冯桂海，博士，研究员。2007年获得山东大学（威海）生物科学专业学士学位，2010年获得军事医学科学院生物安全专业硕士学位（指导老师：王玉民研究员），2014年获得中国科学院大学生物信息学专业博士学位（指导老师：王秀杰研究员），随后进入中国科学院动物研究所进行博士后训练（合作导师：周琪研究员），2018年在中国科学院动物研究所任副研究员，2024年1月起任研究员。

基因表达剂量的精准控制对个体发育至关重要。基因表达剂量受到表观、基因组、转录及翻译等多层次的复杂机制调控。通过对调控机制的解析，最终实现对细胞的数字化建模，这在理解细胞运作原理和指导定制人工细胞方面具有重要意义。基于这一目标，研究主要分为两个方向：

1. 基因表达剂量的控制机制研究：在哺乳动物基因组中，大部分基因以双等位形式表达，而少数基因通过表观遗传机制实现精确的单等位表达控制。我们主要关注两种控制机制，即常染色体上的印记表达基因和雌性细胞中的X染色体选择性失活。通过组学分析方法，我们从单等位表达基因的鉴定、功能与调控机制解析以及模型构建等方面展开研究。

2. 基因表达剂量的人工智能建模：借助海量的多模态组学大数据，结合现有的生物学先验知识，我们利用各种人工智能工具在调控元件效率预测、单基因表达控制及多基因相互作用等不同层面上进行建模。最终目标是实现对细胞的数字化模拟。

（#共同一作，*共同通讯）

1. Jiang L, Wang X, Wang L, Ma S, Ding Y, Liu C, Wang S, Shao X, Zhang Y, Li Z, Li W, Feng G*, Zhou Q*. Deciphering the placental abnormalities associated with somatic cell nuclear transfer at single-nucleus resolution. Protein Cell. 2023 Dec 1;14(12):924-928.
2. Wang Y, Yang N, Sun W, Zhao C, Hu X, Lu S, Cao S, Wang N, Hai T, Feng G*, An C*, Wang H*. Characterisation of X chromosome status of human extended pluripotent stem cells. Cell Prolif. 2023 May;56(5):e13468.
3. Fang Z, Tian Y, Sui C, Guo Y, Hu X, Lai Y, Liao Z, Li J, Feng G*, Jin L*, Qian K*. Single-Cell Transcriptomics of Proliferative Phase Endometrium: Systems Analysis of Cell-Cell Communication Network Using CellChat. Front Cell Dev Biol. 2022 Jul 22;10:919731.
4. Gu Z#, Guo J#, Zhai J#, Feng G#, Wang X, Gao Z, Li K, Ji S, Wang L, Xu Y, Chen X, Wang Y, Guo S, Yang M, Li L, Han H, Jiang L, Wen Y, Wang L, Hao J, Li W, Wang S, Wang H, Gu Q. A Uterus-Inspired Niche Drives Blastocyst Development to the Early Organogenesis. Adv Sci (Weinh). 2022 Oct;9(28):e2202282.
5. He ZQ#, Li YH#, Feng GH#, Yuan XW#, Lu ZB#, Dai M, Hu YP, Zhang Y, Zhou Q, Li W. Pharmacological Perturbation of Mechanical Contractility Enables Robust Transdifferentiation of Human Fibroblasts into Neurons. Adv Sci (Weinh). 2022 May;9(13):e2104682.
6. Wan H, Fu R, Tong M, Wang Y, Wang L, Wang S, Zhang Y, Li W, Wang XJ, Feng G*. Influence of feeder cells on transcriptomic analysis of pluripotent stem cells. Cell Prolif. 2022 Feb;55(2):e13189.
7. Zhu H, Sun H, Yu D, Li T, Hai T, Liu C, Zhang Y, Chen Y, Dai X, Li Z, Li W, Liu R*, Feng G*, Zhou Q*. Transcriptome and DNA Methylation Profiles of Mouse Fetus and Placenta Generated by Round Spermatid Injection. Front Cell Dev Biol. 2021 Mar 16;9:632183.
8. An C#, Feng G#, Zhang J, Cao S, Wang Y, Wang N, Lu F, Zhou Q, Wang H. Overcoming Autocrine FGF Signaling-Induced Heterogeneity in Naive Human ESCs Enables Modeling of Random X Chromosome Inactivation. Cell Stem Cell. 2020 Sep 3;27(3):482-497.e4.
9. Wang LY#, Li ZK#, Wang LB#, Liu C#, Sun XH#, Feng GH#, Wang JQ, Li YF, Qiao LY, Nie H, Jiang LY, Sun H, Xie YL, Ma SN, Wan HF, Lu FL, Li W, Zhou Q. Overcoming Intrinsic H3K27me3 Imprinting Barriers Improves Post-implantation Development after Somatic Cell Nuclear Transfer. Cell Stem Cell. 2020 Aug 6;27(2):315-325.e5.
10. Li J#, Wang C#, Feng G#, Zhang L, Chen G, Sun H, Wang J, Zhang Y, Zhou Q, Li W. Rbm14 maintains the integrity of genomic DNA during early mouse embryogenesis via mediating alternative splicing. Cell Prolif. 2020 Jan;53(1):e12724.
11. Wang J#, Wang L#, Feng G#, Wang Y#, Li Y, Li X, Liu C, Jiao G, Huang C, Shi J, Zhou T, Chen Q, Liu Z, Li W, Zhou Q. Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos. Cell. 2018 Dec 13;175(7):1887-1901.e18.
12. Li ZK#, Wang LY#, Wang LB#, Feng GH#, Yuan XW#, Liu C, Xu K, Li YH, Wan HF, Zhang Y, Li YF, Li X, Li W, Zhou Q, Hu BY. Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions. Cell Stem Cell. 2018 Nov 1;23(5):665-676.e4.
13. Zhang W#, Wan H#, Feng G#, Qu J#, Wang J, Jing Y, Ren R, Liu Z, Zhang L, Chen Z, Wang S, Zhao Y, Wang Z, Yuan Y, Zhou Q, Li W, Liu GH, Hu B. SIRT6 deficiency results in developmental retardation in cynomolgus monkeys. Nature. 2018 Aug;560(7720):661-665.
14. Li TD#, Feng GH#, Li YF#, Wang M#, Mao JJ, Wang JQ, Li X, Wang XP, Qu B, Wang LY, Zhang XX, Wan HF, Cui TT, Wan C, Liu L, Zhao XY, Hu BY, Li W, Zhou Q. Rat embryonic stem cells produce fertile offspring through tetraploid complementation. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):11974-11979.
15. Xu K#, Yang Y#, Feng GH#, Sun BF#, Chen JQ#, Li YF, Chen YS, Zhang XX, Wang CX, Jiang LY, Liu C, Zhang ZY, Wang XJ, Zhou Q, Yang YG, Li W. Mettl3-mediated m6A regulates spermatogonial differentiation and meiosis initiation. Cell Res. 2017 Sep;27(9):1100-1114.
16. Feng G#, Tong M#, Xia B#, Luo GZ, Wang M, Xie D, Wan H, Zhang Y, Zhou Q, Wang XJ. Ubiquitously expressed genes participate in cell-specific functions via alternative promoter usage. EMBO Rep. 2016 Sep;17(9):1304-13.
17. Li Z#, Wan H#, Feng G#, Wang L#, He Z, Wang Y, Wang XJ, Li W, Zhou Q, Hu B. Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells. Cell Res. 2016 Jan;26(1):135-8.

全部文章列表：https://pubmed.ncbi.nlm.nih.gov/?term=feng+guihai&sort=date