王金勇，中国科学院动物研究所器官再生与智造全国重点实验室，研究员（二级），中国科学院大学博士生导师。研究组长期从事血液与免疫细胞再生的新理论测试、新技术开发、以及新型细胞的临床转化研究。代表性研究贡献包括系统建立“体外诱导种子、体内发育成熟”的两步法再生策略，基于转录因子操纵谱系命运关口前移理论，干细胞再生医学手段实现了多能干细胞（PSC）诱导分化来源T淋巴谱系、B淋巴谱系、NK谱系以及造血免疫多谱系在体移植重建。基于两步法策略开发了NK祖细胞（NKP)疗法，有效解决了过继输注NK细胞体内存续时间短、疗效不显著的固有难题。在国际上首次开发出基于类器官诱导体系诱导多能干细胞/脐血造血干祖细胞高效分化为iNK及CAR-iNK的技术体系，为基于NK细胞疗法的研究与临床转化提供支撑。

个人经历

2021年6月至今：中国科学院动物研究所，研究员

2012年3月-2021年5月：中国科学院广州生物医药与健康研究院，研究员

2007年9月-2012年2月：美国威斯康星医学院、威斯康星大学麦迪逊医学与公共卫生学院，博士后

2006年8月-2007年8月：中国农业科学院上海兽医研究所， 博士后

2001年-2006年：浙江大学， 博士

1997年-2001年：莱阳农学院，学士

血液与免疫细胞再生

1. 干细胞与造血干祖细胞再生

基于多能干细胞(ESC/iPSC)谱系分化原理，结合基因编辑，诱导获得可移植的造血干祖细胞种子，探索代替传统骨髓移植细胞来源，实现治疗肿瘤、遗传病、感染、器官退行衰老、病理炎症等适应症的目的。

2. 干细胞与免疫细胞再生（T, B, NK等免疫细胞）

基于多能干细胞（ESC/iPSC)谱系分化原理，结合基因编辑，获得可移植的淋巴细胞祖细胞，模拟淋巴细胞发育微环境，进一步制备成熟的B, T, NK细胞。结合细胞疗法原理，探索治疗肿瘤和相关免疫疾病。

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