于乐谦，中科学院动物研究所研究员，博士生导师，器官再生与智造重点实验室副主任，获得国家级青年人才基金支持。2017年博士毕业于日本国立京都大学，随后于美国得克萨斯大学西南医学中心从事博士后研究工作。2022年8月全职加入中国科学院动物研究所。主要利用多能干细胞与人工胚胎进行早期胚胎发育相关的生理病理研究。近五年以第一作者或通讯作者身份在Nature，Cell (2024,2023)，Cell Stem Cell (2025,2023,2021)，Nature Cell Biology等杂志发表论文12篇，并取得4项国际专利。2021年入选MIT科技评论中国“35岁以下科技创新35人”。2024年入选细胞生物学会干细胞生物学分会“干细胞卓越青年研究员”。代表性工作包括体外构建首个人类胚胎完整模型“类囊胚”，为研究人类早期胚胎发育打开了一扇新的大门。工作同时入选2024 Cell最佳论文“Cell Best of 2024”、Science杂志“2021年度科技十大突破进展”以及我国两院院士评选“2021年中国/世界十大科技进展新闻”。目前担任中国细胞生物学学会干细胞生物学分会委员，中国细胞生物学学会科学普及工作委员会副主任，北京青年科协委员，《中国科学：生命科学》青年编委。

基于人类多能干细胞，结合微流控等技术，构建可在体外高度模拟人类早期发育生理与病理过程的人工胚胎模型，用于探索发育基础原理和生殖健康临床应用。

1. Xiao, Z.#; Cui, L.#; Yuan, Y.#; He, N.#; Xie, X.; Lin, S.; Yang, X.; Zhang, X.; Shi, P.; Wei, Zh.; Li,Y.; Wang, H.; Wang, X.*; Wei, Y. *; Guo, J.*; Yu, L.*, 3D Reconstruction of a Gastrulating Human Embryo, Cell, 2024 （*通讯作者,# Co-frist authors）

• 入选2024 Cell最佳论文“Cell Best of 2024”

2. Yu, L. #; Wei, Y. #; Duan, J. #; Schmitz, D. A.; Sakurai, M.; Wang, L.; Wang, K.; Zhao, S.; Hon, G. C.*; Wu, J.*, Blastocyst-like structures generated from human pluripotent stem cells, Nature, 2021 (# Co-frist authors)

• 该工作入选Science杂志评选“Sicence 2021年科学10大突破进展”
• 该工作入选我国两院院士评选“2021年中国/世界十大科技进展新闻”
• 该工作被Natrue杂志（Vol 591, Issue 7851）选为当期封面故事
• 当期Nature杂志评论该工作“First complete model of the human embryo”
• Nature新闻评论该工作“Lab-grown structures mimic human embryo's earliest stage yet”
• Science新闻评论该工作 “Researchers re-create key human embryo stage in lab”
• 该工作同时被世界范围600多家媒体机构报道，包括 Xinhua News, NPR News, US News, New York Times, NHK News, Asahi News, NBC News等

3. Yuan, Y.#; Wang, X.#; Yan, X.#; He, N.#; Lu, X.#; Yang, J.#; Xie, X.#; Yuan, H.; Chen, N.; Liu, Y.; Ren, H.; Zhang, R.; Cui, L.; Ren, P.; Lin, S.; Cheng, S.; Yang, X.; Guo, Y.; Li, R.; Yan, T.; Guo, J.*; Xiao, Z.*; Wei, Y.*; Yu, L.*, 3D reconstruction of a human Carnegie stage 9 embryo provides a snapshot of early body plan formation. Cell Stem Cell, 2025 （*通讯作者,# Co-frist authors）

• 该工作被 Cell Stem Cell杂志（Vol 32, Issue 6）选为当期封面故事

4. Cui, L.#; Lin, S.#; Yang, X.#; Xie, X.#; Wang, X.#; He, N.#; Yang, J.; Zhang, X.; Lu, X.; Yan, X.; Guo, Y.; Zhang, B.; Li, R.; Miao, H.; Ji, M.; Zhang, R.; Yu, L.*; Xiao, Z.*; Wei, Y.*; Guo, J.*, Nature cell biology, 2025（*通讯作者,# Co-frist authors）
5. Liu, T. #; Li, J. #; Yu, L. #; Sun, H.; Li, J.; Dong, G.; Hu, Y.; Li, Y.; Shen, Y.; Wu, J.*; Gu, Y.*, Cross-species single-cell transcriptomic analysis reveals pre-gastrulation developmental differences among pigs, monkeys, and humans, Cell discovery, 2021 (# Co-frist authors)
6. Zheng, C. #; Hu, Y. #; Sakurai, M. #; Pinzon-Arteaga, C. A.; Li, J.; Wei, Y.; Okamura, D.; Ravaux, B.; Barlow, H. R.; Yu, L.; Sun, H.; Chen, E. H.; Gu, Y.; Wu, J.*, Cell competition constitutes a barrier for interspecies chimerism, Nature, 2021
7. Yu, L.#; Logsdon, D. #; Pinzon-Arteaga, C.A. #; Duan, J. #; Ezashi, T. #; Wei, Y. #; Oura, S.; Liu, L.; Wang, L.; Liu, K.; Ding, X.; Zhan, L.; Zhang, J.; Nahar, A.; Stobbe, C.; Katz-Jaffe, M.; Schoolcraft, W.B.; Tan, T.; Hon, G.C. *; Yuan, Y. *; Wu, J.*, Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk, Cell Stem Cell, 2023 (# Co-frist authors)
8. Wu, X.#; Zhao, W.;#, Wu, H.#; Zhang, Q.#; Wang, Y.; Yu, K.; Zhai, J.; Mo, F.; Wang, M.; Li, S.; Zhu, X.; Liang, X.; Hu, B.; Liu, G. H.; Wu, J. *; Wang, H. *; Guo, F. *; Yu, L.*, An aggregation of human embryonic and trophoblast stem cells reveals the role of trophectoderm on epiblast differentiation, Cell proliferation, 2023(# Co-frist authors)
9. Wei Y#, Zhang E#, Yu L#, Ci B#, Sakurai M, Guo L, Zhang X, Lin S, Takii S, Liu L, Liu J, Schmitz DA, Su T, Zhang J, Shen Q, Ding Y, Zhan L, Sun HX, Zheng C, Xu L, Okamura D, Ji W*, Tan T*, Wu J*. Dissecting embryonic and extraembryonic lineage crosstalk with stem cell co-culture.,Cell.,2023(# Co-frist authors)
10. Yu, L. #; Wei, Y. #; Sun, H. #; Mahdi, A. K.; Pinzon Arteaga, C. A.; Sakurai, M.; Schmitz, D. A.; Zheng, C.; Ballard, E. D.; Li, J.; Tanaka, N.; Kohara, A.; Okamura, D.; Mutto, A. A.; Gu, Y.; Ross, P. J.; Wu, J.*, Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification, Cell Stem Cell, 2020 (# Co-frist authors)

• Cell Stem Cell杂志评论该工作“Stabilizing Formative Pluripotent States with Germ Cell Competency”
• ScienceDaily New评论该工作 “Development of new stem cell type may lead to advances in regenerative medicine”
• GEN News评论该工作“New Stem Cell Derived from Mice, Horses, and Humans”

11. Vilarino, M.; Soto, D.A.; Bogliotti, Y. S.; Yu, L.; Zhang, Y.; Wang, C.; Paulson, E.; Zhong, C.; Jin, C.; Izpisua Belmonte, J. C.; Wu, J.; Ross, P .J.*, Derivation of sheep embryonic stem cells under optimized conditions. Reproduction, 2020
12. Li, J. #; Zhang, L. #; Yu, L.; Minami, I.; Miyagawa, S.; Horning, M.; Dong, J.; Qiao, J.; Qu, X.; Hua, Y.; Fujimoto, N.; Shiba, Y.; Zhao, Y.; Tang, F.; Chen, Y.; Sawa, Y.*; Tang, C.*; Liu, L.*, Circulating re-entrant waves promote maturation of hiPSC-derived cardiomyocytes in self-organized tissue ring, Communications biology, 2020
13. Yu, L. #; Li, J. #; Itsunari, M.; Qu, X.; Miyagawa, S.; Fujimoto, N.; Hasegawa, K.; Chen, Y.; Sawa, Y.; Kotera, H.; Liu, L.*, Clonal Isolation of Human Pluripotent Stem Cells on Nanofibrous Substrates Reveals an Advanced Subclone for Cardiomyocyte Differentiation. Advanced Healthcare Materials, 2019 (# Co-frist authors)

• 该工作被Advanced Healthcare Materials杂志选为当期封面故事

14. Li, R. #; Zhong, C. #; Yu, Y. #; Liu, H.; Sakurai, M.; Yu, L.; Min, Z.; Shi, L.; Wei, Y.; Takahashi, Y.; Liao, H.; Qiao, J.; Deng, H.; Nunez-Delicado, E.; Rodriguez Esteban, C.; Wu, J. *; Izpisua Belmonte, J. C.*; Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures. Cell, 2019
15. Zhang, Y.; Li, T.; Preissl, S.; Amaral, M.L.; Grinstein, J.D.; Farah, E.N.; Destici, E.; Qiu, Y.; Hu, R. Lee, A.Y.; Chee, S.; Ma, K.; Ye, Z.; Zhu, Q.; Huang, H.; Fang, R.; Yu, L.; Izpisua Belmonte, J.C.; Wu, J.; Evans, S.M.; Chi, N.C.*; Ren B*. Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells. Nature Genetics, 2019
16. Xu, J.; Yu, L.; Guo, J.; Xiang, J.; Zheng, Z.; Gao, D.; Shi, B.; Hao, H.; Jiao, D.; Zhong, L.; Wang, Y.; Wu, J.*; Wei, H. *; Han, J*. Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system. Stem Cell Research & Therapy, 2019
17. Yu, L.; Li, J.; Hong, J.; Takashima, Y.; Fujimoto, N.; Nakajima, M.; Dong, X.; Dang, Y.; Yang, W.; Okita, K.; Luo, C.; Tang, F.; Chen, Y.; Tang, C.*; Kotera, H.*; Liu, L.*, Low Cell-Matrix Adhesion Reveals Two Novel Subtypes of Human Pluripotent Stem Cells. Stem Cell Reports, 2018
18. Li, J. #; Minami, I. #; Yu, L.; Shiozaki, M.; Shiba, Y.; Yajima, S.; Morone, N.; Fukushima, S.; Yoshioka, M.; Li, S.; Qiao, J.; Li, X.; Wang, L.; Kotera, H.; Miyagawa, S.; Nakatsuji, N.; Sawa, Y.; Chen, Y.; Liu, L., Human Pluripotent Stem Cell-Derived Cardiac Tissue-Like Constructs for Repairing of the Infarcted Myocardium. Stem Cell Reports, 2017
19. Li, J.; Zhang, F.; Yu, L.; Fujimoto, N.; Yoshioka, M.; Li, X.; Shi, J.; Kotera, H.; Liu, L.* and Chen, Y. * , Culture substrates made of elastomeric micro-tripod arrays for long-term expansion of human pluripotent stem cells, J. Mater. Chem. B, 2017
20. Li, X.#; Yu, L.#; Li, J.; Minami, I.; Nakajima, M.; Noda, Y.; Kotera, H.; Liu, L.*; Chen, Y.*, On chip purification of hiPSC-derived cardiomyocytes using a fishnet-like microstructure, Biofabrication, 2016. (# Co-frist authors)
21. Tang, Y.; Liu, L.; Li, J.; Yu, L.; Wang, L.; Shi, J.; Chen, Y.*, Induction and Differentiation of Human Induced Pluripotent Stem Cells into Functional Cardiomyocytes on a Compartmented Monolayer of Gelatin Nanofibers. Nanoscale, 2016
22. Li, J.; Minami, I.; Yu, L.; Tsuji, K.; Nakajima, M.; Qiao, J.; Suzuki, M.; Shimono, K.; Nakatsuji, N.; Kotera, H.; Liu, L.*; Chen, Y.*, Extracellular Recordings of Patterned Human Pluripotent Stem Cell-Derived Cardiomyocytes on Aligned Fibers. Stem cells international, 2016
23. Tang, Y.; Liu, L.; Li, J.; Yu, L.; Severino, F. P. U.; Wang, L.; Shi, J.; Tu, X.; Torre, V.; Chen, Y.*, Effective Motor Neuron Differentiation of Hipscs on a Patch Made of Crosslinked Monolayer Gelatin Nanofibers. Journal of Materials Chemistry B, 2016