王昱凯，男，博士，副研究员，硕士生导师。

2011年博士毕业于山东大学，随后加入中国科学院动物研究所从事博士后研究，先后担任助理研究员、副研究员。主要方向为干细胞命运调控与神经再生，重点关注帕金森病、脑血管病、阿尔兹海默病的神经修复和治疗，相关研究成果以第一或通讯作者（含共同）发表在Cell，Immunity，Cell Proliferation、Advanced Science等刊物共30余篇。授权国家发明专利7项，国际PCT1项，完成6个专利技术的转化，牵头和参与制定团体标准4项、国家标准1项、国际标准1项。

担任Stroke & Vascular Neurology青年编委，npj Regenerative Medicine，Advanced Science等期刊审稿人，国际标准化组织ISO/TC 276委员会成员。主要工作被Nature、The Scientist杂志和中央台专题报道，荣获2019年度“中国生命科学十大进展”。开发的神经细胞产品获第22届中国国际高新技术成果交易会“优秀产品奖”，角膜内皮细胞产品入选2023中关村论坛国际技术交易大会“百项新技术新产品榜单”。

　　研究多能干细胞向特定亚型神经细胞的命运调控和定向分化技术；建立人神经类器官并将其用于疾病建模、药物筛选；开发神经细胞药物，用于重大神经系统疾病的替代治疗。

国家重点研发计划“揭榜挂帅”项目，2025-2027，课题负责人

北京市自然科学基金重点研究专题，2023-2027，课题负责人

国家自然基金委面上基金项目，2020-2023，课题负责人

国家自然基金委青年科学基金项目，2017-2019，课题负责人

中国科学院稳定支持基础研究领域青年团队计划，2022-2027，参加

中国科学院战略性先导科技专项，2017-2022，参加

1. Gaoying Sun^#; Yukai Wang^#; Man Wang^#; Xinyue Wang; Mingming Tang; Da Li; Jianhuan Qi; Xue Wang; Shujuan Sun; Lei Chen; Weibin An; Ligang Kong; Anqi Suo; Haibo Wang*; Wenwen Liu*; Lei Xu*; Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation, Advanced Science, 2026 Feb;13(7):e05663.
2. Weizheng Liang^#, Guipeng Li^#, Yukai Wang^#, Wencheng Wei, Rui Chen, Siyue Sun, Diwen Gan, Hongyang Yi, Bernhard Schaefke, Yuhui Hu, Qi Zhou, Wei Li, Huanhuan Cui*, Wei Chen*. Evolutionary Analysis of Transcriptional Regulation Mediated by Cdx2 in Rodents. Cell Proliferation. 2026 Mar;59(3):e70103.
3. Tingting Zhang^#, Da Li^#, Qibiao Guan, Bin An, Yun Sun, Qiang Wang, Yukai Wang*, Baoyang Hu*. Lineage-Biased Neural Stem Cell Grafting Promotes Neuronal Differentiation and Vascular Repair in the Chronic Phase of Stroke. CNS Neurosci Ther. 2026 Jan;32(1):e70701.
4. Jing Liu; Zhimeng Wang; Wenwen Liang; Zhenhao Zhang; Yusen Deng; Xiaowei Chen; Zongren Hou; Yuanzhi Xie; Qi Wang; Yuan Li; Chaobo Bai; Da Li; Fan Mo; Huinan Wang; Dongmei Wang; Junliang Yuan*; Yukai Wang*; Zhao-Qian Teng*; Baoyang Hu*; Microglial TMEM119 binds to amyloid-β to promote its clearance in an Aβ-depositing mouse model of Alzheimer’s disease, Immunity, 2025, 58(7): 1830-1846.E7.
5. Xinyue Wang, Gaoying Sun, Mingming Tang, Da Li, Jianhuan Qi, Chuanyue Wang, Yukai Wang*, Baoyang Hu*. Human midbrain organoids enriched with dopaminergic neurons for long- term functional evaluation. Cell Proliferation. 2025 58(7): e70005.
6. Feng L, Li D, Tian Y, Zhao CS, Sun Y, Kou XL, Wu J, Wang L, Gu Q, Li W, Hao J, Hu BY*, Wang YK*. One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation in vitro and survival after transplantation in vivo. Neural Regen Res. 2024, 19(2):458-464.
7. Yu J#, Yu NY#, Tian Y#, Fang YF#, An B, Feng GH, Wu J, Wang L, Hao J, Wang LQ, Zhou Q, Li W*, Wang YK*, Hu BY*. Safety and efficacy of human ESC-derived corneal endothelial cells for corneal endothelial dysfunction. Cell & Bioscience. 2023, 13, 201
8. Wang YK^#, Feng L, Ma AJ, Hao J, Zhang Y, Chen YJ, Chen ZG, Yu JY, Liu Y, Liu CM, Zhang Y, Wang CL, Teng ZQ, Zhou JQ, Li TQ, Wang L, Fu BQ, Fu Y, Zhu LJ, Liang LM, Cao JN, Wang L, Zhou Q, Xiang P*, Hu BY*, Zhao TB*. Human midbrain dopaminergic progenitors. Cell Proliferation. 2023 Oct 25: e13563.
9. Wang YK^#, Yu J^#, Zhang TT^#, Ma AJ, Hao J, Chen YJ, Liu CM, Liu Y, Wang CL, Zhai PJ, Xiang P, Li TQ, Tang TS, Chen H, Bao XJ, Wang YL, He WY, Fan J, Teng ZQ, Wang L, Zhou JX, Fu BQ, Fu Y, Feng L, Cao JN, Liang LM, Wang L, Zhou Q, Zhang Y*, Hu BY*, Zhao TB*. Human neural stem cells. Cell Proliferation. 2023, Oct 18:e13564.
10. Liang LM^#, Tian Y^#, Feng L^#, Wang CQ^#, Feng GH, Stacey GN, Chang NS, Wu J, Hu BY, Li W, Hao J, Wang L*, Wang YK*. Single‑cell transcriptomics reveals the cell fate transitions of human dopaminergic progenitors derived from hESCs. Stem Cell Research & Therapy. 2022, 13:412
11. Zhao YL^#, Wu J, Li D, Liu J, Chen WQ, Hou ZR, Liu KL, Jiang LL, Chen XW, Wang L, Hu BY, Zong FR*, Wang YK*, Wang YL*. Human ESC-derived immunity- and matrix- regulatory cells ameliorated white matter damage and vascular cognitive impairment in rats subjected to chronic cerebral hypoperfusion. Cell Proliferation. 2022, Apr 19;e13223.
12. Sun Y^#, Feng L^#, Liang LM^#, Stacey GN, Wang CQ, Wang YK*, Hu BY*. Neuronal cell-based medicines from pluripotent stem cells: development, production, and pre-clinical assessment. STEM CELLS Translational Medicine. 2021, Nov;10 Suppl 2(Suppl 2):S31-S40.
13. Liu J^#, Hou ZR^#, Wu J^#, Liu KL, Li D, Gao TT, Liu WJ, An B, Sun Y, Mo F, Wang L, Wang YK*, Hao J*, Hu BY*. Infusion of hESC derived Immunity-and-matrix regulatory cells improves cognitive ability in early-stage AD mice. Cell Proliferation. 2021, Aug;54(8):e13085.
14. Wang YK^#, Zhu WW^#, Wu MH^#, Wu YH, Liu ZX, Liang LM, Sheng C, Hao J, Wang L, Li W, Zhou Q, Hu BY, Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease, Stem Cell Reports, 2018, 11(1): 171-182. 
15. Wang JQ^#, Wang LY^#, Feng GH^#, Wang YK^#, Li YF, Li X, Liu C, Jiao GY, Huang C, Shi JC, Zhou T, Chen Q, Liu ZH, Li W, Zhou Q, Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos, Cell, 2018, 175(7): 1887-1901.
16. He ZQ^#, Xia BL^#, Wang YK^#, Li J, Feng GH, Zhang LL, Li YH, Wan HF, Li TD, Xu K, Yuan XW, Li YF, Zhang XX, Zhang Y, Wang L, Li W, Zhou Q, Generation of Mouse Haploid Somatic Cells by Small Molecules for Genome-wide Genetic Screening, Cell Reports, 2017, 20(9): 2227-2237.
17. Lu XY^#, Wang YK^#, Yan L, Wang LB, Li W, Wang HM, Variations in mesenchymal-epithelial transition-related transcription factors during reprogramming of somatic cells from different germ layers into iPSCs, Journal of Genetics and Genomics, 2016, 43(10): 609-612.
18. Li X^#, Cu XLi^#, Wang JQ^#, Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Liu ZH, Wang XJ, Li W, Zhou Q, Generation and Application of Mouse-Rat Allodiploid Embryonic Stem Cells, Cell, 2016, 164(1-2): 279-292. 
19. Li ZK^#, Wang LB^#, Wang YK^#, Liu L, Wang L, Li W, Zhou Q, Generation of an LncRNA Gtl2-GFP Reporter for Rapid Assessment of Pluripotency in Mouse Induced Pluripotent Stem Cells, Journal of Genetics and Genomics, 2015, 42(3): 125-128. 
20. Shuai L^#, Wang YK^#, Dong MZ^#, Wang XP^#, Sang LS, Wang M, Wan HF, Luo GZ, Gu TT, Yuan Y, Feng CJ, Teng F, Li W, Liu XY, Li TD, Wang L, Wang XJ, Zhao XY, Zhou Q, Durable pluripotency and haploidy in epiblast stem cells derived from haploid embryonic stem cells in vitro, J Mol Cell Biol, 2015, 7(4): 326-337. 
21. Wang LB^#, Cao JN^#, Wang YK^#, Lan TS^#, Liu L, Wang WX, Jin N, Gong JQ, Zhang C, Teng F, Yan GL, Li C, Li JL, Wan HF, Hu BY, Li W, Zhao XY, Qi ZQ, Zhao TB, Zhou Q, Immunogenicity and functional evaluation of iPSC-derived organs for transplantation, Cell Discovery, 2015, 7;1:15015.