吕赫喆， 中国科学院动物研究所膜生物学国家重点实验室研究员。2011年于北京师范大学获得细胞生物学博士学位，后于美国宾夕法尼亚大学、加拿大Lunenfeld-Tanenbaum研究所从事肿瘤异质性方面的博士后研究。2020年7月加入中国科学院动物研究所成立细胞异质性与命运决定研究组。研究内容围绕膜信号在引发重大疾病的罕见细胞中的作用，利用单细胞分析技术和DNA条形码技术研究细胞命运轨迹，并应用高通量药物筛选技术筛选抗肿瘤先导化合物。取得了系列研究成果，分别发表于Nature、Cell Reports、Development Cell等杂志。目前任International journal of biological sciences、Journal of Genetics and Genomics等杂志特邀审稿人。
　　现有博士研究生2名、硕士研究生2名、联合培养研究生1名。

　　实验室主要聚焦细胞异质性在疾病发生、发展中的作用，结合细胞生物学和生物信息学等手段，研究（1）探寻罕见耐药肿瘤细胞并设计靶点药物；（2）研究细胞发生致癌基因突变后的命运轨迹；（3）研究T细胞异质性，筛选刺激T细胞向肿瘤侵袭的小分子药物。

1. Hezhe Lu, Shujing Liu, Gao Zhang, Bin Wu, Yueyao Zhu, Dennie T. Frederick, Yi Hu, Wenqun Zhong, Sergio Randell, Norah Sadek, Wei Zhang, Gang Chen, Chaoran Cheng, Jingwen Zeng, Lawrence Wu, Jie Zhang, Xiaoming Liu, Wei Xu, Clemens Krepler, Katrin Sproesser, Min Xiao, Benchun Miao, Jianglan Liu, Claire D. Song, Jephrey Y. Liu, Giorgos C. Karakousis, Lynn M. Schuchter, Yiling Lu, Gordon Mills, Yusheng Cong, Jonathan Chernoff, Jun Guo, Genevieve M. Boland, Ryan J. Sullivan, Zhi Wei, Jeffrey Field, Ravi K. Amaravadi, Keith T. Flaherty, Meenhard Herlyn*, Xiaowei Xu*, Wei Guo*  PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas. Nature (2017) 550(7674):133-136.   
2. Hezhe Lu, Shujing Liu, Gao Zhang, Lawrence N. Kwong, Yueyao Zhu, John P. Miller, Yi Hu, Wenqun Zhong, Jingwen Zeng, Lawrence Wu, Clemens Krepler, Katrin Sproesser, Min Xiao, Wei Xu, Giorgos C. Karakousis, Lynn M. Schuchter, Jeffery Field, Paul J. Zhang, Meenhard Herlyn, Xiaowei Xu*, Wei Guo* Oncogenica BRAF-induced invadopodia formation and melanoma invasion. Cell Reports. (2016) 15(9): 2012–2024.  
3. Hezhe Lu, Jianglan Liu, Shujing Liu, Jingwen Zeng, Deqiang Ding, Russ P. Carstens, Yusheng Cong, Xiaowei Xu and Wei Guo* Exo70 isoform switching upon Epithelial-Mesenchymal transition mediates cancer cell invasion. Developmental Cell. (2013) 27(5): 560-573.  
4. Hezhe Lu, Ellen Fan, Suozhu Sun, Xiaoxiao Ma, Xiaoyan Zhang, David M.K. Han, and Yu-Sheng Cong* Cyr61 Is Up-Regulated in Prostate Cancer and Associated With the p53 Gene Status. J Cell Biochem. (2009) 106 (4): 738-744. 
5. Shujing Liu, Suresh M Kumar, Hezhe Lu, Aihua Liu, Ruifeng Yang, Anitha Pushparajan, Wei Guo and Xiaowei Xu* MicroRNA-9 up-regulates E-cadherin through inhibition of NF-κB1–Snail1 pathway in melanoma. Journal of Pathology. (2012) 226: 61–72.
6. Suresh M Kumar, Shujing Liu, Hezhe Lu, Hongtao Zhang, Paul J. Zhang, Phyllis A. Gimotty, Matthew Guerra, Wei Guo and Xiaowei Xu* Acquired cancer stem cell phenotypes through Oct4-mediated dedifferentiation. (2012) Oncogene. 31(47):4898-91.1
7. Claude C Warzecha, Peng Jiang, Karine Amirikian, Kimberly A Dittmar, Hezhe Lu, Shihao Shen, Wei Guo, Yi Xing and Russ P Carstens* An ESRP-regulated splicing programme is abrogated during the epithelial–mesenchymal transition. EMBO J. (2010) 29 (19):3286-3300.