prolif. 2020;53(5):e12802.
16. Shao X^#, Wang Y^#, Liu Y, Guo X, Li D, Huo R, Jia W, Cao G, Li YX, Liu M, Sha J, Zhao Y, Wang YL*. Association of imbalanced sex hormone production with excessive procoagulation factor SerpinF2 in preeclampsia. J Hypertens. 2019;37:197–205
17. Shao X^#, Liu Y^#, Liu M, Wang Y, Yan L, Wang H, Ma L, Lia YX, Zhao Y*, Wang YL*. Testosterone represses estrogen signaling via upregulating mir-22: mechanism for imbalanced steroid hormone production in preeclampsia. Hypertension. 2017;69:721-730. (Editorial highlight)
18. Xu P^#, Zhao Y^#, Liu M, Wang Y, Wang H, Li YX, Zhu X, Yao Y, Wang H, Qiao J, Ji L*, Wang YL*. Variations of micrornas in human placentas and plasma from preeclamptic pregnancy. Hypertension. 2014;63:1276-1284.
19. Ji L^#, Brkić J^#, Liu M^#, Fu G, Peng C*, Wang YL*. Placental trophoblast cell differentiation: physiological regulation and pathological relevance to preeclampsia. Mol Asp Med. 2013;34:981-1023.