宋默识，中国科学院动物研究所器官再生与智造全国重点实验室研究员，长期从事心脏衰老的机制与干预研究。2011年于瑞典卡罗琳斯卡医学院获医学硕士学位，2015年于美国圣路易斯华盛顿大学获理学博士学位，后于美国斯坦福大学从事心血管方向的博士后研究。2018年初全职加入中国科学院动物研究所，成立线粒体与疾病研究组并担任研究组组长。课题组基于人心血管细胞衰老模型和动物心血管衰老及相关疾病模型，解析心血管衰老的分子机制，发现心血管衰老的生物标记物，开发心血管衰老及相关疾病的干预策略。发表论文104篇，被引9200余次，H指数47。近五年，以通讯作者 (含共同) 在Cell、Circ Res (x2)、Nat Aging (x2)、Nat Commun (x2)、Cell Res、iMeta、Adv Sci (x3)等杂志合作发表论文34篇，平均影响因子＞13。申请发明专利23项，授权9项。

心脏衰老及相关疾病的机制与干预

国家自然科学基金重大研究计划培育项目，主持

中国科学院稳定支持基础研究领域青年团队计划，骨干

国家重点研发计划项目青年项目，主持，已结题

北京市自然科学基金杰出青年科学基金项目，主持，已结题

国家自然科学基金优秀青年科学基金项目，主持，已结题

国家自然科学基金面上项目，主持，已结题

中国科学院A类战略性先导科技专项子课题，主持，已结题

国家自然科学基金创新研究群体，骨干，已结题

1. Du H, You X, Zhang J, Liu S, Zhou Y, Wang Y, Yang C, Meng Y, Liu X, Zhang H, Li Y, Shen J, Yuan H, Xu P, He C, Xiao Y, Gao Z, Zang J, Wei T*, Song M*. CAR Macrophages Engineered In Vivo for Attenuating Myocardial Ischemia-Reperfusion Injury. Circulation Research (Featured Article). 2025 Aug 29;137(6):846-859. 
2. Geng L, Ping J, Wu R, Yan H, Zhang H, Zhuang Y, Ning T, Wang J, Liang C, Zhang J, Chu Q, Zhang J, Wen Y, Jing Y, Sun S, Qiao Q, Zhao Q, Ji Q, Ma S, Cai Y, Zheng Y, Zou Z, Diao Z, Li M, Zhang H, Hu J, Fu L, Kang W, Bai R, Zhao H, Zhang S, Ding Y, Lei J, Wang W, Ji Y, Gou B, Sun G, Yin J, Yan P, Li H, Wang Z, Ma S, Liu Z, Shan H, Wang Q, Cao T, Yang S, Wang C, Yang P, Fan Y, Ye Y, Hu J, Jiang M, Wang Y, Liu K, Li Y, Li Y, Li J, Ci W, Jin ZB, Fu X, Zhang X, Zhao G, Izpisua Belmonte JC, Wang S*, Song M*, Zhang W*, Qu J*, Liu GH*. Systematic Profiling Reveals Betaine as an Exercise Mimetic for Geroprotection. Cell. 2025 Jun 25:S0092-8674(25)00635-X. 
3. Xiao Y, Zhang H, Liu X, Xu P, Du H, Wang J, Shen J, Li Y, Wang Y, He C, Feng H, Liu J, Zhou Y, Liu S, Gao Z, Zang J, Bi J, Tang TS, Gu Q, Wei T, Wang J, Song M*. Medium From Human iPSC-Derived Primitive Macrophages Promotes Adult Cardiomyocyte Proliferation and Cardiac Regeneration. Nature Communications. 2025 Mar 27;16(1):3012. 
4. Du H, Liu X, Shen J, Yuan H, Zhang H, Xi G, Li Y, Wang Y, Zhang J, Yang C, Xu P, Wang J, Wang F, Liu S, Zhou Y, Gu Q, Lu J, Wei T, Gao Z, Zang J, Wang J*, Song M*. Flavonifractor Plautii or Its Metabolite Desaminotyrosine as Prophylactic Agents for Alleviating Myocardial Ischemia/Reperfusion Injury. Advanced Science (Frontispiece Article). 2025 Mar 16:e2417827. 
5. Xiao Y, Xu P, Bi J, Song M*. Human iPSC-Derived Self-Assembled Cardiac Organoids for Evaluating Drug Developmental Cardiotoxicity. Life Medicine. 2025;4(4):lnaf018. 
6. Wang J, Du H, Xie W, Bi J, Zhang H, Liu X, Wang Y, Zhang S, Lei A, He C, Yuan H, Zhang J, Li Y, Xu P, Liu S, Zhou Y, Shen J, Wu J, Cai Y, Yang C, Li Z, Liang Y, Zhao Y, Zhang J*, Song M*. CAR-Macrophage Therapy Alleviates Myocardial Ischemia-Reperfusion Injury. Circulation Research (Cover Story). 2024 Oct 28. 
7. Wang J*, Wang W, Zhang J, Xiao F, Li Z, Xu P, Wang H, Du H, Liu S, Li H, Zhang X, Chen S, Gao Z, Wang S, Wang J*, Song M*. Deficiency of Flavin-Containing Monooxygenase 3 Protects Kidney Function After Ischemia-Reperfusion in Mice. Communications Biology. 2024 Aug 27;7(1):1054. 
8. Su S, He C, Ren J*, Song M*. Global Insights Into Aging: A Multidisciplinary Approach to Understanding and Addressing Age-Related Challenges. Life Medicine. 2024 June;3(3):lnae029. 
9. Zhang H, Wang J, Shen J, Chen S, Yuan H, Zhang X, Liu X, Yu Y, Li X, Gao Z, Wang Y, Wang J*, Song M*. Prophylactic Supplementation With Bifidobacterium infantis or Its Metabolite Inosine Attenuates Cardiac Ischemia/Reperfusion Injury. iMeta. 2024 Jul 2;3(4):e220. 
10. Wang J, Zhang H, Yuan H, Chen S, Yu Y, Zhang X, Gao Z, Du H, Li W, Wang Y, Xia P, Wang J*, Song M*. Prophylactic Supplementation With Lactobacillus reuteri or Its Metabolite GABA Protects Against Acute Ischemic Cardiac Injury. Advanced Science (Frontispiece Article). 2024 Mar 15:e2307233. 
11. Chu Q, Liu F, He Y, Jiang X, Cai Y, Wu Z, Yan K, Geng L, Zhang Y, Feng H, Zhou K, Wang S, Zhang W, Liu GH*, Ma S*, Qu J*, Song M*. mTORC2/RICTOR Exerts Differential Levels of Metabolic Control in Human Embryonic, Mesenchymal and Neural Stem Cells. Protein Cell. 2022 Sep;13(9):676-682. 
12. Shen J, Liu GH*, Song M*. Potential Approaches for Intervening Aging. National Science Open. 2022;1(2):20220021. 
13. Zhang J, Liu GH*, Qu J*, Song M*. Treating Osteoarthritis Via Gene Therapy With Rejuvenation Factors. Gene Therapy. 2020 Aug;27(7-8):309-311. 
14. Wang Y, Li Y, He C, Gou B, Song M*. Mitochondrial Regulation of Cardiac Aging. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2019 Jul 1;1865(7):1853-1864. 
15. Song M, Franco A, Fleischer JA, Zhang L, Dorn GW 2nd. Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence. Cell Metabolism. 2017 Dec 5;26(6):872-883.e5. 
16. Gong G#, Song M#, Csordas G, Kelly DP, Matkovich SJ, Dorn GW 2nd. Parkin-Mediated Mitophagy Directs Perinatal Cardiac Metabolic Maturation in Mice. Science. 2015 Dec 4;350(6265):aad2459. 
17. Song M, Dorn GW 2nd. Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart. Cell Metabolism. 2015 Feb 3;21(2):195-205. 
18. Song M, Mihara K, Chen Y, Scorrano L, Dorn GW 2nd. Mitochondrial Fission and Fusion Factors Reciprocally Orchestrate Mitophagic Culling in Mouse Hearts and Cultured Fibroblasts. Cell Metabolism. 2015 Feb 3;21(2):273-286. 
19. Song M, Gong G, Burelle Y, Gustafsson ÅB, Kitsis RN, Matkovich SJ, Dorn GW 2nd. Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts. Circulation Research. 2015 Jul 31;117(4):346-51. 
20. Song M#, Matkovich SJ#, Zhang Y, Hammer DJ, Dorn GW 2nd. Combined Cardiomyocyte PKCδ and PKCε Gene Deletion Uncovers Their Central Role in Restraining Developmental and Reactive Heart Growth. Science Signaling. 2015 Apr 21;8(373):ra39. 
21. Song M, Chen Y, Gong G, Murphy E, Rabinovitch PS, Dorn GW 2nd. Super-Suppression of Mitochondrial Reactive Oxygen Species Signaling Impairs Compensatory Autophagy in Primary Mitophagic Cardiomyopathy. Circulation Research. 2014 Jul 18;115(3):348-53.