郝捷，博士，研究员，中国科学院动物研究所国家干细胞资源库主任。2004年获西北农林科技大学理学学士学位，2010年获中国科学院理学博士学位，2012年中国科学院动物研究所博士后出站并加入中国科学院动物研究所工作。作为通讯/第一作者（含共同）在Cell Research等杂志发表文章60余篇，参编著作6部；主持或参与20余项国家及省部级科研项目，获授权发明专利20余项，牵头制定国内外标准30余项，获国家及省部级奖励10余项。基于工作进展，已参与开展十余项国家两委局备案的干细胞临床研究，获得五项国家药品监督管理局批准的I/II期药物临床试验批件，多项工作实现科技成果转化。获得抗击新冠肺炎疫情全国三八红旗手等多项荣誉称号，所带团队也获得全国五一巾帼标兵岗、中国科学院先进集体等荣誉称号。

主要从事新型干细胞与工具细胞等创新细胞资源研发与干细胞药物研制，致力于构建标准化的干细胞资源库和探索干细胞成药及科技创新支撑路径。

主持或参与中国科学院关键核心技术攻坚先导专项、国家重点研发计划、中国科学院重点部署项目等。

1. Song D#, Li Z#, Sun F#, Wu K#, Zhang K, Liu W, Liu K, An B, Wang Z, Zhao T, Chen H, Xiao L, Wang L, Xie L, Li W, Peng L, Hao J*, Wu J*, Dai H*. Optimized administration of human embryonic stem cell-derived immunity-and-matrix regulatory cells for mouse lung injury and fibrosis. Stem Cell Res Ther. 2024 Oct 8;15(1):344.
2. Niu S#, Xia C#, Huang D#, Wang L#, Hu H, Yu S, Wu N, Dong Z, Zhou J, Wu J, Yu J, Zhang Y, Wang C, Fu B, Cao J, Liang L, Xu L, Chen L, Zhou Q, Ma A*, Zhao T*, Hao J*, Wang J*.Requirements for human natural killer cells. Cell Prolif. 2024 May;57(5):e13588.
3. Peng Y#, Ma A#, Xiao Z#, Hao J#, Feng R, Wang C, Hu B, Zhai P, Li K, Wang L, Cao J, Xiang P, Zhang Y, Wei J, Wang X, Fu B, Chen Q, Wei Q, Gao H, Lv J, Liu X, Ma Y, Cheng T, Huang X, Su Y, Zhang H*, Zhou Q*, Zhao T*. Technical specifications for ethics review of human stem cell research. Cell Prolif. 2024 Mar;57(3):e13556.
4. Huang L#, Zhang S#, Wu J#, Guo B#, Gao T, Shah SZA, Huang B, Li Y, Zhu B, Fan J, Wang L, Xiao Y, Liu W, Tian Y, Fang Z, Lv Y, Xie L, Yao S, Ke G, Huang X, Huang Y, Li Y, Jia Y, Li Z, Feng G, Huo Y, Li W, Zhou Q, Hao J*, Hu B*, Chen H*. Immunity-and-matrix-regulatory cells enhance cartilage regeneration for meniscus injuries: a phase I dose-escalation trial. Signal Transduct Target Ther. 2023 Nov 1;8(1):417.
5. Ji T#, Niu S#, Fang M#, Xu L#, Wang X, Wu J, Xu F, Zhang M. Niu R, Wu J, Wang L, Li Z, Yang Y, Hao J*, Li W*, Hu Z*, Zhou Q*. Genome editing HLA alleles for a pilot immunocompatible hESC line in a Chinese hESC bank for cell therapies. Cell Proliferation 56. Cell Prolif. 2023 May;56(5):e13471.
6. Guo B#, Duan Y#, Li Z#, Tian Y, Cheng X, Liang C, Liu W, An B, Wei W, Gao T, Liu S, Zhao X, Niu S, Wang C, Wang Y, Wang L, Feng G, Li W, Hao J*, Gu Q*, Zhou Q*, Wu J*. High-Strength Cell Sheets and Vigorous Hydrogels from Mesenchymal Stem Cells Derived from Human Embryonic Stem Cells. ACS Appl Mater Interfaces. 2023 Jun 14;15(23):27586-27599.
7. Gao T#, Zhao X#, Hao J#, Tian Y, Ma H, Liu W, An B, Sun F, Liu S, Guo B, Niu S, Li Z, Wang C, Wang Y, Feng G, Wang L, Li W, Wu J*, Guo M*, Zhou Q*, Gu Q*. A scalable culture system incorporating microcarrier for specialised mesenchymal stem cells from human embryonic stem cells. Mater Today Bio. 2023 May 5:20:100662.
8. Zhou H#, Cui Z#, Wang H#, Gao T, Wang L, Wu J, Xiong Z*, Hao J*, Zhao M*. The therapeutic effects of human embryonic stem cells-derived immunity-and-matrix regulatory cells on membranous nephropathy. Stem Cell Res Ther. 2022 Jun 7;13(1):240.
9. Yang S#, Liu P#, Gao T#, Song D, Zhao X, Li Y, Wu J, Wang L, Wang Z*, Hao J*, Wang C*, and Dai H*. Every road leads to Rome: therapeutic effect and mechanism of the extracellular vesicles of human embryonic stem cell-derived immune and matrix regulatory cells administered to mouse models of pulmonary fibrosis through different routes. Stem Cell Res Ther. 2022 Apr 12;13(1):163.
10. Wang L#, Cao J#, Peng Y#, Fu B#, Jin Z, Hu Y, Wu W, Xiang AP, Hu S, Yu J, Zhang Y, Wei J, Zhang Y, Li Q, Zhou J, Zhai P, Zhu H, Liang L, Ma A*, Stacey G*, Zhao T*, Hao J*. Human retinal pigment epithelial cells. Cell Prolif. 2022 Apr;55(4):e13153.
11. Zhang B, Wu X, Zi G, He L, Wang S, Chen L, Fan Z, Nan X, Xi J, Yue W, Wang L, Wang L, Hao J*, Pei X*, Li Y*. Large-scale generation of megakaryocytes from human embryonic stem cells using transgene-free and stepwise defined suspension culture conditions. Cell Prolif. 2021 Apr;54(4):e13002.
12. Cao J#, Hao J#, Wang L#, Tan Y, Tian Y, Li S, Ma A, Fu B, Dai J, Zhai P, Xiang P, Zhang Y, Cheng T, Peng Y*, Zhou Q*, Zhao T*. Developing standards to support the clinical translation of stem cells. Stem Cells Transl Med. 2021 Nov;10 Suppl 2(Suppl 2):S85-S95.
13. Wu J#, Song D#, Li Z#, Guo B#, Xiao Y, Liu W, Liang L, Feng C, Gao T, Chen Y, Li Y, Wang Z, Wen J, Yang S, Liu P, Wang L, Wang Y, Peng L, Stacey GN, Hu Z, Feng G, Li W, Huo Y, Jin R, Shyh-Chang N, Zhou Q, Wang L*, Hu B, Dai H*, Hao J*. Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis. Cell Res. 2020 Sep;30(9):794-809.
14. Xing D, Wu J, Wang B, Liu W, Liu W, Zhao Y, Wang L, Li JJ, Liu A, Zhou Q, Hao J*, Lin J*. Intra-articular delivery of umbilical cord-derived mesenchymal stem cells temporarily retard the progression of osteoarthritis in a rat model. Int J Rheum Dis. 2020 Apr 21.
15. Li Z#, Wu J#, Wang L#, Han W, Yu J, Liu X, Wang Y, Zhang Y, Feng G, Li W, Stacey GN, Gu Q, Hu B, Wang L, Zhou Q*, Hao J*. Generation of qualified clinical-grade functional hepatocytes from human embryonic stem cells in chemically defined conditions. Cell Death Dis. 2019 Oct 10;10(10):763.
16. Wang L#, Wu W#, Gu Q#, Liu Z, Li Q, Li Z, Fang J, Liu W, Wu J, Zhang Y, Wang L, Xu H, Li W, Hu B, Zhou Q*, Yin Z*, Hao J*. The effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies. Protein Cell. 2019 Jun;10(6):455-460.
17. Ma J#, Wu J#, Han L, Jiang X, Yan L, Hao J*, Wang H*. Comparative analysis of mesenchymal stem cells derived from amniotic membrane, umbilical cord and chorionic plate under serum-free condition. Stem Cell Res Ther. 2019 Jan 11;10(1):19.
18. Li X#, Ma R#, Gu Q#, Liang L, Wang L, Zhang Y, Wang X, Liu X, Li Z, Fang J, Wu J, Wang Y, Li W, Hu B, Wang L*, Zhou Q*, Hao J*. A fully defined static suspension culture system for large-scale human embryonic stem cell production. Cell Death Dis. 2018 Sep; 9(9): 892.
19. Cao Y#, Sun H#, Zhu H#, Zhu X, Tang X, Yan G, Wang J, Bai D, Wang J, Wang L, Zhou Q, Wang H, Dai C, Ding L, Xu B, Zhou Y, Hao J*, Dai J*, Hu Y*. Allogeneic cell therapy using umbilical cord MSCs on collagen scaffolds for patients with recurrent uterine adhesion: a phase I clinical trial. Stem Cell Res Ther. 2018 Jul 11; 9(1): 192.
20. Tan Y#, Han P#, Gu Q#, Chen G, Wang L, Ma R, Wu J, Feng C, Zhang Y, Wang L, Hu B, Li W, Hao J*, and Zhou Q*. (2018) Generation of clinical-grade functional cardiomyocytes from human embryonic stem cells in chemically defined conditions. J Tissue Eng Regen Med. 2018 Jan; 12(1):153-63.
21. Gu Q#, Wang J#, Wang L#, Liu Z, Zhu, W Tan, Y Q, Han W, Wu J, Feng C, Fang J, Liu L, Wang L, Li W, Zhao X, Hu B, Hao J*, Zhou Q*. Accreditation of Biosafe Clinical-Grade Human Embryonic Stem Cells According to Chinese Regulations. Stem cell reports. 2017 Jul 11; 9(1): 366-80.
22. Gu Q#, Zhu H#, Chen L, Shuai L, Fang J, Wu J, Liu L, Li W, Dai J, Hao J*, Zhou Q*. Three dimensional collagen scaffolds promote iPSC induction with higher pluripotency. Protein cell. 2016 Nov; 7(11): 844-8.
23. Wang J#, Hao J#, Bai D, Gu Q, Han W, Wang L, Tan Y, Li X, Xue K, Han P, Liu Z, Jia Y, Wu J, Liu L, Wang L, Li W, Liu Z*, Zhou Q*. Generation of clinical-grade human induced pluripotent stem cells in Xeno-free conditions. Stem Cell Res Ther. 2015 Nov 12; 6(1):223.
24. Gu Q#, Hao J#, Lu Y, Wang L, Wallace GG*, Zhou Q*. Three-dimensional bio-printing. Sci China Life Sci. 2015 May; 58(5):411-9.
25. Gu Q#, Hao J#, Hai T, Wang J, Jia Y, Kong Q, Wang J, Feng C, Xue B, Xie B, Liu S, Li J, He Y, Sun J, Liu L, Wang L, Liu Z*, Zhou Q*. Efficient generation of mouse ESCs-like pig induced pluripotent stem cells. Protein Cell. 2014 May; 5(5):338-42.
26. Wang J#, Gu Q#, Hao J#, Bai D, Liu L, Zhao X, Liu Z, Wang L, Zhou Q*. Generation of induced pluripotent stem cells with high efficiency from human umbilical cord blood mononuclear cells. Genomics Proteomics Bioinformatics. 2013 Oct; 11(5):304-11.
27. Wang J#, Gu Q#, Hao J#, Jia Y, Xue B, Jin H, Ma J, Wei R, Hai T, Kong Q, Bou G, Xia P, Zhou Q, Wang L*, Liu Z*. Tbx3 and Nr5α2 play important roles in pig pluripotent stem cells. Stem Cell Rev and Rep. 2013; 9(5):700-8.
28. Gu Q#, Hao J#, Zhao XY, Li W, Liu L, Wang L, Liu ZH, Zhou Q*. Rapid conversion of human ESCs into mouse ESC-like pluripotent state by optimizing culture conditions. Protein Cell. 2012 Jan; 3(1):71-9.
29. Hai T#, Hao J#, Li W, Jouneau A*, Zhou Q*. Pluripotency maintenance in mouse somatic cell nuclear transfer embryos and its improvement by treatment with the histone deacetylase inhibitor TSA. Cell Reprogram. 2011 Feb; 13(1):47-56.
30. Dai X#, Hao J#, Hai T, Fan Y, Yu Y, Jouneau A, Zhou Q*. Somatic nucleus reprogramming is significantly improved by m-carboxycinnamic acid bishydroxamide (CBHA), a histone deacetylase inhibitor. J Biol Chem. 2010 Oct 1; 285(40):31002-10.