教育经历：

2007.09-2012.06，安徽医科大学，预防医学专业，学士

2012.09-2015.06，北京大学，细胞生物学专业，硕士研究生

2015.09-2019.01，北京大学，免疫学，博士研究生

工作经历：

2019.09-2021.09，北京大学，博士后

2021.12-现在，中国科学院动物研究所，副研究员

长期从事天然免疫相关研究。以昆虫病原真菌为主要研究对象，以生物互作为主线，综合运用多学科交叉研究手段，致力于探索病原微生物与宿主互作的分子机理，研发基于互作关系的害虫防控新策略。

1.2024.01-2027.12，国家自然科学基金面上项目（32370507），主持，在研；

2.2023.01-2028.12，国家重点研发计划青年科学家项目（2022YFA0806900），子课题主持，在研；

3.2022.09-2025.12，国家重点研发计划项目（2022YFD1400500）,子课题主持，在研；

4.2021.01-2023.12，国家自然科学基金青年科学基金项目（32000113），主持，已结题;

5.2021.01-2022.12，中国博士后科学基金第14批特别资助（2021T140026），主持，已结题。

1. Li J,Li JJ,Cao L,Chen Q,Ding D*,& Kang L*. An iron-binding protein of entomopathogenic fungus suppresses the proliferation of host symbiotic bacteria. Microbiome. 2024 Oct 15;12(1):202. doi: 10.1186/s40168-024-01928-4.
2. Cao L^# Luo Y^#,Guo X,Liu S,Li S,Li J,Zhang Z,Zhao Y,Zhang Q,Gao F,Ji X,Gao X,Li Y^*,You F^*. SAFA facilitates chromatin opening of immune genes through interacting with anti-viral host RNAs. PLOS Pathogens. 2022 Jun 3;18(6):e1010599.
3. Cao L^#,Liu S^#,Li Y,Yang G, Luo Y, Li S, Du H, Lin R, Wang P, You F^*. The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers. Cell Host & Microbe. 2019 Sep 11;26(3):369-384.e8.
4. Li S^#, Kuang M^#, Chen L, Li Y, Liu S, Du H, Cao L^*, You F^*. The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling. Cell Reports. 2021 Jan 19;34(3):108631.
5. Cao L^#, Yang G^#, Gao S, Jing C, Montgomery R, Yin Y, Wang P, Fikrig E, You F. HIPK2 is necessary for type I interferon–mediated antiviral immunity. Science Signaling. 2019. Mar 19;12(573).
6. Li Y^#, Xu J^#, Guo X^#, Li Z^#, Cao L, Liu S, Guo Y, Wang G, Luo Y, Zhang Z, Wei X, Zhao Y, Liu T, Wang X, Xia H, Kuang M, Guo Q, Li J, Chen L, Wang Y, Li Q, Wang F, Liu Q^*, You F^*. The collateral activity of RfxCas13d can induce lethality in a RfxCas13d knock-in mouse model. Genome Biology. 2023 Feb 1;24(1):20.
7. Chen J, Wei X, Wang X, Liu T, Zhao Y, Chen L, Luo Y, Du H, Li Y, Liu T, Cao L, Zhou Z, Zhang Z, Liang L, Li L, Yan X, Zhang X, Deng X, Yang G, Yin P, Hao J, Yin Z, You F. TBK1-METTL3 axis facilitates antiviral immunity. Cell Reports. 2022 Feb 15;38(7):110373.
8. Sun G, Qiu L, Yu L, An Y, Ding Y, Zhou L, Wu J, Yang X, Zhang Z, Tang X, Xia H, Cao L, You F, Zhao X, Du H. Loss of Function Mutation in ELF4 Causes Autoinflammatory and Immunodeficiency Disease in Human. Journal of Clinical Immunology. 2022 May;42(4):798-810.
9. Guo Q^#, Zhao Y^#, Li J^#, Liu J^#, Yang X^#, Guo X, Kuang M, Xia H, Zhang Z, Cao L, Luo Y, Bao L, Wang X, Wei X, Deng W, Wang N, Chen L, Chen J, Zhu H, Gao R, Qin C^#, Wang X^#, You F^#. Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19. Cell Host & Microbe. 2021 Feb 10;29(2):222-235.e4.
10. Li Y, Liu S, Cao L, Luo Y, Du H,Li S,Zhang Z, Guo X, Tian W, Wong C, You F. CBRPP: a new RNA-centric method to study RNA-protein interactions. RNA Biology. 2021 Feb 17;1-14.
11. Wang Y^#, Li S^#,Zhao Y, Zhang B, Li Y,Liu S, Du H,Cao L, Ou M,Ye X,Li P,Gao X, Wang P, Jing C, Shao F, Yang G, You F. The GRA15 protein from Toxoplasma gondii enhances host defense responses by activating the interferon stimulator STING. J Biol Chem. 2019 Nov 8;294(45):16494-16508.
12. Cao L, Zhang L, Zhao X, Zhang Y. A Hybrid Chalcone Combining the Trimethoxyphenyl and Isatinyl Groups Targets Multiple Oncogenic Proteins and Pathways in Hepatocellular Carcinoma Cells. Plos One. 2016. 15;11(8).

(^#共同一作，^*通讯作者)