刘垒，中国科学院动物研究所膜生物学国家重点实验室研究员。主要从事线粒体自噬机制的研究，鉴定了一个新的哺乳动物线粒体自噬受体蛋白FUNDC1，并进一步阐明了FUNDC1介导线粒体自噬的分子机制。发表SCI论文30余篇，以第一作者或通讯作者在Nature Cell Biology，EMBO Journal，EMBO Reports，Cell Research, Autophagy等杂志发表多篇论文，其中Nature Cell Biology论文他引800余次，相关的研究工作受到了国际同行的广泛认可和高度评价。目前主要从事线粒体及其他细胞器质量控制的分子机制、生理和病理意义的研究。

　　线粒体及其他细胞器稳态调控与疾病。

　　卢嘉锡青年人才奖 2014

• 　　国家自然科学基金重大研究计划培育项目，主持
• 　　国家自然科学基金面上项目，主持
• 　　国家重点研发计划重点专项子课题，负责人

1. Wu H*, Wei H, Zhang D, Sehgal SA, Zhang D, Wang X, Qin Y, Liu L*, Chen Q*. Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy. Redox Biol. 2020 Sep; 36:101661. (Co-corresponding author)
2. Liu L, Liao X, Wu H, Li Y, Zhu Y, Chen Q*. Mitophagy and its contribution to metabolic and aging associated disorders. Antioxidants & Redox Signaling (invited review) 2020 Apr 20;32(12):906-927.  
3. Wu H, Wang Y, Li W, Chen H, Du L, Liu D, Wang X, Xu T, Liu L*, Chen Q*. Deficiency of mitophagy receptor FUNDC1 impairs mitochondrial quality and aggravates dietary-induced obesity and metabolic syndrome. Autophagy 2019 Mar 22:1-17 (Co-corresponding author)  
4. Li Y, Xue Y, Xu X, Wang G, Liu Y, Wu H, Li W, Wang Y, Chen Z, Zhang W, Zhu Y, Ji W, Xu T, Liu L*, Chen Q* A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity. EMBO Journal 2019 Feb 1 38(3).
5. Liu D, Wu H, Wang C, Li Y, Tian H, Siraj S, Sehgal SA, Wang X, Wang J, Shang Y, Jiang Z, Liu L*, Chen Q*. STING directly activates autophagy to tune the innate immune response. Cell Death and Differentiation 2019 Sep;26(9):1735-1749.(Co-corresponding author)  
6. Chen M, Chen Z, Wang Y, Tan Z, Zhu C, Li Y, Han Z, Chen L, Gao R, Liu L*, Chen Q*. Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy. Autophagy 2016 2(4)：689-702 (Co-corresponding author; Highlighted by both EMBO Journal and by Faculty 1000 )
7. Wu H, Xue D, Chen G, Han Z, Huang L, Zhu C, Wang X, Jin H, Wang J, Zhu Y, Liu L*, Chen Q*.The Bcl-xL and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy. Autophagy 2014 10:1712-25 (Co-corresponding author)
8. Liu L, Sakakibara K, ChenQ*, Okamoto K*. Receptor-mediated mitophagy in yeast and mammalian systems. Cell Research, 2014 24(7):787-95.
9. Liu L, Feng D, Chen G, Chen M, Zheng Q, Song P, Ma Q, Zhu C, Wang R, Qi W, Huang L, Xue P, Li B, Wang X, Jin H, Wang J, Yang F, Liu P, Zhu Y, Sui S, Chen Q*. Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nature Cell Biology, 2012 14(2)177-85 (Landmark paper for mitophagy, Highlighted by Nature China and by Faculty 1000)