于乐谦，中科学院动物研究所研究员，博士生导师，器官再生与智造重点实验室副主任。2017年获于日本国立京都大学博士学位，随后于美国得克萨斯大学西南医学中心从事博士后研究，2022年加入动物研究所组建独立实验室。长期专注于利用干细胞与体外胚胎模型进行人类早期胚胎发育相关研究。基于“体外-体内”双轨研究体系，解析人类胚胎早期发育3D时空特征（“图纸”），构建完整的人类人工胚胎（“模型”），进而研究人类早期发育与器官形成的生理病理过程（“机制”），并探索疾病解析与再生医疗临床应用的可能性。代表性工作包括体外构建世界首个完整人类人工胚胎以及3D数字胚胎模型，为研究人类早期胚胎发育打开了一扇新的大门。近五年以通讯或第一作者身份在Cell (2025, 2024, 2023)，Nature，Cell Stem Cell (2025, 2023, 2021)，Nature Cell Biology (2025a, 2025b)等杂志发表论文20余篇（引用2232次），并取得3项国际专利。现主持国家A类青年基金（原杰青）与中国科学院B类先导专项。入选2021年MIT科技评论中国“35岁以下科技创新35人”，2024年细胞生物学会干细胞生物学分会“干细胞卓越青年研究员”。工作曾入选2024年度Cell最佳论文“Cell Best of 2024”、Science 2021年度科技十大突破进展、以及2021年世界十大科技进展新闻等。现在担任中国细胞生物学学会干细胞生物学分会与类器官研究与应用分会委员、以及《中国科学：生命科学》青年编委。

基于人类多能干细胞，结合微流控等技术，构建可在体外高度模拟人类早期发育生理与病理过程的人工胚胎模型，用于探索发育基础原理和生殖健康临床应用。

1. Xiao, Z.^#; Cui, L.^#; Yuan, Y.^#; He, N.^#; Xie, X.; Lin, S.; Yang, X.; Zhang, X.; Shi, P.; Wei, Z.; Li,Y.; Wang, H.; Wang, X.*; Wei, Y. *; Guo, J.*; Yu, L.*, 3D Reconstruction of a Gastrulating Human Embryo, Cell, 2024 (最后通讯)

• 该工作入选Cell 2024年最佳文章“Best of Cell 2024”

2. Yuan, Y. ^#; Wang, X. ^#; Yan, X. ^#; He, N. ^#; Lu, X. ^#; Yang, J. ^#; Xie, X. ^#; Yuan, H.; Chen, N.; Liu, Y.; Ren, H.; Zhang, R.; Cui, L.; Ren, P.; Lin, S.; Cheng, S.; Yang, X.; Guo, Y.; Li, R.; Yan, T.; Guo, J.*; Xiao, Z.*; Wei, Y.*; Yu, L.*, 3D reconstruction of a human Carnegie stage 9 embryo provides a snapshot of early body plan formation. Cell Stem Cell, 2025a (最后通讯)
3. Wu, Z.; Ren, H.; Yu, L.*, Building the Start: Unlocking Advanced Stem Cell–Based Embryo. Cell Stem Cell, 2025b (最后通讯)
4. Ni, C.; Wei, Y.; Vona, B.; et al.; Yu, L.*; Maroofian, R.*; Wu, J.*; Buszczak, M.*, A programmed decline in ribosome levels governs human early neurodevelopment. Nature Cell Biology, 2025a (共同通讯)
5. Cui, L. ^#; Lin, S. ^#; Yang, X. ^#; Xie, X. ^#; Wang, X. ^#; He, N. ^#; Yang, J.; Zhang, X.; Lu, X.;  Yan, X.; Guo, Y.; Zhang, B.; Li, R.; Miao, H.; Ji, M.; Zhang, R.; Yu, L.*; Xiao, Z. *; Wei, Y.*; Guo, J.*, Spatial transcriptomic characterization of a Carnegie stage 7 human embryo, Nature Cell Biology, 2025b (共同通讯)
6. Yu, L.^#; Logsdon, D. ^#; Pinzon-Arteaga, C.A. ^#; Duan, J. ^#; Ezashi, T. ^#; Wei, Y. ^#; Oura, S.; Liu, L.; Wang, L.; Liu, K.; Ding, X.; Zhan, L.; Zhang, J.; Nahar, A.; Stobbe, C.; Katz-Jaffe, M.; Schoolcraft, W.B.; Tan, T.; Hon, G.C. *; Yuan, Y. *; Wu, J. *, Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross-talk, Cell Stem Cell, 2023 (第一作者)
7. Yu, L. ^#; Wei, Y. ^#; Duan, J. ^#; Schmitz, D. A.; Sakurai, M.; Wang, L.; Wang, K.; Zhao, S.; Hon, G. C.*; Wu, J.*, Blastocyst-like structures generated from human pluripotent stem cells, Nature, 2021 (第一作者)

• 该工作入选Science杂志评选“Sicence 2021年科学10大突破进展”
• 该工作入选我国两院院士评选“2021年中国/世界十大科技进展新闻”
• 该工作被Natrue杂志（Vol 591, Issue 7851）选为当期封面故事
• 当期Nature杂志评论该工作“First complete model of the human embryo”
• Nature新闻评论该工作“Lab-grown structures mimic human embryo's earliest stage yet”
• Science新闻评论该工作 “Researchers re-create key human embryo stage in lab”
• 该工作同时被世界范围600多家媒体机构报道，包括 Xinhua News, NPR News, US News, New York Times, NHK News, Asahi News, NBC News等

8. Wei, Y.^#; Zhang, E.^#; Yu, L.^#; Ci, B.^#, Sakurai, M.; Guo, L.; Zhang, X.; Lin, S.; Takii, S.; Liu, L.; Liu, J.; Schmitz, DA.; Su, T.; Zhang, J.; Shen, Q.; Ding, Y.; Zhan, L.; Sun, HX.; Zheng, C.; Xu, L.; Okamura, D.; Ji, W.*; Tan, T.*; Wu, J.*, Dissecting embryonic and extraembryonic lineage crosstalk with stem cell co-culture, Cell, 2023 (共同一作)
9. Ren, H.; Jia, X.; Yu, L.*, Building the Start: Unlocking Advanced Stem Cell–Based Embryo. Cell Discovery, 2025 (最后通讯)
10. Wu, X.^#; Zhao, W.^#; Wu, H.^#; Zhang, Q.^#; Wang, Y.; Yu; K.; Zhai, J.; Mo, F.; Wang, M.; Li, S.; Zhu, X.; Liang, X.; Hu, B.; Liu, G. H.; Wu, J.*; Wang, H.*; Guo, F.*; Yu, L.*, An aggregation of human embryonic and trophoblast stem cells reveals the role of trophectoderm on epiblast differentiation, Cell proliferation, 2023 (最后通讯)
11. Pinzón-Arteaga, C.A.; Yu, L.*, From clones to synthetic embryos, Life Medicine, 2024 (最后通讯)
12. Angeles, A.D.L.; Benvenisty, N.; Deng, H.; Hanna, J.; Koplin, J.; Li, T.; Liu, P.; Loh, Y.H.; Pei, D.; Sugimura, R.; Tam, T.T.K.K.; Tao, T.; Trounson, A.; Xu, S.; Yu, L.; Zambidis, E.; Zernicka-Goetz, M.; Lovell-Badge, R.; Human embryo research: how to move towards a 28-day limit, Nature, 2025 (共同评论，首字母排名)
13. Yu, L. ^#; Wei, Y. ^#; Sun, H. ^#; Mahdi, A. K.; Pinzon Arteaga, C. A.; Sakurai, M.; Schmitz, D. A.; Zheng, C.; Ballard, E. D.; Li, J.; Tanaka, N.; Kohara, A.; Okamura, D.; Mutto, A. A.; Gu, Y.; Ross, P. J.; Wu, J.*, Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification, Cell Stem Cell, 2021 (第一作者)
14. Yu, L.; Wei, Y.; Schmitz, D. A.; Sakurai, M.; Wu, J.*, A protocol for the generation of blastocyst-like structures from human pluripotent stem cells, Protocol Exchange, 2021 (第一作者)
15. Liu, T. ^#; Li, J. ^#; Yu, L. ^#; Sun, H.; Li, J.; Dong, G.; Hu, Y.; Li, Y.; Shen, Y.; Wu, J.*; Gu, Y.*, Cross-species single-cell transcriptomic analysis reveals pre-gastrulation developmental differences among pigs, monkeys, and humans, Cell discovery, 2021 (共同一作)
16. Yu, L. ^#; Li, J. ^#; Itsunari, M.; Qu, X.; Miyagawa, S.; Fujimoto, N.; Hasegawa, K.; Chen, Y.; Sawa, Y.; Kotera, H.; Liu, L.*, Clonal Isolation of Human Pluripotent Stem Cells on Nanofibrous Substrates Reveals an Advanced Subclone for Cardiomyocyte Differentiation. Advanced Healthcare Materials, 2019 (第一作者)
17. Yu, L.; Li, J.; Hong, J.; Takashima, Y.; Fujimoto, N.; Nakajima, M.; Dong, X.; Dang, Y.; Yang, W.; Okita, K.; Luo, C.; Tang, F.; Chen, Y.; Tang, C.*; Kotera, H.*; Liu, L.*, Low Cell-Matrix Adhesion Reveals Two Novel Subtypes of Human Pluripotent Stem Cells. Stem Cell Reports, 2018 (第一作者)
18. Li, X.^#; Yu, L.^#; Li, J.; Minami, I.; Nakajima, M.; Noda, Y.; Kotera, H.; Liu, L.*; Chen, Y.*, On chip purification of hiPSC-derived cardiomyocytes using a fishnet-like microstructure, Biofabrication, 2016 (共同一作)
19. Ballard, E.; Sakurai, M.; Yu, L.; Liu, L.; Oura, S.; Huang, J.; Wu, J., Incompatibility in cell adhesion constitutes a barrier to interspecies chimerism, Cell Stem Cell, 2025 (共同作者)
20. Zheng, C. ^#; Hu, Y. ^#; Sakurai, M. ^#; Pinzon-Arteaga, C. A.; Li, J.; Wei, Y.; Okamura, D.; Ravaux, B.; Barlow, H. R.; Yu, L.; Sun, H.; Chen, E. H.; Gu, Y.; Wu, J.*, Cell competition constitutes a barrier for interspecies chimerism, Nature, 2021 (共同作者)
21. Vilarino, M.; Soto, D.A.; Bogliotti, Y. S.; Yu, L.; Zhang, Y.; Wang, C.; Paulson, E.; Zhong, C.; Jin, C.; Izpisua Belmonte, J. C.; Wu, J.; Ross, P. J.*, Derivation of sheep embryonic stem cells under optimized conditions. Reproduction, 2020 (共同作者)
22. Li, J. ^#; Zhang, L. ^#; Yu, L.; Minami, I.; Miyagawa, S.; Hörning, M.; Dong, J.; Qiao, J.; Qu, X.; Hua, Y.; Fujimoto, N.; Shiba, Y.; Zhao, Y.; Tang, F.; Chen, Y.; Sawa, Y.*; Tang, C.*; Liu, L.*, Circulating re-entrant waves promote maturation of hiPSC-derived cardiomyocytes in self-organized tissue ring, Communications biology, 2020 (共同作者)
23. Li, R. ^#; Zhong, C. ^#; Yu, Y. ^#; Liu, H.; Sakurai, M.; Yu, L.; Min, Z.; Shi, L.; Wei, Y.; Takahashi, Y.; Liao, H.; Qiao, J.; Deng, H.; Nuñez-Delicado, E.; Rodriguez Esteban, C.; Wu, J. *; Izpisua Belmonte, J. C.*; Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures. Cell, 2019 (共同作者)
24. Zhang, Y.; Li, T.; Preissl, S.; Amaral, M.L.; Grinstein, J.D.; Farah, E.N.; Destici, E.; Qiu, Y.; Hu, R. Lee, A.Y.; Chee, S.; Ma, K.; Ye, Z.; Zhu, Q.; Huang, H.; Fang, R.; Yu, L.; Izpisua Belmonte, J.C.; Wu, J.; Evans, S.M.; Chi, N.C.*; Ren B*. Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells. Nature Genetics, 2019 (共同作者)
25. Xu, J.; Yu, L.; Guo, J.; Xiang, J.; Zheng, Z.; Gao, D.; Shi, B.; Hao, H.; Jiao, D.; Zhong, L.; Wang, Y.; Wu, J.*; Wei, H. *; Han, J*. Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system. Stem Cell Research & Therapy, 2019 (共同作者)
26. Li, J. ^#; Minami, I. ^#; Yu, L.; Shiozaki, M.; Shiba, Y.; Yajima, S.; Morone, N.; Fukushima, S.; Yoshioka, M.; Li, S.; Qiao, J.; Li, X.; Wang, L.; Kotera, H.; Miyagawa, S.; Nakatsuji, N.; Sawa, Y.; Chen, Y.; Liu, L., Human Pluripotent Stem Cell-Derived Cardiac Tissue-Like Constructs for Repairing of the Infarcted Myocardium. Stem Cell Reports, 2017 (共同作者)
27. Li, J.; Zhang, F.; Yu, L.; Fujimoto, N.; Yoshioka, M.; Li, X.; Shi, J.; Kotera, H.; Liu, L.* and Chen, Y. * , Culture substrates made of elastomeric micro-tripod arrays for long-term expansion of human pluripotent stem cells, J. Mater. Chem. B, 2017 (共同作者)
28. Tang, Y.; Liu, L.; Li, J.; Yu, L.; Wang, L.; Shi, J.; Chen, Y.*, Induction and Differentiation of Human Induced Pluripotent Stem Cells into Functional Cardiomyocytes on a Compartmented Monolayer of Gelatin Nanofibers. Nanoscale, 2016 (共同作者)
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