王晓琰，医学博士，中国科学院动物研究所副研究员。主要研究方向为性腺发育与生殖健康相关的基础研究及其临床转化应用。以第一作者或通讯作者（含共同）在 Cell、Cell Stem Cell、Nature Cell Biology、Cell Reports Medicine、Nucleic Acids Research、Cell Reports等国际高影响力期刊发表研究论文十余篇。曾获得研究生国家奖学金、山东省优秀博士学位论文、山东省优秀毕业生等多项荣誉。目前主持中国科学院B类战略性先导科技专项课题、国家自然科学基金项目2项、中国科学院特别研究助理资助项目、中国博士后科学基金面上项目等科研项目。

教育经历

• 2009.09-2016.06，山东大学齐鲁医学院，临床医学（本硕连读），医学学士/硕士，导师：陈子江院士
• 2016.09-2020.06，山东大学齐鲁医学院，妇产科学，医学博士，导师：陈子江院士

工作经历

• 2021.12-2025.02，中国科学院动物研究所，博士后，合作导师：郭靖涛研究员
• 2025.02-至今，中国科学院动物研究所，副研究员

• 利用跨物种多组学数据与人工智能等技术手段，系统性解析性腺发育与配子发生的进化保守性规律与物种特异性机制；
• 以干湿融合的创新研究体系驱动生殖障碍疾病的机制解析与临床转化，系统性鉴定关键致病基因和新型诊断靶标，为精准诊疗提供新理论与新策略。

• 国家自然科学基金面上项目，2026.01-2029.12，项目负责人
• 中国科学院战略先导专项（B类），2025.04-2028.03，课题负责人
• 国家自然科学基金青年科学基金C类，2024.01-2026.12，项目负责人
• 中国科学院动物研究所自主部署前沿培育项目，2024.01-2026.12，项目负责人
• 中国科学院特别研究助理资助项目，2022.11-2024.10，项目负责人
• 中国博士后科学基金面上项目，2022.07-2024.06，项目负责人

（^#共同第一作者，^*共同通讯作者）

1. Yang Yuan^#, Xiaoyan Wang^#, Xiaodi Yan^#, Nannan He^#, Xiaojian Lu^#, Jingyu Yang^#, Xinwei Xie^#, Huiyao Yuan, Naixin Chen, Yinbo Liu, Hongan Ren, Runzhao Zhang, Lina Cui, Pengcheng Ren, Sirui Lin, Shuhan Cheng, Xiaolong Yang, Yifei Guo, Rong Li, Tianyi Yan, Jingtao Guo, Zhenyu Xiao, Yulei Wei, Leqian Yu. 3D reconstruction of a human Carnegie stage 9 embryo provides a snapshot of early body plan formation. Cell Stem Cell. 2025 Jun 5;32(6):1006-1024.e5.
2. Qiaoling Jiang, Lina Cui, Xichen Nie, Hui Cai, Wenxiu Zhang, Xiaojian Lu, Yifei Guo, James M Hotaling, Bradley R Cairns, Xiaoyan Wang^*, Jingtao Guo^*. A Single-Cell Transcriptome Atlas Characterizes the Immune Landscape of Human Testes During Aging. Aging Cell. 2025 Mar 6:e70032.
3. Lina Cui^#, Sirui Lin^#, Xiaolong Yang^#, Xinwei Xie^#, Xiaoyan Wang^#, Nannan He^#, Jingyu Yang, Xin Zhang, Xiaojian Lu, Xiaodi Yan, Yifei Guo, Bailing Zhang, Ran Li, Hefan Miao, Mei Ji, Runzhao Zhang, Leqian Yu^*, Zhenyu Xiao^*, Yulei Wei^*, Jingtao Guo^*. Spatial Transcriptomic Characterization of a Carnegie Stage 7 Human Embryo. Nat Cell Biol. 2025 Feb;27(2):360-369.
4. Xiaoyan Wang^#, Liping Cheng^#, Xiaojian Lu^#, He Jin^#, Lina Cui, Yifei Guo, Jingtao Guo^*, Eugene Yujun Xu^*. Cross-Species Comparative Single-Cell Transcriptomics Highlights the Molecular Evolution and Genetic Basis of Male Infertility. Cell Rep. 2025 Jan 28;44(1):115118.
5. Xiaoyan Wang^#, Qiang Liu^#, Ziyan Zhuang^#, Jianxing Cheng, Wenxiu Zhang, Qiaoling Jiang, Yifei Guo, Ran Li, Xiaojian Lu, Lina Cui, Jiaming Weng, Yanlin Tang, Jingwei Yue, Songzhan Gao, Kai Hong, Jie Qiao, Hui Jiang^*, Jingtao Guo^*, Zhe Zhang^*. Decoding the pathogenesis of spermatogenic failure in cryptorchidism through single-cell transcriptomic profiling. Cell Rep Med. 2024 Sep 17;5(9):101709.
6. Xiaoyan Wang^#, Yang Wang^#, Yu Wang^#, Yifei Guo^#, Ruojun Zong, Shuaitao Hu, Jingwei Yue, Jing Yao, Chunsheng Han^*, Jingtao Guo^*, Jianguo Zhao^*. Single-cell transcriptomic and cross-species comparison analyses reveal distinct molecular changes of porcine testes during puberty. Commun Biol. 2024 Nov 9;7(1):1478.
7. Zhenyu Xiao^#, Lina Cui^#, Yang Yuan^#, Nannan He^#, Xinwei Xie, Sirui Lin, Xiaolong Yang, Xin Zhang, Peifu Shi, Zhifeng Wei, Yang Li, Hongmei Wang, Xiaoyan Wang^*, Yulei Wei^*, Jingtao Guo^*, Leqian Yu^*. 3D reconstruction of a gastrulating human embryo. Cell. 2024 May 23;187(11):2855-2874.e19.
8. Xiaoyan Wang, Zi-Jiang Chen. A decade of discovery: the stunning progress of premature ovarian insufficiency research in China. Biol Reprod. 2022 Jul 25;107(1):27-39. Review.
9. Xiaoyan Wang, Bradley R Cairns, Jingtao Guo. When spermatogenesis meets human aging and elevated body mass. Life Med. 2022 Jul 9;1(3):267-269. Research Highlight.
10. Xiaoyan Wang, Xinyue Zhang, Yujie Dang, Duan Li, Gang Lu, Wai-Yee Chan, Peter C K Leung, Shidou Zhao, Yingying Qin, Zi-Jiang Chen. Long noncoding RNA HCP5 participates in premature ovarian insufficiency by transcriptionally regulating MSH5 and DNA damage repair via YB1. Nucleic Acids Res. 2020 May 7;48(8):4480-4491.
11. Xiaoyan Wang, Xiruo Zhang, Shan Liu, Guangyu Li, Linlin Cui, Yingying Qin, Zi-Jiang Chen, Novel mutations in the TP63 gene are potentially associated with Müllerian duct anomalies. Hum Reprod. 2016 Dec;31(12):2865-2871.