本研究组的研究方向是以小鼠和果蝇等模式动物作为研究系统，利用分子生物学、细胞生物学、遗传学和生物化学等技术在分子、细胞和个体（包括果蝇和小鼠）三个水平上进行探讨：1）天然免疫反应的调控机制；2）免疫调控与癌症治疗和自身免疫疾病的关系；3）干细胞命运调控的分子机制。近年来所取得的研究成果发表在国际核心学术期刊，包括Nature Communications, Molecular Cell，PNAS，PLoS Pathogens, Stem Cell Reports, Immunity,和Blood等。

　　科技部国家重点研发计划、中国科学院先导项目、国家自然科学基金项目等。

1. Sun J, Yang Q, Liu E, Chen D*, Sun Q*. KIZ/GM114 balances the NF-？B signaling by antagonizing the association of TRAF2/6 with their upstream adaptors. Front Cell Dev Biol. 10:877039 (2022）
2. Gu H, Yang, Zhang J, Song Y, Zhang Y, Xu P, Zhu Y, Wang L, Zhang P, Li L, Chen D*, Sun Q*. PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensation. Nat Commun. 2022 Mar 23;13(1):1564.
3. Gao Y, Zhu Y, Wang H, Cheng Y, Zhao D, Sun Q*, Chen D*. Lipid mediated–phase separation of AGO proteins on ER controls nascent peptide ubiquitination. Mol Cell. 2022 Mar 15:S1097-2765(22)00209-X.
4. Zhang G, Xu Y, Wang X, Zhu Y, Wang L, Zhang W, Wang Y, Gao Y, Wu X, Cheng Y, Sun Q*, Chen D*. Dynamic FMR1 granule phase switch instructed by m6A modification contributes to maternal RNA decay. Nat Commun. 13(1):859 （2022）
5. Liu E, Sun J, Yang J, Li L, Yang Q, Zeng J, Zhang J, Chen D, Sun Q*. ZDHHC11 Positively Regulates NF-？B Activation by Enhancing TRAF6 Oligomerization, Front Cell Dev Biol. 2021 Aug 19;9:710967.
6. Tao X, Chu B, Xin D, Li L, Sun Q*. USP27X negatively regulates antiviral signaling by deubiquitinating RIG-I. PLoS Pathog. 16(2): e1008293. (2020)
7. He S, Zhang G, Wang J, Gao Y, Sun R, Cao Z, Chen Z, Zheng X, Yuan J, Luo Y, Wang X, Zhang W, Zhang P, Zhao Y, He C, Tao Y*, Sun Q*, Chen D*. 6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda. Nat Commun. 10(1):2219.（2019）
8. Ji S, Luo Y, Cai Q, Cao Z, Zhao Y, Mei J, Li C, Xia P, Xie Z, Xia Z, Zhang J, Sun Q*, Chen D. LC* Domain-Mediated Coalescence Is Essential for Otu Enzymatic Activity to Extend Drosophila Lifespan. Mol Cell. S1097-2765(19)30094-2. (2019)
9. Xin D, Gu H, Liu E, Sun Q*. Parkin negatively regulates the antiviral signaling pathway by targeting TRAF3 for degradation. J Biol Chem. 293(31):11996-12010. (2018)
10. Li W, Li W, Zou L, Ji S, Li C, Liu K, Zhang G, Sun Q*, Xiao F*, Chen D*. Membrane targeting of inhibitory Smads through palmitoylation controls TGF-β/BMP signaling. PNAS. 114 (50):13206-13211.（2017）
11. Ji S, Li C, Hu L, Liu K, Mei J, Luo Y, Tao Y, Xia Z, Sun Q*, Chen D*. Bam-dependent deubiquitinase complex can disrupt germ-line stem cell maintenance by targeting cyclin A. Proc Natl Acad Sci U S A. 114(24):6316-6321.（2017）
12. Lin W, Zhang J, Lin H, Li Z, Sun X, Xin D, Yang M, Sun L, Li L1, Wang H, Chen D, Sun Q*. Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD. Nat Commun. 7:11848. (2016)
13. Sun X, Sun L, Zhao Y, Li Y, Lin W, Chen D, Sun Q*. MAVS maintains mitochondrial homeostasis via autophagy. Cell Discov. 2:16024 (2016)
14. Jin W, Wang L, Zhu F, Tan W, Lin W, Chen D, Sun Q*, Xia Z*.Critical POU domain residues confer Oct4 uniqueness in somatic cell reprogramming. Sci Rep. 6:20818. (2016)
15. Sun Q*, Huang S, Wang X, Zhu Y, Chen Z, Chen D*.N6-methyladenine functions as a potential epigenetic mark in eukaryotes. Bioessays. 37(11):1155-62. (2015)
16. Li Z, Liu G, Sun L, Teng Y, Guo X, Jia J, Sha J, Yang X, Chen D, Sun Q*. PPM1A regulates antiviral signaling by antagonizing TBK1-mediated STING phosphorylation and aggregation.PLoS Pathog. 11 (3): e1004783. (2015)
17. Ji S, Sun M, Zheng X, Li L, Sun L, Chen D* and Sun Q*. Cell-surface localization of Pellino antagonizes Toll-mediated innate immune signaling by controlling MyD88 turnover in Drosophila. Nature Commun. 5:3458. (2014)
18. Zhu G, Li Y, Zhu F, Wang T, Jin W, Mu W, Lin W, Tan W, Sun Q*, Jin P* and Chen D*. Coordination of engineered factors with TET 1/2 promotes the early stage epigenetic modification during somatic cell reprogramming. Stem Cell Reports, 2:253-261. (2014)
19. Huang S, Zhang Z, Zhang C, Lv X, Zheng X, Chen Z, Sun L, Wang H, Zhu Y, Zhang J, Yang S, Lu Y, Sun Q, Tao Y, Liu F, Zhao Y, Chen D. Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover. PLoS Biol. 11(11):e1001721 (2013).
20. Wang F, Yang Y, Lin X, Wang JQ, Wu YS, Xie W, Wang D, Zhu S, Liao YQ, Sun Q, Yang YG, Luo HR, Guo C, Han C, Tang TS. Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease. Hum Mol Genet. 22(18):3641-53. (2013)
21. Wang JQ, Chen Q, Wang X, Wang QC, Wang Y, Cheng HP, Guo C, Sun Q, Chen Q, Tang TS. Dysregulation of mitochondrial calcium signaling and superoxide flashes cause mitochondrial genomic DNA damage in Huntington disease. J Biol Chem. 288(5):3070-84. (2013)
22. Zhao Y, Sun X, Nie X, Sun L, Tang TS, Chen D, Sun Q*. COX5B Regulates MAVS-mediated Antiviral Signaling through Interaction with ATG5 and Repressing ROS Production. PLoS Pathog.;8(12):e1003086. (2012)
23. Dong X, Feng H, Sun Q, Li H, Wu TT, Sun R, Tibbetts SA, Chen ZJ, Feng P*. Murine gamma-herpesvirus 68 hijacks MAVS and IKKbeta to initiate lytic replication. PLoS Pathog. 29;6(7): e1001001. (2010)
24. Xia L, Jia S, Huang S, Wang H, Zhu Y, Mu Y, Kan L, Zheng W, Wu D, Li X, Sun Q, Meng A, Chen D*. The Fused/Smurf complex controls the fate of Drosophila germline stem cells by generating a gradient BMP response. Cell. 10;143(6):978-90. (2010)
25. Bhoj VG, Sun Q, Bhoj EJ, Somers C, Chen X, Torres JP, Mejias A, Gomez AM, Jafri H, Ramilo O, Chen ZJ*. MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virus. Proc Natl Acad Sci U S A. 105(37):14046-51. (2008)
26. Chiu YH, Sun Q, Chen ZJ*. E1-L2 activates both ubiquitin and FAT10. Mol Cell.; 27(6):1014-23. (2007)
27. Sun Q, Matta H, Lu G, Chaudhary PM. Induction of IL-8 expression by human herpesvirus 8 encoded vFLIP K13 via NF-kappaB activation.Oncogene. 2006 May 4;25(19):2717-26.
28. Sun Q, Sun L, Liu HH, Chen X, Seth RB, Forman J, Chen ZJ*. The specific and essential role of MAVS in antiviral innate immune responses. Immunity. 24(5):633-42. (2006)
29. Sun Q, Matta H, Chaudhary PM*. Kaposi's sarcoma associated herpes virus-encoded viral FLICE inhibitory protein activates transcription from HIV-1 Long Terminal Repeat via the classical NF-kappaB pathway and functionally cooperates with Tat.Retrovirology 2:9. 2005
30. Sun Q, Zachariah S, Chaudhary PM*. The human herpes virus 8-encoded viral FLICE-inhibitory protein induces cellular transformation via NF-kappaB activation. J Biol Chem. 2003 Dec 26;278(52):52437-45.(2003)
31. Sun Q, Matta H, Chaudhary PM*. The human herpes virus 8-encoded viral FLICE inhibitory protein protects against growth factor withdrawal-induced apoptosis via NF-kappa B activation. Blood. 101(5):1956-61(2003)

　　欢迎对免疫和癌症免疫治疗感兴趣同学加盟我们的研究团队。