王金勇，研究员（二级），中国科学院大学博士生导师，中国科学院大学优秀教师，中国科学院动物研究所-干细胞与生殖生物学国家重点实验室-血液与免疫细胞再生研究组组长。国家重点研发计划项目首席科学家、获国家自然科学基金委医学部杰出青年科学基金资助。研究组长期从事血液与免疫细胞再生的新理论测试、新技术开发、以及临床转化研究。课题组的研究发现包括：Runx1+Hoxa9二因子驱动干细胞向T细胞谱系命运决定；Lhx2+Runx1+Hoxa9三因子驱动干细胞向B细胞谱系命运决定；Hoxa10+Runx1+Hoxa9三因子驱动干细胞向多谱系造血命运决定等。在理论上，上述研究支持了血液与免疫谱系命运可以通过转录因子操纵实现关口前移到内皮细胞阶段的理论。应用和临床转化方面，开发出诱导干细胞分化获得NK细胞（iNK）的类器官培养工艺，较传统方法提高效率100倍，大幅提高iNK细胞成熟度，实现iNK细胞和CAR-iNK细胞GMP放大生产。iNK细胞产品（JK500细胞注射液）进入研究者发起的临床试验(ClinicalTrials.gov 临床试验注册号: NCT05519384）,初步证明了iNK制剂的安全性。

个人经历

2021年6月至今：中国科学院动物研究所，研究员

2012年3月-2021年5月：中国科学院广州生物医药与健康研究院，研究员

2007年9月-2012年2月：美国威斯康星医学院、威斯康星大学麦迪逊医学与公共卫生学院，博士后

2006年8月-2007年8月：中国农业科学院上海兽医研究所， 博士后

2001年-2006年：浙江大学， 博士

1997年-2001年：莱阳农学院，学士

血液与免疫细胞再生

基于多能干细胞谱系分化原理，结合基因编辑，诱导获得可移植的血液种子细胞。模拟淋巴细胞发育微环境，体外制备多能干细胞的NK、T等免疫细胞。结合细胞疗法原理，探索治疗肿瘤和免疫相关疾病。

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