姓  名: 蔚欣
学  科: 发育生物学
电话/传真: +86-10-64807083 / 
电子邮件: davidyx95@163.com
通讯地址: 北京市朝阳区大屯路甲3号干细胞与再生医学创新研究院 100101
更多信息: 生殖病理学研究组     

简历介绍:

蔚欣,男,博士,副研究员;中国科学院动物研究所生殖病理学研究组成员。主持中国博士后科学基金第76批面上资助项目,作为主要参与人参与国家自然科学基金企业联合基金项目和国家自然科学基金重大项目等。2017年毕业于西北农林科技大学;2023年于中国科学院动物研究所获得医学博士学位,师从王雁玲研究员;2026年晋升为副研究员。

主要从事母胎营养传输与代谢调节、母胎界面免疫调控及关键功能单元模拟体系构建研究。围绕合体滋养层细胞(STB)分化与内分泌/屏障功能建立、母胎界面免疫耐受形成及母体供给通路重塑等核心科学问题,系统解析“代谢重编程—表观遗传调控—细胞命运决定/功能执行”的分子机制,并探索其在子痫前期、胎儿生长受限、早期流产及反复妊娠失败等妊娠相关疾病中的胎盘源性致病机制与潜在干预靶点。以第一作者/共同第一作者在Cell Stem Cell、Nature Reviews Endocrinology、National Science Review、Cell Communication and Signaling等国际期刊发表10篇论文,参与发表论文9篇。目前担任Cell Proliferation, Placenta, Seminars in Immunopathology等期刊的审稿人。

研究领域:

社会任职:

获奖及荣誉:

承担科研项目情况:

  1. 国家自然科学基金企业联合基金(U25C2007):基于免疫-成纤维细胞互作调控探究病理性子宫瘢痕-胎盘植入性疾病的发生机制与干预策略(2026.01至今),主要参与人,210万元
  2. 中国博士后科学基金第76批面上自助(2024M763250):组蛋白乙酰化控制人胎盘滋养层细胞命运的机制(2024.12-2026.01),承担,8万元

代表论著:

  1. Xin Yu#, Qianqian Li#; Xuan Shao*; Amanda N Sferruzzi-Perri*, Yan-Ling Wang*. Fine-tuned programming of placenta trophoblast determines optimal maternal–fetal nutrient allocation[J], Current Opinion in Genetics & Development, 2025, 91:102305.
  2. Xin Yu#, Hao Wu#, Jiali Su#, Xupeng Liu, Kun Liang, Qianqian Li, Ruoxuan Yu, Xuan Shao, Hongmei Wang*, Yan-Ling Wang*, Ng Shyh-Chang*. Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells[J]. Cell Stem Cell, 2024, S1934-5909(24)00253-4. 
  3. Xin Yu#, Hongyu Wu#, Yun Yang, Feiyang Wang, Yan-Ling Wang*, Xuan Shao*. Placental development and pregnancy-associated diseases[J]. Maternal-Fetal Medicine, 2022, 4(1): 36-51.
  4. Yuanfeng Gao#, Xin Yu#, Yuefan Wang#, Hongmei Wang*, Yan-Ling Wang*, Ng Shyh-Chang*. Metabolic control of feto–placental development and pregnancy outcomes[J], Nature Reviews Endocrinology, 2025
  5. Yuelin Zhu#, Qianqian Li#, Xin Yu#, Yun Yang, Qian Yang, Yongqing Wang*, Xuan Shao*, Yan-Ling Wang*. Lactate shuttle between cytotrophoblast and syncytiotrophoblast in the placenta enhances ferroptosis resistance and maintains placental homeostasis: implications for early pregnancy loss[J], Cell Communication and Signaling, 2025, 23, 438 
  6. Shenglong Ye#, Xin Yu#, Wentong Jia, Wenlong Li, Yan-Ling Wang*, Yongqing Wang*, Hydroxychloroquine improves pregnancy outcomes by inhibiting excessive autophagy in extravillous trophoblast caused by an anti-phospholipid syndrome[J], International Immunopharmacology, 2025, 157:114749. 
  7. Wentong Jia#, Liyang Ma#, Xin Yu#, Feiyang Wang, Qian Yang, Xiaoye Wang, Mengjie Fan, Yan Gu, Ran Meng, Jian Wang, Yu-Xia Li, Rong Li*, Xuan Shao*, Yan-Ling Wang*. Human CD56+CD39+ dNK cells support fetal survival through controlling trophoblastic cell fate: immune mechanisms of recurrent early pregnancy loss[J]. National Science Review, 2024, 11(6):142. 
  8. Yeling Ma#; Xin Yu#; Shenglong Ye#; Wenlong Li; Qian Yang; Yu-Xia Li; Yongqing Wang*, Yan-Ling Wang*. Immune-regulatory properties of endovascular extravillous trophoblast cells in human placenta[J]. Placenta, 2024, 145:107-116. 
  9. Yeling Ma#, Xin Yu#, Yu-Xia Li, Yan-Ling Wang*. HGF/c-Met signal regulates early differentiation of placental trophoblast cells[J]. Journal of Reproduction and Development, 2021, 67(2):89-97.
  10. Yeling Ma#, Xin Yu#, Lanmei Zhang#, Juan Liu, Xuan Shao, Yu-Xia Li, Yan-Ling Wang*. Uterine decidual niche modulates the progressive dedifferentiation of spiral artery vascular smooth muscle cells during human pregnancy[J]. Biology of Reproduction, 2020, 104(3):624-637.
  11. Mingming Fan#, Hongyu Wu#, Yuan Xie#, Ming Liu, Xin Yu, Feiyang Wang, Zhenyu Xiao, Hongmei Wang, Xuan Shao*, Yan-Ling Wang*, Maternal Nutritional Status Governs Fetal Development by Modulating Imprinting Gene GAB1-Mediated Trophoblast Differentiation in the Placenta[J], Cell Proliferation. 2025, 23:e 70069.
  12. Wenlong Li#, Shanshan Zhang#, Shenglong Ye#, Xiao Fang, Xin Yu, Xiaoye Wang*, Yeling Ma*, Yan-Ling Wang*, Evaluation of optimal trophoblastic models to mimic uterine vessel remodeling in human pregnancy[J], Biology of Reproduction. 2025, 13:ioaf 108.
  13. Qianqian Li#, Yuelin Zhu#, Xin Yu, Xuan Shao*, Yan-Ling Wang*. Molecular regulation and functional benefits of trophoblast syncytialization in optimizing maternal-fetal nutrient allocation[J]. Placenta, 2025, 6:S0143-4004(25)00208-5.
  14. Juan Liu#, Yun Yang#, Hongyu Wu#, Feihong Dang, Xin Yu, Feiyang Wang, Yongqing Wang, Yangyu Zhao, Xiaoming Shi, Wei Qin, Yanling Zhang, Yu-Xia Li, Chu Wang, Xuan Shao*, Yan-Ling Wang*. Hypoxia-Induced O-GlcNAcylation of GATA3 Leads to Excessive Testosterone Production in Preeclamptic Placentas[J]. MedComm, 2025, Feb 23;6(3):e70115.
  15. Xuan Shao#, Yun Yang#, Yanlei Liu#, Yongqing Wang#, Yangyu Zhao, Xin Yu, Juan Liu, Yu-Xia Li, Yan-Ling Wang*. Orchestrated feedback regulation between melatonin and sex hormones involving GPER1-PKA-CREB signaling in the placenta[J]. Journal of Pineal Research, 2023, 75(4):e12913.
  16. Xuan Shao#; Wenzhe Yu#; Yun Yang#; Feiyang Wang; Xin Yu; Hongyu Wu; Yeling Ma; Bin Cao*, Yan-Ling Wang*. The mystery of the life tree: the placentas[J]. Biology of Reproduction, 2022, 107(1):301-316.
  17. Qian Yang#, Yeling Ma#, Yanlei Liu, Xuan Shao, Wentong Jia, Xin Yu, Yu-Xia Li, Long Yang, Wenwen Gu, Haibin Wang, Jian Wang*, Yan-Ling Wang*. MNSFβ regulates placental development by conjugating IGF2BP2 to enhance trophoblast cell invasiveness[J]. Cell Proliferation, 2021, 54(12): e13145. 
  18. Juan Liu#, Xuan Shao#, Wei Qin#, Yanling Zhang#, Feihong Dang, Qian Yang, Xin Yu, Yu-Xia Li, Xing Chen, Chu Wang*, Yan-Ling Wang*. Quantitative chemoproteomics reveals O-GlcNAcylation of Cystathionine γ-lyase (CSE) represses trophoblast syncytialization[J].Cell Chemical Biology, 2021, 28(6):788-801.
  19. Peng Xu#, Zhilang Li#, Yongqing Wang#, Xin Yu, Xuan Shao, Yu-xia Li, Chun Peng, Yangyu Zhao*, Yan-Ling Wang*. miR-18a Contributes to Preeclampsia by Downregulating Smad2 (Full Length) and Reducing TGF-β Signaling[J]. Molecular Therapy Nucleic Acids, 2020, 22:542-556.

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