胡宝洋，博士，中国科学院动物研究所研究员，中国科学院大学医学院常务副院长。入选中国科学院相关人才计划、教育部高层次人才奖励计划特聘教授、中青年科技创新领军人才、百千万人才工程国家级人选等。中国细胞生物学学会理事、干细胞分会副会长。

2004年获复旦大学上海医学院博士学位，2005年赴美国威斯康星大学（University of Wisconsin-Madison）从事博士后研究，2011年1月回国任职。主要从事干细胞与再生医学研究。担任干细胞及相关领域国家重要规划编制专家，积极参与生物技术领域发展规划、重大项目设计、新兴交叉学科设立、重大科技基础设施建设等。

承担科技部、国家自然科学基金委、中国科学院、北京市等多项科技任务。领导团队在人脑发育及退行病变研究等方面取得系列重要成果。首次揭示 lncRNA起源人特异新基因产物对大脑皮层扩增和折叠的作用及机制；首次阐明 TMEM119 在维持小胶质细胞稳态及调控阿尔茨海默病进程中的作用机制；首次把人iPS细胞分化为神经细胞；开发基于干细胞的再生医学产品，率先针对帕金森病等适应证开展临床研究。在Nature、Science等期刊发表高水平论文80余篇，获多项国内外专利。获中华医学科技一等奖（8/15）、中国科学院杰出科技成就奖（主要完成者）、第七届侨届杰出贡献奖一等奖、中国细胞生物学会干细胞分会创新奖、转化奖等。

领导中国科学院大学医学学科建设，系统规划再生医学、精准医学、智慧医学等新兴交叉学科和专业领域。突出科学精神、学术视野、创新思维和实战能力，构建医药领域创新领军人才培养体系；领导建设新型研发机构北京干细胞与再生医学研究院，探索以高价值知识产权为载体，联接并促进更原创突破和更高效成果转化的模式。

作为主要成员发起成立亚洲干细胞与再生医学联盟（AASCRM）；牵头组织干细胞领域高端国际会议PSConf，并任PSConf 2025主席。

当选北京市第十六届人大代表、政协北京市怀柔区第六届委员会常委、怀柔区科协副主席等。

揭示人脑发育与疾病机理

结合人多能干细胞神经定向分化和类器官系统，揭示人脑发育与疾病机制。

研发神经退行疾病创新疗法

创新理念、范式和技术，开发衰老和神经退行病变的‘生物技术+’解决方案。

开发治疗重大疾病的细胞新药

以多能干细胞定向分化和体细胞直接转分化为基础，研制新型干细胞药物。

享受国务院特殊津贴专家（2020）；中青年科技创新领军人才（2020）；教育部高层次人才奖励计划特聘教授（2019）；百千万人才工程国家级人选（2019）

2023 北京市自然科学二等奖（证书号 2023-Z04-2-03-R04）4/10

2020 中国科学院杰出科技成就奖

2021 全国科技系统抗击新冠肺炎疫情先进个人，科技部

2020 抗击新冠肺炎疫情先进个人，中国农工民主党中央委员会

2019 干细胞成果创新奖，中国细胞生物学会干细胞生物学分会

2018 干细胞成果转化奖，中国细胞生物学会干细胞生物学分会

2018 第七届中国侨届杰出贡献奖一等奖，中国侨联

2018 中华医学科技奖一等奖 (证书号201801069P1508) 8/15

2017 中华医学科技奖三等奖 (证书号201703185P0804) 4/8

国家重大科学研究计划项目，国家重点研发计划项目，国家自然科学基金项目，中国科学院重点部署项目，中国科学院战略性先导科技专项，等。

1. Jing Liu^#, Zhimeng Wang^#, Wenwen Liang, Zhenhao Zhang, Yusen Deng, Xiaowei Chen, Zongren Hou, Yuanzhi Xie, Qi Wang, Yuan Li, Chaobo Bai, Da Li, Fan Mo, Huinan Wang, Dongmei Wang, Junliang Yuan^*, Yukai Wang^*, Zhaoqian Teng^*, Baoyang Hu^*. Microglial TMEM119 binds to amyloid-β to promote its clearance in an Aβ-depositing mouse model of Alzheimer's disease. Immunity, 2025. 58(7):1830-1846.e7.
2. Yuanzi Xie^#, Jing Liu^#, Zongren Hou^#, Huan Wang^#, Kailun Liu, Xiaowei Chen, Zhen Fan, Da Li, Can Li, Yuhualei Pan, Yushang Zhao, Yanbing Zhu^*, Baoyang Hu^*. CD4-Derived Double-Negative T Cells Ameliorate Alzheimer's Disease-Like Phenotypes in the 5xFAD Mouse Model. CNS Neuroscience & Therapeutics, 2025. 31(1):e70187.
3. Xinyue Wang, Gaoying Sun, Mingming Tang, Da Li, Jianhuan Qi, Chuanyue Wang, Yukai Wang^*, Baoyang Hu^*. Human Midbrain Organoids Enriched With Dopaminergic Neurons for Long- Term Functional Evaluation. Cell Proliferation, 2025. 58(7):e70005.
4. Kailun Liu, Xiaowei Chen, Zhen Fan, Fei Ren^*, Jing Liu^*, Baoyang Hu^*. From organoids to organoids-on-a-chip: Current applications and challenges in biomedical research. Chinese Medical Journal, 2025. 138(7):792-807.
5. Yanyu Li^#, Liwei Zhou^#, Fengcui Qian^#, Qiaoli Fang^#, Zhengmin Yu, Ting Cui, Fujuan Dong, Fuhong Cai, Tingting Yu, Lidong Li, Qiuyu Wang, Yanbing Zhu^*, Huifang Tang^*, Baoyang Hu^*, Chunquan L^i*. scImmOmics: a manually curated resource of single-cell multi-omics immune data. Nucleic Acids Research, 2024. 53(D1):D1162-D1172.
6. Lin Feng^#, Da Li^#, Yao Tian^#, Chengshun Zhao, Qi Gu, Wei Li, Jie Hao, Baoyang Hu^*, Yukai Wang^*. One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation in vitro and survival after transplantation in vivo. Neural Regeneration Research, 2024. 19 (2): 458-464.
7. Liangjiang Huang^#, Song Zhang^#, Jun Wu^#, Baojie Guo^#, Tingting Gao, Sayed Zulfiqar Ali Shah, Bo Huang, Yajie Li, Bo Zhu, Jiaqi Fan, Liu Wang, Yani Xiao, Wenjing Liu, Yao Tian, Zhengyu Fang, Yingying Lv, Lingfeng Xie, Sheng Yao, Gaotan Ke, Xiaolin Huang, Ying Huang, Yujuan Li, Yi Jia, Zhongwen Li, Guihai Feng, Yan Huo, Wei Li, Qi Zhou, Jie Hao^*, Baoyang Hu^*, Hong Chen^*. Immunity-and-matrix-regulatory cells enhance cartilage regeneration for meniscus injuries: a phase I dose-escalation trial. Signal Transduction and Targeted Therapy, 2023. 8(1):417.
8. Ni A An^#, Jie Zhang^#, Fan Mo^#, Xuke Luan^#, Lu Tian, Qing Sunny Shen, Xiangshang Li, Chunqiong Li, Fanqi Zhou, Boya Zhang, Mingjun Ji, Jianhuan Qi, Weizhen Zhou, Wanqiu Ding, Jiayu Chen, Jia Yu, Li Zhang, Shaokun Shu, Baoyang Hu^*, Chuanyun Li^*. De novo genes with an lncRNA origin encode unique human brain developmental functionality. Nature Ecology & Evolution, 2023. 7(2): 264-278.
9. Jianhuan Qi^#, Fan Mo^#, Ni A An^#, Tingwei Mi, Jiaxin Wang, Juntian Qi, Xiangshang Li, Boya Zhang, Longkuo Xia, Yingfei Lu, Gaoying Sun, Xinyue Wang, Chuanyun Li^*, Baoyang Hu^*. A Human-Specific De Novo Gene Promotes Cortical Expansion and Folding. Advanced Science, 2023. 13: e2204140.
10. Juan Yu^#, Nianye Yu^#, Yao Tian^#, Yifan Fang#, Bin An, Guihai Feng, Jun Wu, Liu Wang, Jie Hao, Liqiang Wang, Qi Zhou, Wei Li^*, Yukai Wang^*, Baoyang Hu^*. Safety and efficacy of human ESC-derived corneal endothelial cells for corneal endothelial dysfunction. Cell & Bioscience, 2023. 13(1):201.
11. Wenliang Zhu^#, Mengqi Li^#, Jun Zou^#, Da Zhang, Minghui Fang, Yun Sun, Can Li, Mingming Tang, Yukai Wang, Qi Zhou, Tongbiao Zhao^*, Wei Li^*, Zheng Hu^*, Baoyang Hu^*. Induction of local immunosuppression in allogeneic cell transplantation by cell-type-specific expression of PD-L1 and CTLA4Ig. Stem Cell Reports, 2023. 18(12):2344-2355.
12. Gaoying Sun^#, Mingming Tang^#, Xinyue Wang^#, Da Li, Wenwen Liu, Jianhuan Qi, Haibo Wang^*, Baoyang Hu^*. Generation of human otic neuronal organoids using pluripotent stem cells. Cell Proliferation, 2023. 56(5):e13434.
13. Jing Liu^#, Zongren Hou^#, Jun Wu^#, Kailun Liu, Da Li, Tingting Gao, Wenjing Liu, Bin An, Yun Sun, Fan Mo, Liu Wang, Yukai Wang^*, Jie Hao^*, Baoyang Hu^*, Infusion of hESC derived Immunity-and-matrix regulatory cells improves cognitive ability in early-stage AD mice. Cell Proliferation, 2021. 54(8): p. e13085.
14. Han Sun, Jing Liu, Fengting Lv, Libing Liu, Qi Gu, Baoyang Hu^*, Shu Wang^*, Selective reaction of conjugated polymers with basic proteins for broad-spectrum antivirulence therapy. NPG Asia Materials, 2021. 13(21).
15. Jun Wu^#, Dingyun Song^#, Zhongwen Li^#, Baojie Guo^#, Yani Xiao, Wenjing Liu, Lingmin Liang, Chunjing Feng, Tingting Gao, Yanxia Chen, Ying Li, Zai Wang, Jianyan Wen, Shengnan Yang, Peipei Liu, Lei Wang, Yukai Wang, Liang Peng, Glyn Nigel Stacey, Zheng Hu, Guihai Feng, Wei Li, Yan Huo, Ronghua Jin, Ng Shyh-Chang, Qi Zhou, Liu Wang, Baoyang Hu^*, Huaping Dai^*, Jie Hao^*. Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis. Cell Research, 2020. 30 (9): p. 794-809.
16. Wenliang Zhu^#, Boya Zhang^#, Mengqi Li^#, Fan Mo, Tingwei Mi, Yihui Wu, Zhaoqian Teng, Qi Zhou^*, Wei Li^*, Baoyang Hu^*. Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome. Nature Communications, 2019. 10(1): p. 928.
17. Weiqi Zhang^#, Haifeng Wan^#, Guihai Feng^#, Jing Qu#, Jiaqiang Wang, Yaobin Jing, Ruotong Ren, Zunpeng Liu, Linlin Zhang, Zhiguo Chen, Shuyan Wang, Yong Zhao, Zhaoxia Wang, Yun Yuan, Qi Zhou, Wei Li^*, Guanghui Liu^*, Baoyang Hu^*. SIRT6 deficiency results in developmental retardation in cynomolgus monkeys. Nature, 2018. 560(7720): p. 661-665.
18. Zhikun Li^#, Leyun Wang^#, Libin Wang^#, Guihai Feng^#, Xuewei Yuan^#, Chao Liu, Kai Xu, Yuhuan Li, Haifeng Wan, Ying Zhang, Yufei Li, Xin Li, Wei Li*, Qi Zhou^*, Baoyang Hu^*. Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions. Cell Stem Cell, 2018. 23(5): p. 665-676.
19. Xuepeng Wang^#, Tianda Li^#, Tongtong Cui^#, Dawei Yu^#, Chao Liu^#, Liyuan Jiang, Guihai Feng, Lei Wang, Rui Fu, Xinxin Zhang, Jie Hao, Yukai Wang, Liu Wang, Qi Zhou^*, Wei Li^*, Baoyang Hu^*. Human embryonic stem cells contribute to embryonic and extraembryonic lineages in mouse embryos upon inhibition of apoptosis. Cell Research, 2018. 28(1): p. 126-129.
20. Menghua Wu, Da Zhang, Chunying Bi, Tingwei Mi, Wenliang Zhu, Longkuo Xia, Zhaoqian Teng, Baoyang Hu^*, Yihui Wu^*. A Chemical Recipe for Generation of Clinical-Grade Striatal Neurons from hESCs. Stem Cell Reports, 2018. 11(3): p. 635-650.
21. Yukai Wang, Wanwan Zhu, Menghua Wu, Yihui Wu, Zhengxin Liu, Lingmin Liang, Chao Sheng, Jie Hao, Liu Wang, Wei Li, Qi Zhou^*, Baoyang Hu^*. Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease. Stem Cell Reports, 2018. 11(1):171-182.
22. Boya Zhang^#, Yangzhige He^#, Yanpeng Xu^#, Fan Mo, Tingwei Mi, Qing Sunny Shen, Chunfeng Li, Yali Li, Jing Liu, Yihui Wu, Guilai Chen, Wenliang Zhu, Chengfeng Qin^*, Baoyang Hu^*, Guomin Zhou^*. Differential antiviral immunity to Japanese encephalitis virus in developing cortical organoids. Cell Death and Disease, 2018. 9(7):719.
23. Yuan Jiang^#, Long Yan^#, Longkuo Xia, Xiaoyin Lu, Wenliang Zhu, Dewen Ding, Mingxia Du, Da Zhang, Hongmei Wang^*, Baoyang Hu^*. Zinc finger E-box-binding homeobox 1 (ZEB1) is required for neural differentiation of human embryonic stem cells. The Journal of Biological Chemistry, 2018. 293(50): p. 19317-19329.
24. Zhikun Li^#, Haifeng Wan^#, Guihai Feng^#, Leyun Wang^#, Zhengquan He, Yukai Wang, Xiujie Wang, Wei Li^*, Qi Zhou^*, Baoyang Hu^*. Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells. Cell Research, 2016. 26(1):135-138.
25. Lixiang Ma, Baoyang Hu, Yan Liu, Scott Christopher Vermilyea, Huisheng Liu, Lu Gao, Yan Sun, Xiaoqing Zhang, Suchun Zhang^*. Human embryonic stem cell-derived GABA neurons correct locomotion deficits in quinolinic acid-lesioned mice. Cell Stem Cell, 2012. 10(4):455-464.
26. Yuan Jiang, Meijiang Zhang, Baoyang Hu^*. Specification of functional neurons and glia from human pluripotent stem cells. Protein Cell, 2012. 3(11):818-825.
27. Baoyang Hu, Jason P Weick, Junying Yu, Lixiang Ma, Xiaoqing Zhang, James A Thomson, Suchun Zhang^*. Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proceedings of National Academy of Sciences of The United States of America, 2010. 107(9):4335-4340.
28. Baoyang Hu, Suchun Zhang^*, Differentiation of spinal motor neurons from pluripotent human stem cells. Nature Protocols, 2009. 4(9):1295-1304.
29. Baoyang Hu, Zhongwei Du, Suchun Zhang^*. Differentiation of human oligodendrocytes from pluripotent stem cells. Nature Protocols, 2009. 4(11): 1614-1622.
30. Baoyang Hu, Zhongwei Du, Xuejun Li, Melvin Ayala, Suchun Zhang^*. Human oligodendrocytes from embryonic stem cells: conserved SHH signaling networks and divergent FGF effects. Development, 2009. 136(9):1443-1452.

Notes:  # These authors contributed equally; * Correspondence.

专利：

1. 周琪; 李伟; 胡宝洋; 郝捷; 王磊; 王柳。具有特定HLA配型的人胚干细胞。发明专利，ZL202010949011.X
2. 周琪; 李伟; 胡宝洋; 何正泉; 王柳; 郝捷。一种将非神经元细胞转化为神经元细胞的方法。发明专利，ZL202010322427.9
3. 周琪; 胡宝洋; 郝捷; 李伟; 吴骏; 王柳; 郭保杰; 李仲文; 高婷婷; 陈燕霞; 王红梅。一种多能干细胞、药物组合物及其制备方法与用途。发明专利，ZL202010998258.0
4. 周琪; 李伟; 郝捷; 王昱凯; 胡宝洋; 冯琳; 梁灵敏; 王柳。一种神经细胞组合和其应用。发明专利，ZL202211191890.X
5. 周琪; 李伟; 胡宝洋; 郝捷; 王磊; 王柳。一种简单的视网膜色素上皮细胞的配制方法。发明专利，ZL202111136904.3
6. 周琪; 胡宝洋; 李伟; 王昱凯; 王鑫阁; 郝捷; 冯桂海; 田瑶; 冯琳; 王柳。一种通过血样检测判断动物体内存在移植物的方法。发明专利，ZL202211324662.5
7. 周琪; 李伟; 胡宝洋; 郝捷; 王磊; 王柳; 王昱凯。一种视网膜色素上皮细胞的扩增培养基及培养方法。发明专利，ZL202211205216.2
8. 周琪; 李伟; 胡宝洋; 郝捷; 王磊; 王柳。将胚胎干细胞诱导为视网膜色素上皮细胞的培养基及应用。发明专利，ZL202011220950.7
9. 王崧; 胡宝洋。一种TALE重复序列载体的构建方法。发明专利，ZL201610266044.8
10. 蒋远; 杜明霞; 胡宝洋。一种提高体细胞重编程效率的培养基及方法。发明专利，ZL201510528329.X
11. Zhang SC, Hu BY, Du ZW. Method of Generating Myelinating Oligodendrocytes from Embryonic Stem Cells, US patent, 2012: US 8227247 B2
12. Zhang SC, Hu BY, Du ZW. Myelinating Oligodendrocyte Precursor Populations, US patent, 2014: US 8658424 B2

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