王昱凯，男，博士，副研究员，硕士生导师。

　　2011年博士毕业于山东大学，随后加入中国科学院动物研究所从事博士后研究，先后担任助理研究员、副研究员。主要方向为干细胞命运调控与神经再生，重点关注帕金森病、脑血管病、阿尔兹海默病的神经修复和治疗，相关研究成果发表在Cell，Cell reports，Stem cell reports，Cell proliferation等刊物共30余篇，授权专利3项，主导制定干细胞团体标准2项。担任Stroke & Vascular Neurology审委，npj Regenerative Medicine，Neural Regeneration Research等期刊审稿人。

　　成果包括：发现长非编码RNA调控小鼠胚胎第一次命运选择并揭示机制；建立临床级人多巴胺神经细胞制备技术；在帕金森病猴模型中证明神经替代疗法的长期安全性和有效性；合作开展细胞治疗帕金森病的临床研究；建立阿尔茨海默病和脑小血管病的细胞治疗策略等。主要工作被Nature、The Scientist杂志和中央台专题报道，荣获2019年度“中国生命科学十大进展”。开发的神经细胞产品获第22届中国国际高新技术成果交易会“优秀产品奖”，角膜内皮细胞产品入选2023中关村论坛国际技术交易大会“百项新技术新产品榜单”。

　　研究多能干细胞向特定亚型神经细胞的命运调控和定向分化技术；建立人神经类器官并将其用于疾病建模、药物筛选；开发神经细胞药物，用于重大神经系统疾病的替代治疗。

　　北京市自然科学基金重点研究专题-课题（Z230011），2023-2027，主持

　　中国科学院稳定支持基础研究领域青年团队计划（YSBR-041），2022-2027，参加

　　国家自然基金委联合基金项目（U21A20396），2022-2025，参加

　　国家自然基金委面上基金项目（31970821），2020-2023，主持

　　国家重点研发计划（2019YFA0903800），2020-2024，参加

　　国家重点研发计划（2019YFA0110800），2019-2023，参加

　　中国科学院战略性先导科技专项，2017-2022，参加

　　国家自然基金委青年科学基金项目（31601173），2017-2019，主持

1. Feng L, Li D, Tian Y, Zhao CS, Sun Y, Kou XL, Wu J, Wang L, Gu Q, Li W, Hao J, Hu BY*, Wang YK*. One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation in vitro and survival after transplantation in vivo. Neural Regen Res. 2024, 19(2):458-464.
2. Yu J#, Yu NY#, Tian Y#, Fang YF#, An B, Feng GH, Wu J, Wang L, Hao J, Wang LQ, Zhou Q, Li W*, Wang YK*, Hu BY*. Safety and efficacy of human ESC-derived corneal endothelial cells for corneal endothelial dysfunction. Cell & Bioscience. 2023, 13, 201
3. Wang YK^#, Feng L, Ma AJ, Hao J, Zhang Y, Chen YJ, Chen ZG, Yu JY, Liu Y, Liu CM, Zhang Y, Wang CL, Teng ZQ, Zhou JQ, Li TQ, Wang L, Fu BQ, Fu Y, Zhu LJ, Liang LM, Cao JN, Wang L, Zhou Q, Xiang P*, Hu BY*, Zhao TB*. Human midbrain dopaminergic progenitors. Cell Proliferation. 2023 Oct 25:e13563.
4. Wang YK^#, Yu J^#, Zhang TT^#, Ma AJ, Hao J, Chen YJ, Liu CM, Liu Y, Wang CL, Zhai PJ, Xiang P, Li TQ, Tang TS, Chen H, Bao XJ, Wang YL, He WY, Fan J, Teng ZQ, Wang L, Zhou JX, Fu BQ, Fu Y, Feng L, Cao JN, Liang LM, Wang L, Zhou Q, Zhang Y*, Hu BY*, Zhao TB*. Human neural stem cells. Cell Proliferation. 2023, Oct 18:e13564.
5. Liang LM^#, Tian Y^#, Feng L^#, Wang CQ^#, Feng GH, Stacey GN, Chang NS, Wu J, Hu BY, Li W, Hao J, Wang L*, Wang YK*. Single-cell transcriptomics reveals the cell fate transitions of human dopaminergic progenitors derived from hESCs. Stem Cell Research & Therapy. 2022, 13:412
6. Zhao YL^#, Wu J, Li D, Liu J, Chen WQ, Hou ZR, Liu KL, Jiang LL, Chen XW, Wang L, Hu BY, Zong FR*, Wang YK*, Wang YL*. Human ESC-derived immunity- and matrix- regulatory cells ameliorated white matter damage and vascular cognitive impairment in rats subjected to chronic cerebral hypoperfusion. Cell Proliferation. 2022, Apr 19;e13223.
7. Sun Y^#, Feng L^#, Liang LM^#, Stacey GN, Wang CQ, Wang YK*, Hu BY*. Neuronal cell-based medicines from pluripotent stem cells: development, production, and pre-clinical assessment. STEM CELLS Translational Medicine. 2021, Nov;10 Suppl 2(Suppl 2):S31-S40.
8. Liu J^#, Hou ZR^#, Wu J^#, Liu KL, Li D, Gao TT, Liu WJ, An B, Sun Y, Mo F, Wang L, Wang YK*, Hao J*, Hu BY*. Infusion of hESC derived Immunity-and-matrix regulatory cells improves cognitive ability in early-stage AD mice. Cell Proliferation. 2021, Aug;54(8):e13085.
9. Wang YK^#, Zhu WW^#, Wu MH^#, Wu YH, Liu ZX, Liang LM, Sheng C, Hao J, Wang L, Li W, Zhou Q, Hu BY, Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease, Stem Cell Reports, 2018, 11(1): 171-182
10. Wang JQ^#, Wang LY^#, Feng GH^#, Wang YK^#, Li YF, Li X, Liu C, Jiao GY, Huang C, Shi JC, Zhou T, Chen Q, Liu ZH, Li W, Zhou Q, Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos, Cell, 2018, 175(7): 1887-1901
11. He ZQ^#, Xia BL^#, Wang YK^#, Li J, Feng GH, Zhang LL, Li YH, Wan HF, Li TD, Xu K, Yuan XW, Li YF, Zhang XX, Zhang Y, Wang L, Li W, Zhou Q, Generation of Mouse Haploid Somatic Cells by Small Molecules for Genome-wide Genetic Screening, Cell Reports, 2017, 20(9): 2227-2237
12. Lu XY^#, Wang YK^#, Yan L, Wang LB, Li W, Wang HM, Variations in mesenchymal-epithelial transition-related transcription factors during reprogramming of somatic cells from different germ layers into iPSCs, Journal of Genetics and Genomics, 2016, 43(10): 609-612
13. Li X^#, Cu XLi^#, Wang JQ^#, Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Liu ZH, Wang XJ, Li W, Zhou Q, Generation and Application of Mouse-Rat Allodiploid Embryonic Stem Cells, Cell, 2016, 164(1-2): 279-292
14. Li ZK^#, Wang LB^#, Wang YK^#, Liu L, Wang L, Li W, Zhou Q, Generation of an LncRNA Gtl2-GFP Reporter for Rapid Assessment of Pluripotency in Mouse Induced Pluripotent Stem Cells, Journal of Genetics and Genomics, 2015, 42(3): 125-128
15. Shuai L^#, Wang YK^#, Dong MZ^#, Wang XP^#, Sang LS, Wang M, Wan HF, Luo GZ, Gu TT, Yuan Y, Feng CJ, Teng F, Li W, Liu XY, Li TD, Wang L, Wang XJ, Zhao XY, Zhou Q, Durable pluripotency and haploidy in epiblast stem cells derived from haploid embryonic stem cells in vitro, J Mol Cell Biol, 2015, 7(4): 326-337
16. Wang LB^#, Cao JN^#, Wang YK^#, Lan TS^#, Liu L, Wang WX, Jin N, Gong JQ, Zhang C, Teng F, Yan GL, Li C, Li JL, Wan HF, Hu BY, Li W, Zhao XY, Qi ZQ, Zhao TB, Zhou Q, Immunogenicity and functional evaluation of iPSC-derived organs for transplantation, Cell Discovery, 2015, 7;1:15015