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姓　　名： 于乐谦
学　　科： 再生医学
电话/传真： +86-10-64807952 / 
电子邮件： leqianyu@ioz.ac.cn
通讯地址： 北京市朝阳区北辰西路1号院5号
中国科学院动物研究所 器官再生与智造全国重点实验室 100101
更多信息： 干细胞与人工胚胎研究组     

简历介绍：

于乐谦，中科学院动物研究所研究员，博士生导师，器官再生与智造重点实验室副主任。2017年获于日本国立京都大学博士学位，随后于美国得克萨斯大学西南医学中心从事博士后研究，2022年加入动物研究所组建独立实验室。长期专注于利用干细胞与体外胚胎模型进行人类早期胚胎发育相关研究。基于“体外-体内”双轨研究体系，解析人类胚胎早期发育3D时空特征（“图纸”），构建完整的人类人工胚胎（“模型”），进而研究人类早期发育与器官形成的生理病理过程（“机制”），并探索疾病解析与再生医疗临床应用的可能性。代表性工作包括体外构建世界首个完整人类人工胚胎以及3D数字胚胎模型，为研究人类早期胚胎发育打开了一扇新的大门。近五年以通讯或第一作者身份在Cell (2026，2025, 2024, 2023)，Nature，Cell Stem Cell (2025, 2023, 2021)，Nature Cell Biology (2026，2025a, 2025b)等杂志发表论文20余篇（引用2232次），并取得3项国际专利。现主持国家A类青年基金（原杰青）与中国科学院B类先导专项。入选2021年MIT科技评论中国“35岁以下科技创新35人”，2024年细胞生物学会干细胞生物学分会“干细胞卓越青年研究员”，2025年获中国科学院青年科学家奖。工作曾入选2024年度Cell最佳论文“Cell Best of 2024”、Science 2021年度科技十大突破进展、以及2021年世界十大科技进展新闻等。现在担任中国细胞生物学学会干细胞生物学分会与类器官研究与应用分会委员、以及《中国科学：生命科学》青年编委。

研究领域：

基于人类多能干细胞，结合微流控等技术，构建可在体外高度模拟人类早期发育生理与病理过程的人工胚胎模型，用于探索发育基础原理和生殖健康临床应用。

社会任职：

获奖及荣誉：

承担科研项目情况：

代表论著：

  1. Shen, Q.#; Zhang, X.#; Chen, N.#; Yan, X.#; Ren, H.#; Sun, X.; Xu, L.; Zhao, J.; Jia, X.; Yuan, Y.; Li, R.; Lin, S.; Yuan, H.; Li, Y.; Yu, L.*; Wei, Y.* Reconstituting Human Primitive Streak Formation through Extra-Embryonic Cell Coordination. Cell, 2026 (Accepted) (共同通讯/ Co-correspondence)
  2. Li, Q.#; Yuan, Y.#; Zhao, W.; Li, Y.; Shi, J.; Xiu, Y.; Han, M.; Han, Y.; Zhang, J.; Cheng, S.; Qi, X.; Sun, X.; Jia, T.; Xing, J.; Deng, S.; Yan, X.; Oura, S.; Li, H.; Sun, Y.; Yuan, H.; Ma, X.; Xin, M.; Zhao, J.; Zhu, X.; Wang, C.; Wang, Q.; Lin, G.; Yang, X.*; Wei, Y.*; Wu, J.*; Wang, H.*; Yu, L.* A 3D in vitro model for studying human implantation and implantation failure. Cell, 2026. (最后通讯/ Last correspondence)
  3. Tan, J.P.#; Liu, Y.#; Fu, Y.#; Liang, L.#; Wu, Y.#; Guo, T.#; Jia, S.; Jiang, Y.; Yuan, T.; Li, J.; Li, Y.; Huang, Z.; Li, S.; Li, J.; Yan, X.; Liao, Z.; Liu, X.; Hu, B.; Fu, S.; Hao, S.; Tian, L.; Liu, Z.; Yu, L.*; Liu, L.*; Liu, X.* A three-dimensional spatial transcriptome atlas reconstructs early organogenesis in primate Carnegie stages 9 and 10 embryos. Nature Cell Biology, 2026 (共同通讯/ Co-correspondence)
  4. De Los Angeles, A.; Bayne, T.; Benvenisty, N.; Deng, H.; Fujita, M.; Ji, W.; Latham, S.; Li, T.; Liu, P.; Loh, Y.H.; Lunshof, J.; Pei, D.; Pho, N.; Silva, J.C.R.; Ka Ki Tam, T.T.; Tao, T.; Trounson, A.; Xu, S.; Yu, L.; Koplin, J.; Regenberg, A.; Sugaya, K.; Savulescu, J.; Zernicka-Goetz, M.; Lovell-Badge, R. A two-tier framework for responsible research on human embryo models. Cell, 2026. (字母排序)
  5. Arias, A.M.; Rivron, N.; Tajbakhsh, S.; Johnston, J.; Alev, C.; Bally-Cuif, L.; Boke, E.; Cave, E.; Cyranoski, D.; David, L.; Esteban, M.A.; Fu, J.; Geijsen, N.; de Graeff, N.; Hanna, J.H.; Hopwood, N.; Inamdar, M.S.; Lanner, F.; Leeners, B.; Liu, Z.; Jean Leon, M.; Minchiotti, G.; Moris, N.; Munsie, M.; Niakan, K.K.; Pourquie, O.; Pasque, V.; Pera, M.; Peng, Y.; Petropoulos, S.; Ramanathan, S.; Rossant, J.; Rugg-Gunn, P.; Saitou, M.; Sermon, K.; Silva, J.; Theunissen, T.; Turco, M.; Wallingford, J.; Wang, H.; Warmflash, A.; Wu, J.; Yu, L. Human stem cell-based embryo models: innovation, ethics, and policy. Human Reproduction, 2026. (字母排序)
  6. Gao, L.#; Gao, Q.#; Hai, N.#; Wu, Z.#; Li, P.#; Kang, H.; Song, X.; Hua, J.; Zhang, S.; Ren, G.; Yang, J.; Yu, L.*; Wei, Y.*; Ding, J.*; Yang, F.* Phase separation of DUX family proteins drives totipotent-like state via 3D genome reorganization and retrotransposon activation. Protein & Cell, 2026. (共同通讯/ Co-correspondence)
  7. Guo, J.#; Lyu, J.#; Gao, Z.#; Jia, T.#; Wang, L.#; Dong, J.; Gu, Z.; Ji, S.; Li, W.; Wang, H.; Zhai, J.*; Yu, L.*; Feng, G.*; Zhou, Q.*; Gu, Q.* 3D biomimetic niche niche embryo development in vitro. Nature Communications, 2026. (共同通讯/ Co-correspondence)
  8. Yuan, Y.#; Wang, X.#; Yan, X.#; He, N.#; Lu, X.#; Yang, J.#; Xie, X.#; Yuan, H.; Chen, N.; Liu, Y.; Ren, H.; Zhang, R.; Cui, L.; Ren, P.; Lin, S.; Cheng, S.; Yang, X.; Guo, Y.; Li, R.; Yan, T.; Guo, J.*; Xiao, Z.*; Wei, Y.*; Yu, L.* 3D reconstruction of a human Carnegie stage 9 embryo provides a snapshot of early body plan formation. Cell Stem Cell, 2025. (最后通讯/ Last correspondence)
  9. Ni, C.#; Wei, Y.#; Vona, B.#; Park, D.; Wei, Y.; Schmitz, D.A.; Ding, Y.; Sakurai, M.; Ballard, E.; Li, L.; Liu, Y.; Kumar, A.; Xing, C.; Qin, S.; Kim, S.; Fogliazzo, M.; Zhao, J.; Kim, H.G.; Ekmekci, C.; Karimiani, E.G.; Imannezhad, S.; Eghbal, F.; Badv, R.S.; Schwaibold, E.M.C.; Dehghani, M.; Mehrjardi, M.Y.V.; Metanat, Z.; Eslamiyeh, H.; Khouj, E.; Alhajj, S.M.N.; Chedrawi, A.; Ramzan, K.; Hashmi, J.A.; Alluqmani, M.M.; Basit, S.; Veltra, D.; Marinakis, N.M.; Niotakis, G.; Vorgia, P.; Sofocleous, C.; Lee, H.; Jeong, W.C.; Umair, M.; Bilal, M.; Alves, C.A.P.F.; Sieber, M.; Kruer, M.; Houlden, H.; Alkuraya, F.S.; Cenik, C.; Yu, L.*; Maroofian, R.*; Wu, J.*; Buszczak, M.* A programmed decline in ribosome levels governs human early neurodevelopment. Nature Cell Biology, 2025. (共同通讯/ Co-correspondence)
  10. Cui, L.#; Lin, S.#; Yang, X.#; Xie, X.#; Wang, X.; He, N.; Yang, J.; Zhang, X.; Lu, X.; Yan, X.; Guo, Y.; Zhang, B.; Li, R.; Miao, H.; Ji, M.; Zhang, R.; Yu, L.*; Xiao, Z.*; Wei, Y.*; Guo, J.* Spatial transcriptomic characterization of a Carnegie stage 7 human embryo. Nature Cell Biology, 2025. (共同通讯/ Co-correspondence)
  11. Ren, H.#; Jia, X.#; Yu, L.*, The building blocks of embryo models: embryonic and extraembryonic stem cells. Cell Discovery, 2025. (最后通讯/ Last correspondence)
  12. De Los Angeles, A.; Benvenisty, N.; Deng, H.; Hanna, J.H.; Koplin, J.; Li, T.; Liu, P.; Loh, Y.H.; Pei, D.; Sugimura, R.; Tam, T.T.K.K.; Tao, T.; Trounson, A.; Xu, S.; Yu, L.; Zambidis, E.; Zernicka-Goetz, M.; Lovell-Badge, R. Human embryo research: how to move towards a 28-day limit. Nature, 2025. (字母排序)
  13. Wu, Z.#; Ren, H.#; Yu, L.* Building the start: Unlocking advanced stem cell-based embryo models. Cell Stem Cell, 2025. (最后通讯/ Last correspondence)
  14. Xiao, Z.#; Cui, L.#; Yuan, Y.#; He, N.#; Xie, X.; Lin, S.; Yang, X.; Zhang, X.; Shi, P.; Wei, Z.; Li, Y.; Wang, H.; Wang, X.; Wei, Y.; Guo, J.; Yu, L.* 3D reconstruction of a gastrulating human embryo. Cell, 2024. (最后通讯/ Last correspondence)
  15. Pinzon-Arteaga, C.A.; Yu, L.* From clones to synthetic embryos. Life Medicine, 2024. (最后通讯/ Last correspondence)
  16. Wei, Y.#*; Zhang, E.#; Yu, L.#; Ci, B.#; Sakurai, M.; Guo, L.; Zhang, X.; Lin, S.; Takii, S.; Liu, L.; Liu, J.; Schmitz, D.A.; Su, T.; Zhang, J.; Shen, Q.; Ding, Y.; Zhan, L.; Sun, H.X.; Zheng, C.; Xu, L.; Okamura, D.; Ji, W.; Tan, T.; Wu, J.*. Dissecting embryonic and extraembryonic lineage crosstalk with stem cell co-culture. Cell, 2023. (共同一作/ Co-first authors)
  17. Wu, X.#; Zhao, W.#; Wu, H.#; Zhang, Q.#; Wang, Y.; Yu, K.; Zhai, J.; Mo, F.; Wang, M.; Li, S.; Zhu, X.; Liang, X.; Hu, B.; Liu, G.H.; Wu, J.; Wang, H.; Guo, F.*; Yu, L.* An aggregation of human embryonic and trophoblast stem cells reveals the role of trophectoderm on epiblast differentiation. Cell Proliferation, 2023. (最后通讯/ Last correspondence)
  18. Yu, L.#; Logsdon, D.#; Pinzon-Arteaga, C.A.#; Duan, J.#; Ezashi, T.#; Wei, Y.#; Ribeiro Orsi, A.E.; Oura, S.; Liu, L.; Wang, L.; Liu, K.; Ding, X.; Zhan, L.; Zhang, J.; Nahar, A.; Stobbe, C.; Katz-Jaffe, M.; Schoolcraft, W.B.; Tan, T.; Hon, G.C.*; Yuan, Y.*; Wu, J.* Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk. Cell Stem Cell, 2023. (第一作者/ First author)
  19. Yu, L.#; Wei, Y.#; Duan, J.#; Schmitz, D.A.; Sakurai, M.; Wang, L.; Wang, K.; Zhao, S.; Hon, G.C.*; Wu, J.* Blastocyst-like structures generated from human pluripotent stem cells. Nature, 2021. (第一作者/ First author)
  20. Yu, L.#; Wei, Y.#; Sun, H.X.#; Mahdi, A.K.; Pinzon Arteaga, C.A.; Sakurai, M.; Schmitz, D.A.; Zheng, C.; Ballard, E.D.; Li, J.; Tanaka, N.; Kohara, A.; Okamura, D.; Mutto, A.A.; Gu, Y.; Ross, P.J.; Wu, J.* Derivation of intermediate pluripotent stem cells amenable to primordial germ cell specification. Cell Stem Cell, 2021. (第一作者/ First author)
  21. Liu, T.#; Li, J.#; Yu, L.#; Sun, H.X.; Li, J.; Dong, G.; Hu, Y.; Li, Y.; Shen, Y.; Wu, J.*; Gu, Y.* Cross-species single-cell transcriptomic analysis reveals pre-gastrulation developmental differences among pigs, monkeys, and humans. Cell Discovery, 2021. (共同一作/ Co-first authors)
  22. Zhang, J.#; Qi, X.#; Zhao, W.; Yuan, S.; Hai, N.; Yu, L.; Hua, J.; Yu, D.*; Wei, Y.* Depicting the dynamic transcriptional and epigenetic landscape of testis development in pubertal Simmental cattle. Journal of Animal Science and Biotechnology, 2026, 17(1): 96.
  23. Schmitz, D.A.; Oura, S.; Li, L.; Ding, Y.; Dahiya, R.; Ballard, E.; Pinzon-Arteaga, C.A.; Sakurai, M.; Okamura, D.; Yu, L.; Ly, P.; Wu, J.* Unraveling mitochondrial influence on mammalian pluripotency via enforced mitophagy. Cell, 2025, 188(17): 4773–4789.e22.
  24. Pinzon-Arteaga, C.A.#; Wang, Y.#; Wei, Y.#; Ribeiro Orsi, A.E.; Li, L.; Scatolin, G.; Liu, L.; Sakurai, M.; Ye, J.; Hao, M.; Yu, L.; Li, B.; Jiang, Z.*; Wu, J.* Bovine blastocyst-like structures derived from stem cell cultures. Cell Stem Cell, 2023, 30(5): 611–616.e7.
  25. Zheng, C.#; Hu, Y.#; Sakurai, M.#; Pinzon-Arteaga, C.A.; Li, J.; Wei, Y.; Okamura, D.; Ravaux, B.; Barlow, H.R.; Yu, L.; Sun, H.X.; Chen, E.H.; Gu, Y.; Wu, J*. Cell competition constitutes a barrier for interspecies chimerism. Nature, 2021, 592(7853): 272–276.
  26. Wang, R.; Qi, Y.; Liu, J.; Li, Y.; An, H.; Wang, H.; Song, J.; Hu, W.; Wu, S.; Yu, L.; Chen, Y.*; Xue, X.* Metal-organic polyhedra maintain the self-renewal of embryonic stem cells. Nature Communications, 2025, 16(1): 8684.
  27. Guo, F.#; He, C.F.#; Xu, Y.H.#; Wu, H.H.#; Li, D.M.#; Jiang, S.Y.#; Ma, X.S.; Huang, C.; Gu, Q.; Du, P.; Yu, L.; Feng, G.H.*; Wang, H.M.*; Li, W.*; Li, X.* High-efficiency generation of blastoids with gastrulation potential through Gata4-induced PrE specification in mESCs. Cell Discovery, 2025, 11(1): 94.
  28. Luo, Y.; Luo, L.; Wang, L.; Yang, S.; Ren, H.; Liang, S.; Wang, X.; Su, Y.; Yu, L.; Wang, X.*; Xu, M.*; Yao, R.* Large-scale bioprinting of human epiblast-like models featuring disc-shaped morphogenesis and gastrulation events. Advanced Science, 2025, 12(33): e05340.
  29. Luo, Q.; Pui, H.P.; Chen, J.; Yu, L.; Jannik, P.R.; Pei, Y.; Zhao, L.; Chen, X.; Petropoulos, S.; Ruas, J.L.; Wu, J.; Deng, Q.* Epiblast-like stem cells established by Wnt/beta-catenin signaling manifest distinct features of formative pluripotency and germline competence. Cell Reports, 2023, 42(1): 112021.
  30. Wang, Y.; Ming, H.; Yu, L.; Li, J.; Zhu, L.; Sun, H.X.; Pinzon-Arteaga, C.A.; Wu, J.*; Jiang, Z.* Establishment of bovine trophoblast stem cells. Cell Reports, 2023, 42(5): 112439.
  31. Sivakumar, S.#; Wang, Y.#; Goetsch, S.C.; Pandit, V.; Wang, L.; Zhao, H.; Sundarrajan, A.; Armendariz, D.; Takeuchi, C.; Deng, M.; Nzima, M.; Chen, W.C.; Dederich, A.E.; El Hayek, L.; Gao, T.; Gogate, A.; Kaur, K.; Kim, H.B.; McCoy, M.K.; Niederstrasser, H.; Oura, S.; Pinzon-Arteaga, C.A.; Sanghvi, M.; Schmitz, D.A.; Yu, L.; Zhang, Y.; Zhou, Q.; Kraus, W.L.; Xu, L.; Wu, J.; Posner, B.A.; Chahrour, M.H.; Hon, G.C.*; Munshi, N.V.* Benchmarking and optimizing Perturb-seq in differentiating human pluripotent stem cells. Stem Cell Reports, 2025, 20(12): 102713.
  32. Schmitz, D.A.#; Okamura, D.#*; Sakurai, M.; Ding, Y.; Oura, S.; Ballard, E.; Wei, Y.; Yu, L.; Hu, Y.; Wu, J.* Dissecting Oct4 enhancer function in pluripotent stem cells and mouse embryogenesis. Stem Cell Reports, 2025, 20(12): 102706.

写给考生的话：

2025年招生视频：https://mp.weixin.qq.com/s/IGLgXI7Le6feYBvby9g8UQ
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