叶燕霞  博士 中国科学院动物研究所副研究员。

工作经历：

2024.02-至今，中国科学院动物研究所，副研究员

2016.01-2024.01，中国科学院动物研究所，助理研究员

2012.10-2016.01，中国医学科学院北京协和医院，风湿免疫科，博士后

主要致力于免疫、血液循环和心血管系统的衰老及相关疾病的研究，利用人干细胞、灵长类动物模型、单细胞测序、多层次组学和基因编辑等技术系统解析衰老以及相关疾病的分子机制及干预措施。以第一/共同第一作者在 Cell Stem Cell、Nature Aging（封面论文）、Science Translational Medicine 等期刊发表研究论文，相关研究成果入选2023年度“中国生命科学十大进展”。

基金委，面上基金项目，项目负责人。项目时间：2025.01-2028.12

科技部，国家重点研发计划，课题骨干。项目时间：2022.12-2027.11

科技部，国家重点研发计划，课题骨干。项目时间：2022.12-2025.12

基金委，青年科学基金项目，项目负责人。项目时间：2017.01-2019.12

1. Yanxia Ye^#, Honghao Zhang^#, Zijuan Xin^#, Wanling Sun^#, Lixiao Liu, Muzhao Xiong, Hongkai Zhao, Yiyuan Zhang, Jiaqi Geng, Liyun Zhao, Jingyi Li, Xiaoyu Jiang, Yuesheng Zuo, Shuai Ma, Hongjia Zhang, Si Wang, Guoguang Zhao, Juan Carlos Izpisua Belmonte, Jing Qu*, Weiqi Zhang*, Guang-Hui Liu*. Vitamin C attenuates primate bone marrow aging at the molecular and progenitor level. Cell Stem Cell. 2026. 33(8):1379-1397.
2. Yanxia Ye^#, Kuan Yang^#, Haisong Liu^#, Yang Yu^#, Moshi Song^#, Daoyuan Huang, Jinghui Lei, Yiyuan Zhang, Zunpeng Liu, Qun Chu, Yanling Fan, Sheng Zhang, Yaobin Jing, Concepcion Rodriguez Esteban, Si Wang, Juan Carlos Izpisua Belmonte, Jing Qu*, Weiqi Zhang*, Guang-Hui Liu*. SIRT2 counteracts primate cardiac aging via deacetylation of STAT3 that silences CDKN2B. Nature Aging. 2023. 3(10): 1269-1287. (Cover story)
3. Shuai Ma^#, Si Wang^#, Yanxia Ye^#, Jie Ren, Ruiqing Chen, Wei Li, Jiaming Li, Liyun Zhao, Qian Zhao, Guoqiang Sun, Ying Jing, Yuesheng Zuo, Muzhao Xiong, Yuanhan Yang, Qiaoran Wang, Jinghui Lei, Shuhui Sun, Xiao Long, Moshi Song, Shuyang Yu, Piu Chan, Jianwei Wang, Qi Zhou, Juan Carlos Izpisua Belmonte, Jing Qu*, Weiqi Zhang*, Guang-Hui Liu*. Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues. Cell Stem Cell. 2022. 29(6): 990-1005.e10.
4. Shuai Ma^#, Shuhui Sun^#, Lingling Geng^#, Moshi Song^#, Wei Wang, Yanxia Ye, Qianzhao Ji, Zhiran Zou, Si Wang, Xiaojuan He, Wei Li, Concepcion Rodriguez Esteban, Xiao Long, Guoji Guo, Piu Chan, Qi Zhou, Juan Carlos Izpisua Belmonte*, Weiqi Zhang*, Jing Qu*, Guang-Hui Liu*. Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. Cell. 2020. 180(5): 984-1001.e22.
5. Shuyan Wang^#, Zhongfeng Liu^#, Yanxia Ye^#, Bingnan Li, Tiantian Liu, Weiqi Zhang, Guang-Hui Liu, Y. Alex Zhang, Jing Qu*, Dawei Xu*, Zhiguo Chen*. Ectopic hTERT expression facilitates reprograming of fibroblasts derived from patients with Werner syndrome as a WS cellular model. Cell Death & Disease. 2018. 9(9): 923.
6. Lidan Zhao, Yanxia Ye, Xuan Zhang*. B cells biology in systemic lupus erythematosus-from bench to bedside. Sci China Life Sci. 2015. 58(11): 1111-1125.
7. Xiangni Wu^#, Yanxia Ye^#, Jingwen Niu^#, Yang Li, Xin Li, Xin You, Hua Chen, Lidan Zhao, Xiaofeng Zeng, Fengchun Zhang, Fulin Tang, Wei He, Xuetao Cao, Xuan Zhang*, Peter E Lipsky*. Defective PTEN regulation contributes to B cell hyperresponsiveness in systemic lupus erythematosus. Sci Transl Med. 2014. 6(246): 246ra99.
8. Yanxia Ye, Xiuyan Huang, Yaxing Zhang, Xinqiang Lai, Xiaoping Wu, Xiangfeng Zeng, Xiangao Tang, Yaoying Zeng*. Calcium influx blocked by SK&F 96365 modulates the LPS plus IFN-γ-induced inflammatory response in murine peritoneal macrophages. International Immunopharmacology. 2012. 12(2):384-393.
9. Yanxia Ye, Yaxing Zhang, Xiaoyu Lu, Xiuyan Huang, Xiangfeng Zeng, Xinqiang Lai, Yaoying Zeng*. The anti-inflammatory effect of the SOCC blocker SK&F 96365 on mouse lymphocytes after stimulation by Con A or PMA/ionomycin. Immunobiology. 2011. 216(9):1044-1053.