马帅，北京干细胞与再生医学研究院“致一”研究员，中国科学院动物研究所副研究员。优青，科技部重点研发计划课题负责人。中国科学院青促会会员，入选中国科协“青年人才托举工程”。主要研究方向为系统衰老生物学研究，利用单细胞测序和基因编辑等技术开展系统水平衰老、衰老相关疾病以及衰老干预的新型分子机制的挖掘与解析。以（共）通讯/第一作者在Cell、Cell Stem Cell、Cell Research、Nature Cell Biology、Nature Aging、The Innovation等杂志上发表多篇研究论文。代表性成果获2024年度“中国生命科学十大进展”、2020年度“中国科学十大进展”及“中国生命科学十大进展” 、2020及2022年度Cell Press最受欢迎中国论文，作为主要贡献者之一获2020年度“中国科学院杰出科技成就奖”、 2024年度北京市自然科学二等奖。现任中国遗传学会衰老遗传学分会委员、中国老年医学学会基础与转化医学分会委员、中国老年学和老年医学学会抗衰老分会委员、中国衰老标志物研究联合体（ABC）委员。

围绕机体系统衰老的生物学研究，通过啮齿类和灵长类研究模型体系，利用单细胞测序等技术，开展衰老、衰老相关疾病及其干预的新型分子机制的挖掘与解析。

基金委，优秀青年科学基金项目，项目负责人。项目时间：2024.01-2026.12

基金委，面上基金项目，项目负责人。项目时间：2023.01-2026.12

基金委，青年科学基金项目，项目负责人。项目时间：2021.01-2023.12

科技部，国家重点研发计划，课题组长。项目时间：2022.12-2027.11

科技部，国家重点研发计划，课题骨干。项目时间：2018.12-2022.12

1. Ma S^#, Ji Z^#, Zhang B^#, Geng L^#, Cai Y^#, Nie C^#, Li J^#, Zuo Y^#, Sun Y^#, Xu G^#, Liu B, Ai J, Liu F, Zhao L, Zhang J, Zhang H, Sun S, Huang H, Zhang Y, Ye Y, Fan Y, Zheng F, Hu J, Zhang B, Li J, Feng X, Zhang F, Zhuang Y, Li T, Yu Y, Bao Z, Pan S, Esteban CR, Liu Z, Deng H, Wen F, Song M, Wang S, Zhu G, Yang J, Jiang T, Song W, Belmonte JCI, Qu J*, Zhang W*, Gu Y*, Liu GH*. Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging. Cell, 2024. doi:10.1016/j.cell.2024.10.019.
2. Ma S^#, Sun S^#, Geng L^#, Song M^#, Wang W, Ye Y, Ji Q, Zou Z, Wang S, He X, Li W, Esteban CR, Long X, Guo G, Chan P, Zhou Q, Belmonte JCI*, Zhang W*, Qu J*, Liu GH*. Caloric restriction reprograms the single-cell transcriptional landscape of Rattus norvegicus aging. Cell, 2020. 180(5): 984-1001.
3. Yang Y^#, Lu X^#, Liu N^#, Ma S^#, Zhang H, Zhang Z, Yang K, Jiang M, Zheng Z, Qiao Y, Hu Q, Huang Y, Zhang Y, Xiong M, Liu L, Jiang X, Reddy P, Dong X, Xu F, Wang Q, Zhao Q, Lei J, Sun S, Jing Y, Li J, Cai Y, Fan Y, Yan K, Jing Y, Haghani A, Xing M, Zhang X, Zhu G, Song W, Horvath S, Rodriguez Esteban C, Song M, Wang S, Zhao G, Li W, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. Metformin decelerates aging clock in male monkeys. Cell, 2024. 187(22):6358-6378.
4. Ma S^#, Wang S^#, Ye Y^#, Ren J^#, Chen R^#, Li W, Li J, Zhao L, Zhao Q, Sun G, Jing Y, Zuo Y, Xiong M, Yang Y, Wang Q, Lei J, Sun S, Long X, Song M, Yu S, Chan P, Wang J, Zhou Q, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues. Cell Stem Cell, 2022. 29(6): 990-1005. e10.
5. Ma S^#, Sun S^#, Li J^#, Fan Y^#, Qu J^#, Sun L^#, Wang S, Zhang Y, Yang S, Liu Z, Wu Z, Zhang S, Wang Q, Zheng A, Duo S, Yu Y, Belmonte JCI, Chan P, Zhou Q, Song M*, Zhang W*, Liu GH*. Single-cell transcriptomic atlas of primate cardiopulmonary aging. Cell Research, 2020. 31(4): 415-432.
6. Ma S^#, Chi X^#, Cai Y^#, Ji Z^#, Wang S*, Ren J*, Liu GH*. Decoding Aging Hallmarks at the Single-Cell Level. Annual Review of Biomedical Data Science, 2023.  doi:10.1146/annurev-biodatasci-020722-120642.
7. Ma S^#, Wu Q, Hu Y*, Wei F. Patterns and effects of GC3 heterogeneity and parsimony informative sites on phylogenetic tree of genes. Gene, 2018. 655: 56-60.
8. Wang S^#, Yao X^#, Ma S^#, Ping Y^#, Fan Y^#, Sun S^#, He Z^#, Shi Y^#, Sun L^#, Xiao S^#, Song M^#, Cai J, Li J, Tang R, Zhao L, Wang C, Wang Q, Zhao L, Hu H, Liu X, Sun G, Chen L, Pan G, Chen H, Li Q, Zhang P, Xu Y, Feng H, Zhao GG, Wen T, Yang Y, Huang X, Li W, Liu Z, Wang H, Wu H, Hu B, Ren Y, Zhou Q, Qu J*, Zhang W*, Liu GH*, Bian XW*. A single-cell transcriptomic landscape of the lungs of patients with COVID-19. Nature Cell Biology, 2021. 23(12), 1314-1328.
9. Wang Q^#, Wang X^#, Liu B^#, Ma S^#, Zhang F^#, Sun S, Jing Y, Fan Y, Ding Y, Xiong M, Li J, Zhai Q, Zheng Y, Liu C, Xu G, Yang J, Wang S, Ye J, Izpisua Belmonte JC, Qu J*, Liu GH*, Zhang W*. Aging induces region-specific dysregulation of hormone synthesis in the primate adrenal gland. Nature Aging, 2024. 4(3): 396-413.
10. Sun S^#, Ma S^#, Cai Y^#, Wang S^#, Ren J^#, Yang Y^#, Ping J, Wang X, Zhang Y, Yan H, Li W, Concepcion Rodriguez Esteban, Yu Y, Liu F, Belmonte JCI, Zhang W*, Qu J*, Liu GH*. A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body, The Innovation, 2023. 5(1): 100380.
11. Lu H^#, Jing Y^#, Zhang C^#, Ma S^#, Zhang W^#, Huang D, Zhang B, Zuo Y, Qin Y, Liu GH*, Yu Y*, Qu J*, Wang S*. Aging hallmarks of the primate ovary revealed by spatiotemporal transcriptomics. Protein & Cell, 2024. 15(5): 364-384.
12. Hu Q^#, Zhang B^#, Jing Y^#, Ma S^#, Hu L^#, Li J, Zheng Y, Xin Z, Peng J, Wang S, Cheng B, Qu J*, Zhang W*, Liu GH*, Wang S*. Single-nucleus transcriptomics uncovers a geroprotective role of YAP in primate gingival aging. Protein & Cell. 2024. doi:10.1093/procel/pwae017.
13. Li H^#, Zhao W^#, Yang F^#, Qiao Q^#, Ma S^#, Yang K^#, Song S^#, Wang S, Qu J*, Liu GH*, Bao Y*, Zhang W*. Immunosenescence Inventory—a multi-omics database for immune aging research. Nucleic Acids Research, 2024. 53(D1), D1047-D1054.
14. Yan H^#, Wang R^#, Ma S^#, Huang D^#, Wang S^#, Ren J^#, Lu C, Chen X, Lu X, Zheng Z, Zhang W*, Qu J*, Zhou Y*, Liu GH*. Lineage Landscape: a comprehensive database that records lineage commitment across species, Nucleic Acids Research, 2023. doi.org/10.1093/nar/gkac951.
15. Wang Q^#, Wang X^#, Liu B^#, Ma S^#, Zhang F^#, Sun S, Jing Y, Fan Y, Ding Y, Xiong M, Li J, Zhai Q, Zheng Y, Liu C, Xu G, Yang J, Wang S, Ye J, Izpisua Belmonte JC, Qu J*, Liu GH*, Zhang W*. Regeneration Roadmap: database resources for regenerative biology. Nucleic Acids Research, 2022. 50(D1): D1085-D1090.
16. Hu Y^#, Wu Q^#, Ma S^#, Ma T^#, Shan L, Wang X, Nie Y, Ning Z, Yan L, Xiu Y, Wei F*. Comparative genomics reveals convergent evolution between the bamboo-eating giant and red pandas. Proc. Natl. Acad. Sci, 2017. 114(5):1081-1086.
17. Sun S^#, Jiang M^#, Ma S*, Ren J*, Liu GH*. Exploring the heterogeneous targets of metabolic aging at single-cell resolution. Trends in Endocrinology & Metabolism, 2024, doi: 10.1016/j.tem.2024.07.009.
18. Yan H^#, Lu C^#, Lan C^#, Wang S^#, Zhang W^#, He Z, Hu J, Ai J, Liu GH*, Ma S*, Zhou Y*, Qu J*. Degeneration Directory: A multi-omics web resource for degenerative diseases. Protein & Cell, 2024. doi:10.1093/procel/pwad066.
19. Zhang Y^#, Zheng Y^#, Wang S^#, Fan Y, Ye Y, Jing Y, Liu Z, Yang S, Xiong M, Yang K, Hu J, Che S, Chu Q, Song M, Liu GH*, Zhang W*, Ma S*, Jing Qu^#. Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging. Protein & Cell, 2023, doi:10.1093/procel/pwac038.
20. Li LZ^#, Yang K^#, Jing Y^#, Fan Y^#, Jiang X, Wang S, Liu GH*, Qu J*, Ma S*, Zhang W*. CRISPR-based screening identifies XPO7 as a positive regulator of senescence, Protein & Cell, 2023. doi:10.1093/procel/pwad012.
21. Chu Q^#, Liu F^#, He Y^#, Jiang X^#, Cai Y, Wu Z, Yan K, Geng L, Zhang Y, Feng H, Zhou K, Wang S, Zhang W, Liu GH*, Ma S*, Qu J*, Song M*. mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells. Protein & Cell, 2022. doi:10.1007/s13238-021-00898-9.