宋默识，中国科学院动物研究所膜生物学国家重点实验室研究员。2011年于瑞典卡罗琳斯卡医学院获医学硕士学位，2015年于美国圣路易斯华盛顿大学获理学博士学位，后于美国斯坦福大学从事心血管方向的博士后研究。2018年初全职加入中国科学院动物研究所，成立线粒体与疾病研究组并担任研究组组长。主要从事线粒体调控心脏衰老及相关疾病的机制与干预研究，解析心脏衰老的分子机制，发现心脏衰老的生物标记物，开发心脏衰老及相关疾病的干预策略。共发表论文88篇，引用6100余次。近五年，以 (共同) 通讯或一作身份在Cell、Cell Research (x2)、Advanced Science (x2)、Nature Communications (x2)、Nature Aging (x2)、Nucleic Acids Research (x2)等杂志发表论文44篇，平均影响因子>18。申请发明专利16项，授权8项。

　　心脏衰老及相关疾病

• 国家重点研发计划项目青年项目，主持
• 国家自然科学基金重大研究计划培育项目，主持
• 国家自然科学基金创新研究群体，骨干
• 中国科学院稳定支持基础研究领域青年团队计划，骨干
• 北京市自然科学基金杰出青年科学基金项目，主持，已结题
• 国家自然科学基金优秀青年科学基金项目，主持，已结题
• 国家自然科学基金面上项目，主持，已结题
• 中国科学院A类战略性先导科技专项子课题，主持，已结题

1. Wang J, Zhang H, Yuan H, Chen S, Yu Y, Zhang X, Gao Z, Du H, Li W, Wang Y, Xia P, Wang J*, Song M*.Prophylactic supplementation with Lactobacillus reuteri or its metabolite GABA protects against acute ischemic cardiac injury.Adv Sci. 2024.
2. He Y, Ji Q, Wu Z, Cai Y, Yin J, Zhang Y, Zhang S, Liu X, Zhang W, Liu GH*, Wang S*, Song M*, Qu J*. 4E-BP1 counteracts human mesenchymal stem cell senescence via maintaining mitochondrial homeostasis. Protein Cell. 2023 Apr 13;14(3):202-216.
3. Aging Biomarker Consortium, Zhang W, Che Y, Tang X, Chen S, Song M*, Wang L*, Sun A*, Chen H*, Xu M*, Wang M*, Pu J*, Li Z*, Xiao J*, Cao C*, Zhang Y*, Lu Y*, Zhao Y*, Wang Y*, Zhang C*, Shen T*, Zhang W*, Tao L*, Qu J*, Tang Y*, Liu GH*, Pei G*, Li J*, Cao F*. A biomarker framework for cardiac aging: the Aging Biomarker Consortium consensus statement, Life Medicine, Volume 2, Issue 5, October 2023, lnad035.
4. Ren J#, Song M#, Zhang W#, Cai JP, Cao F, Cao Z, Chan P, Chen C, Chen G, Chen HZ, Chen J, Chen XC, Ci W, Ding BS, Ding Q, Gao F, Gao S, Han JJ, He QY, Huang K, Ju Z, Kong QP, Li J, Li J, Li J, Li X, Liu B, Liu F, Liu JP, Liu L, Liu Q, Liu Q, Liu X, Liu Y, Luo X, Ma S, Ma X, Mao Z, Nie J, Peng Y, Qu J, Ren R, Song W, Songyang Z, Sun L, Sun YE, Sun Y, Tian M, Tian XL, Tian Y, Wang J, Wang S, Wang S, Wang W, Wang X, Wang X, Wang YJ, Wang Y, Wong CCL, Xiang AP, Xiao Y, Xiao ZX, Xie Z, Xiong W, Xu D, Yang Z, Ye J, Yu W, Yue R, Zhang C, Zhang H, Zhang L, Zhang X, Zhang Y, Zhang YW, Zhang Z, Zhao T, Zhao Y, Zhou Z, Zhu D, Zou W, Pei G, Liu GH. The Aging Biomarker Consortium represents a new era for aging research in China. Nat Med. 2023 Sep;29(9):2162-2165.
5. Liu X, Ma Y, Yu Y, Zhang W, Shi J, Zhang X, Dai M, Wang Y, Zhang H, Zhang J, Shen J, Zhang F*, Song M*, Wang J*. Gut microbial methionine impacts circadian clock gene expression and reactive oxygen species level in host gastrointestinal tract. Protein Cell. 2023 Apr 21;14(4):309-313.
6. Ma Y, Liu X, Zhang X, Yu Y, Li Y, Song M*, Wang J*. Efficient Mining of Anticancer Peptides from Gut Metagenome. Adv Sci. 2023 Sep;10(25):e2300107.
7. Aging Biomarker Consortium; Bao H, Cao J, Chen M, Chen M, Chen W, Chen X, Chen Y, Chen Y, Chen Y, Chen Z, Chhetri JK, Ding Y, Feng J, Guo J, Guo M, He C, Jia Y, Jiang H, Jing Y, Li D, Li J, Li J, Liang Q, Liang R, Liu F, Liu X, Liu Z, Luo OJ, Lv J, Ma J, Mao K, Nie J, Qiao X, Sun X, Tang X, Wang J, Wang Q, Wang S, Wang X, Wang Y, Wang Y, Wu R, Xia K, Xiao FH, Xu L, Xu Y, Yan H, Yang L, Yang R, Yang Y, Ying Y, Zhang L, Zhang W, Zhang W, Zhang X, Zhang Z, Zhou M, Zhou R, Zhu Q, Zhu Z, Cao F*, Cao Z*, Chan P*, Chen C*, Chen G*, Chen HZ*, Chen J*, Ci W*, Ding BS*, Ding Q*, Gao F*, Han JJ*, Huang K*, Ju Z*, Kong QP*, Li J*, Li J*, Li X*, Liu B*, Liu F*, Liu L*, Liu Q*, Liu Q*, Liu X*, Liu Y*, Luo X*, Ma S*, Ma X*, Mao Z*, Nie J*, Peng Y*, Qu J*, Ren J*, Ren R*, Song M*, Songyang Z*, Sun YE*, Sun Y*, Tian M*, Wang S*, Wang S*, Wang X*, Wang X*, Wang YJ*, Wang Y*, Wong CCL*, Xiang AP*, Xiao Y*, Xie Z*, Xu D*, Ye J*, Yue R*, Zhang C*, Zhang H*, Zhang L*, Zhang W*, Zhang Y*, Zhang YW*, Zhang Z*, Zhao T*, Zhao Y*, Zhu D*, Zou W*, Pei G*, Liu GH*. Biomarkers of aging. Sci China Life Sci. 2023 May;66(5):893-1066.
8. Chu Q, Liu F, He Y, Jiang X, Cai Y, Wu Z, Yan K, Geng L, Zhang Y, Feng H, Zhou K, Wang S, Zhang W, Liu GH*, Ma S*, Qu J*, Song M*. mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells. Protein Cell. 2022 Sep;13(9):676-682.
9. Zhao H, Ji Q, Wu Z, Wang S, Ren J, Yan K, Wang Z, Hu J, Chu Q, Hu H, Cai Y, Wang Q, Huang D, Ji Z, Li J, Belmonte JCI, Song M*, Zhang W*, Qu J*, Liu GH*. Destabilizing heterochromatin by APOE mediates senescence. Nat Aging. 2022 Apr;2(4):303-316.
10. Shen J, Liu GH*, Song M*.Potential approaches for intervening aging. Natl Sci Open, 1 2 (2022) 20220021.
11. Yu Y, Liu B, Liu X, Zhang X, Zhang W, Tian H, Shui G, Wang W, Song M*, Wang J*. Mesenteric lymph system constitutes the second route in gut-liver axis and transports metabolism-modulating gut microbial metabolites. J Genet Genomics. 2022 Jul;49(7):612-623.
12. Chen L, Zhao N, Cao J, Liu X, Xu J, Ma Y, Yu Y, Zhang X, Zhang W, Guan X, Yu X, Liu Z, Fan Y, Wang Y, Liang F, Wang D, Zhao L, Song M*, Wang J*. Short- and long-read metagenomics expand individualized structural variations in gut microbiomes. Nat Commun. 2022 Jun 8;13(1):3175.
13. Li W, Zou Z, Cai Y, Yang K, Wang S, Liu Z, Geng L, Chu Q, Ji Z, Chan P, Liu GH*, Song M*, Qu J*, Zhang W*. Low-dose chloroquine treatment extends the lifespan of aged rats. Protein Cell. 2022 Jun;13(6):454-461.
14. Cai Y, Song W, Li J, Jing Y, Liang C, Zhang L, Zhang X, Zhang W, Liu B, An Y, Li J, Tang B, Pei S, Wu X, Liu Y, Zhuang CL, Ying Y, Dou X, Chen Y, Xiao FH, Li D, Yang R, Zhao Y, Wang Y, Wang L, Li Y, Ma S*, Wang S*, Song X*, Ren J*, Zhang L*, Wang J*, Zhang W*, Xie Z*, Qu J*, Wang J*, Xiao Y*, Tian Y*, Wang G*, Hu P*, Ye J*, Sun Y*, Mao Z*, Kong QP*, Liu Q*, Zou W*, Tian XL*, Xiao ZX*, Liu Y*, Liu JP*, Song M*, Han JJ*, Liu GH*. The landscape of aging. Sci China Life Sci. 2022 Dec;65(12):2354-2454.
15. Ma S, Sun S, Li J, Fan Y, Qu J, Sun L, Wang S, Zhang Y, Yang S, Liu Z, Wu Z, Zhang S, Wang Q, Zheng A, Duo S, Yu Y, Belmonte JCI, Chan P, Zhou Q, Song M*, Zhang W*, Liu GH*. Single-cell transcriptomic atlas of primate cardiopulmonary aging. Cell Res. 2021 Apr;31(4):415-432.
16. Diao Z, Ji Q, Wu Z, Zhang W, Cai Y, Wang Z, Hu J, Liu Z, Wang Q, Bi S, Huang D, Ji Z, Liu GH*, Wang S*, Song M*, Qu J*. SIRT3 consolidates heterochromatin and counteracts senescence. Nucleic Acids Res. 2021 May 7;49(8):4203-4219.
17. Lei J, Wang S, Kang W, Chu Q, Liu Z, Sun L, Ji Y, Esteban CR, Yao Y, Belmonte JCI, Chan P, Liu GH*, Zhang W*, Song M*, Qu J*. FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocardial infarction. Protein Cell. 2021 Feb;12(2):145-151.
18. Ma S#, Sun S#, Geng L#, Song M#, Wang W, Ye Y, Ji Q, Zou Z, Wang S, He X, Li W, Esteban CR, Long X, Guo G, Chan P, Zhou Q, Belmonte JCI, Zhang W, Qu J, Liu GH. Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. Cell. 2020 Mar 5;180(5):984-1001.e22.
19. Bi S, Liu Z, Wu Z, Wang Z, Liu X, Wang S, Ren J, Yao Y, Zhang W*, Song M*, Liu GH*, Qu J*. SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer. Protein Cell. 2020 Jul;11(7):483-504.
20. Zhang J, Liu GH*, Qu J*, Song M*. Treating osteoarthritis via gene therapy with rejuvenation factors. Gene Ther. 2020 Aug;27(7-8):309-311.
21. Wang Y, Li Y, He C, Gou B, Song M. Mitochondrial regulation of cardiac aging. Biochim Biophys Acta Mol Basis Dis. 2019 Jul 1;1865(7):1853-1864.
22. Geng L, Liu Z, Zhang W, Li W, Wu Z, Wang W, Ren R, Su Y, Wang P, Sun L, Ju Z, Chan P, Song M*, Qu J*, Liu GH*. Chemical screen identifies a geroprotective role of quercetin in premature aging. Protein Cell. 2019 Jun;10(6):417-435.
23. Zhang W#, Song M#, Qu J, Liu GH. Epigenetic Modifications in Cardiovascular Aging and Diseases. Circ Res. 2018 Sep 14;123(7):773-786.
24. Wang P, Liu Z, Zhang X, Li J, Sun L, Ju Z, Li J, Chan P, Liu GH*, Zhang W*, Song M*, Qu J*. CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells. Protein Cell. 2018 Nov;9(11):945-965.
25. Song M, Franco A, Fleischer JA, Zhang L, Dorn GW 2nd. Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence. Cell Metab. 2017 Dec 5;26(6):872-883.e5.
26. Gong G#, Song M#, Csordas G, Kelly DP, Matkovich SJ, Dorn GW 2nd. Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice. Science. 2015 Dec 4;350(6265):aad2459.
27. Song M, Dorn GW 2nd. Mitoconfusion: noncanonical functioning of dynamism factors in static mitochondria of the heart. Cell Metab. 2015 Feb 3;21(2):195-205.
28. Song M, Mihara K, Chen Y, Scorrano L, Dorn GW 2nd. Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts. Cell Metab. 2015 Feb 3;21(2):273-286.
29. Song M, Gong G, Burelle Y, Gustafsson ÅB, Kitsis RN, Matkovich SJ, Dorn GW 2nd. Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts. Circ Res. 2015 Jul 31;117(4):346-51.
30. Song M, Chen Y, Gong G, Murphy E, Rabinovitch PS, Dorn GW 2nd. Super-suppression of mitochondrial reactive oxygen species signaling impairs compensatory autophagy in primary mitophagic cardiomyopathy. Circ Res. 2014 Jul 18;115(3):348-53.