冯桂海，博士，中国科学院动物研究所研究员，博士生导师。2007年获得山东大学（威海）生物科学专业学士学位，2010年获得军事医学科学院生物安全专业硕士学位（指导老师：王玉民研究员），2014年获得中国科学院大学生物信息学专业博士学位（指导老师：王秀杰研究员），随后进入中国科学院动物研究所进行博士后训练，2018年在中国科学院动物研究所任副研究员，2024年1月起任研究员。

聚焦跨物种知识迁移研究。通过系统比较模式生物（如小鼠、非人灵长类等）与人类在多层级调控过程中的异同，识别生物性状关键调控机制与核心模块；进而开发跨物种迁移的人工智能方法，将模式生物中的知识可靠映射到人类相关场景中，为基础发现走向临床应用提供可解释、可量化的模型框架。

（#共同一作，*共同通讯）

29: Feng G#*, Qin X#, Zhang J#, Huang W#, Zhang Y#, Cui W#, Chen Y#, Li S#, Liu W, Tian Y, Liu Y, Dong J, Xu P, Man Z, Liu G, Liang Z, Jiang X, Yang X, Wang P, Yang G, Wang H, Wang X, Tong MH*, Zhou Y*, Zhang S*, Chen Y*, Wang Y*, Li X*. CellPolaris: Transfer Learning for Gene Regulatory Network Construction to Guide Cell State Transitions. Adv Sci. 2026 Jan 7:e08697.

28: Huang W#, Chen S#, Li K#, Ding Y#, Zhan B#, Zhao D, Xu G, Guo H, Sun C, Yuan R, Gu H, Zhang J, Guo K, Wu J, Dai J, Li W, Zheng X*, Feng G*, Hu B*, Gu Q*. Nanoengineered extrusion-aligned tract bioprinting enables functional repair of spinal cord injuries. Cell Stem Cell. 2026 Jan 13:S1934-5909(25)00455-2.

27: Guo J#, Lyu J#, Gao Z#, Jia T#, Wang L#, Dong J, Gu Z, Ji S, Li W, Wang H, Zhai J*, Yu L*, Feng G*, Zhou Q*, Gu Q*. 3D biomimetic niche modulates embryo development in vitro. Nat Commun. 2026 Jan 2. doi: 10.1038/s41467-025-68039-y.

26: Zhao YL#, Zhao YM#, Yan YF#, Yang N#, Ma SN#, Wang RJ, Feng GH*, Li ZK*, Li W*, Wang LB*. Chromosome length is constrained by spindle scaling to ensure faithful mitosis in mammals. Mol Syst Biol. 2026 Jan 15. doi: 10.1038/s44320-026-00188-8.

25: Wang S, Li W, Feng G*. De-extinction and beyond: trait design powered by generative AI. Trends Biotechnol. 2025 Oct 11:S0167-7799(25)00403-2 (Opinion article).

24: Guo F#, He CF#, Xu YH#, Wu HH#, Li DM#, Jiang SY#, Ma XS, Huang C, Gu Q, Du P, Yu LQ, Feng GH*, Wang HM*, Li W*, Li X*. High-efficiency generation of blastoids with gastrulation potential through Gata4-induced PrE specification in mESCs. Cell Discov. 2025 Nov 25;11(1):94.

23: Fang C#, Cui W#, Hu Z#, Liu W, Chen S, Chang S, Long Q, Li C, Liu Y, Jiang H, Wang P, Pan J, Hu G, Liu G, Meng Z*, Zhou Y*, Chen L*, Feng G*, Li X*. Cell-GraphCompass: Modeling Single Cells with Graph Structure Foundation Model. Natl Sci Rev. 2025 Jun 24;12(10):nwaf255.

22: Wang X#, Ma Y#*, Li F#, Cui W#, Pan T, Wang S, Ma S, Shan Q, Liu C, Wang Y, Zhang Y, Zhou Y, Li W, Wang P*, Zhou Q*, Feng G*. FemXpress: Systematic Analysis of X Chromosome Inactivation Heterogeneity in Female Single-Cell RNA-Seq Samples. Adv Sci. 2025:e04754.

21: Yang N#, Sun W#, Cao S#, Zhao C#, Wang N, Li P, Zou Y, Wang S, Cui T, Guo S, Li W, Wang H*, Feng G*. KIAA1522 isoform switching regulates LTR-RTs activity in distinct pluripotency states of hESCs. Sci China Life Sci. 2025. Epub 20250623.

20: Wang P#, Liu W#, Wang J#, Liu Y#, Li P#, Xu P, Cui W, Zhang R, Long Q, Hu Z, Fang C, Dong J, Zhang C, Chen Y, Wang C, Liu G, Xie H, Zhang Y, Xiao M, Chen S, Jiang H, Consortium XC, Chen Y, Yang G, Zhang S, Meng Z*, Wang X*, Feng G*, Li X*, Zhou Y*. scCompass: An Integrated Multi-Species scRNA-seq Database for AI-Ready. Adv Sci. 2025;12(25):e2500870.

19: Yang X#, Liu G#, Feng G#, Bu D#, Wang P#, Jiang J#, Chen S#, Yang Q#, Miao H, Zhang Y, Man Z, Liang Z, Wang Z, Li Y, Li Z, Liu Y, Tian Y, Liu W, Li C, Li A, Dong J, Hu Z, Fang C, Cui L, Deng Z, Jiang H, Cui W, Zhang J, Yang Z, Li H, He X, Zhong L, Zhou J, Wang Z, Long Q, Xu P; X-Compass Consortium; Wang H, Meng Z, Wang X, Wang Y, Wang Y, Zhang S, Guo J, Zhao Y*, Zhou Y*, Li F*, Liu J*, Chen Y*, Yang G*, Li X*. GeneCompass: deciphering universal gene regulatory mechanisms with a knowledge-informed cross-species foundation model. Cell Res. 2024 Dec;34(12):830-845.

18: Li F#, Karimi N#, Wang S#, Pan T#, Dong J, Wang X, Ma S, Shan Q, Liu C, Zhang Y, Li W*, Feng G*. mRNA isoform switches during mouse zygotic genome activation. Cell Prolif. 2024 Jul;57(7):e13655.

17. Jiang L, Wang X, Wang L, Ma S, Ding Y, Liu C, Wang S, Shao X, Zhang Y, Li Z, Li W, Feng G*, Zhou Q*. Deciphering the placental abnormalities associated with somatic cell nuclear transfer at single-nucleus resolution. Protein Cell. 2023 Dec 1;14(12):924-928.

16. Wang Y, Yang N, Sun W, Zhao C, Hu X, Lu S, Cao S, Wang N, Hai T, Feng G*, An C*, Wang H*. Characterisation of X chromosome status of human extended pluripotent stem cells. Cell Prolif. 2023 May;56(5):e13468.

15. Fang Z, Tian Y, Sui C, Guo Y, Hu X, Lai Y, Liao Z, Li J, Feng G*, Jin L*, Qian K*. Single-Cell Transcriptomics of Proliferative Phase Endometrium: Systems Analysis of Cell-Cell Communication Network Using CellChat. Front Cell Dev Biol. 2022 Jul 22;10:919731.

14. Gu Z#, Guo J#, Zhai J#, Feng G#, Wang X, Gao Z, Li K, Ji S, Wang L, Xu Y, Chen X, Wang Y, Guo S, Yang M, Li L, Han H, Jiang L, Wen Y, Wang L, Hao J, Li W, Wang S, Wang H, Gu Q. A Uterus-Inspired Niche Drives Blastocyst Development to the Early Organogenesis. Adv Sci. 2022 Oct;9(28):e2202282.

13. He ZQ#, Li YH#, Feng GH#, Yuan XW#, Lu ZB#, Dai M, Hu YP, Zhang Y, Zhou Q, Li W. Pharmacological Perturbation of Mechanical Contractility Enables Robust Transdifferentiation of Human Fibroblasts into Neurons. Adv Sci. 2022 May;9(13):e2104682.

12. Wan H, Fu R, Tong M, Wang Y, Wang L, Wang S, Zhang Y, Li W, Wang XJ, Feng G*. Influence of feeder cells on transcriptomic analysis of pluripotent stem cells. Cell Prolif. 2022 Feb;55(2):e13189.

11. Zhu H, Sun H, Yu D, Li T, Hai T, Liu C, Zhang Y, Chen Y, Dai X, Li Z, Li W, Liu R*, Feng G*, Zhou Q*. Transcriptome and DNA Methylation Profiles of Mouse Fetus and Placenta Generated by Round Spermatid Injection. Front Cell Dev Biol. 2021 Mar 16;9:632183.

10. An C#, Feng G#, Zhang J, Cao S, Wang Y, Wang N, Lu F, Zhou Q, Wang H. Overcoming Autocrine FGF Signaling-Induced Heterogeneity in Naive Human ESCs Enables Modeling of Random X Chromosome Inactivation. Cell Stem Cell. 2020 Sep 3;27(3):482-497.e4.

9. Wang LY#, Li ZK#, Wang LB#, Liu C#, Sun XH#, Feng GH#, Wang JQ, Li YF, Qiao LY, Nie H, Jiang LY, Sun H, Xie YL, Ma SN, Wan HF, Lu FL, Li W, Zhou Q. Overcoming Intrinsic H3K27me3 Imprinting Barriers Improves Post-implantation Development after Somatic Cell Nuclear Transfer. Cell Stem Cell. 2020 Aug 6;27(2):315-325.e5.

8. Li J#, Wang C#, Feng G#, Zhang L, Chen G, Sun H, Wang J, Zhang Y, Zhou Q, Li W. Rbm14 maintains the integrity of genomic DNA during early mouse embryogenesis via mediating alternative splicing. Cell Prolif. 2020 Jan;53(1):e12724.

7. Wang J#, Wang L#, Feng G#, Wang Y#, Li Y, Li X, Liu C, Jiao G, Huang C, Shi J, Zhou T, Chen Q, Liu Z, Li W, Zhou Q. Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos. Cell. 2018 Dec 13;175(7):1887-1901.e18.

6. Li ZK#, Wang LY#, Wang LB#, Feng GH#, Yuan XW#, Liu C, Xu K, Li YH, Wan HF, Zhang Y, Li YF, Li X, Li W, Zhou Q, Hu BY. Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions. Cell Stem Cell. 2018 Nov 1;23(5):665-676.e4.

5. Zhang W#, Wan H#, Feng G#, Qu J#, Wang J, Jing Y, Ren R, Liu Z, Zhang L, Chen Z, Wang S, Zhao Y, Wang Z, Yuan Y, Zhou Q, Li W, Liu GH, Hu B. SIRT6 deficiency results in developmental retardation in cynomolgus monkeys. Nature. 2018 Aug;560(7720):661-665.

4. Li TD#, Feng GH#, Li YF#, Wang M#, Mao JJ, Wang JQ, Li X, Wang XP, Qu B, Wang LY, Zhang XX, Wan HF, Cui TT, Wan C, Liu L, Zhao XY, Hu BY, Li W, Zhou Q. Rat embryonic stem cells produce fertile offspring through tetraploid complementation. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):11974-11979.

3. Xu K#, Yang Y#, Feng GH#, Sun BF#, Chen JQ#, Li YF, Chen YS, Zhang XX, Wang CX, Jiang LY, Liu C, Zhang ZY, Wang XJ, Zhou Q, Yang YG, Li W. Mettl3-mediated m6A regulates spermatogonial differentiation and meiosis initiation. Cell Res. 2017 Sep;27(9):1100-1114.

2. Feng G#, Tong M#, Xia B#, Luo GZ, Wang M, Xie D, Wan H, Zhang Y, Zhou Q, Wang XJ. Ubiquitously expressed genes participate in cell-specific functions via alternative promoter usage. EMBO Rep. 2016 Sep;17(9):1304-13.

1. Li Z#, Wan H#, Feng G#, Wang L#, He Z, Wang Y, Wang XJ, Li W, Zhou Q, Hu B. Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells. Cell Res. 2016 Jan;26(1):135-8.

全部文章列表：https://pubmed.ncbi.nlm.nih.gov/?term=feng+guihai&sort=date

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