1. Lei J, Xin Z, Liu N, Ning T, Jing Y, QiaoY, He Z, Jiang M, Yang Y, Zhang Z, Zhao L, Li J, Lv D, Yan Y, Zhang H, Xiao L, Zhang B, Huang H, Sun S, Zheng F, Jiang X, Lu H, Dong X, Yue S, Ma C, Shuai J, Ji Z, Liu F, Ye Y, Yan K, Hu Q, Xu G, Zhao Q, Wu R, Cai Y, Fan Y, Jing Y, Wang Q, Reddy P, Lu X, Zheng Z, Liu B, Haghani A, Ma S, Suzuki K, Rodriguez Esteban C, Yang J, Song M, Horvath S, Zhang W, Li W, Xiang AP, Zhu L, Fu X, Zhao G, Izpisua Belmonte JC, Qu J^*, Wang S^*, Liu GH^*. Senescence-resistant human mesenchymal progenitor cells counter aging in primates. Cell. 2025.188(18):5039-5061.

—Featured Article by Cell

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—Featured in Wikipedia's "Ageing" entry

—Altmetric Score 533

2. Geng L, Ping J, Wu R, Yan H, Zhang H, Zhuang Y, Ning T, Wang J, Liang C, Zhang J, Chu Q, Zhang J, Wen Y, Jing Y, Sun S, Qiao Q, Zhao Q, Ji Q, Ma S, Cai Y, Zheng Y, Zou Z, Diao Z, Li M, Zhang H, Hu J, Fu L, Kang W, Bai R, Zhao H, Zhang S, Ding Y, Lei J, Wang W, Ji Y, Gou B, Sun G, Yin J, Yan P, Li H, Wang Z, Ma S, Liu Z, Shan H, Wang Q, Cao T, Yang S, Wang C, Yang P, Fan Y, Ye Y, Hu J, Jiang M, Wang Y, Liu K, Li Y, Li Y, Li J, Ci W, Jin ZB, Fu X, Zhang X, Zhao G, Izpisua Belmonte JC, Wang S*, Song M*, Zhang W*, Qu J*, Liu GH*. Systematic profiling reveals betaine as an exercise mimetic for geroprotection. Cell. 2025. 188(19):5426-5428.

—Highlighted by Nature (news)

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—Altmetric Score 369

3. Ding Y, Zuo Y, Zhang B, Fan Y, Xu G, Cheng Z, Ma S, Fang S, Tian A, Gao D, Xu X, Wang Q, Jing Y, Jiang M, Xiong M, Li J, Han Z, Sun S, Wang S, He F, Yang J*, Qu J*, Zhang W*, Liu GH*. Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures. Cell. 2025. 188(20): 5763-5784.

—Highlighted by Nature (news)

—Featured in Wikipedia's "Ageing" entry

—Altmetric Score 1137

4. Jing Y, Lu H, Li J, Zhao L, Zhang C, Huang Z, Liu L, Sun S, Ma S, Rodriguez Esteban C, Fu X, Zhao G, Belmonte JCI, Zhang W*, Qu J*, Wang S*, Liu GH*. Vitamin C conveys geroprotection on primate ovaries. Cell Stem Cell. 2025. doi.org/10.1016/j.stem.2025.09.008
5. Sun X, Che S, Wang H, Fan Y, Ding Y, Tan A, Yang K, Hu J, Zhang Y, Ma M, Hu J, Sun S, Li J, Ma S, Wang S, Izpisua Belmonte JC, Qu J*, Zhang W*, Liu GH*. Vascular organoid model of Hutchinson Gilford Progeria Syndrome uncovers repression of the SRF pathway in premature aging. Developmental Cell. 2025. in press.
6. Zhao Q, Jing Y, Jiang X, Zhang X, Liu F, Huang H, Zhang Z, Wang H, Sun S, Ma S, Zhang W, Yu Y, Fu X, Zhao G, Qu J*, Wang S*, Liu GH*. SIRT5 safeguards against primate skeletal muscle ageing via desuccinylation of TBK1. Nature Metabolism. 2025. 7(3):556-573.

—Highlighted by Nature Metabolism (news & views)

7. Sun G, Fu X, Zheng Y, Hong G, Liu Z, Luo B, Lei J, Lv D, Chang M, Xiao Y, Guo S, Ma S, Lu L, Zhang W, Belmonte JCI, Qu J*, Wang S*, Chai R*, Liu GH*. Single-cell profiling identifies hair cell SLC35F1 deficiency as a signature of primate cochlear aging. Nature Aging. 2025. 5(9):1862-1879.

—Featured by Nature Briefing

8. Sun G, He Z, Lv D, Wang Q, Xu G, Liu F, Wang P, Luo B, Zheng Y, Hu J, Sun S, Ma S, Rodriguez Esteban C, Yang J, Fu X, Belmonte JCI, Zhang W*, Qu J*, Wang S*, Liu GH*. Reprogramming the GRHL2-CDK19 axis by gene therapy alleviates prostate aging. Nature Aging. 2025. in press.
9. Sun G, Li K, Ping J, Zhao L, Cui C, Wu J, Xie L, Yao X, Xu G, Ma S, Fan Y, Wang Q, Yang D, Luo B, Liu H, Yang J, Zhang W, Song W, Zhao G, Fu X, Bian XW, Qu J*, Wang S*, Chen H*, Liu GH*. A single-cell transcriptomic atlas reveals senescence and inflammation in the post-tuberculosis human lung. Nature Microbiology. 2025. 10(8):2073-2091 .
10. Fan Y, Zheng Y, Zhang Y, Xu G, Liu C, Hu J, Ji Q, Zhang S, Fang S, Lei J, Li LZ, Wang X, Xu X, Wang C, Wang S, Ma S, Song M, Jiang W, Zhu J, Feng Y, Wang J, Yang Y, Zhu G, Tian XL, Zhang H, Song W, Yang J, Yao Y*, Liu GH*, Qu J*, Zhang W*. ARID5A orchestrates cardiac aging and inflammation through MAVS mRNA stabilization. Nature Cardiovascular Research. 2025. 4(5):602-623 .

—Highlighted by Nature Cardiovascular Research (news & views)

11. Li Y, Huang Z, Xu L, Fan Y, Ping J, Li G, Chen Y, Yu C, Wang Q, Song T, Lin T, Liu M, Xu Y, Ai N, Meng X, Qiao Q, Ji H, Qin Z, Jin S, Jiang N, Wang M, Shu S*, Zhang F*, Zhang W*, Liu GH*, Chen L*, Jiang L*. UDA-seq: universal droplet microfluidics-based combinatorial indexing for massive-scale multimodal single-cell sequencing. Nature Methods. 2025. 22(6):1199-1212.

—Highlighted by Nature Methods (news & views)

12. Wang Z, Ji Q, Liu Z, Jiao C, Zhang Y, Liu F, Sun S, Chu Q, Wu Z, Li J, Li H, Hu J, Gao Y, Cao G, Izpisua Belmonte JC, Zhang W*, Qu J*, Liu GH*. Nuclear lamins-guided plastic positioning and folding of the human genome, Cell Reports. 2025. in press.
13. Li H, Zhao W, Yang F, Qiao Q, Ma S, Yang K, Song S, Wang S, Qu J*, Liu GH*, Bao Y*, Zhang W*. Immunosenescence Inventory-a multi-omics database for immune aging research. Nucleic Acids Research. 2025. 53(D1):D1047-D1054.
14. Yang Y, Lu X, Liu N, Ma S, Zhang H, Zhang Z, Yang K, Jiang M, Zheng Z, Qiao Y, Hu Q, Huang Y, Zhang Y, Xiong M, Liu L, Jiang X, Reddy P, Dong X, Xu F, Wang Q, Zhao Q, Lei J, Sun S, Jing Y, Li J, Cai Y, Fan Y, Yan K, Jing Y, Haghani A, Xing M, Zhu G, Song W, Horvath S, Esteban CR, Song M, Wang S, Zhao G, Li W, Izpisua Belmonte JC, Qu J*, Zhang W*, Liu GH*. Metformin Decelerates Aging Clock in Male Monkeys. Cell. 2024. 187(22):6358-6378.

—Featured Article by Cell

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—Altmetric Score 863

—Selected by Essential Science Indicators (ESI) - Highly Cited Papers

—Selected by 2024 Top 10 Scientific Advances in Life Sciences of China

15. Ma S, Ji Z, Zhang B, Geng L, Cai Y, Nie C, Li J, Zuo Y, Sun Y, Xu G, Liu B, Ai J, Liu F, Zhao L, Zhang J, Zhang H, Sun S, Huang H, Zhang Y, Ye Y, Fan Y, Zheng F, Hu J, Zhang B, Li J, Feng X, Zhang F, Zhuang Y, Li T, Yu Y, Bao Z, Pan S, Esteban CR, Liu Z, Deng H, Wen F, Song M, Wang S, Zhu G, Yang J, Jiang T, Song W, Belmonte JCI, Qu J*, Zhang W*, Gu Y*, Liu GH*. Spatial Transcriptomic Landscape Unveils Immunoglobin-associated Senescence as a Hallmark of Aging. Cell. 2024. 187(24):7025-7044.

—Featured article by Cell

—Selected by 2024 Top 10 Scientific Advances in Life Sciences of China

16. Li HY, Wang M, Jiang X, Jing Y, Wu Z, He Y, Yan K, Sun S, Ma S, Wang S, Belmonte JCB, Qu J*, Zhang W*, Wei T*, Liu GH*. CRISPR screening uncovers nucleolar RPL22 as a heterochromatin destabilizer and senescence driver. Nucleic Acids Research. 2024. 52(19):11481-11499.
17. Wang Q, Wang X, Liu B, Ma S, Zhang F, Sun S, Jing Y, Fan Y, Ding Y, Xiong M, Li J, Zhai Q, Zheng Y, Liu C, Xu G, Yang J, Wang S, Ye J, Belmonte JCI, Qu J*, Liu GH*, Zhang W*. Aging induces region-specific dysregulation of hormone synthesis in the primate adrenal gland. Nature Aging. 2024. 4(3):396-413.

—Featured by Nature Briefing

18. Bi S, Jiang X, Ji Q, Wang Z, Ren J, Wang S, Yu Y, Wang R, Liu Z, Liu J, Hu J, Sun Q, Wu Z, Diao Z, Li J, Sun L, Belmonte JCI, Zhang W*, Liu GH*, Qu J*. The Sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA. Developmental Cell. 2024. 59(8):991-1009.
19. Yang S, Liu C, Jiang M, Liu X, Geng L, Zhang Y, Sun S, Wang K, Yin J, Ma S, Wang S, Izpisua Belmonte JC, Zhang W*, Qu J*, Liu GH*. A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes. Protein Cell. 2024. 15(2):98-120.

—Selected as Cover Story

20. Sun S, Li J, Wang S, Li J, Ren J, Bao Z, Sun L, Ma X, Zheng F, Ma S, Sun L, Wang M, Yu Y, Ma M, Wang Q, Chen Z, Ma H, Wang X, Wu Z, Zhang H, Yan K, Yang Y, Zhang Y, Zhang S, Lei J, Teng ZQ, Liu CM, Bai G, Wang YJ, Li J, Wang X, Zhao G, Jiang T, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. CHIT1-positive microglia drive motor neuron ageing in the primate spinal cord. Nature. 2023. 624(7992):611-620.

—Highlighted by Cell Metabolism (Preview)

—Highlighted by Forbes

—Selected by 2023 Top 10 Scientific Advances in Life Sciences of China

21. Liu X, Liu Z, Wu Z, Ren J, Fan Y, Sun L, Cao G, Niu Y, Zhang B, Ji Q, Jiang X, Wang C,  Wang Q, Ji Z, Li L, Esteban CR, Yan K, Li W, Cai Y, Wang S, Zheng A, Zhang YE, Tan S, Cai Y, Song M, Lu F, Tang F, Ji W, Zhou Q, Belmonte JCI, Zhang W*, Qu J*, Liu GH*. Resurrection of endogenous retroviruses during aging reinforces senescence. Cell. 2023. 186(2):287-304.

—Featured article by Cell

—Highlighted by Cell (Preview)

—Highlighted by Nature Reviews Molecular Cell Biology (Research Highlight)

—Highlighted by Nature Aging (Research Highlight)

—Highlighted by Trends in Microbiology (SPOTLIGHT)

—Altmetric Score 618

—Recommended by F1000

—Featured in Wikipedia's "Ageing" entry

—Selected by Essential Science Indicators (ESI) - Highly Cited Papers

—Selected by Top 10 Scientific Advances of 2023, China

22. Cai Y, Xiong M, Xin Z, Liu C, Jie R，Yang X, Lei J, Li W, Liu F, Chu Q, Yin J, Ye Y, Liu D, Fan Y, Sun S, Zhao Q, Zhao L, Che S, Zheng Y, Yan H, Ma S, Wang S, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. Decoding aging-dependent regenerative decline across tissues at single-cell resolution. Cell Stem Cell. 2023. 30(12):1674-1691.
23. Ye Y, Yang K, Liu H, Yu Y, Song M, Huang D, Lei J, Zhang Y, Liu Z, Chu Q, Fan Y, Zhang S, Jing Y, Esteban CR, Wang S, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. SIRT2 counteracts primate cardiac aging via deacetylation of STAT3 that silences CDKN2B. Nature Aging. 2023. 3(10):1269-1287.

—Selected as Cover Story

24. Wu Z, Lu M, Liu D, Shi Y, Ren J, Wang S, Jing Y, Zhang S, Zhao Q, Li H, Yu Z, Liu Z, Bi S, Wei T, Yang Y, Xiao J, Belmonte JCI, Qu J*, Zhang W*, Ci W*, Liu GH*. M⁶A epitranscriptomic regulation of tissue homeostasis during primate aging. Nature Aging. 2023. 3(6):705-721.

—Selected as Cover Story

25. Li J, Xiong M, Fu XH, Fan Y, Dong C, Sun X, Zheng F, Wang SW, Liu L, Xu M, Wang C, Ping J, Che S, Wang Q, Yang K, Zuo Y, Lu X, Zheng Z, Lan T, Wang S, Ma S, Sun S, Zhang B, Chen CS, Cheng KY, Ye J, Qu J, Xue Y, Yang YG*, Zhang F*, Zhang W*, Liu GH*. Determining a Multimodal Aging Clock in a Cohort of Chinese Women. Med. 2023. 4(11):825-848.

—Selected as Cover Story

—Awarded “Best Paper Award” at the 2023 Cell Press Awards for Chinese Scientists

26. Cheng F, Ji Q, Wang L, Wang CC, Liu GH*, Wang L*. Reducing oxidative protein folding alleviates senescence by minimizing ER-to-nucleus H₂O₂ release. EMBO Reports. 2023. 24(8):e56439.

—Selected as Cover Story

27. Wang C, Yang K, Liu X, Wang S, Song M, Belmonte JC, Qu J*, Liu GH*, Zhang W*. MAVS antagonizes human stem cell senescence as a mitochondrial stabilizer. Research. 2023. 6:0192.
28. Jing Y, Zuo Y, Sun L, Yu ZR, Ma S, Hu H, Zhao Q, Huang D, Zhang W, Belmonte JCI, Yu Y*, Qu J*, Liu GH*, Wang S*. SESN1 is a FOXO3 effector that counteracts human skeletal muscle ageing. Cell Proliferation. 2023. 56(5):e13455.
29. Ma S, Wang S, Ye Y, Ren J, Chen R, Li W, Li J, Zhao L, Zhao Q, Sun G, Jing Y, Zuo Y, Xiong M, Yang Y, Wang Q, Lei J, Sun S, Long X, Song M, Yu S, Chan P, Wang J, Zhou Q, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues. Cell Stem Cell. 2022. 29(6):990-1005.

—Awarded “Most Picked Award” at the 2022 Cell Press Awards for Chinese Scientists

30. Liu Z, Ji Q, Ren J, Yan P, Wu Z, Wang S, Sun L, Wang Z, Li J, Sun G, Liang C, Sun R, Jiang X, Hu J, Ding Y, Wang Q, Bi S, Wei G, Cao G, Zhao G, Wang H, Zhou Q, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. Large-Scale Chromatin Reorganization Reactivates Placenta-Specific Genes that Drive Cellular Aging. Developmental Cell. 2022. 57(11):1347-1368.

—Cover image highlighted by Developmental Cell (Voices)

31. Zhao H, Ji Q, Wu Z, Wang S, Ren J, Yan K, Wang Z, Hu J, Chu Q, Hu H, Cai Y, Wang Q, Huang D, Ji Z, Li J, Belmonte JCI, Song M*, Zhang W*, Qu J*, Liu GH*. Destabilizing heterochromatin by APOE mediates senescence. Nature Aging. 2022. 2(4):303-316.

—Highlighted by Nature Aging (News ＆ Views)

32. Liang C, Ke Q, Liu Z, Ren J, Zhang W, Hu J, Wang Z, Chen H, Xia K, Lai X, Wang Q, Yang K, Li W, Wu Z, Wang C, Yan H, Jiang X, Ji Z, Ma M, Long X, Wang S, Wang H, Sun H, Belmonte JCI, Qu J*, Xiang AP*, Liu GH*. BMAL1 moonlighting as a gatekeeper for LINE1 repression and cellular senescence in primates. Nucleic Acids Research. 2022. 50(6):3323-3347.
33. Kang W, Jin T, Zhang T, Ma S, Yan H, Liu Z, Ji Z, Cai Y, Wang S, Song M, Ren J, Hu B, Zhou Q, Zhang W*, Qu J*, Bao Y*, Liu GH*. Regeneration Roadmap: database resources for regenerative biology. Nucleic Acids Research. 2022. 50(D1):D1085-D1090.
34. Yan H, Wang R, Ma S, Huang D, Wang S, Ren J, Lu C, Chen X, Zhang W*, Qu J*, Zhou Y*, Liu GH*. Lineage Landscape: A comprehensive database that records lineage commitment across species. Nucleic Acids Research. 2022. 51(D1):D1061-D1066.
35. Liu ZP, Li W, Geng L, Sun L, Wang Q, Yu Y, Yan P, Liang C, Ren J, Song M, Zhao Q, Lei J, Cai Y, Li J, Yan K, Wu Z, Chu Q, Li J, Wang S, Li C, Han JD, Hernandez-Benitez R, Shyh-Chang Ng, Izpisua Belmonte JC, Zhang WQ*, Qu J*, Liu GH*. Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor. Cell Discovery. 2022. 1;8(1):6.
36. Hishida T, Yamamoto M, Hishida-Nozaki Y, Shao C, Huang L, Wang C, Shojima K, Xue Y, Hang Y, Shokhirev M, Memczak S, Sahu SK, Hatanaka F, Ros RR, Maxwell MB, Chavez J, Shao Y, Liao HK, Martinez-Redondo P, Guillen-Guillen I, Hernandez-Benitez R, Esteban CR, Qu J, Holmes MC, Yi F, Hickey RD, Garcia PG, Delicado EN, Castells A, Campistol JM, Yu Y, Hargreaves DC, Asai A, Reddy P, Liu GH, Izpisua Belmonte JC. In vivo partial cellular reprogramming enhances liver plasticity and regeneration. Cell Reports. 2022. 39(4):110730.
37. Wang W, Zheng Y, Sun S, Li W, Song M, Ji Q, Wu Z, Liu Z, Fan Y, Liu F, Li J, Esteban CR, Wang S, Zhou Q, Belmonte JCI, Zhang W*, Qu J*, Tang F*, Liu GH*. A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence. Science Translational Medicine. 2021.13, Jan 6;13(575):eabd2655.

—Video-interviewed by Thomson-Ruters

—Recommended by F1000

38. Zou Z, Long X, Zhao Q, Zheng Y, Song M, Ma S, Wang S, He Y, Esteban CR, Huang J, Yu N, Chan P, Belmonte JCI, Zhang W*, Qu J*, Liu GH*. A single-cell transcriptomic atlas of human skin aging. Developmental Cell. 2021. 56(3):383-397 (Cover story)

—Selected as Cover Story

—Previewed by Developmental Cell (Previews)

—Selected by Essential Science Indicators (ESI) - Highly Cited Papers

39. Liang C, Liu Z, Song M, Li W, Wu Z, Wang Z, Wang Q, Wang S, Yan K, Sun L, Hishida T, Cai Y, Izpisua Belmonte JC, Guillen P, Chan P, Zhou Q, Zhang W*, Qu J*, Liu GH*. Stabilization of Heterochromatin by CLOCK Promotes Stem Cell Rejuvenation and Cartilage Regeneration. Cell Research. 2021. 31(2):187-205.
40. Wang S, Yao X, Ma S, Ping Y, Fan Y, Sun S, He Z, Shi Y, Sun L, Xiao S, Song M, Cai J, Li J, Tang R, Zhao L, Wang C, Wang Q, Zhao L, Hu H, Liu X, Sun G, Chen L, Pan G, Chen H, Li Q, Zhang P, Xu Y, Feng H, Zhao GG, Wen T, Yang Y, Huang X, Li W, Liu Z, Wang H, Wu H, Hu B, Ren Y, Zhou Q, Qu J*, Zhang W*, Liu GH*, Bian XW*. A single-cell transcriptomic landscape of the lungs of patients with COVID-19. Nature Cell Biology. 2021. 23(12):1314-1328 (Leading contact)
41. Zhang H, Li J, Ren J, Sun S, Ma S, Zhang W, Yu Y, Cai Y, Yan K, Li W, Hu B, Chan P, Zhao GG, Belmonte JC, Zhou Q, Qu J*, Wang S*, Liu GH*. Single-nucleus transcriptomic landscape of primate hippocampal aging. Protein Cell. 2021. 12(9):695-716.

—Selected as Cover Story

42. Aging Atlas Consortium, Zhang W*, Qu J*, Bao Y*, Liu GH*. Aging Atlas: a multi-omics database for aging biology. Nucleic Acids Research. 2021. 8;49(D1):D825-D830.

—Selected by Essential Science Indicators (ESI) - Highly Cited Papers

43. Wang S, Zheng Y, Li J, Yu Y, Zhang W, Song M, Liu Z, Min Z, Hu H, Jing Y, He X, Sun L, Esteban C, Chan P, Qiao J, Zhou Q, Belmonte JC*, Qu J*, Tang F*, Liu GH*. Single-Cell Transcriptomic Atlas of Primate Ovarian Aging. Cell. 2020. 180(3):585-600.

—Selected as Cover Story

—Recommended by F1000

—Selected by 2020 Top 10 Scientific Advances in Life Sciences of China

—Selected by Essential Science Indicators (ESI) - Highly Cited Papers

44. Ma S, Sun S, Geng L, Song M, Wang W, Ye Y, Ji Q, Zou Z, Wang S, He X, Li W, Rodriguez Esteban C, Long X, Guo G, Chan P, Zhou Q, Belmonte JC*, Zhang W*, Qu J*, Liu GH*. Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. Cell. 2020. 180(5):984-1001.

—Highlighted by Nature (research highlights)

—Highlighted by Science Translational Medicine (editors' choice)

—Most Picked Paper Award 2020 by Cell Press

—Altmetric Score 731

—Selected by Top 10 Scientific Advances of 2020, China

45. Ma S, Sun S, Li J, Fan Y, Qu J, Sun L, Wang S, Zhang Y, Yang S, Liu Z, Wu Z, Zhang S, Wang Q, Zheng A, Duo S, Yu Y, Belmonte JCI, Chan P, Zhou Q, Song M*, Zhang W*, Liu GH*. Single-Cell Transcriptomic Atlas of Primate Cardiopulmonary Aging. Cell Research. 2020. 31(4):415-432.
46. Yan P, Liu Z, Song M, Wu Z, Xu W, Li K, Ji Q, Wang S, Liu X, Yan K, Esteban CR, Ci W, Izpisua Belmonte JC, Xie W, Ren J, Zhang W*, Sun Q*, Qu J*, Liu GH*. Genome-wide R-loop landscapes during cell differentiation and reprogramming. Cell Reports. 2020. 32(1):107870
47. Wang F, Zhang W, Yang Q, Kang Y, Fan Y, Wei J, Liu Z, Dai S, Li H, Li Z, Xu L, Chu C, Qu J, Si C, Ji W*, Liu GH*, Long C*, Niu Y*. Generation of a Hutchinson-Gilford progeria syndrome monkey model by base editing. Protein Cell. 2020. 11(11):809-824.

—Selected as Cover Story

48. Yan P, Li Q, Wang L, Lu P, Suzuki K, Liu Z, Lei J, Li W, Ren R, He X, Wang S, Ding J, Chan P, Zhang W, Song M, Belmonte JC, Qu J*, Tang F*, Liu GH*. FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration. Cell Stem Cell. 2019. 24(3), 447-461.

—Selected as Cover Story

—Highlighted by Cell Stem Cell (Preview)

49. Deng L, Ren R, Liu Z, Song M, Li J, Wu Z, Ren X, Fu L, Li W, Zhang W, Guillen P, Belmonte J, Chan P, Qu J*, Liu GH*. Stabilizing Heterochromatin by DGCR8 Alleviates Senescence and Osteoarthritis. Nature Communications. 2019.10(1):3329.
50. Fu L, Hu Y, Song M, Liu Z, Zhang W, Yu FX, Wu J, Wang S, Belmonte JC, Chan P, Qu J*, Tang F*, Liu GH*. Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis. PLoS Biology. 2019. 17(4):e3000201.
51. Ren X, Hu B, Song M, Ding Z, Dang Y, Liu Z, Zhang W, Ji Q, Ren R, Ding J, Chan P, Jiang C, Ye K, Qu J*, Tang F*, Liu GH*. Maintenance of Nucleolar Homeostasis by CBX4 Alleviates Senescence and Osteoarthritis. Cell Reports. 2019. 26(13):3643-3656.
52. Zhang W, Wan H, Feng G, Qu J, Wang J, Jing Y, Ren R, Liu Z, Zhang L, Chen Z, Wang S, Zhao Y, Wang Z, Yuan Y, Zhou Q, Li W*, Liu GH*, Hu B*. SIRT6 Deficiency Results in Developmental Retardation in Cynomolgus Monkeys. Nature. 2018. 560(7720):661-665 (Leading contact)

—Highlighted by Nature (NEWS AND VIEWS)

—Selected by 2018 Top 10 Scientific Advances in Life Sciences of China

53. Wang S, Hu B, Ding Z, Dang Y, Wu J, Li D, Liu X, Xiao B, Zhang W, Ren R, Lei J, Hu H, Chen C, Chan P, Li D, Qu J*, Tang F*, Liu GH*. ATF6 Safeguards Organelle Homeostasis and Cellular Aging in Human Mesenchymal Stem Cells. Cell Discovery. 2018. Jan 5;4:2. 
54. Fang J, Yang J, Wu X, Zhang G, Li T, Wang X, Zhang H, Wang CC, Liu GH*, Wang L*. Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7. Aging Cell. 2018.17(4):e12765.
55. Wu Z, Zhang W, Song M, Wang W, Wei G, Li W, Lei J, Huang Y, Sang Y, Chan P, Chen C, Qu J*, Suzuki K*, Belmonte JC*, Liu GH*. Differential Stem Cell Aging Kinetics in Hutchinson–Gilford Progeria Syndrome and Werner Syndrome. Protein Cell. 2018. 9(4):333-350.

—Selected as Cover Story

56. Ren R, Deng L, Xue Y, Suzuki K, Zhang W, Yu Y, Wu J, Sun L, Gong X, Luan H, Yang F, Ju Z, Ren X, Wang S, Tang H, Geng L, Zhang W, Li J, Qiao J, Xu T*, Qu J*, Liu GH*. Visualization of Aging-associated Chromatin Alterations with an Engineered TALE System. Cell Research. 2017. 27(4):483-504.

—Selected as Cover Story

57. Wang L, Yi F, Fu L, Yang J, Wang S, Wang Z, Suzuki K, Sun L, Xu X, Yu Y, Qiao J, Belmonte JC, Yang Z, Yuan Y*, Qu J*, Liu GH*. CRISPR/Cas9-Mediated Targeted Gene Correction in Amyotrophic Lateral Sclerosis Patient iPSCs. Protein Cell. 2017. 8(5):365-378.  

—Selected as Cover Story 

58. Kubben N, Zhang W, Wang L, Voss T, Yang J, Qu J, Liu GH*, Misteli T*, Repression of the Antioxidant NRF2 Pathway in Premature Aging. Cell. 2016. 165(6):1361-1374.

—Highlighted by Cell (Preview)

—Recommended by F1000

59. Pan H, Guan D, Liu X, Li J, Wang L, Wu J, Zhou J, Zhang W, Ren R, Zhang W, Li Y, Yang J, Hao Y, Yuan T, Yuan G, Wang H, Ju Z, Mao Z, Li J, Qu J*, Tang F*, Liu GH*. SIRT6 Safeguards Human Mesenchymal Stem Cells from Oxidative Stress by Coactivating NRF2. Cell Research. 2016. 26(2):190-205.

—Highlighted by Cell (Preview)

综述或观点：

1. Biomarkers of ageing of humans and non-human primates. Nature Reviews Molecular Cell Biology. 2025. 26(11):826-847.
2. The X-Age Project to construct a Chinese aging clock. Nature Aging. 2025. 5(9):1669-1685.
3. Exploring the heterogeneous targets of metabolic aging at single-cell resolution. Trends in Endocrinology & Metabolism. 2025. 36(2):133-146.

—Selected as Cover Story

—Selected by Essential Science Indicators (ESI) - Highly Cited Papers

4. Insights and Interventions in Age-Associated Inflammation. Current Opinion in Genetics and Development. 2025. 91:102306.
5. Metabolic heterogeneity in humans. Cell. 2024. 187(15):3821-3823.

—Leading Edge Voices

6. Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases. Nature Reviews Molecular Cell Biology. 2024. 25(12):979-1000.
7. Stress, epigenetics, and aging: unraveling the intricate crosstalk. Molecular Cell. 2024. 84(1):34-54.

—Selected by Essential Science Indicators (ESI) - Highly Cited Papers

8. Perspectives on biomarkers of reproductive aging for fertility and beyond. Nature Aging. 2024. 4(12):1697-1710.
9. Targeting aging and age-related diseases with vaccines. Nature Aging. 2024. 4(4):464-482.

—Selected by Essential Science Indicators (ESI) - Highly Cited Papers

10. Emerging epigenetic insights into aging mechanisms and interventions. Trends in Pharmacological Sciences. 2024. 45(2):157-172.
11. Multimodal omics approaches to aging and age-related diseases. Phenomics. 2024. 4(1):56-71.
12. The Aging Biomarker Consortium represents a new era for aging research in China. Nature Medicine. 2023. 29(9):2162-2165.
13. Endogenous retroviruses in development and health. Trends in Microbiology. 2023. 32(4):342-354.

—Selected by Essential Science Indicators (ESI) - Highly Cited Papers

14. Acting on ethics and governance of aging research. Trends in Molecular Medicine. 2023. 29(6):419-421.
15. Decoding Aging Hallmarks at the Single-Cell Level. Annual Review of Biomedical Data Science. 2023. 10:6:129-152.
16. Biomarkers of aging. Science China Life Science. 2023. 66(5):893-1066.

—Selected as Cover Story

—Selected by Essential Science Indicators (ESI) - Highly Cited Papers

17. Q&A with Guang-Hui Liu. Cell Reports. 2023. 42(8):112862.
18. Deciphering RNA m⁶A regulation in aging: Perspectives on current advances and future directions. Aging Cell. 2023. 22(10):e13972.
19. A framework of biomarkers for brain aging: a consensus statement by the Aging Biomarker Consortium. Life Medicine. 2023. 2(3): lnad017 

—Selected as Cover Story

20. Hepatocyte reprogramming in liver regeneration: biological mechanisms and applications. The FEBS Journal. 2023. 290(24):5674-5688.
21. Glutathione restoration: a sword to combat skeletal muscle stem cell aging. Life Metabolism. 2023. 2(3):load012.
22. A narrative review of organoids for investigating organ aging: opportunities and challenges. Journal of Bio-X Research. 2023. 6(1):p 3-14.

—Selected as Cover Story

23. Fecal microbiota transplantation: a new strategy to delay aging. hLife. 2023. 1(1):8-11.
24. Longevity secret - a pluripotent superpower. Cell Metabolism. 2022. 34(6):803-804.
25. Voicing the story behind the cover. Developmental Cell. 2022. 57(24):2679-2682.

—Voices

26. A Stem Cell Aging Framework, from Mechanisms to Interventions. Cell Reports. 2022. 41(3):111451.
27. The landscape of aging. Science China Life Science. 2022. 2:1-101.

—Selected by Essential Science Indicators (ESI) - Highly Cited Papers

28. Opening up the black box of human cell plasticity. Innovation. 2022. 3(5):100276.
29. Epigenetic regulation of aging: implications for interventions of aging and diseases. Signal Transduction and Targeted Therapy. 2022. 7(1):374.

—Selected by Essential Science Indicators (ESI) - Highly Cited Papers

30. Genetic Enhancement: an Avenue to Combat Aging-related Diseases. Life Medicine. 2022. 1(3): 307–318.
31. Emerging role of RNA m⁶A modification in aging regulation. Current Medicine. 2022. 1(8).
32. Potential Approaches for Intervening Aging. National Science Open. 2022. 1(2): 20220021.
33. Deciphering aging at three-dimensional genomic resolution. Cell Insight. 2022. 1(3):100034.
34. Rejuvenation of Tissue Stem Cells by Intrinsic and Extrinsic Factors. Stem Cells Translational Medicine.2022. 11(3):231-238.
35. Mitochondrial sirtuins, metabolism, and aging. J Genet Genomics. 2022. 49(4):287-298.
36. The ageing epigenome and its rejuvenation. Nature Reviews Molecular Cell Biology. 2020. 21(3):137-150.
37. Engineering Tissues and Organs: The Road to the Clinic. Cell. 2020. 181(1):22-23.

—Leading Edge Voices

38. Single-cell omics in ageing: a young and growing field. Nature Metabolism. 2020. 2(4):293-302.
39. A β-galactosidase kiss of death for senescent cells. Cell Research. 2020. 30(7):556-557.
40. Treating Osteoarthritis via Gene Therapy with Rejuvenation Factors. Gene Therapy. 2020. 27(7-8):309-311. 
41. Protein Quality Control of Cell Stemness. Cell Regeneration. 2020. 12;9(1):22.
42. Age-Related Cardiopathies Gene Editing. Aging. 2019. 11(5):1327-1328.
43. Epigenetic Modifications in Cardiovascular Aging and Diseases. Circulation Research. 2018. 123(7):773-786.
44. Regulation of Stem Cell Aging by Metabolism and Epigenetics. Cell Metabolism. 2017. 26(3):460-474.