姓  名: 郭晓娇
学  科: 神经行为学
电话/传真: +86-10-64807217/+86-10-64807099 / 
电子邮件: guoxj@ioz.ac.cn
通讯地址: 北京市朝阳区北辰西路1号院5号 中国科学院动物研究所,动物多样性保护与有害动物防控全国重点实验室 100101
更多信息: 生态基因组学及适应性研究组     

简历介绍:

郭晓娇,博士,研究员,硕士生导师,中国科学院特聘骨干。主要以我国重大农业害虫飞蝗为研究对象,聚焦散居-群居两型转变与大规模群聚发生过程,从行为表型、生理调控、神经编码及基因调控等多个层面,系统解析种群内个体间信息交流与相互作用模式,深入阐明飞蝗群聚行为形成的生理生化基础与神经分子机制。相关成果发表于Nature,Science Advances,PNAS,Advanced Science,Nature Communications等重要杂志。同时受邀在Annual Review of Entomology, Current Opinion in Insect Science等国内外重要期刊撰写多篇综述。主持自然科学基金青年科学基金(B类)项目和面上项目多项,是国家重点研发计划的课题负责人,中国科学院前瞻战略科技先导专项(A类先导专项)的课题负责人。担任腾冲科学家论坛发展咨询委员会学部主任委员、昆虫学会青年工作委员会委员,以及Science China Life Sciences,Current Zoology, 昆虫学报与生命科学的青年编委。

教育与工作经历

2026.03至今 研究员,中国科学院动物研究所

2020.07-2026.03 副研究员,中国科学院动物研究所

2016.01-2020.07 助理研究员,中国科学院动物研究所

2014.01 – 2016.01  博士后,中国科学院北京生命科学研究院,方向:生态基因组学

2008.09 – 2014.01  博士,中国科学院动物研究所,方向:生态学

2004.09 – 2008.07  本科,中国科学技术大学,专业:生物技术

研究领域:

  研究方向为昆虫的神经行为学。以群居型和散居型飞蝗作为模式生物,研究群散飞蝗中枢神经系统对外界刺激的差异反应以及内部的信息处理差异,结合神经和分子检测手段揭示飞蝗两型差异行为的神经分子机制。

社会任职:

获奖及荣誉:

腾冲青年科学家奖提名奖(2025)

中国昆虫学会第十一届青年科学技术奖(2023)

承担科研项目情况:

  国家自然科学基金面上项目,飞蝗对苯乙腈响应的行为与神经可塑性的调控机制 (2021.1-2024.12)

  国家自然科学基金青年科学基金项目,两型飞蝗对群聚信息素编码处理的神经机制 (已结题)

  中国博士后第55批面上资助二等奖(已结题)

  中国博士后科学基金第8批特别资助(已结题)

代表论著:

  1. Guo X#, Gao L#, Li S#, Gao J, Wang Y, Lv J, Wei J, Yang J, Ke H, Ding Q, Yang J, Guo F, Zhang H, Lei X*, Kang L* (2025) Decoding 4-vinylanisole biosynthesis and pivotal enzymes in locusts. Nature 644: 420–429
  2. Yang J, He H, Dong S, Lv J, Cheng L, Yu Q, Kang L, Guo X* (2025) Locusts adopt IP3 as a second messenger for olfactory signal transduction. Sci Adv 11: eads1352
  3. Yu QQ, Yang J, Yu J, Lei H, Kang L*, Guo X* (2025) Locusts employ neuronal sensory prioritization to reconcile two conflicting olfactory signals while aggregating. P Natl Acad Sci USA 122
  4. Hu Z#, Zhou Y#, Wang H, Wu Y, Han R, Liu S, Jiang F, Guo X*, Yang M* (2025) Dynamic eIF3-S6 Phase Separation Switch Instructed by m(6)A Modification Drives the Molting of Locusts. Adv Sci (Weinh): e10505
  5. Guo X, Kang L (2025) Phenotypic Plasticity in Locusts: Trade-Off Between Migration and Reproduction. Annu Rev Entomol 70: 23-44
  6. Yang J, Yu Q, Yu J, Kang L*, Guo X.* (2023). 4-Vinylanisole promotes conspecific interaction and acquisition of gregarious behavior in the migratory locust. Proc Natl Acad Sci U S A 120:e2306659120
  7. Guo X, He H, Sun J, Kang L. (2023). Plasticity of aggregation pheromones in insects. Curr Opin Insect Sci 59:101098
  8. Guo, X #, Yu, Q #, Chen, D#, Wei, J #, Yang, P, Yu, J, Wang, X *, and Kang, L* (2020). 4-Vinylanisole is an aggregation pheromone in locusts. Nature 584, 584-588.
  9. Guo, X#, Ma, Z #, Du, B, Li, T, Li, W, Xu, L, He, J, and Kang, L. * (2018). Dop1 enhances conspecific olfactory attraction by inhibiting miR-9a maturation in locusts. Nat Commun 9, 1193.
  10. Guo, X #, Wang, Y #, Sinakevitch, I, Lei, H, and Smith, B.H. * (2018). Comparison of RNAi knockdown effect of tyramine receptor 1 induced by dsRNA and siRNA in brains of the honey bee, Apis mellifera. J Insect Physiol 111, 47-52.
  11. Guo, X #, Ma, Z. #, and Kang, L. * (2015). Two dopamine receptors play different roles in phase change of the migratory locust. Front Behav Neurosci 9, 80.
  12. Guo, X #, Ma, Z #, and Kang, L. * (2013). Serotonin enhances solitariness in phase transition of the migratory locust. Front Behav Neurosci 7, 129.
  13. Ma, Z #, Guo, X #, Lei, H., Li, T., Hao, S., and Kang, L. * (2015). Octopamine and tyramine respectively regulate attractive and repulsive behavior in locust phase changes. Sci Rep 5, 8036.
  14. Chang H, Cassau S, Krieger J, Guo X, Knaden M, et al. (2023). A chemical defense deters cannibalism in migratory locusts. Science 380:537-43
  15. Latshaw, J.S, Mazade, R.E, Petersen, M, Mustard, J.A, Sinakevitch, I, Wissler, L., Guo, X, Cook, C, Lei, H, Gadau, J, Smith, B. (2023) Tyramine and its Amtyr1 receptor modulate attention in honey bees (Apis mellifera). eLife 12
  16. Ma, Z, Guo, X, and Liu, J. (2020). Translocator protein mediates olfactory repulsion. Faseb J 34, 513-524.
  17. Ma, Z, Liu, J, and Guo, X. (2019). A retinal-binding protein mediates olfactory attraction in the migratory locusts. Insect Biochem Mol Biol 114, 103214.
  18. Yang, M, Wang, Y, Liu, Q, Liu, Z, Jiang, F, Wang, H, Guo, X, Zhang, J, and Kang, L. * (2019). A beta-carotene-binding protein carrying a red pigment regulates body-color transition between green and black in locusts. Elife 8.
  19. Ma, Z, Guo, X, and Kang, L. * (2016). Octopamine and Tyramine Signaling in Locusts. 221-233.
  20. He, J, Chen, Q, Wei, Y, Jiang, F, Yang, M, Hao, S, Guo, X, Chen, D, and Kang, L. * (2016). MicroRNA-276 promotes egg-hatching synchrony by up-regulating brm in locusts. Proc Natl Acad Sci USA 113, 584-589.
  21. Chen, B, Ma, R, Ma, G, Guo, X, Tong, X, Tang, G, and Kang, L. * (2015). Haemocyanin is essential for embryonic development and survival in the migratory locust. Insect Mol Biol 24, 517-527.
  22. Wang, X, Fang, X, Yang, P, Jiang, X, Jiang, F, Zhao, D, Li, B, Cui, F, Wei, J, Ma, C….Guo, X, et al. (2014). The locust genome provides insight into swarm formation and long-distance flight. Nat Commun 5.
  23. Yang, M, Wei, Y, Jiang, F, Wang, Y, Guo, X, He, J, and Kang, L. * (2014). MicroRNA-133 Inhibits Behavioral Aggregation by Controlling Dopamine Synthesis in Locusts. PLoS Genet 10.
  24. Ma, Z, Guo, W, Guo, X, Wang, X, and Kang, L. * (2011). Modulation of behavioral phase changes of the migratory locust by the catecholamine metabolic pathway. Proc Natl Acad Sci U S A. 108, 3882-3887.
  25. Zhang, S, Wei, J, Guo, X, Liu, T, and Kang, L. * (2010). Functional Synchronization of Biological Rhythms in a Tritrophic System. PloS One 5.
  26. 郭晓娇,康乐; 蝗虫群聚信息素研究的过去、现在和未来,应用昆虫学报,2023, 60(2): 315-322.
  27. 程李莉, 康乐*, 郭晓娇* (2023). 昆虫嗅觉系统编码规律. 自然杂志 45, 239-246.

(Cheng, L, Kang, L *, and Guo, X* (2023). Principles of insect olfactory system coding. Chinese Journal of Nature 45, 239-246.)

授权专利

  1. 郭晓娇,李世炜,康乐. 一种昆虫信息素释放与昆虫诱捕装置,实用新型专利授权,专利号:ZL 2024 21813259.3

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