滕兆乾，博士，研究员，博士生导师，干细胞与脑损伤修复研究组组长。

2005年博士毕业于中国科学院动物研究所，先后在中国农业大学、美国新墨西哥大学医学院、路易斯安那州立大学健康科学中心以及约翰·霍普金斯大学医学院做博士后与Research Associate。主要从事神经再生、脑损伤、神经退行性疾病与精神疾病方面的研究，研究成果发表在Nature Neuroscience、Immunity、Molecular Psychiatry、Cell、Cell Stem Cell、Stem Cell Reports、Glia等国际学术期刊上。

研究工作主要集中在脑损伤、神经退行性疾病与精神疾病的致病机理以及神经再生修复策略的应用研究。研究组的主要研究方向包括：（1）神经再生障碍的细胞与分子机制；（2）小胶质细胞在疾病发生发展过程中表型转化与靶向干预；（3）人小胶质细胞与神经元的定向分化与功能增强；（4）基因/细胞药物的开发与应用。

承担国家重点研发计划、中国科学院A类战略性先导科技专项、国家自然科学基金、北京市自然科学基金项目/课题等。

1. Liu C^#, Shao FH^#, He XC^#, Du HZ, Liu CM*, Zhou B*, Teng ZQ*. Single-Cell RNA Sequencing Uncovers Molecular Features Underlying the Disrupted Neurogenesis Following Traumatic Brain Injury. Glia. 2025, 73(5):1036-1050.
2. Liu J^#, Wang Z^#, Liang W, Zhang Z, Deng Y, Chen X, Hou Z, Xie Y, Wang Q, Li Y, Bai C, Li D, Mo F, Wang H, Wang D, Yuan J*, Wang Y*, Teng ZQ*, Hu B*. Microglial TMEM119 binds to amyloid-β to promote its clearance in an Aβ-depositing mouse model of Alzheimer's disease. Immunity. 2025, 58(7):1830-1846.
3. Li CP^#, Wu S^#, Sun YQ, Peng XQ, Gong M, Du HZ, Zhang J, Teng ZQ*, Wang N*, Liu CM*. Lhx2 promotes axon regeneration of adult retinal ganglion cells and rescues neurodegeneration in mouse models of glaucoma. Cell Reports Medicine. 2024, 5(5):101554.
4. Liu C^#, Gao X^#, Shi RX^#, Wang YY, He XC, Du HZ, Hu B, Jiao J, Liu CM, Teng ZQ*. Microglial transglutaminase 2 deficiency causes impaired synaptic remodelling and cognitive deficits in mice. Cell Proliferation. 2023, 56(9):e13439.
5. Liu PP^#, Dai SK^#, Mi TW^#, Tang GB, Wang Z, Wang H, Du HZ, Tang Y*, Teng ZQ*, Liu CM*. Acetate supplementation restores cognitive deficits caused by ARID1A haploinsufficiency in excitatory neurons. EMBO Molecular Medicine. 2022, 14(12):e15795.
6. Wang YY, Deng YS, Dai SK, Mi TW, Li RY, Liu PP, Liu C, He BD, He XC, Du HZ, Yang HC, Tang Y, Liu CM*, Teng ZQ*. Loss of microglial EED impairs synapse density, learning, and memory. Molecular Psychiatry. 2022, 27(7):2999-3009.
7. Dai SK, Liu PP, Du HZ, Liu X, Xu YJ, Liu C, Wang YY, Teng ZQ*, Liu CM*. Histone crotonylation regulates neural stem cell fate decisions by activating bivalent promoters. EMBO Reports. 2021, 22 (10): e52023.
8. Liu C^#, Dai SK^#, Shi RX, He XC, Wang YY, He BD, Sun XW, Du HZ, Liu CM*, Teng ZQ*. Transcriptional profiling of microglia in the injured brain reveals distinct molecular features underlying neurodegeneration. Glia. 2021, 69 (5): 1292-1306.
9. Wang ZM, Liu C, Wang YY, Deng YS, He XC, Du HZ, Liu CM*, Teng ZQ*. SerpinA3N deficiency deteriorates impairments of learning and memory in mice following hippocampal stab injury. Cell Death Discovery. 2020, 6 (1): 1-11.
10. Cheng Y^#, Wang ZM^#, Tan W^#, Wang X^#, Li Y, Bai B, Li Y, Zhang SF, Yan HL, Chen ZL, Liu CM, Mi TW, Xia S, Zhou Z, Liu A, Tang GB, Liu C, Dai ZJ, Wang YY, Wang H, Wang X, Kang Y, Lin L, Chen Z, Xie N, Sun Q, Xie W, Peng J, Chen D*, Teng ZQ*, Jin P*. Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a. Nature Neuroscience. 2018, 21(12): 1689-1703.
11. Chen R^#, Zhang J^#, Fan N^#, Teng ZQ^#, Wu Y^#, Yang H, Tang YP, Sun H, Song Y, Chen C*. Δ9-THC-caused synaptic and memory impairments are mediated through COX-2 signaling. Cell. 2013, 155(5): 1154-1165.
12. Liu C^#, Teng ZQ^#, Santistevan NJ, Szulwach KE, Guo W, Jin P, Zhao X*. Epigenetic regulation of miR-184 by MBD1 governs neural stem cell proliferation and differentiation. Cell Stem Cell. 2010, 6(5): 433-44.

专利情况：

1. 发明名称：一种高效感染原代小胶质细胞的重组突变腺相关病毒及其相关生物材料。发明人：滕兆乾；何炫程；刘长梅；杜洪震。专利号：ZL 2021 1 0021870.7。授权公告日：2022年05月10日。
2. 发明名称：一种多能干细胞诱导产生小胶质细胞的方法及试剂盒。发明人：滕兆乾；李骞；刘长梅；杜洪震。专利号：ZL 2019 1 0558177.6。授权公告日：2021年10月29日。