韩玉岭，博士，中国科学院动物所器官再生与智造全国重点实验室研究员，博士生导师，类器官与疾病病理研究组课题组长，获国家级青年人才项目支持。2013年于南开大学生命科学学院获学士学位，2019年获中国科学院生物物理研究所博士学位，同年赴康奈尔大学威尔医学院从事博士后研究。2024年1月全职加入中国科学院动物研究所，研究方向是基于类器官的疾病模型构建和疾病病理研究。自2019年来，以通讯和第一作者（含共同）发表论文15篇，包括Nature (2021) ，Cell (2019) ，Nature Methods (2022) ，Cell Stem Cell (2020, 2022, 2024a, 2024b) ，Circulation Research (2021, 2022), Advanced Science (2025) 等，总引用2000余次。担任国家自然科学基金面上项目负责人，重点研发项目课题负责人，中国科学院B类先导专项项目负责人，同时承担国家自然科学基金创新研究群体项目（A类），中国科学院C类先导专项，中国科学院稳定支持基础研究领域青年团队计划等。担任多本杂志副主编、编委和审稿人。

利用人类胚胎干细胞和多能干细胞分化不同组织细胞/类器官（包括肺、肝脏、肾脏及胰腺等类器官）构建生理相关的疾病模型，来克服传统细胞系对复杂的人体细胞和器官系统建模的局限。通过模拟各类器官相关疾病的发生与发展过程，结合多组学测序技术和高通量药物筛选平台，深入研究呼吸系统、消化系统、免疫系统及代谢系统等疾病进程中的分子机制，并探索潜在的治疗策略。

1.遗传与变异对疾病进程的影响

2.构建复杂类器官的生理病理模型

3.开发与鉴定潜在的干预策略

1. Han Y^#, Duan X^#, Yang L^#, Nilsson-Payant BE^#, Wang P^#, Duan F^#, Tang X^#, Yaron TM^#, Zhang T, Uhl S, Bram Y, Richardson C, Zhu J, Zhao Z, Redmond D, Houghton S, Nguyen DT, Xu D, Wang X, Jessurun J, Borczuk A, Huang Y, Johnson JL, Liu Y, Xiang J, Wang H^#, Cantley LC^*, tenOever BR^*, Ho DD^*, Pan FC^*, Evans T^*, Chen HJ^*, Schwartz RE^* and Chen S^*. Identification of SARS-CoV-2 inhibitors using lung and colonic organoids. Nature. 2021; 589: 270-275.
2. Wang X^#, Xuan Y^#, Han Y^#, Ding X, Ye K, Yang F, Gao P, Goff SP and Gao G^*. Regulation of HIV-1 Gag-Pol Expression by Shiftless, an Inhibitor of Programmed-1 Ribosomal Frameshifting. Cell. 2019; 176:625-635 e14.
3. Han Y^#, Yang L^#, Lacko L and Chen S^*. Human Organoid Models to Study SARS-CoV-2 Infection. Perspective, Nature Methods. 2022; 4:418-428.
4. Yang L^#, Kim TW^#, Han Y^#, Nair MS^#, Harschnitz O^#, Zhu J^#, Wang P^#, Koo SY, Lacko LA, Chandar V, Bram Y, Zhang T, Zhang W, He F, Pan C, Wu J, Huang Y, Evans T, van der Valk P, Titulaer MJ, Spoor JKH, Furler O'Brien RL, Bugiani M, Van de Berg WDJ, Schwartz RE^*, Ho DD^*, Studer L^*, Chen S^*. SARS-CoV-2 infection causes dopaminergic neuron senescence. Cell Stem Cell. 2024; 31(2):196-211.e6.
5. Yang L^#, *, Han Y^#, Zhang T^#, Dong X, Ge J, Roy A, Zhu J, Lu T, Jeya Vandana J, de Silva N, Robertson CC, Xiang JZ, Pan C, Sun Y, Que J, Evans T, Liu C, Wang W, NajiA, Parker SCJ, Schwartz RE^* and Chen S^*. Human vascularized macrophage-islet organoids to model immune-mediated pancreatic beta cell pyroptosis upon viral infection. Cell Stem Cell. 2024; 31(11):1612-1629.e8.
6. Yang L^#, Kim TW^#, Han Y^#, Nair MS^#, Harschnitz O^#, Zhu J^#, Wang P^#, Koo SY, Lacko LA, Chandar V, Bram Y, Zhang T, Zhang W, He F, Pan C, Wu J, Huang Y, Evans T, van der Valk P, Titulaer MJ, Spoor JKH, Furler O'Brien RL, Bugiani M, W DJVdB, Schwartz RE^*, Ho DD^*, Studer L^* and Chen S^*. SARS-CoV-2 infection causes dopaminergic neuron senescence. Cell Stem Cell. 2024.
7. Yang L#, Han Y#, Zhou T#, Lacko LA, Saeed M, Tan C, Danziger R, Zhu J, Zhao Z, Cahir C, GianiAM, Li Y, Dong X, Moroziewicz D, Team NGSCA, Paull D, Chen Z, Zhong A, Noggle SA, Rice CM, Qi Q, Evans T and Chen S* . Isogenic human trophectoderm cells demonstrate the role of NDUFA4 and associated variants in ZIKV infection. iScience. 2023; 26:107001.
8. Han Y^#, Tan L^#, Zhou T^#, Yang L^#, Carrau L^#, Lacko LA, Saeed M, Zhu J, Zhao Z, Nilsson-Payant BE, Lira Neto FT, Cahir C, Giani AM, Chai JC, Li Y, Dong X, Moroziewicz D, Team NGSCA, Paull D, Zhang T, Koo S, Tan C, Danziger R, Ba Q, Feng L, Chen Z, Zhong A, Wise GJ, Xiang JZ, Wang H, Schwartz RE, tenOever BR, Noggle SA, Rice CM, Qi Q, Evans T and Chen S^*. A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants. Cell Stem Cell. 2022; 29:1475-1490 e6.
9. Han Y^#, Zhu J^#, Yang L^#, Nilsson-Payant BE^#, Hurtado R, Lacko L, Sun X, Gade AR, Higgins CA, Sisso WJ, Dong X, Wang M, Zhengming Chen, Ho DD, Pitt GS, Schwartz RE^*, tenOever BR^*, Evans T^* and Chen S^*. SARS-CoV-2 infection Induces Ferroptosis of Sinoatrial Node-like Pacemaker Cells. Circ Res. 2022; 130:963-977. Circulation Research Best Manuscript 2022.
10. Yang L^#, Han Y^#, Jaffre F^#, Nilsson-Payant BE^#, Bram Y^#, Wang P, Zhu J, Zhang T, Redmond D, Houghton S, Uhl S, Borczuk A, Huang Y, Richardson C, Chandar V, Acklin JA, Lim JK, Chen Z, Xiang J, Ho DD, tenOever BR^*, Schwartz RE^*, Evans T^* and Chen S^*. An Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts. Circ Res. 2021;129:33-46. Cover story.
11. Han Y^#, Leng D^#, Zhang T^#, Ge J, Fang Y, Lu T, Dong X, Nair MS, de Silva N, Han Z, Jiao T, Huang Y, Zhao M, Saqi A, Hibshoosh H, Meng Z, Xiang JZ, Pan C, Sun Y, Ho DD, Evans T, Liu J, Yang L^*, Que J^*, Chen S^*. A Human Immuno-Lung Organoid Model to Study Macrophage-Mediated Lung Cell Senescence Upon SARS-CoV-2 Infection. Advanced Science. 2025; 12, e03932.
12. Yang L^#, Nilsson-Payant BE^#, Han Y^#, Jaffré F^#, Zhu J^#, Wang P, Zhang T, Redmond D, Houghton S and Møller R, Hoagland D, Carrau L, Horiuchi S, Goff M, Lim JK, Bram Y, Richardson C, Chandar V, Borczuk A, Huang Y, Xiang J, Ho DD^*, Schwartz RE^*, tenOever BR, Evans T^* and Chen S^*. Cardiomyocytes Recruit Monocytes upon SARS-CoV-2 Infection by Secreting CCL2. Stem Cell Reports. 2021; Jul 20.
13. Yang L^#, Han Y^#, Nilsson-Payant BE^#, Gupta V^#, Wang P, Duan X, Tang X, Zhu J, Zhao Z, Jaffre F, Zhang T, Kim TW, Harschnitz O, Redmond D, Houghton S, Liu C, Naji A, Ciceri G, Guttikonda S, Bram Y, Nguyen DT, Cioffi M, Chandar V, Hoagland DA, Huang Y, Xiang J, Wang H, Lyden D, Borczuk A, Chen HJ, Studer L, Pan FC^*, Ho DD^*, tenOever BR^*, Evans T^*, Schwartz RE^* and Chen S^*. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids. Cell Stem Cell. 2020; 27:125-136 e7. Best of Cell Stem Cell 2020.

2024年招生视频：https://mp.weixin.qq.com/s/rU_TE7n6Cbi0UsFKVxl_Wg